Dna molecules encoding human nhl, a dna helicase

ABSTRACT

The present invention disclosed isolated nucleic acid molecules (polynucleotides) which encode NHL, a putative DNA helicase. The present invention in turn relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding NHL, substantially purified forms of associated NHL, associated mutant proteins, and methods associated with identifying compounds which modulate NHL, which will be useful in the treatment of various neoplastic disorders. Both a genomic clone containing regulatory and intron sequences, as well as the exon structure and open reading frame of human NHL are disclosed.

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit, under 35 U.S.C. §119(e), ofU.S. provisional application 60/169,970 filed Dec. 9, 1999.

STATEMENT REGARDING FEDERALLY-SPONSORED R&D

[0002] Not Applicable

REFERENCE TO MICROFICHE APPENDIX

[0003] Not Applicable

FIELD OF THE INVENTION

[0004] The present invention relates in part to isolated nucleic acidmolecules (polynucleotides) which encode NHL, a putative DNA helicase.The present invention also relates to recombinant vectors andrecombinant hosts which contain a DNA fragment encoding NHL,substantially purified forms of associated NHL, associated mutantproteins, and methods associated with identifying compounds whichmodulate NHL, which will be useful in the treatment of variousneoplastic disorders, given that this gene is located at 20q13.3 andimmediately adjacent to M68/DcR3, which is involved in tumor growth.Also included within the present invention is a human genomic fragmentrepresenting this portion of the human genome, along with threeadditional genes (M68/DcR3, SCLIP, and ARP).

BACKGROUND OF THE INVENTION

[0005] Naumovski et al. (1985, Mol. Cell Biol. 5:17-26; Reynolds et al.(1985 Nucleic Acid Res 13:2357-2372) and Weber et al. (1990 EMBO J.9:1437-1447) disclose members of the RAD3/FRCC2 gene family of DNAhelicases.

[0006] It is known that several chemotherapeutic agents inhibithelicases, including actinomycin CI, daunorubicin and nogalamycin(Tuteja, et al., 1997, Biochem. Biophys. Res. Comm. 236(3):636-640), anda prostate cancer drug, CI-958 (Lun, et al.,1998, Cancer Chemother.Pharmacol. 42(6):447-453). In addition, some topoisomerases have beenshown to have anti-cancer activity.

[0007] Despite the identification of the aforementionedhelicase-encoding genes and chemotherapeutic agents, it would beadvantageous to identify additional genes which reside withinchromosomal regions associated with a disease state such as cancer aswell as a gene which encodes a type of protein which may be associatedwith that disease. The present invention addresses and meets this needby disclosing a DNA molecule encoding a DNA helicase with a chromosomallocation suggestive of association with cancer.

SUMMARY OF THE INVENTION

[0008] The present invention relates to an isolated or purified nucleicacid molecule (polynucleotide) which encodes a novel mammalian DNAhelicase.

[0009] The present invention also relates to an isolated nucleic acidmolecule (polynucleotide) which encodes mRNA which expresses a novelhuman DNA helicase, NHL.

[0010] A preferred aspect of the present invention relates to anisolated or purified DNA molecule which encodes human NHL, thenucleotide sequence as set forth in FIG. 1A-B and SEQ ID NO: 1.

[0011] The present invention also relates to biologically activefragments or mutants of SEQ ID NO: 1 which encode a mRNA moleculeexpressing a novel DNA helicase, NHL. Any such biologically activefragment and/or mutant will encode either a protein or protein fragmentwhich at least substantially mimics the biological properties of thehuman NHL protein disclosed herein in FIG. 2 and as set forth as SEQ IDNO: 2. Any such polynucleotide includes but is not necessarily limitedto nucleotide substitutions, deletions, additions, amino-terminaltruncations and carboxy-terminal truncations such that these mutationsencode mRNA which express a functional NHL protein in a host cell, so asto be useful for screening for agonists and/or antagonists of NHLactivity.

[0012] The present invention also relates to recombinant vectors andrecombinant hosts, both prokaryotic and eukaryotic, which contain thesubstantially purified nucleic acid molecules disclosed throughout thisspecification.

[0013] The present invention also relates to a substantially purifiedform of a human NHL protein which comprises the amino acid sequencedisclosed in FIG. 2 and set forth as SEQ ID NO: 2.

[0014] A preferred aspect of this portion of the present invention is aNHL protein which consists of the amino acid sequence disclosed in FIG.2 and set forth as SEQ ID NO: 2.

[0015] Another preferred aspect of the present invention relates to asubstantially purified NHL protein, preferably a human NHL protein,obtained from a recombinant host cell containing a DNA expression vectorcomprises a nucleotide sequence as set forth in SEQ ID NO: 1 andexpresses the respective NHL protein. It is especially preferred is thatthe recombinant host cell be a eukaryotic host cell, such as a mammaliancell line.

[0016] The present invention also relates to biologically activefragments and/or mutants of a NHL protein comprising the amino acidsequence as set forth in SEQ ID NO: 2, including but not necessarilylimited to amino acid substitutions, deletions, additions, aminoterminal truncations and carboxy-terminal truncations such that thesemutations provide for proteins or protein fragments of diagnostic,therapeutic or prophylactic use and would be useful for screening forselective modulators, including but not limited to agonists and/orantagonists for human NHL pharmacology.

[0017] A preferred aspect of the present invention is disclosed in FIG.2 and is set forth as SEQ ID NO: 2, a respective amino acid sequencewhich encodes human NHL. Characterization of one or more of these DNAhelicase-like proteins allows for screening methods to identify novelNHL modulators that may be useful in the treatment of human neoplasticdisorders. The modulators selected through such screening and selectionprotocols may be used alone or in conjunction with other cancertherapies. As noted above, heterologous expression of a NHL protein willallow the pharmacological analysis of compounds which modulate NHLactivity and hence may be useful in various cancer therapies. To thisend, heterologous cell lines expressing a NHL protein can be used toestablish functional or binding assays to identify novel NHL modulators.

[0018] The present invention also relates to polyclonal and monoclonalantibodies raised in response to either the NHL or a biologically activefragment of NHL.

[0019] The present invention relates to transgenic mice comprisingaltered genotypes and phenotypes in relation to NHL and its in vivoactivity.

[0020] The present invention also relates to NHL fusion constructs,including but not limited to fusion constructs which express a portionof the NHL protein linked to various markers, including but in no waylimited to GFP (Green fluorescent protein), the MYC epitope, and GST.Any such fusion constructs may be expressed in the cell line of interestand used to screen for NHL modulators.

[0021] Therefore, the present invention relates to methods of expressingmammalian NHL, and preferably human NHL, biological equivalentsdisclosed herein, assays employing these gene products, recombinant hostcells which comprise DNA constructs which express these proteins, andcompounds identified through these assays which act as agonists orantagonists of NHL activity.

[0022] The present invention also relates to the isolated genomicsequence which comprises SEQ ID NO: 1, a 115 kb genomic fragment setforth herein as SEQ ID NO: 3. As especially preferred aspect of thisportion of the invention is the region of the genomic fragment of SEQ IDNO: 3 which comprises the regulatory and coding regions of human NHL, aswell as intervening sequences (introns). This 115 kb fragment containsat least the coding region of four genes, NHL, M68/DcR3, SCLIP and ARP.As discussed herein, it has been shown that this region of chromosome 20is associated with tumor growth. Therefore, an aspect of this inventionalso comprises the use of one or more regions of this 115 kb genomicsequence to identify compounds which up or downregulate expression ofone or more of the genes localized within this 115 kb region, whereinthis up or down regulation results in an interference of tumor growth.For example, a transcription element of one of these four genes may beresponsible for M68/DcR3 ( and/or NHL) overexpression in tumors, and ifM68 or NHL overexpression in tumors has a caustic role, blockage ofM68/DcR3 or NHL overexpression in tumors by interfering with thistranscription site will be useful.

[0023] It is an object of the present invention to provide an isolatednucleic acid molecule (e.g., SEQ ID NO: 1) which encodes novel form ofhuman NHL, or fragments, mutants or derivatives of human NHL as setforth in FIG. 2 and SEQ ID NO: 2. Any such polynucleotide includes butis not necessarily limited to nucleotide substitutions, deletions,additions, amino-terminal truncations and carboxy-terminal truncationssuch that these mutations encode mRNA which express a protein or proteinfragment of diagnostic, therapeutic or prophylactic use and would beuseful for screening for selective modulators of human NHL activity.

[0024] It is a further object of the present invention to provide themammalian, and especially human, NHL proteins or protein fragmentsencoded by the nucleic acid molecules referred to in the precedingparagraph.

[0025] It is a further object of the present invention to providerecombinant vectors and recombinant host cells which comprise a nucleicacid sequence encoding mammalian, and especially human, NHL protein andbiological equivalent thereof.

[0026] It is an object of the present invention to provide asubstantially purified form of human NHL, as set forth in FIG. 2 and SEQID NO: 2.

[0027] Is another object of the present invention to provide asubstantially purified recombinant form of a NHL protein which has beenobtained from a recombinant host cell transformed or transfected with aDNA expression vector which comprises and appropriately expresses acomplete open reading frame as set forth in SEQ ID NO: 1, resulting in afunctional, processed form of NHL. It is especially preferred is thatthe recombinant host cell be a eukaryotic host cell, such as a mammaliancell line.

[0028] It is an object of the present invention to provide forbiologically active fragments and/or mutants of mammalian, andespecially human, NHL, such as set forth in SEQ ID NO: 2, including butnot necessarily limited to amino acid substitutions, deletions,additions, amino terminal truncations and carboxy-terminal truncationssuch that these mutations provide for proteins or protein fragments ofdiagnostic, therapeutic and/or prophylactic use.

[0029] It is also an object of the present invention to use NHL proteinsor biological equivalent to screen for modulators, preferably selectivemodulators, of human NHL activity. Any such compound may be useful inscreening for and selecting compounds active against human neoplasticdisorders.

[0030] As used herein, “substantially free from other nucleic acids”means at least 90%, preferably 95%, more preferably 99%, and even morepreferably 99.9%, free of other nucleic acids. Thus, a human NHL DNApreparation that is substantially free from other nucleic acids willcontain, as a percent of its total nucleic acid, no more than 10%,preferably no more than 5%, more preferably no more than 1%, and evenmore preferably no more than 0.1%, of non-NHL nucleic acids. Whether agiven NHL DNA preparation is substantially free from other nucleic acidscan be determined by such conventional techniques of assessing nucleicacid purity as, e.g., agarose gel electrophoresis combined withappropriate staining methods, e.g., ethidium bromide staining, or bysequencing.

[0031] As used herein, “substantially free from other proteins” or“substantially purified” means at least 90%, preferably 95%, morepreferably 99%, and even more preferably 99.9%, free of other proteins.Thus, a NHL protein preparation that is substantially free from otherproteins will contain, as a percent of its total protein, no more than10%, preferably no more than 5%, more preferably no more than 1%. andeven more preferably no more than 0.1%, of non-NHL proteins. Whether agiven NHL protein preparation is substantially free from other proteinscan be determined by such conventional techniques of assessing proteinpurity as, e.g., sodium dodecyl sulfate polyacrylamide gelelectrophoresis (SDS-PAGE) combined with appropriate detection methods,e.g., silver staining or immunoblotting. As used interchangeably withthe terms “substantially free from other proteins” or “substantiallypurified”, the terms “isolated NHL protein” or “purified NHL protein”also refer to NHL protein that has been isolated from a natural source.Use of the term “isolated” or “purified” indicates that NHL protein hasbeen removed from its normal cellular environment. Thus, an isolated NHLprotein may be in a cell-free solution or placed in a different cellularenvironment from that in which it occurs naturally. The term isolateddoes not imply that an isolated NHL protein is the only protein present,but instead means that an isolated NHL protein is substantially free ofother proteins and non-amino acid material (e.g., nucleic acids, lipids,carbohydrates) naturally associated with the NHL protein in vivo. Thus,a NHL protein that is recombinantly expressed in a prokaryotic oreukaryotic cell and substantially purified from this host cell whichdoes not naturally (i.e., without intervention) express this protein isof course “isolated NHL protein” under any circumstances referred toherein. As noted above, a NHL protein preparation that is an isolated orpurified NHL protein will be substantially free from other proteins willcontain, as a percent of its total protein, no more than 10%, preferablyno more than 5%, more preferably no more than 1%, and even morepreferably no more than 0.1%, of non-NHL proteins.

[0032] As used interchangeably herein, “functional equivalent” or“biologically active equivalent” means a protein which does not haveexactly the same amino acid sequence as naturally occurring NHL, due toalternative splicing, deletions, mutations, substitutions, or additions,but retains substantially the same biological activity as NHL. Suchfunctional equivalents will have significant amino acid sequenceidentity with naturally occurring NHL and genes and cDNA encoding suchfunctional equivalents can be detected by reduced stringencyhybridization with a DNA sequence encoding naturally occurring NHL. Forexample, a naturally occurring NHL disclosed herein comprises the aminoacid sequence shown as SEQ ID NO: 2 and is encoded by SEQ ID NO: 1. Anucleic acid encoding a functional equivalent has at least about 50%identity at the nucleotide level to SEQ ID NO: 1.

[0033] As used herein, “a conservative amino acid substitution” refersto the replacement of one amino acid residue by another, chemicallysimilar, amino acid residue. Examples of such conservative substitutionsare: substitution of one hydrophobic residue (isoleucine, leucine,valine, or methionine) for another; substitution of one polar residuefor another polar residue of the same charge (e.g., arginine for lysine;glutamic acid for aspartic acid).

[0034] As used herein, the term “mammalian” will refer to any mammal,including a human being.

BRIEF DESCRIPTION OF THE DRAWINGS

[0035]FIG. 1A-B shows the nucleotide sequence which comprises the openreading frame which encodes human NHL, the nucleotide sequence set forthas SEQ ID NO: 1. The initiating Met residue (ATG) and the stop codon(TAG) are underlined.

[0036]FIG. 2 shows the amino acid sequence of human NHL as set forth inSEQ ID NO: 2.

[0037]FIG. 3 shows the alignment of amino acid sequences of human NHL toERCC2/RAD3 gene family members. Rep D (Dictyosteliem discoideum); RAD 3(S. cerevisiae); RAD 15 (S. pombe) and XP_GroupD (Homo sapien).

[0038]FIG. 4 shows Northern analysis of NHL expression in multi-humantissues.

[0039]FIG. 5A-B show the genomic structure of the NHL gene (FIG. 5A) andthe entire 115 kb genomic region (FIG. 5B) containing the NHL, M68/DcR3,SCLIP and ARP genes.

DETAILED DESCRIPTION OF THE INVENTION

[0040] The present invention relates to an isolated or purified nucleicacid molecule (polynucleotide) which encodes a novel mammalian DNAhelicase. An especially preferred aspect of this invention relates to anisolated nucleic acid molecule (polynucleotide) which encodes mRNA whichexpresses a novel human DNA helicase, NHL.

[0041] The gene M68/DcR3 is a secreted TNFR member that is overexpressedin a number of human tumors. M68/DcR3 is located at 20q 13.3, a knownsite that is associated with frequent gene amplification in cancer.M68/DcR3 protein binds to FASL and inhibit FAS mediated apoptosis. Thus,genes tightly linked to M68/DcR3 may be coregulated (e.g. cooverexpressed and/or amplified in tumors). During the course of cloningthe genomic M68/DcR3 fragment and identifying genes that are linked toM68/DcR3 at 20q13.3, three genes, including a novel gene that is similarto the Rad3/ERCC2 helicase family, were identified (termed NHL) in theimmediately adjacent (overlapping) region. Given NHL's chromosomallocation and the frequent association of DNA helicases with humangenetic disorders (mutations in DNA helicases have been found associatedwith multiple diseases, including xeroderma pigmentosum, Cockayne'ssyndrome, Bloom's syndrome, and Werner's syndrome), NHL is a candidatefor contribution to certain human neoplastic disorders. To this end, thegenomic clone for this gene is disclosed and the complete sequence isdetermined. The transcript was identified through exon prediction usingGRAIL2 and sequence alignment to a contiguous 4.5 kilobase region ofchromosome 4 (88% sequence identity). The complete exon structure of NHLwas subsequently confirmed by RT-PCR analysis. Multiple sequencealignment of NHL to known helicases showed that NHL contains all theseven critical helicase domains. BLAST analysis of the predicted 1,219amino acid sequence revealed an approximately 26% sequence identity and48% sequence similarity to the RAD3/ERCC2 gene family of DNA helicases(Naumovski et al., 1985 Mol. Cell Biol. 5:17-26; Reynolds et al., 1985Nucleic Acid Res 13:2357-72; Weber et al., 1990 EMBO J. 9:1437-1447).The mRNA expression pattern of NHL was also examined in multiple humantissues. Radiation hybrid chromosomal mapping reconfirms that it islinked to M68/DcR3 locus.

[0042] A preferred aspect of the present invention relates to anisolated or purified DNA molecule which encodes human NHL, thenucleotide sequence as set forth in FIG. 1A-B and SEQ ID NO: 1, which isas follows: AGTCAGCCCT GCTGCCAGCC AGTGCCGGGT GCTGGCCACT CAGGGAGGCCGCCCGGCACC (SEQ ID NO:1) ACTGCGGGAC AGTGAGCCCA GCAGAAGCTG GAACGCAGGAGAGGAAGGAG AGGCGCCGGT CAGGGCTCTC AGGAGCCGGG TCCTGGGCAA GGCGCAGCCGTTTTCAAATT TTCAGGAAAG CGGTCGGCTC ACACTCGAGC AGTAAAAAGA TGCCTCTGGCGAGGAGGCCC GTGCAGCTCT CCGGCCAATG GTGGTCGCTC GGCCTAGAGA GGCGGTAGTCGAACGCAGAC CCTGCTGGGG GAATCACATC AAGGGAGGAG ACGGGCGGGA CCCCAGATTTCTGCCTGTGG GCGATGGAAG TGAGGTTCAC TGGCCAGCGG AGCCGGACAC AGAACGCGCAAAACGCCGTC TAGGCCTGCA GGAGCCGAAG AGCAGGCGGA CCCCCTCCGC GGGGGAACAGTTTCCGCCGG GAGCACAAAG CAACGGACCG GAAGTGGGGG GCGGAAGTGC AGTGGGCTCAGCGCCGACTG CGCGCCTCTG CCCGCGAAAA CTCTGAGCTG GCTGACAGCT GGGGACGCCTGGCGGCCCTC GACTGGAGTC GGTTGAGTTC CTGAGGGACC CCGGTTCTGG AAGGTTCGCCGCGGAGACAA GTGAGCAGTC TGTGCCATAG GGATTCTCGA AGAGAACAGC GTTGTCTCCCAGTGCACATG CTCGCATCGC TTACCAGGAG TGCCCGAGAC CCTAAGATGT TCGGAGTGGTTTTTTCGCAC AGACCCGAAT AGCCTGCCCC TCAGCCACGC TCTGTGCCCT TCTGAGAACAGGCTGATATG CCCAAGATAG TCCTGAATGG TGTGACCGTA GACTTCCCTT TCCAGCCCTACAAATGCCAA CAGGAGTACA TGACCAAGGT CCTGGAATGT CTGCAGCAGA AGGTGAATGCCATCCTGGAG AGCCCTACGG GTACAGGGAA GACGCTGTGC CTGCTGTGCA CCACGCTCGCCTGGCGAGAA CACCTCCGAG ACGGCATCTC TGCCCGCAAG ATTGCCGAGA GGGCGCAAGGAGAGCTTTTC CCGGATCGGG CCTTGTCATC CTGGGGCAAC GCTGCTGCTG CTGCTGGAGACCCCATAGCT TGCTACACGG ACATCCCAAA GATTATTTAC GCCTCCAGGA CCCACTCGCAACTCACACAG GTCATCAACG AGCTTCGGAA CACCTCCTAC CGGCCTAAGG TGTGTGTGCTGGGCTCCCGG GAGCAGCTGT GCATCCATCC TGAGGTCAAG AAACAAGAGA GTAACCATCTACAGATCCAC TTGTGCCGTA AGAAGGTCCC AAGTCGCTCC TGTCATTTCT ACAACAACGTACAAGAAAAA AGCCTGGAGC AGGAGCTGGC CAGCCCCATC CTGGACATTG AGGACTTGGTCAAGAGCGGA ACCAAGCACA GGGTGTGCCC TTACTACCTG TCCCGGAACC TGAAGCAGCAAGCCGACATC ATATTCATGC CGTACAATTA CTTGTTGGAT GCCAAGAGCC GCAGAGCACACAACATTGAC CTGAAGGGCA CAGTCGTGAT CTTTGACGAA GCTCACAACG TGGAGAAGATGTCTGAAGAA TCGCCATCCT TTGACCTGAC TCCCCATGAC CTGGCTTCAG GACTGGACGTCATAGACCAG GTGCTGGAGG AGCAGACCAA GGCAGCGCAG CACCGTGAGC CCCACCCGGAGTTCAGCGCG GACTCCCCCA GCCCAGGGCT GAACATGGAG CTGGAAGACA TTGCAAAGCTGAAGATGATC CTGCTGCGCC TGGACGGGGC CATCGATGCT GTTGACCTGC CTGGAGACGACAGCGGTGTC ACCAAGCCAG GGAGCTACAT CTTTCAGCTG TTTGCTGAAG CCCAGATCACGTTTCAGACC AAGGGCTGCA TCCTGGACTC GCTGGACCAG ATCATCCAGC ACCTGGCAGGACGTCCTGGA GTGTTCACCA ACACGGCCCG ACTGCAGAAG CTGGCGGACA TTATCCAGATTGTCTTCAGT GTGGACCCCT CCGAGGGCAC CCCTGGTTCC CCAGCAGGGC TGGGGGCCTTACAGTCCTAT AAGGTGCACA TCCATCCTGA TCCTGGTCAC CGGAGGACGG CTCAGCGGTCTGATGCCTGG AGCACCACTG CAGCCAGAAA GCGAGGGAAG GTGCTGAGCT ACTGGTGCTTCAGTCCCGGC CACAGCATGC ACGAGCTGGT CCGCCAGGGC GTCCGCTCCC TCATCCTTACCAGCGGCACG CTGGCCCCOG TGTCCTCCTT TGCTCTGGAG ATGCAGATCC CTTTCCCAGTCTGCCTGGAG AACCCACACA TCATCGACAA GCACCAGATC TGGGTGGGGG TCGTCCCCAGAGCCCCCGAT GGAGCCCAGT TGAGCTCCGC GTTTGACAGA CGGTTTTCCG AGGAGTCCTTATCCTCCCTG GGCAAGGCTC TGGGCAACAT CGCCCGCGTG GTCCCCTATG GCCTCCTGATCTTCTTCCCT TCCTATCCTG TCATGGACAA GAGCCTGCAC TTCTGGCGGG CCCCCGACTTGGCCAGGAAG ATCGACGCGC TGAAGCCGCT GTTTGTCGAG CCCAGGAGCA AAGGCAGCTTCTCCGAGACC ATCAGTGCTT ACTATGCAAG GOTTGCCGCC CCTGGGTCCA CCGGCCCCACCTTCCTGCCG GTCTGCCGGG GCAAGGCCAG CGAGGGGCTG GACTTCTCAG ACACGAATGGCCGTGGTGTG ATTGTCACGG GCCTCCCGTA CCCCCCACGC ATGGACCCCC GGGTTCTCCTCAAGATGCAG TTCCTGGATG AGATGAAGGG CCAGGGTGGG CCTGGGGGCC ACTTCCTCTCTGGGCAGCAG TGGTACCGGC AGCAGGCGTC CAGGGCTGTG AACCAGGCCA TCGGGCGAGTGATCCGGCAC CGCCAGGACT ACGGAGCTGT CTTCCTCTGT GACCACAGGT TCGCCTTTGCCGACGCAAGA GCCCAACTGC CCTCCTCGGT GCGTCCCCAC GTCAGGGTGT ATGACAACTTTGGCCATGTC ATCCGAGACG TGGCCCACTT CTTCCGTGTT GCCGAGCGAA CTATGCCAGCGCCGGCCCCC CGGGCTACAG CACCCAGTGT GCGTGGAGAA GATGCTGTCA GCGAGGCCAAGTCGCCTGGC CCCTTCTTCT CCACCAGGAA AGCTAAGAGT CTGGACCTGC ATGTCCCCAGCCTGAAGCAG AGGTCCTCAG GGTCACCAGC TGCCGGGGAC CCCGAGAGTA GCCTGTGTGTGGAGTATGAG CAGGAGCCAG TTCCTGCCCC GCAGAGGCCC AGGGGGCTGC TGGCCGCCCTGGAGCACAGC GAACAGCGGG CGGGGAGCCC TGGCGAGGAG CAGGCCCACA GCTGCTCCACCCTGTCCCTC CTGTCTCAGA AGAGGCCGGC AGAAGAACCG CGAGGAGGGA GGAAGAAGATCCGGCTCGTC AGCCACCCGG AGGAGCCCGT GGCTGGTGCA CAGACOGACA GGGCCAAGCTCTTCATGGTG GCCGTGAAGC AGGAGTTGAG CCAAGCCAAC TTTGCCACCT TCACCCAGGCCCTGCAGGAC TACAAGGGTT CCGATGACTT CGCCGCCCTG GCCGCCTGTC TCGGCCCCCTCTTTGCTGAG GACCCCAAGA AGCACAACCT GCTCCAAGGC TTCTACCAGT TTGTGCGGCCCCACCATAAG CAGCAGTTTG AGGAGGTCTG TATCCAGCTG ACAGGACGAG GCTGTGGCTATCGGCCTGAG CACAGCATTC CCCGAAGGCA GCGGGCACAG CCCGTCCTGG ACCCCACTGGAAGAACGGCG CCGGATCCCA AGCTGACCGT GTCCACGGCT GCAGCCCAGC AGCTGGACCCCCAAGAGCAC CTGAACCAGG GCAGGCCCCA CCTGTCGCCC AGGCCACCCC CAACAGGAGACCCTGGCAGC CAACCACAGT GGGGGTCTGG AGTGCCCAGA GCAGGGAAGC AGGGCCAGCACGCCGTGAGC GCCTACCTGG CTGATGCCCG CAGGGCCCTG GGGTCCGCGG GCTGTAGCCAACTCTTGGCA GCGCTGACAG CCTATAAGCA AGACGACGAC CTCGACAAGC TGCTGGCTGTGTTGGCCGCC CTGACCACTG CAAAGCCACA GGACTTCCCC CTGCTGCACA GGTTCAGCATGTTTGTGCGT CCACACCACA AGCAGCGCTT CTCACAGACG TGCACAGACC TGACCGCCCGGCCCTACCCG GCCATGGACC CACCGGGACC CCAGGAGGAG AGGCTTGCCG TGCCTCCTGTGCTTACCCAC AGGGCTCCCC AACCAGGCCC cTCACGGTCC GAGAAGACCC GGAAGACCCAGAGCAAGATC TCGTCCTTCC TTAGACACAG GCCAGCAGGG ACTGTGCGGG CGCGCCGTGAGGATGCAGGT CCCACCCACT CCTCAGGACC TCCCCACGGG CCTGCAGCAT CTCAGTGGGGCCTCTAGGAT GTGCCCAGCC TGCCACACCG CCTCCAGGAA GCAGAGCGTC ATGCAGGTCTTCTGGCCAGA GCCCCAGTGA GTGCCCACGG AGGCCCCCAG CACACCCAAC GTGGCTTGATCACCTGCCTG TCCAGCTCTG GTGGGCCAAG AACCCACCCA ACAGAATAGG CCAGCCCATCCCAGCCGGCT TGGCCCCCTG CAGGCCTCAC CCAGGCCGGG CCCATGGTTG GTCCCTCCGGTCGGACCGGA TCTGGGCCTG CCTCTGAGAA GCCCTCACCT ACCTTGGGGT CTGCGGTGGGTTTCTGGGAA AGTGCTTCCC CAGAACTTCC CTGCCTCCTG GCCTGTGAGT GGTGCCACACGGGCACCCCA GCTGAGCCCC TCACCGGGAA GGAGGAGACC CCCGTGGGCA CGTCTCCACTTTTAATCAGG GGACAGGGCT CTCTAATAAA GCTGCTGGCA GTGCCC

[0043] The above-exemplified isolated DNA molecule shown in FIG. 1A-Band SEQ ID NO: 1 comprise 4946 nucleotides, with an initiating Met atnucleotides 828-830 and a “TAG” termination codon at nucleotides4585-4587. The initiating Met and TAG termination codon are underlined.

[0044] The present invention also relates to biologically activefragments or mutants of SEQ ID NO: 1 which encode a mRNA moleculeexpressing a novel DNA helicase, NHL. Any such biologically activefragment and/or mutant will encode either a protein or protein fragmentwhich at least substantially mimics the biological properties of thehuman NHL protein disclosed herein in FIG. 2 and as set forth as SEQ IDNO: 2. Any such polynucleotide includes but is not necessarily limitedto nucleotide substitutions, deletions, additions, amino-terminaltruncations and carboxy-terminal truncations such that these mutationsencode mRNA which express a functional NHL protein in a host cell, so asto be useful for screening for agonists and/or antagonists of NHLactivity.

[0045] The isolated nucleic acid molecules of the present invention mayinclude a deoxyribonucleic acid molecule (DNA), such as genomic DNA andcomplementary DNA (cDNA), which may be single (coding or noncodingstrand) or double stranded, as well as synthetic DNA, such as asynthesized, single stranded polynucleotide. The isolated nucleic acidmolecule of the present invention may also include a ribonucleic acidmolecule (RNA).

[0046] The present invention also relates to recombinant vectors andrecombinant hosts, both prokaryotic and eukaryotic, which contain thesubstantially purified nucleic acid molecules disclosed throughout thisspecification.

[0047] The degeneracy of the genetic code is such that, for all but twoamino acids, more than a single codon encodes a particular amino acid.This allows for the construction of synthetic DNA that encodes the NHLprotein where the nucleotide sequence of the synthetic DNA differssignificantly from the nucleotide sequence of SEQ ID NO: 1 but stillencodes the same NHL protein as SEQ ID NO: 2. Such synthetic DNAs areintended to be within the scope of the present invention. If it isdesired to express such synthetic DNAs in a particular host cell ororganism, the codon usage of such synthetic DNAs can be adjusted toreflect the codon usage of that particular host, thus leading to higherlevels of expression of the NHL protein in the host. In other words,this redundancy in the various codons which code for specific aminoacids is within the scope of the present invention. Therefore, thisinvention is also directed to those DNA sequences which encode RNAcomprising alternative codons which code for the eventual translation ofthe identical amino acid, as shown below:

[0048] A=Ala=Alanine: codons GCA, GCC, GCG, GCU

[0049] C=Cys=Cysteine: codons UGC, UGU

[0050] D=Asp=Aspartic acid: codons GAC, GAU

[0051] E=Glu=Glutamic acid: codons GAA, GAG

[0052] F=Phe=Phenylalanine: codons UUC, UUU

[0053] G=Gly=Glycine: codons GGA, GGC, GGG, GGU

[0054] H=His=Histidine: codons CAC, CAU

[0055] I=Ilc=Isoleucine: codons AUA, AUC, AUU

[0056] K=Lys=Lysinc: codons AAA, AAG

[0057] L=Leu=Leucinc: codons UUA, UUG, CUA, CUC, CUG, CUU

[0058] M=Met=Methionine: codon AUG

[0059] N=Asp=Asparagine: codons AAC, AAU

[0060] P=Pro=Proline: codons CCA, CCC, CCG, CCU

[0061] Q=Gln=Glutamine: codons CAA, CAG

[0062] R=Arg=Arginine: codons AGA, AGC, CGA, CGC, CGG, CGU

[0063] S=Ser=Serine: codons AGC, AGU, UCA, UCC, UCG, UCU

[0064] T=Thr=Threonine: codons ACA, ACC, ACG, ACU

[0065] V=Val=Valine: codons GUA, GUC, GUG, GUU

[0066] W=Trp=Tryptophan: codon UGG

[0067] Y=Tyr=Tyrosine: codons UAC, UAU

[0068] Therefore, the present invention discloses codon redundancy whichmay result in differing DNA molecules expressing an identical protein.For purposes of this specification, a sequence bearing one or morereplaced codons will be defined as a degenerate variation. Also includedwithin the scope of this invention are mutations either in the DNAsequence or the translated protein which do not substantially alter theultimate physical properties of the expressed protein. For example,substitution of valine for leucine, arginine for lysine, or asparaginefor glutamine may not cause a change in functionality of thepolypeptide.

[0069] It is known that DNA sequences coding for a peptide may bealtered so as to code for a peptide having properties that are differentthan those of the naturally occurring peptide Methods of altering theDNA sequences include but are not limited to site directed mutagenesis.Examples of altered properties include but are not limited to changes inthe affinity of an enzyme for a substrate or a receptor for a ligand.

[0070] The present invention also relates to recombinant vectors andrecombinant hosts, both prokaryotic and eukaryotic, which contain thesubstantially purified nucleic acid molecules disclosed throughout thisspecification. The nucleic acid molecules of the present inventionencoding a NHL protein, in whole or in part, can be linked with otherDNA molecules, i.e, DNA molecules to which the NHL coding sequence arenot naturally linked, to form “recombinant DNA molecules” which encode arespective NHL protein. The novel DNA sequences of the present inventioncan be inserted into vectors which comprise nucleic acids encoding N ora functional equivalent. These vectors may be comprised of DNA or RNA;for most cloning purposes DNA vectors are preferred. Typical vectorsinclude plasmids, modified viruses, bacteriophage, cosmids, yeastartificial chromosomes, and other forms of episomal or integrated DNAthat can encode a NHL protein. It is well within the purview of theskilled artisan to determine an appropriate vector for a particular genetransfer or other use.

[0071] Included in the present invention are DNA sequences thathybridize to SEQ ID NO: 1 under stringent conditions. By way of example,and not limitation, a procedure using conditions of high stringency isas follows: Prehybridization of filters containing DNA is carried outfor 2 hours to overnight at 65° C. in buffer composed of 6×SSC, 5×Denhardt's solution, and 100 μg/ml denatured salmon sperm DNA. Filtersare hybridized for 12 to 48 hrs at 65° C. in prehybridization mixturecontaining 100 μg/ml denatured salmon sperm DNA and 5-20×10⁶ cpm of ³²P-labeled probe. Washing of filters is done at 37° C. for 1 hr in asolution containing 2×SSC, 0.1% SDS. This is followed by a wash in0.1×SSC, 0.1% SDS at 50° C. for 45 min. before autoradiography. Otherprocedures using conditions of high stringency would include either ahybridization step carried out in 5×SSC, 5×Denhardt's solution, 50%formamide at 42° C. for 12 to 48 hours or a washing step carried out in0.2×SSPE, 0.2% SDS at 65° C. for 30 to 60 minutes.

[0072] Reagents mentioned in the foregoing procedures for carrying outhigh stringency hybridization are well known in the art. Details of thecomposition of these reagents can be found in, e.g., Sambrook et al.,1989, Molecular Cloning: A Laboratory Manual; Cold Spring HarborLaboratory, Cold Spring Harbor, N.Y. In addition to the foregoing, otherconditions of high stringency which may be used are well known in theart.

[0073] The present invention also relates to a substantially purifiedform of a human NHL protein which comprises the amino acid sequence(1219 amino acid residues) disclosed in FIG. 2 and set forth as SEQ IDNO: 2. A preferred aspect of this portion of the present invention is aNHL protein which consists of the amino acid sequence disclosed in FIG.2 and set forth as SEQ ID NO: 2, as follows: MPKIVLNCVT VDFPFQPYKCQQEYMTKVLE CLQQKVNGTL ESPTGTGKTL CLLCTTLAWR (SEQ ID NO:2) EHLRDGISARKIAERAQCEL FPDRALSSWG NAAAAAGDPI ACYTDLPKII YASRTHSQLT QVINELRNTSYRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCKFYNNVEE KSLEQELASPILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI DLKGTVVIFDEAHNVEKMCE ESASFDLTPH DLASGLDVTD QVLEEQTKAA QQCEPHPEFS ADSPSPGLNMELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ TKCCILDSLDQIIQHLAGRA GVFTNTACLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS YKVHIHPDAGHRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRO GVRSLILTSG TLAPVSSFALEMQIPFPVCL ENPHTIDKHQ IWVGVVPRGP DGAQLSSAFD RRFSEECLSS LGKALGNIARVVPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE TISAYYARVAAPGSTGATPL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKN QFLDEMKGQGGAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA RAQLPSWVRPHVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP GPFFSTRKAKSLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH SEQRAGSPGEEQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM VAVKQELSQANFATFTQALQ DYKGSDDFAA LAACLCPLFA EDPKKHNLLQ GFYQFVRPHH KQQFEEVCIQLTGRGCGYRP EHSTPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE HLNQGRPHLSPRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL AALTAYKQDDDLDKVLAVLA ALTTAKPEOF PLLHRPSMFV RPHHKQRFSQ TCTDLTCRPY PGMEPPGPQEERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA GPSQSSGPPHGPAASEWCL*

[0074] The present invention also relates to biologically activefragments and/or mutants of the human NHL protein comprising the aminoacid sequence as set forth in SEQ ID NO: 2, including but notnecessarily limited to amino acid substitutions, deletions, additions,amino terminal truncations and carboxy-terminal truncations such thatthese mutations provide for proteins or protein fragments of diagnostic,therapeutic or prophylactic use and would be useful for screening foragonists and/or antagonists of NHL function.

[0075] Another preferred aspect of the present invention relates to asubstantially purified, fully processed NHL protein obtained from arecombinant host cell containing a DNA expression vector which comprisesa nucleotide sequence as set forth in SEQ ID NO: 1 and expresses thehuman NHL protein. It is especially preferred is that the recombinanthost cell be a eukaryotic host cell, such as a mammalian cell line.

[0076] As with many proteins, it is possible to modify many of the aminoacids of NHL protein and still retain substantially the same biologicalactivity as the wild type protein. Thus this invention includes modifiedNHL polypeptides which have amino acid deletions, additions, orsubstitutions but that still retain substantially the same biologicalactivity as a respective, corresponding NHL. It is generally acceptedthat single amino acid substitutions do not usually alter the biologicalactivity of a protein (see, e.g., Molecular Biology of the Genie, Watsonet al., 1987, Fourth Ed., The Benjamin/Cummings Publishing Co., Inc.,page 226; and Cunningham & Wells, 1989, Science 244:1081-1085).Accordingly, the present invention includes a polypeptide where oneamino acid substitution has been made in SEQ ID NO: 2 wherein thepolypeptide still retains substantially the same biological activity asa corresponding NHL protein. The present invention also includespolypeptides where two or more amino acid substitutions have been madein SEQ ED NO: 2 wherein the polypeptide still retains substantially thesame biological activity as a corresponding NHL protein. In particular,the present invention includes embodiments where the above-describedsubstitutions are conservative substitutions.

[0077] One skilled in the art would also recognize that polypeptidesthat are functional equivalents of NHL and have changes from the NHLamino acid sequence that are small deletions or insertions of aminoacids could also be produced by following the same guidelines, (i.e,minimizing the differences in amino acid sequence between NHL andrelated proteins. Small deletions or insertions are generally in therange of about 1 to 5 amino acids). The effect of such small deletionsor insertions on the biological activity of the modified NHL polypeptidecan easily be assayed by producing the polypeptide synthetically or bymaking the required changes in DNA encoding NHL and then expressing theDNA recombinantly and assaying the protein produced by such recombinantexpression.

[0078] The present invention also includes truncated forms of NHL whichcontain the region comprising the active site of the enzyme. Suchtruncated proteins are useful in various assays described herein, forcrystallization studies, and for structure-activity-relationshipstudies.

[0079] The present invention also relates to isolated nucleic acidmolecules which are fusion constructions expressing fusion proteinsuseful in assays to identify compounds which modulate wild-type NHLactivity, as well as generating antibodies against NHL. One aspect ofthis portion of the invention includes, but is not limited to,glutathione S-transferase (GST)-NHL fusion constructs. RecombinantGST-NHL fusion proteins may be expressed in various expression systems,including Spodoptera frugiperda (Sf21) insect cells (Invitrogen) using abaculovirus expression vector (pAcG2T, Pharmingen). Another aspectinvolves NHL fusion constructs linked to various markers, including butnot limited to GFP (Green fluorescent protein), the MYC epitope, andGST. Again, any such fusion constructs may be expressed in the cell lineof interest and used to screen for modulators of one or more of the NHLproteins disclosed herein.

[0080] Any of a variety of procedures may be used to clone NHL. Thesemethods include, but are not limited to, (1) a RACE PCR cloningtechnique (Frohman, et al., 1988, Proc. Natl. Acad. Sci. USA 85:8998-9002). 5′ and/or 3′ RACE may be performed to generate a full-lengthcDNA sequence. This strategy involves using gene-specificoligonucleotide primers for PCR amplification of NHL cDNA. Thesegene-specific primers are designed through identification of anexpressed sequence tag (EST) nucleotide sequence which has beenidentified by searching any number of publicly available nucleic acidand protein databases; (2) direct functional expression of the NHL cDNAfollowing the construction of a NHL-containing cDNA library in anappropriate expression vector system; (3) screening a NHL-containingcDNA library constructed in a bacteriophage or plasmid shuttle vectorwith a labeled degenerate oligonucleotide probe designed from the aminoacid sequence of the NHL protein; (4) screening a NHL-containing cDNAlibrary constructed in a bacteriophage or plasmid shuttle vector with apartial cDNA encoding the NHL protein. This partial cDNA is obtained bythe specific PCR amplification of NHL DNA fragments through the designof degenerate oligonucleotide primers from the amino acid sequence knownfor other kinases which are related to the NHL protein; (5) screening aNHL-containing cDNA library constructed in a bacteriophage or plasmidshuttle vector with a partial cDNA or oligonucleotide with homology to amammalian NHL protein. This strategy may also involve usinggene-specific oligonucleotide primers for PCR amplification of NHL cDNAidentified as an EST as described above; or (6) designing 5′ and 3′ genespecific oligonucleotides using SEQ ID NO. 1 as a template so thateither the full-length cDNA may be generated by known RACE techniques,or a portion of the coding region may be generated by these same knownRACE techniques to generate and isolate a portion of the coding regionto use as a probe to screen one of numerous types of cDNA and/or genomiclibraries in order to isolate a full-length version of the nucleotidesequence encoding NHL.

[0081] It is readily apparent to those skilled in the art that othertypes of libraries, as well as libraries constructed from other celltypes or species types, may be useful for isolating a NHL-encoding DNAor a NHL homologue. Other types of libraries include, but arc notlimited to, cDNA libraries derived from other cells.

[0082] It is readily apparent to those skilled in the art that suitablecDNA libraries may be prepared from cells or cell lines which have NHLactivity. The selection of cells or cell lines for use in preparing acDNA library to isolate a cDNA encoding NHL may be done by firstmeasuring cell-associated NHL activity using any known assay availablefor such a purpose.

[0083] Preparation of cDNA libraries can be performed by standardtechniques well known in the art. Well known cDNA library constructiontechniques can be found for example, in Sambrook et al., 1989, MolecularCloning: A Laboratory Manual; Cold Spring Harbor Laboratory, Cold SpringHarbor, N.Y. Complementary DNA libraries may also be obtained fromnumerous commercial sources, including but not limited to ClontechLaboratories, Inc. and Stratagene.

[0084] It is also readily apparent to those skilled in the art that DNAencoding NHL may also be isolated from a suitable genomic DNA library.Construction of genomic DNA libraries can be performed by standardtechniques well known in the art. Well known genomic DNA libraryconstruction techniques can be found in Sambrook, et al., supra. One mayprepare genomic libraries, especially in P1 artificial chromosomevectors, from which genomic clones containing the NHL gene can beisolated, using probes based upon the NHL nucleotide sequences disclosedherein. Methods of preparing such libraries are known in the art(Ioannou et al., 1994, Nature Genet. 6:84-89).

[0085] In order to clone a NHL gene by one of the preferred methods, theamino acid sequence or DNA sequence of a NHL or a homologous protein maybe necessary. To accomplish this, a respective NHL protein may bepurified and the partial amino acid sequence determined by automatedsequenators. It is not necessary to determine the entire amino acidsequence, but the linear sequence of two regions of 6 to 8 amino acidscan be determined for the PCR amplification of a partial NHL DNAfragment. Once suitable amino acid sequences have been identified, theDNA sequences capable of encoding them are synthesized. Because thegenetic code is degenerate, more than one codon may be used to encode aparticular amino acid, and therefore, the amino acid sequence can beencoded by any of a set of similar DNA oligonucleotides. Only one memberof the set will be identical to the No sequence but others in the setwill be capable of hybridizing to NHL DNA even in the presence of DNAoligonucleotides with mismatches. The mismatched DNA oligonucleotidesmay still sufficiently hybridize to the NHL DNA to permit identificationand isolation of NHL encoding DNA. Alternatively, the nucleotidesequence of a region of an expressed sequence may be identified bysearching one or more available genomic databases. Gene-specific primersmay be used to perform PCR amplification of a cDNA of interest fromeither a cDNA library or a population of cDNAs. As noted above, theappropriate nucleotide sequence for use in a PCR-based method may beobtained from SEQ ID NO: 1 either for the purpose of isolatingoverlapping 5′ and 3′ RACE products for generation of a full-lengthsequence coding for NHL, or to isolate a portion of the nucleotidesequence coding for NHL for use as a probe to screen one or more cDNA-or genomic-based libraries to isolate a full-length sequence encodingNHL or NHL-like proteins.

[0086] This invention also includes vectors containing a NHL gene, hostcells containing the vectors, and methods of making substantially pureNHL protein comprising the steps of introducing the NHL gene into a hostcell, and cultivating the host cell under appropriate conditions suchthat NHL is produced. The NHL so produced may be harvested from the hostcells in conventional ways. Therefore, the present invention alsorelates to methods of expressing the NHL protein and biologicalequivalents disclosed herein, assays employing these gene products,recombinant host cells which comprise DNA constructs which express theseproteins, and compounds identified through these assays which act asagonists or antagonists of NHL activity.

[0087] The cloned NHL cDNA obtained through the methods described abovemay be recombinantly expressed by molecular cloning into an expressionvector (such as pcDNA3.neo, pcDNA3.1, pCR2.1, pBlueBacHis2 or pLITMUS28)containing a suitable promoter and other appropriate transcriptionregulatory elements, and transferred into prokaryotic or eukaryotic hostcells to produce recombinant NHL. Expression vectors are defined hereinas DNA sequences that are required for the transcription of cloned DNAand the translation of their mRNAs in an appropriate host. Such vectorscan be used to express eukaryotic DNA in a variety of hosts such asbacteria, blue green algae, plant cells, insect cells and animal cells.Specifically designed vectors allow the shuttling of DNA between hostssuch as bacteria-yeast or bacteria-animal cells. An appropriatelyconstructed expression vector should contain: an origin of replicationfor autonomous replication in host cells, selectable markers, a limitednumber of useful restriction enzyme sites, a potential for high copynumber, and active promoters. A promoter is defined as a DNA sequencethat directs RNA polymerase to bind to DNA and initiate RNA synthesis. Astrong promoter is one which causes mRNAs to be initiated at highfrequency. To determine the NHL cDNA sequence(s) that yields optimallevels of NHL, cDNA molecules including but not limited to the followingcan be constructed: a cDNA fragment containing the full-length openreading frame for NHL as well as various constructs containing portionsof the cDNA encoding only specific domains of the protein or rearrangeddomains of the protein. All constructs can be designed to contain none,all or portions of the 5′ and/or 3′ untranslated region of a NHL cDNA.The expression levels and activity of NHL can be determined followingthe introduction, both singly and in combination, of these constructsinto appropriate host cells. Following determination of the NHL cDNAcassette yielding optimal expression in transient assays, this NHL cDNAconstruct is transferred to a variety of expression vectors (includingrecombinant viruses), including but not limited to those for mammaliancells, plant cells, insect cells, oocytes, bacteria, and yeast cells.Techniques for such manipulations can be found described in Sambrook, etal, supra, are well known and available to the artisan of ordinary skillin the art. Therefore, another aspect of the present invention includeshost cells that have been engineered to contain and/or express DNAsequences encoding the NHL protein. An expression vector containing DNAencoding a NHL-like protein may be used for expression of NHL in arecombinant host cell. Such recombinant host cells can be cultured undersuitable conditions to produce NHL or a biologically equivalent form.Expression vectors may include, but are not limited to, cloning vectors,modified cloning vectors, specifically designed plasmids or viruses.Commercially available mammalian expression vectors which may besuitable for recombinant NHL expression, include but are not limited to,pcDNA3.neo (Invitrogen), pcDNA3.1 (Invitrogen), pCI-neo (Promega),pLITMUS28, pLITMUS29, pLITMUS38 and pLITMUS39 (New England Bioloabs),pcDNAI, pcDNAIamp (Invitrogen), pcDNA3 (Invitrogen), pMCIneo(Stratagene), pXT1 (Stratagene), pSG5 (Stratagene), EBO-pSV2-neo (ATCC37593) pBPV-1 (8-2) (ATCC 37110), pdBPV-MMTneo(342-12) (ATCC 37224),pRSVgpt (ATCC 37199), pRSVneo (ATCC 37198), pSV2-dhfr (ATCC 37146),pUCTag (ATCC 37460), and IZD35 (ATCC 37565). Also, a variety ofbacterial expression vectors may be used to express recombinant NHL inbacterial cells. Commercially available bacterial expression vectorswhich may be suitable for recombinant NHL expression include, but arenot limited to pCR2.1 (Invitrogen), pET11a (Novagen), lambda gt11(Invitrogen), and pKK223-3 (Pharmacia). In addition, a variety of fungalcell expression vectors may be used to express recombinant NHL in fungalcells. Commercially available fungal cell expression vectors which maybe suitable for recombinant NHL expression include but arc not limitedto pYES2 (Invitrogen) and Pichia expression vector (Invitrogen) Also, avariety of insect cell expression vectors may be used to expressrecombinant protein in insect cells. Commercially available insect cellexpression vectors which may be suitable for recombinant expression ofNHL include but are not limited to pBlueBacIII and pBlueBacHis2(Invitrogen), and pAcG2T (Pharmingen).

[0088] Recombinant host cells may be prokaryotic or eukaryotic,including but not limited to, bacteria such as E. coli, fungal cellssuch as yeast, mammalian cells including, but not limited to, cell linesof bovine, porcine, monkey and rodent origin; and insect cells includingbut not limited to Drosophiila and silkworm derived cell lines. Forinstance, one insect expression system utilizes Spodoptera frugiperda(Sf21) insect cells (Invitrogen) in tandem with a baculovirus expressionvector (pAcG2T, Pharmingen). Also, mammalian species which may besuitable and which are commercially available, include but are notlimited to, L cells L-M(TK⁻) (ATCC CCL 1.3), L cells L-M (ATCC CCL 1.2),Saos-2 (ATCC HTB-85), 293 (ATCC CRL 1573), Raji (ATCC CCL 86), CV-1(ATCC CCL 70), COS-1 (ATCC CRL 1650), COS-7 (ATCC CRL 1651), CHO-K1(ATCC CCL 61), 3T3 (ATCC CCL 92), NIH/3T3 (ATCC CRL 1658), HeLa (ATCCCCL 2), C1271 (ATCC CRL 1616), BS-C-1 (ATCC CCL 26), MRC-5 (ATCC CCL171) and CPAE (ATCC CCL 209).

[0089] As disclosed in Example section 1, a 115 kb BAC clone (fromGenome Systems) was subcloned and subjected to restriction and sequenceanalysis. Four genes at chromosome location 20q13.3 were identified,including M68/DcR3, NHL, SCLIP and ARP (FIG. 5A). The nucleotidesequence of this BAC clone, hbm168, is presented as follows: TGAAGAGCTTTCACCAAGAG GCTGTGACGA GGCCCTACGA GGACTCTGGC TCTCCTCCTG 60 (SEQ ID NO:3)CTAAGCACAC CCAGGCACGT GTCCTGGCAG ATGAGGACCA CATGCACACC CTCGGCCAGC 120CCACCAATGC CCGGATATGC AAGTGAGCCC AGCCTGGACC CCCCCCCGAC GCCCACCAGC 180ACCAGCCCAG CCCCGAAAAC CTTAAGAAAT GACCAGTGTC TGCTGCTTTA AGCCACCAAG 240CTCTGCGGTG GTTTGTTAGG CTCCAACCAT GGCTAATTCA GAAACTGCCA GAAACAAGCA 300CTGCTGTCCC CACCCTCCGA CACACAGCAC CGCCTCTGCG TGGGGAGAGG GCACAGGCTA 360AGGGCACAAA TGCCATCCCA GACCCGGCTC TTGTCTCTGG AAGGGGCCAC TGTCCCATGA 420GGCAGAGCAA ACCTTGGCAG GACCTTATCC CACAGCAATT TAAAAGAGAA GAAACAGGCT 480GGGCGTGGTC GCTCATGCCT ATAATCCCAO CACTTTGGGA GGCCAAGGTG GTGGATCACT 540TCAGGTCAGG AGTTCAAGAC CAGCCTGGCC AATATCGTGA AACCCTGTCT CTACGAAAAA 600TACAAAATTT AGGCAGGCGT GGTGGCGGGT GCCTGTAATC CCTGCTATTC AGGAGGCTGA 660GGCAAGAGAT TTACTTGAAC CCAGGAGGTG GAGGCTGCTG CAGTGAGCTG AGATCATGCC 720ACTGCACTCC ACCCTGTCTG ACGGAGTGAG ACTTGGTCTC AAAAAAAAAA AAGGAAACAC 780ATCTGACTAG TGTGATCTCG CAAGGAACAT TCCAGACACA GTGGAGCTAG AAGGTTCTTC 840TCCAAACAAG GAATCCCCAG GGCATCAAAT TCTTTTGCAT CGGCCAGACA TGCTGGCTCA 900AGCCTGTAAC CCCACTGCTT CGGGAGCCTG AGGTGGGAGG ACTGCTTCAC TCCACGAGTT 960CAACACTAGC TTGOGCAACA CAGTUAGAGC CCATTAGCCA GGCGTGGTGG CACATGCCTG 1020CAGTCCCAGC ACTGTACTAA AAATCTACAC GGCGCCCGCC ATGGTGGCAC ATGCCTGTAG 1080AGTCCCACCT ACTCAGGAGG CTGAGGCACG ACGATTCCTT GAACCCAGGA GGTCACGGCT 1140GCCATCAGCC GTGACTGTGC CACTGCACTC CAGTCTGTGC AACAGAACGA GACTCTGTTT 1200CGAAAAACAA AAAATCATTT CATGTCTCCA GTTTCTCCAC TGGCAAAAGA CTCTGTCAAC 1260GTAAAAAATC GTTCTGACCC ACAGAAATCT AAGAAAGGAA AAAATATAAA AAATAGAAAA 1320TTTAAAAAAG AGATGGTCTC AGAATAAAGA CCAACCTGGG CTATGGTTGT CACTCTTCCC 1380TCACACCTTA GAAAGCTTTC TGCCCGCATC TGGCCAAAGG GCCACCCTGC CCCATCTTGG 1440ATCAGTGAGG TGCCTTCCAA CAAGCCACCT GCCCTGCAGC CCGTCCTGTC TTCTCTGCCA 1500CCCCACGCTC AGTAGGGGAG GGGAAGTCGC TAGGTTTTAG TTCACCAGTC TCTGGATCAA 1560GACGTGCCAT AACCAAGAAG CCCCAGCCAC ACCCAGACCC CATGTGGCCA CAAGCCGTGA 1620GCTGGGAAGG CCCAGGAAAA GGCGGGAGCC GGACGAATCG AAATGTCATT CTGTGGCCAC 1680AGAAATCATC TCAACCTTTT GTAACTTCCT ACCAAGACGC AGTCTTAGCT CTGCCCTTGA 1740ACCAGCACTT GCTGATGTCG CTTGCGTCAA TCAAGGCAAC AGAAGTCAGC AGGAGGCCCA 1800CTTTCCTCTG CAACTGTGCG CTTACGGGGC AAAGAAGTCC AGGCCTCCAG GTGGAGGATC 1860ACACACCGGG CAAAGCAGAG GACAGCCACC CAGCCGAGCC TACCTGTGCC TCAGACTGCC 1920TCCCTCCAGA GACCCCTGTG GCCAAGGCCA CCCAGACCAC CAGGTCCTTG CCAAGCTGTC 1980AGCTGACGAC AGCCGTTCCT GAGCCCGGCC CAGACCACCA GAACCACGAA CCAACCAACA 2040GAATTAAAAA TAATAACAAC TATGTCTTGT CTTAAGCCAC TAAGTTTTGG ATGGTTTCTT 2100TCTTTCTTTT TCTTTTTTTT TTTCGGAGAC GCAGTCTCAC TCTGTTGCCC AGGCTGGAGT 2160GCAGTGGCGC AATCTTGGCT CACTGCAAGC TCTGCCCCCC GGATTCACGC CATTCCCCTG 2220CCTCAGCCTC CTGAGTAACT GCGACTACAG GTGCCTGCCA TTGCGTGTTT TCTTAAACAG 2280CAAAAGAAAA CTGACACAAT CATAAACAGA GCAAGCAAGA GAACTTGGCA ATTATTTCCT 2340CTCTACTTCT CACTGTTCTT CAAAGAGTTA ACTCAAGCAT AAGATGTGAG CAAATTCTTT 2400TAACATCCTA GAAAAAAAGC TCCTACTCAG TCTTCATAAA GCAAAGCTAA CCTACAGGAG 2460CCACCTTCCA CAGTGACCAC AGGAAACCAA GACAGCAAGT GGGACACCAG CCTCCAGGGC 2520ACTGCGCCAG CCGTGCGCCT GTGTCTGCCA CTGCCCTGGT CCGTCACTGC CACCAGCCGG 2580CAAGACACCC ACAGAGGAGA GCTCTAAGCC ACAACTGTGT ACGAAGACAA CTGTGCACCA 2640TTTTATTACT ACAACATTTT TGTTTTCTTT TTTTTTTTTT TTTGAGACTC AGTCTCGCTC 2700TGTCACCCAG GCTGGAGTGC AGTGGCACAA TCTCGGCTCA CTGTAACCTC CATCTCCCTG 2760GTTCAAGCAA TTCTCCTGCT GCAGCCTCCC AACTGGATTA CAGGCGCCCG CCACCACGCC 2820TGGCTAATTT TTGTACTTT AGTAGAGATC CGGTTTCACC ATCTTGGCCA GACTGGTCTC 2880AAATTCCTGA CAAGTCATCC ACCCACCCTG GCCTCCCAAA GTGCTGGGAT TACAGGTGTG 2940AGCCACTCCG CCTGGCCCAT TTTTGTTTAT CAATAAAAAT CTACTTAATG TTGAACTCTC 3000CACATTTCAA ATGGGTAACT CCAGTGTCCT TGATGCTCCT GCGACATGTT CGTGAGACTT 3060CTCTTGGGTC TGAGAGTCTA GCATGTGGGT GGTCTGCACA CGACGGCCAG CCAAGACTGC 3120ACAGCCGGCC AGGGTAAAGA GACCCCCTAG GATGTCAAGC CCGCCCTGCA TTTGTCAGAC 3180TGGGCAACAC CCACTCCATC AGATGGACCC TGGTATGGGC CGCAAGCCAC CTAGGTGCCG 3240AGGCAAGAGA CCGAGCGCAC GACCTGTTCC GGTGTAATAA AATGCATAAA ATAAGAATAG 3300TTATACTAGA TATAGATCAT AAATATGATT ATATATGAAT ATCATTCATC ATTAGTTTGT 3360ACCAATTACT CTTTATTCCA ATATTATAAT AATCCTTGCC TAAGCATAAC CTAGGAAAAA 3420CTACGAAATC ATAACCTAGU AAAAACTAGG CCATACAGAG ATAGGAGCTG AGCGGACATA 3480GTGACAACTC ACCACAAGAC AAGAGTGCGA GCCTTCTGTT ATGCCTCGAC ACGGCCACCA 3540GAGGGCTCCT TGGTCTAGCG GTAACGCCAG CATCTGGGAA CACCCCCGTT GCCAAGTGGA 3600CCGTGGTCTA GCGGTAGCCT CAGTGTCAAG GAAAAACACC CCCTACTTAG CAAACCAGGA 3660AAGAGAGTCT CCCTTTCCCC GGGGGAGTTT AGAGAAGACT CTACTCCTCC ACCTCTTGCG 3720GAGGGCCTGA CATCAGTCAG GCCCGCCCGC AGTTATCCGG AGGCCTAACC GTCTCCCTGT 3780GATCCTGTGC TTCAGTGGTC ACGCTCCTAG TCCGCCTTCA TGTTCCATCC TCTGCACCTC 3840GCTCTGCCTT CTAGATAGCA GCAGCAAATT AGTGAAAGTA CTGAAAGTCT CTGATAAGCA 3900GAAATAATGG CGTAAGCGGT CTCTCTCTCT CTCTCGTCTC TCTCTGCCTC AGCTGCCAGG 3960AAGCGAAGCG CCCCCTGCCC AGTGGGCACG TGACCCACAT GACCTTACCT ATCACTGGAC 4020ATGGTTCACA CTCCTTACCC TGCCCCTTTG TCTTGTATCC AATAAATAGC GCAACCTGGC 4080ATTCGGGGCC GCTACCACTC TCCGCGTCTT GGTGGTAGTG GTCCCCCAGG CCCAGCTGTC 4140TTTTTCTTTT ATCTTTCTCT TCTGTCTTTA TTTCTACACT CTCTCATCTC CGCATACGAG 4200GAGAAAACCC ACCAACCCTG TCCGGCTGGT CCCTACACCC TGGCTTTCTA GACTGGAGCC 4260TAGGCACGAC TCAGCTGCTG TAGTGAATTG CGATCCTCCA AACCCAGCAA GGCACCTGCA 4320GGACATCTGG CCCAGTCTCC TCGTTGAGCC AGTTCACGAA AAAGAGACTT TTCTGAGTGA 4380CATGCTAATG GGCAATATGA GGACTAAATG GGATGGTCTC CAACTTGGAC AAACCAACAG 4440TAAAAGCCAC TTTGCGGCGA AAGAAACTTT TCCTTTTTTC TTTTTTTTGA GACAGGATCT 4500CACCCTGTCA CCCAGGCTCC AGTGCAGTGG CATGACCTTG CCTCACTGCA GCCTCAACCT 4560CTCTCAGGCT CAAGCAATCC TCCCGCCTCA ACCTCCCATC CAGCTGGGAC CATAGGTGCA 4620TGCCACCACA CCCAAATAAT TTTTATATTT TTTGTAGAGA CGAGGTTTCA CTATGTTGCT 4680CGGGCTGGTC TCAACTCCTG GGCTCAAGCA ACCCTCCCAC CTCAGCCTCC CAAACTGCTC 4740AGATTACAGC CACCAGCCAC CAGGCCTGGC CAACATAGGA AGAAATTTAA ATTTGAATTG 4800AATATTAGAA GAGATGAAAA TTCATCAACA TGGAAAGACA AAGATCATTA ACTAAAGCCA 4860AACCAGAATG GAAGCTGTGT GTACACTGGG GTCTCATGCT GGGAACGCGA GGGGCACGTC 4920CAGGGCTCCA CGGTGTGGCG ACGCCCCATG CTCCCTTTGT GGGGGTTCAT CCAGCGGAAC 4980ATGAGGACCT GCGGTGCTTT TCAACATGTA CGTGAGTTTA ATAATAAAAA GGTTTAAGGA 5040AAGAAAAATT CATATCTTTC TATATAAACA CAACATCTGG AAAGATCTAT TCTAAGGTCT 5100TGACAGTAGG AATCTCTAGG TAGTAGTAAT ATGGCCTTTT TGAATTTTTG CTTATCACTA 5160TTTTCTAATT TTCTTTTTCT TTCTAAATAA TTCTACCTAT GAAATAATTT TCTACCATAT 5220ATATTTTGTA ATAAAAATGC TTATATTTAA TTTTTTAAAC CCTGTACAAA CTTCCTGATA 5280AAATGGCAAA TTAGACACAC ACATGTGGGC CCCGTACAGT GGCTCGCGCC TGTAATTCCA 5340GCACTTTGGG AGGCTCAGGC AGGCAGATCA CCTAAGGTCA GGAGTTTGAG ACCAGCCTGG 5400CCAACATGGT GAAACCCCGT CTCTACTAAA TATACAAAAA TGAGCTGGAT GTGGTGCCAC 5460ACACCTATAG TGCCAGCTAC TTGGGAAGCT GAGGCACGAA AATTGCTTCA ACCCGGGAGG 5520CAGAGGTTGT AGTGAGCCGA GATCATGCCA CTGCACTCCA GCCTAGGCAA CAAGAGCGAC 5580ACTCCAACTC AAAAAAAAAT AAAAATAACA CACACGTGAA TAGGCTCCTC ATGGAAGTCA 5640TCACAACAAT CCAGAGGGAA GAGCTTCCAA AGTGTAAACC CAGAAGCGAG GAGCAGGAGG 5700GTGCGCGCAG ACGCAGACAG CAGCAAGGTG CAGACTGAGA GGCGGAGGCT GGCCCTCGGG 5760AGATGACTGA TGCTCAGTTT ATACCCCAAA TCCGTAAATC TAGAGGCCTG GCACATCAAC 5820TACCTCTGCC AGCACGAATC AGGGAAAGCA CGGCAACCAA AAGATGTCCC ACCCTCACCC 5880ATCCAGCTAC CTGCCATCCT CAGCCCCACT GGCAGAAGAC CCTGAGAGGT CGAGGCAGGC 5940CCCTGCCTAC AGGACCCTCA GAGCTAGGGC AAGCCGTTTAT CCTGAACTGT CTCCCCCGTA 6000AAATTCATAT GTTGAAGGCC TCATCCCCAC TGTGACTGTA TTTAAAGATG GCCTCTTCAG 6060GAGATAATTT AAATGAGGTC ATATAAGTTG GCCCTCATCC AGTAAGACTT TGACCTTCTG 6120GTGGTTTTTT TTTTTTTCGA GACTGGGTCT CACTCTNICA CTCAGGTTGG ACTACACTGG 6180CACGATCACG GCTCACTGCT GTCTCCAACT CCTGGGCTCA GGTGATCCTC CTGCTTCAGC 6240CTCCTCAGTA CCTGGGACTA CAGGTGCTTA CCACCGCACC CAGCTGCTGG TGCATTGTGT 6300TTTTTGTAGA GATGGGGTTT TGCCATGTCG CCCAGGCTGG TCCTGAACTG GGCTCAAGTG 6360ATCTGTCTCC CTCGCCCTCC TGCAGTCCTG GAATTACAGG TATGAGCCAC CGCGCCTGGC 6420CGACCGTGAC CTTCTAAGAA OTGAAAGAGA AAGATCTTTC TCTCTCCCTC CCTCTCCATC 6480ATGAGGACAC ACCAAGAAGT CCCCCATCTG CAAGCTAGAA AGCGAGTCCT CCCAACAGCT 6540GAACCTCGCA GACCCTGATC TTGGACTTCA CCCTTCACAG CTGTAAGAAA ATAACTCTCT 6600GCTGTTCACC CCACGCGGTC TACGGCAGCC CGAGCAGACT AAGACACACG CCATCTCGGG 6660AGTCAGACCA GATCAGGAAG AAAGGCCTAG AGCTCAGGAT ACTGAAGGTC CCAACCCGGT 6720GCTCGACCAG ACCACCCCGG CAGCCGCGGC CACGCAGTCA CGGCTCGGGT GAGGTGACCT 6780GGACACCATC CCGGCAGCCC CGGCCACGGA GTCACGGCTC GGGTGAGGTG ACCTGGACAC 6840CATCCCGGCA GCCCCGGCCA CGGTGTCACG GCTCGGATGA GATGACTCGG ACACCACCCC 6900GGCAGCCCCC GCCACCGTCT CAGGGCTCAG GTCAGGAGAG TTGGATATGG CACTCGCCCT 6960ACCCCGAGGC TGCTTCCACC CAGACGCCTC GGTGCGTGAC ACGAAAGCTC GGCTCAGTTG 7020GGATCAGACC AGCCTCTCCC CAGGTCAGAA ATGACCCTGG GCTCCTCACA GTAGCCCTAG 7080GGCACCATGA GAAAGCTACG TGGACTTCTC TGACCAAGGG TCACTGCTGC CACACTACTC 7140ATTGCAGGCC ATGTCAGGGC TCAGCTGAGG AGACGTGGAC ACCACCCCAG CAGCCGCGCC 7200CACGCCGTCC CAAGGGAGGG ACTTGGCCAC TGCCTCTCTG GGCAAGAGTG GGGAGGTGTG 7260GGGTGGGACA TGTCTGGAAA CATCATGGAC ACATGCCGGG AAAACACGGA AGCTCTGCAC 7320CAAGGTGCTG ACAAACGAAA AAGGAGAATG CACCTCTCAA CATCCAGCTA CCAGGTCCCA 7380CTCAGAAACT CCTGCATTTC CAGACATGGC CACCAGCTCT GTGGATGAGA CAGGGGAGGA 7440CAGGGTACCT CACACCAGGA ACCCACACAG GTCCATGTCT TGCTCTGTGA TCACACAACA 7500GCCTCCACCA CCCTGACATG CAGGAGGGAG GTCAAAGCCT CGGGTCCAAC AACAGGCTCC 7560ACAGCAAGGG AAGAAAGGCA GGAAGGAACT CAGGGCCAGG TCCTCCCAGG CAGCAGCTGC 7620CTGCACGCTG TCCACCAAGG GACCTCTGAC CTACACCGCA CAGGGGTTGG CAGTCTAGAG 7680TCGTCCTCTG TCAAACGGTG AGAAAGTCAA AAGCTCATGC TCAGTGATAT GCTAGGTCAG 7740CATCAAGATG CCACACATGA CACACAGCAA GGAPGAGACC AACGGGAAGA CTGCCCCAGA 7800CCAGAGCCCC AGAGCCCTCT GGGGAGGAAG AATAAGGATG GCAGCCTGGG ACTGCCCGGG 7860GCTGACTCTG CCTTTATTTC ACCCCAGCAG AGGCAGGAGT GACACCGCCT CACAGCAGGA 7920GCAGCTCTGC CACCTCCTAC CAGTTCCACC TACGGGCAGC AAAACAAAGC TGGCAGTTTG 7980GGCAAATGTT AGCGTTTTTG CCAACTAACA TTTGAATCGG ACATCTGGTA CAGAGATGAG 8040GAAGAAAACA CTCACAGTTT CATGAAGACT GTCAAGAAAA TCACTGACTC TTCACTTCAT 8100TTATGAAAGG CCAGCTCTCT GACATCCCTA CCACTCCCTC TCACATCAGA AATCACGGCC 8160TTTCAGGACG TGGAGCCACG TGGCCATGCA GGTACGGGAG GCCTCCCCGC AGCTGCAGCT 8220GGGTCTTCTG GTCCCCGTCC CATTTCTGCT TTTCTTCGCT CTCTACTTAC ACACACATTT 8280GAGTCCAGTC TCAGAAGAAC TGCAACTAGA AAAATCCTGA CACTTGTCCC TTACTACGTT 8340AATGCCAGCT GTGCCAAGGA CAGCCCAACC CAAGCCCCCA TCACCCCCAA TGGCACCGAG 8400GCCCGAGCTT ACCCGTGAGG GGCCAAGTTG GTCGTCACCA ACACGGTCTT CACCCCCTCC 8460ACACCACTGC CGTCCACTGC AGTGTCCGGA GTTGTCACAA CCACCACCTC CTCCATGTGC 8520ACACTCACGT CGGGAGTCGC CATGGCTCAG CGGAAGGGGA CGCCCAGGCC AGCAGCGTCA 8580GTCCTCCAGG GTCCCAAGTC CTGGAGGAAG CAAGGCAGGG CACAGGGATG GAGTCATCTC 8640CACATCCACA CAACATAGCA CTCACAAAGG CATCTCTAAT CAGCTCCAAA GACCCACCCT 8700TGACTCCCAG ACTGCTACCT CCTGACAAAA ACGAGCGGCA ACAGAAGGGC TACTCCAGGC 8760TCTGGTTCCG AGGGCGGTGT AAGCGCACTC CACCCCTTTT TCCCACTGGA TAAGCCGAAA 8820CCCTTGGCTA CPAAGCACAG AGCCACTCCC TCCACGTGGG CCTCACAGCA CGAGGACAGC 8880AGGGGCCTGG AATTCCAAGC AACTTCCCTG GACGCACCCT CCCGGCTTGC CAGTTCTTCC 8940GTCTCTCCTG GCCTGAACTC AAAGCCAGCC CCAATCCCTG AACTGAGTTT CAGGTGCAGA 9000AACCACTCCA AGAAGTCCTC GCTGGTCTGT GGAACGGGAA GGGAAACCCA TTCAAGACAG 9060AAAGAGAGGA GGGAAACGCC CTGGGTTTTT TTGGGTTTTT GGGTTTTTTT TGACACGGAG 9120TCTCCCTCTG TCCCCCAGGC TGGAATGCAC TGGCACGACC TCCGCTCACT GCAAGCTCCA 9180CCTCCTGGGT TCAAGTGATT CTCCTGCCTC AGCCTCTCCA ATTGCTGCGA TThCAGGTTT 9240CACCATGTTG CCCAGCCTCG TCTCAAACTC CTGACCTCAC GTGATCCACT CACCTCCGCC 9300TCCCAAAGTG CTGGGATTGC AGGTGTGAGG CACCATGCCT GGCCTGCCCC GGGTTTAAAA 9360ATTATTATTA TTTTGTCTTT CCTGGCTTTG CCTTCAGCAA CTCCAACCCC TGCTAAAACC 9420CGCTGATAAT GGCTGTCCTG GCCCAAAAAG CTTGGAGACA GGCGAATCTT CCTCCTGACT 9480AAAGGAATGG TGGCCCAAGA GTGTGGGGGC TCCCTGTTGC CCTCTCACTC TCCATCCCCT 9540ACCTAGCACA GGGAACACAA AACCCCCTGG TTTCCAGCCA GACGGCAACG AGCCTGGAGT 9600CAGACTGTGG GCCAGGCCAC AAGACCAGAG GGGACAACAG AGGATGGCAC ACAGCTGTGT 9660GTGAGCGCCT GGGTCCTCCC AACACAGTCT CTACGTGCTC CTGACCCTAA AGGGCAAAGG 9720GAAGAAAACT CACCTACAGG ATAGGCCACT GCCCACGTCT CAGATGCGCC CCAGTGGCGC 9780ATATGGGACA CATCCACAGT GCACTGGAAA GTCTCTAAAA TAAACTGGCC TAAGAACACA 9840GACACAGGAA CGGGGTGCAA AATTTGCAGC CTGAACCTAA CCAGGTCGAT TTCTTGCTAT 9900GAAAAAAAAA AGTCTACATT CTCTGTGAAA CTTAAAACAA GACCTAGAGT CCATAGCACA 9960GTAGTCAAAG CATCCAGAAC ACGATCAAAC TTCCTGGCAA AGGGTAGTCT GGTTGATTCT 10020CAAAGGAACA AATACACAAG AGAAGCTGGC TCTTGAACGC AGAATCCAGA GACTTTCAGG 10080TGCTATCGGA CCAGCTCCAA GAGGAAAGCA AACATTCTCA ACCAAGTGGA AAGAAAATCT 10140TGGTATACAA ACAGGAGTTA TAACCAAACA GAAATGTGAA AATTAAAAAC GACAACCAAA 10200AGAAAATACA CAAAGCTGGG ATAGTCTCAG CTACTCGGAA GGCGGGGCTG GAGGATCGTT 10260TGAGCCTAGG AGATTGAGGC TGCAATGAGC TGTGATCACA CCACCGCACT CCAGTCTCGG 10320CAACACAGTG AGAACTCTCT CAAAAAACGA AAAAGAAAGA AACTAGAACA GAAGTGACCA 10380GGGGCTGGGG GAGGGAGTAC AGGGAGTTGT TCTTTAATGA GTACAGAATT TCTGTTTGGG 10440ATGATGAAAA GCTCTGGAAA TCGACGGCGG TGATGGCTGC ACAATCACTG TGGCTGTTCT 10500GAATGGTGCT GAACCACACA TTTAAAAACA GTTAAAATGG GCTGGGCGTG GTGGCTCACG 10560CCTGTAATCC CAGCACTTTG GGAGGCGGAT CGCCTGAGGT CAGGAGTTCG AGACCATCCT 10620CCCCAACACA GTGAAATCCT GTCTTGACTA AAAATACTAA AAATTAGCCA GGCATGGTCG 10680CAGGCACCTG TAGTCCCAGC TACTTGGGAG GCTGGGGCAG GAGACCTGCT TGAACCCAGG 10740AGGCAGAGGT TGCAGTGAGC CGAGATCGTG CCACTGCACT CCAGCCTGGC CAACAAGAGC 10800GAAACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAAAAA AAGTTTAAAA TGGTTAAATT 10860TTATGTTATG TATATTTTAC CCTAATAAAA ACACTGTAAT GCTACTATAA TAGAATCACT 10920CATTAGGATT AGATATAGAC TAGAAAGTAC AGAATATAAA AACTTTTTAA ACAAAGAAAA 10980ATTTTCATGG CCAGGCATGG TGTCACACCT GTAATCCCAG GACTTTGGGA CGCCAAGCCA 11040AGAGGAATGC TTGAGCTCAG GGGTTTGAGA CCAGCCTGGG CAACACAGCA ACACCCCATC 11100TCTGCTAAAT AAATAATAAA AAATAGCCAG GCATGGTGGT GTGCACGCCT GTAGTTGCAG 11160CTACTCTGGA GGCTGACGCA GGAGGATCAC TTAAGCCCAG GAGGTCAAGG CTGCAGTGAG 11220CCATGGTTGT GCCACTGCGC TCCAGCCTGG GCAACAGATC AAGACCTTGT CACAAAAAAA 11280AGAAAGAAAG AAAAGAAAAA AGAAAGAAAA TAAAATCTTC CAGAACTTTT AAAATCATCA 11340TTGTTAATAT AAAAATAACA TCACCTGCCC CTAGGACTGT AACAAACAAG TGTGTCTAAG 11400GACAGGAGTG GGTCCACCCC AACCTGCCAC GCACTGGTCC CCTGCGGAGA GTCTGGCCCT 11460GCACTCACTA AGAGGAGGCA CTCATAGCCC AGCCAGGCCT CTGCAATTAT GCCTTCAATG 11520CCACAACTAA CTCACCCAAA CTGAACAATC GATCACAAAA TGTCCCTTCA GGTCTCAAGG 11580TTCTTGCTAA ATCTTACTCA ACCGACATTT TCCAGCATGG GAACATTTTT CTGAATGTCT 11640TAGGGAGAGG AAGTCCGCAA GAGAACAAAA GGTCCTCAGG CCACCCTAGC TTCTTTTCCT 11700CCATTCCACA GGCTGTCTTT TGTCTGGGTA TCCACTGGAC CAGGGGGCTC TACTTCTTCC 11760TACCTGCGCA TGGGTCTCCA CACAACTCCA AGGTAAAGGG CCACAGGCAA GATAAAGGGG 11820AGAAAAGAAA GCTACGATTT CCTGGGCCAC CAATCGCAAA TGGCAGCCAG TCTCTGAAGT 11880AACCCTTGAC CAGAGATCCA AGGAACCAAG AAATGTAGGT GATCTGAACA CAGCGCATGG 11940TGGTTAAACA CCATGAACGA AAGACCCATT CTCAAAGAAA AGGAAGCAAA AAGAAACCGT 12000GGGGAGCTGG GTACCACCCG CAGCAAAGAC CCCGCACGCG TTACTGACGC CAGCCTGGCC 12060TGGGAGAGCA GTGAGTGTGG CGCACGGTGA GTGGCGGGGA GGGCTGTGGT AGGTTTAGCG 12120TAAGAAGGGG CAGCGCCCAG AGCCCAGAGA ACACCAGTGA GGGCTCCACA GGAACACTAC 12180TCAAAGTATT CACGGAACAC ATCTAAACAC AAGCACTAAG GACTAAGTGC GAGGGACAAG 12240AAAATATTCC CCGTTTCCTC TTTCAGGAGG GTATCGAAAA TGAGTGATGG AAGGAAAATG 12300TATTGTTTAA ATCACGAAAA AAAATTTTTA CAAATTAAGA ACATCCTGGA ACATGATGAG 12360CCGTTTACTG TCACTCAATT TAAATGGTGG CCATCTAGGA CAGAGCGCCT AAGGGGAAAG 12420GGGGCTCACA GGTGAACCCC TCCAGCTGCT GGTGGGCAAT TTCCCATTAG GGCATCAGGG 12480TCTCTGAAGA CTGTCTTCAG ATGCTTTTTA GCCAGGAAAG TTACAATGAT GAATTCGTTT 12540ACACTGGCGG AATTACTTCG TATTTCTCAA ATATAATGTT TTCACTAGCA TAACTTTGTT 12600GTTGTAGACT TAGGCTTCAA AATAAAGAAC TTTAAACAAA CATGAATAAA AACCCACTTT 12660AGGCCGGGCG CGGTGGCTCA CACTTGTAAT CCCAGCACTT TGGGAGGCCG CGGCGGGTGG 12720ATCATAAGGT CAGAAGTTCA AAGACCAGCC TGATCAATAC GGTGAAACCC CGTCTCTACT 12780AAAAATACAA AAATTAGCCG GGCGCGGTGG CAGGTGCCTG TAATCTCAGC TACTTGGGAG 12840CCTGAGGCAG GAGAATCGCT TCAACCTGGG CAGCAGAGGT TGCAGTGAGC CAAGATCATG 12900CCACTGCACT CAAGCCTGGG TGACACAGTG AGACTCTCTC TTAAAAAAAA AAAGCCACTT 12960TAAAATTTTA CTCAGGCCAG GTGTGGTGGC TCACGCCCAT AATCCTAGCA CTTTGGGACC 13020CCGAGGCCAG CAGATCACCT GAGGTCAGGA GTTAGACCAG CCTGGCCAAC ATGGTAAAAC 13080CTTGTCTCTA CTCAAAACAC AAAAATTAGC TCGGCGTGGT GGTCTGCCCA TGTAATCCCA 13140GCTACTCAGG AGGCTGAAGT CAGAGAACTG CTTGAACCCG CGAGGCACAG GCTGCACTGT 13200GCCAAGACTG CACCACTACA CTTCAGCCTG GGCGACAGAG CAAGACCCTG TCTCAGAAAA 13260AAAAAAAATT CAAAAATTTG GCCAGGCGTG GTGGCTCACC CCTGTAATCC CATCACTTTG 13320GAAGGCCGAG GCGGGTGGAT CACCTGAGCT CAGGAATTCA AGACCAGCCT GGCCACCATG 13380ATGAAACCCT CTCTCTACTA AAAATACAAA AAAAAAAAAA CAAATTGGCC GGGCATGGTG 13440GCGGGTGCCT GTAATCCCAC CTACTTGGGA CGCTGAGGCA GGAGAATCTC TCCAACTCCC 13500GAGGCAGAGG TTGCAGCGAG CCAACATTGT GCCACTGCAC TCCAGCCTAG ACAACAGAGC 13560CAGACTCTGT CTCAAAAAA AAAAAATTAA AATTAAAAAA TAAAAATTTC ATTTAAATA 13620CTACTGATCT CCCGTCCTGA CTTCTCGCGG TTTAACTCTC ACTGAGGAGA CCCTGCTTTC 13680ATAAGGGTAA GCTCAGCAGG GGCAACTAAA GTCATTTAAG CAGACACCTG CAAAGAGGCA 13740ACAGCCTCAC TGCAGGCAGC OGTCCTCGTC ACAGCTTCAG GGCTTTGCAG AGGATTACCC 13800AATGTACACG CACAAAACTG AATTCCAGCC TCTCCATTCG CAACTGCATA CATACATATA 13860TTCTTTTTTT GAGACGGAGT CTCGCTCTGT AGCCCAGGTT GGACTGCAGT GGCCCGATCT 13920CGGCTCAATG CAAGCTCTGC CTCCCGGGTT CAAGCGATTC TCTTCCCTCA CCCTCCTGAG 13980TAGCTGGGAT TACAGGCGCC CACCACCACG CCCGGCTAAT TTTTGTATTT TTAGTACAGA 14040CGGGGTTTCA CCATGTTGGC CAGGACACTC TCGATCTCCT GACCTCGTCA TCCGCCCGCC 14100TCTGCCTCCC AAAGTGCTGG GATTACAGGC GTGAGCCACT GAGCCTGGCC TCCAATGGCA 14160ACTATATTAA AGGTTCAAAG CAATATGCAC AAAAGTTACC TCACAGAAAA TAGTGCAAGT 14220CCTTGATACA ATGCTCTTTA GACACAGAAG AAGCACTATA GAATAGAGCA CCTCCCCCTA 14280TTGCCTTCCC AAGGGCGAGC ACCCCCTCCT CTCTCCACAG CTCCTTCTTT CTTTTTTTGA 14340GATGGGAGCT CGCTCTGTCA CCCAGGCTGG AGTGCAATGG CAAAATCTTC GCTCACTGCA 14400ACCTCCGCCT CCCGGGTTGA AGTGATTCTC CTGCCTCAGC CTCCCGAGTA CCTGGCACTh 14460CAGGCACCCA ACACGCCTAG CTAATTTTTG CATTTTTGGT AGAGACGCGG TTTCATCATG 14520TTGGCCAGGC TGGTCTCGAA CTCCTCACCT CCAGTGATCC TCCCACCTTG ACCTCCCATA 14580GTGCTGGGAT TATAGGTGTG ACCCACTACA CCTCGCCTCT CCACAGCCCC TTCTGTGTTG 14640AAGCCAACAC CCACCCAGCT TTGATCCCAA GGCTTGGGTT CCCCACTAGT GTGAAGTGAG 14700TTTCCAAATT ATTAGGTAAA TCAGATATGA GAAAATATTT TATTTTACTT TTTTTTTTTT 14760GAGACGCAAT CTTGCTCCGT CACCCAGGCT GGAGTGCAAT GGCACCATCT CCACTCACTG 14820CAACCTCTCC CTTCTGGGTT CAAGCAATTC TCCTGCCTCA GCCTCCCAAC TAGCTGGGAT 14880TACAAGTGCA CACCACCACC CCCGGCTAAC TTTTGTATTT TTACTACAGA CAGCGTTTCA 14940CCGTGTTAGC CAGGCTGCTC TCAAACTCCT GACCTCATGA TCCCCCCACG TCGGGCTCCC 15000AAAGTGGTGG GATTACAGGT GTGAGCCATC ACACCTGGCC CAACAAAATA TTTTTAAACT 15060AGTATTCTTG ACCCGCACGG TCAACACTGA TGTAATTGAA ACTGTTGTAT TTGAAGTGTT 15120AGCAAAGAAA GAGAATTCTC GTTCAACAGA AAAGTCACTC ACGACTTTTC AGTCACGCAT 15180GAATTACACA GTAACCAAAT AGATAACATG CCATCACTGA CGACGGGCCC ACAACAAATC 15240AGCTCCGACC AACACGGTCC ACACCACCAT GGGTCTACAC AGATCCAGGT CCCGCCTGTG 15300AGCCTACAGT GACGCGGGCC CCTGTGGGGT CGTCCCTCCA GGTCAGGTCC CTGACAGTGG 15360GTCCCAGTGG GGTGATCCCT GCGGGTCGCG TCCCTGCCAG TTOGGTGCCT GCCGGGTGGC 15420CCCTGCCCGT CGGGTGCCTG CGGGGTGGTC CCTATGGGTC GCGTCCCTGC GGGTCCCCTG 15480CCTGCGGGGT GGCCCCTGOG AATCGCCTCC CTGCGGGTCG GGTGCCTGCC GGGTGCCCCC 15540TGCCGATCGC GTCCCTGCGC CTCCGGTCCC TCCGCGGTCG CCCCTGGCGA TCGCGTCCCT 15600CCGGCTCCGG TGCCTGCGGG GTGCTCCTTG TGGCTCGCGT CCCTGTGGGG TGGTCCCTGT 15660GGGTCGCGTC CCTGTGGGGT GCCCCCTGCG GCTCCCGTGG TGGCCCCTGC GGOTCGGGTG 15720CCTGCGGGGT GGTCCCTGTG GGTCGCCTCC CTGCGGGTCG GGTGCCTGCG GGGTGGTCCC 15780TGCGGCTCGC ACCCCTGCGG CCTGGTCCCC CCGGCATCCC TCCACCGAGG AGGCCGCTGG 15840AGGCCGAGCC CCCGCCCCCC CCCCGCGCCA ACATGGAGGC AGGAAGCGCC GCCGCCCGCG 15900CCCGCCACCG CCCCCGCCGC CCGCCTGACG CCCCCGTTGC GCCTGACGCC GCCCCCCGCG 15960CGGCCGCCCC TCCCCCGGCC CTCCCCTCCC CCCGCCGTAA CGTCCTGACG CTCCGCACCG 16020ACCCCTGACT GGACCCCCGC GCGTGACCCC AGCGAGAGGC CTCGCCGCGG GGGGGCCGCG 16080GGCTCGCCGG CGCCGCTTAC CTGGGGCCCC GCCGGGCCTG CTTAGGCACC CGGCCGGGGC 16140GGCGGCGTCG GGAGCTGCGG CGGCGGCGGG CGGCGGCGGC GGCCGCGGGC TTCCCTCCTT 16200GTTGCGGATT CCCCGGCGGC GGCGGCGCGG GCGCGCGCTT CCTAGTGACG CAGGCGCCGG 16260GGCCGCGCAC GCACGGGGCT GGGAGGGCCG GACACTTATT TGGCGCTCGC GGACGAGGAA 16320GGCGGCCCCC TGAAATAAGG CCCGACGGGC CCCGGGGCGC GTGCGCGCAC CGACACTCTC 16380AGCTCCTAAC GCCCCACGTT CCTCCTCGTC CCCCACGCCC CCGGTCGGGC GTTGCCTGCC 16440CCGCGCCGCC GGCCGGGCCG AGGGACGATG GTCACTGGAC GGACGGCCCC AGGGAGCAGT 16500GCCCACGCGC GCCACGGCGG TACCTTCAGG CCTCCAGGTA CGGGCGCTCC TCGCCCGGAC 16560GCTGCTGTGT GrGAATGGGC CCGAGCGGAC TCCCCTGCGG GGCGGACGCC TGAACACGAG 16620GCTGTCGAGG ACGACGCTGT AGGGTGCGCG GACTCACGCG GAACATGCCA CAGGCTCACC 16680CAGCCACGCC GCTCCCAGCG TGGAGGGCGA GGGGCATCCG GGAGCGCCCC GCAGCGCTCC 16740GTCACCCCTC AACCTCTCAC CCCAGTCCCA CAACCAGCAC CCCGATCCTA TCGCAGTCCC 16800ACACCCGACA CCCCCATCCC ACCCCTGCCC AACAGCCCCC ACCCACCCCA ATCCCATAGC 16860TAACACCCCC GTCCCACCGC TGTCCCACGC CCGGCACCCC GATCCCACCC CAGTCCCCCA 16920GCTGCCACCC CGATCCCACC CCAGCCCAAC AGCTGGCACC CACCCCGATC CCACCGCTGT 16980CCCACA~CCG GCACCCCGAT CCCACCCCAC TCCCGCAGCC GGCACCCCGA TCCCACAGCC 17040GGCACTCACC CCGATCGCAT AGCATAGCTG ATACCCCGAT CCCACCCCAG TCCCATAGCC 17100AGCACCCCGA TCCCACCCCA GTCCCATAGC CAGCACCTCG ATCCCATAGA TGACACCCCG 17160ATCACGCCCC AGTCCTATAG CCCGCACCCC GATCCCACCC CAGTCCCGCA GCCGGCACCC 17220CATCCCACCC ATGTCCCACA GTCGGCACCC CGATCCCACT CGGATCCGGC AGCCAGCTTG 17280GATCCTGTGG CCCTCCTCCA GCCCCCAGGG CTCATTTATA TGTTTTATTG GCAGAGGCTG 17340GGGCTGGCTC TCTTGGCCTC TGTGCTGGGT TTCTTCCTCT GCACCGCAGO ACTGCCTCTC 17400CTGACCTCTC CAGGTCTCAT CGAACACCCT TGTGCTTGCT GTCACCCGCT GCCTCTCTGC 17460AGCATCCCGG ATTCCGTATC AGGGGACCGA AATTAGTCGC AAAATAGGAA GCAGGTGCTC 17520CCTTCGATGG AACCCTCACC CTGTGCTCAC ACTTGTAGGA GGAGGGCTCT GCAGGCCGCC 17580TCCCGGAACG GCACGTTCCC AAGCCACTGC ACTTCGGAGG GGCTGTAATT ACAGTTGCAC 17640ATTCATTCAG TTCCCAGTAA AGTAGAACGT GCTCCAGCCA GTGAGGAAAA CGTCTTTTTA 17700AAAATTAGAT TGGCCGAGTG CCGTCGCTCA TGCCTTTTAC CTCAACACTT TGGGAGACAA 17760AGGTGCGAGG ATCACCTCTG GCCAGGAGTT CAAGACCAGC CTCGGCAACA GAGCCTGTCT 17620CTGGGGAAGA ATAAAAAAAA AAATTCAGCC TTTGTCAGTG CTACTATTTT ATTATCTGGT 17860AAATATGAGA CGGTTCACGC GGTCTATGTG TGTCATTTAT CTGAGTTTGC CTATCGTCAC 17940GTTTTGGAAA TAAATGTCAA TAAACTCGAA GACGAGTGCT GAGGGGGCCC TGGGGATGGG 18000AGGGTGGCTA CATCATGCCT CTGTGTTGCG CAACCCCACC GAGGTCGGCC TGGGGTCAGC 18060CCTCCGGCCT GTTCTGCCTC CTTCACTCTG GCCCTCCAAG AGACAAACTG GGCAACAAGA 18120GAGAAACTCC ATCTAAAAAA AAAGAAAAAT CACCTCCAAC ATAACTTAGC TTTCTTCTGC 18180TGGCATAACA AATTATCTCA AACTTAGTCG CTTAAAAATG CAAATTTAGG CTGAGTGCGC 18240AGGCTCACGC CCATAATCCT AGCACTTTCC GAGGCCAAGG CAGGATTGCT TGAGGCCAGG 18300AGTTCGAGAC CAACATGGCC ACAACTGTCT CTTTTTAAAA AATGCAAATG TGTCCGGCAC 18360GGTGGCTCAC GCCTATAATC CCAGCACTTT CTGAGGCCAA CGCGGGCAGA TCACCAGGTC 18420AGGAGATAGA GACCATCCTG GCTAACACTG TGAAACCCCC TCTCTACTAA AAATACAAAA 18480AATTAGCCTG GCGTGGTGGC AGGCCCCTGT AGTCCCAGCT ACTCGGGAGC CTGAGGCAGG 18540AGAATGGCGT GAACCCAGGA AGCGGAGCTT GCAGTGAGCC GAGATGGCGC CACTGCACTC 18600CAGCCTAGGC AACAGAGCAA GACTCCGTCT CAAAAAATAA ATAAATAAAA CTGCAAATGT 18660ATTCTCTAAC TGTTCTGTAG GTCGGAAGTC CAGCCCAGCC TCACTCCGCC AAAATCAGGG 18720TGTCTGCAGG GCCGATTGCT TTTGGAGCTC CAGGGGAGAA GCTGTTCTGG CCTTTCCAGT 18780TTCTGGAAGC ACTTGAGCCC CTTGTCTCGT GGCCTATCCC ACACCTGAAA GCCAGCCAAA 18840GCCAGTTGAC TCCTCACCCT GTTGGCCCCG ACACTGATCT CCTGCCTCCC TCATCTGCTG 18900TCAAGGCCCC TTGTGATGAC ATGGGGCCAC CAGCTGGCCC AGGGCACCTC CTGTCAGAGT 18960CCGCCCACCA GTGACCTTCA TTCCATCTGT CGCTGTAATT CCCCTTTGCT TGGAACCAAC 19020GTTCACAGAT CCCAGGGGTT AGGATGTGAA TATCTTGGGC AGGGCTGTGG GGGGCCTATT 19080CTTCCTTCTA AAATATTTAT CATTTTTGTT TTGGGGATTT TTTTGGTTTG CTTTTTTTTC 19140AGACAGAGTC TCGCTCTGTC GCCCAGGTTC GAGTGCAATG GTGCAATCTC AGCTCACTGC 19200AACCTCTGCC TCCGGGCAGA CGTGAGCCAC TCCACCAGGC CTGTTTTTGT TTTTGTTTGT 19260TTTGTTTTGT TTTTGAGATG GAGTCTCGGC CCGGCGCCGT GCCTCACGCC TGTAATCCCA 19320GCACTTTCGG AGGCCCAGGC GCCCGGATCA GGAGCTCAGG AGATCGAGAC CATCCTGCCT 19380AACACCGTGA AACCCCCTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TGGTAGCGGG 19440CGCCTGTACT CCCAGCTACT CGGGAGGCTG AGGCAGCAGA ATGGCGTGAA CCCGGGAGCC 19500GGAGCTTCCA CTGAGCCGAG ATCGCGCCAC TGCACTCCAG CCTCGCCGAC AGAGCGAGAC 19560TCCGTCTCAA AAAAAAAAAA AAAAAAAAAA AAAAAAAGAG ATGGACTCTC ACTTTGTCAC 19620CCAGGCTGGA GTGTAGTCGC GGGATTATAG GTACGCGCCA TCATGCCCAG TTACTTTTG 19680TATTTTTAGT AGAGACAGGG TTTTACCATG TTGGTCAGAC TGGTCTCAAA CTCCTGATCT 19740CAGGTAATCC ACCCGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGACGTC ACCCACCGTG 19800TCTGGCCATA TTTATTAACT ACAAAGGGAA AGATGATAAT TTTTTTTTTT GAGATGGAGT 19860CTCACTCTGT CACCCACGCT GGAGTACAAT AGCGTCATCT TGCCTCACTG AAACCTCTGC 19920CTCCCAGGTT CAAGCGATTC TCCTGCCTCA GCCTCCCAAC TAGCTCGGAT TACACGCGCA 19980CGCTACCAAG CCCAGCTAAT TTTTGTATTT TTAGTAGAAA CGGAGTTTCA CCATGTTGGT 20040GAGGCTGGTC TCGAACTCCT GACCTTGTGA TCTCCCCACC TCGGCCTCCC AAAGTGCTGG 20100GATTATAGGC ATGAGCCACT GCAACCGGCT GAAAGATGGT AATTTTAAAG TACACAAACT 20160GGGTTGGCTG GGCATGGTGG CTTATGCCTG TAAGCTCAGC ACTTTGGAAG TCCAAGGCAA 20220GAGGATCGCT TGAGTCCAGG AGTTTGAGAC CAGCCTGGAC AATATAGCAA GACCCCATCT 20280CCGCAAAAGC TAAAAAGTTA GCCAGGTGTC GCGGCACATG CCTGTAGTCC CAGCTACTCA 20340GGAGGCTGAC GTGGGAGCAT CACTTGAGAC CAGGAGGTCA AGGCTGAAGT GAGCTGTTAT 20400TGTGCCACTG CACTCAGCCT GGGCAACAGA GCGAGAGTCT GTCTCCAAAG GTAAAAAAAG 20460GTCCAGGCAC AGTGGCTCAC ACCTGTAATC TCAGCACTTT GGCAGCCCGA GGCGGGCAGA 20520TTCGTTGAGG TCAGGAGTTC AAAACGAGCC TGGCTAAATG GTGAAACCCC GTCTCTACTA 20580AAAATACAAA AAAATTAGCC AGGCATGGTG ACGGGCGCCT GTAATCTCAG CTACTTGCCA 20640GACTGAGGCA GGAGAATCAT GTAAACCCAG GAGGCTGAGG TTGCAGCGAG CCAAGATCAT 20700GCCACTGCAC TTCACCCTGG CCGACAGAGC AAGACTGTCT CAAAACAAAA CAAAACAATC 20760TTGACTCCTG AGTTCCTCTA AGGGAAATTC CAGGCACCTC GCCACCCTTC ACAGGCAAAG 20820GAACAATCTG ATGAGGAAGA AGATAGAAAC AGCTTAAACA ATAGTCTCCC GGCCGGGGGC 20880AGTGGCTCAC GCCTCTAATC TGAGCACTTT GGGAGGCCGA CGCGGGTGGA TCACAAGGTC 20940AAGAGATCAA GACCATCCTG CCTAACATGG TGAAACCCCG TCTCTACTAA AAATACAAAA 21000AATTAGCCGG GCGTGGTGGT GGGTGCCTGT AGTCCCAGCT ACTCGGGAGG CTGAGGCAGG 21060AGAATGGCGT GAACCCACGA GGCGGAGCTT TCAGTGAGCT GAGATCGCGC CTCTGCACTC 21120CAGCCTGGGC GACAGAGCCP CGAGACTCCA TCTCAAAAAA AAAAAAAAAT TAGCTGGGTG 21180TGGTGGCTCA CACCTGTAAT CCCAGCTACG TCCCAGGCTG AGGCAGGAGA ATCGCTTGAA 21240CCTGGGACGC GGAGGTTGTA GGGAGCTGAG ATCCCACCAC TGCACTCCAG CCTGGGCAAC 21300AGAGOGAGAC TCTGTCTCAA AAAAAAAAAA AAAAAACAAA AAAACAATAG TCTCCCAAGT 21360AAGTCAGAGT CACAAGGTGT TTTGATTCCC TGTGCAAACT AAAATATAAC AGCTTAACAT 21420ATGTTCTTGA GTTATTTTTC AGAAACTTGG ACATCCACCA GGTGGAAAAT GCTGAGCTAG 21480GAACAGTGGC TATAATTTCA GCCTTTGAG AGGCCAAGGT GGAAGGATCA CTTGAGGCCA 21540GGAGTTAGAG ACCAGCCTGG CCAACATGGT GAAACCCCGT CTCTAGTAAA AATACAAATA 21600TTAGCTGGGC ATGGTGGTGC AACCTGAAAT CCCAGCTACT TCGGAGACCT AGCTGGGAGG 21660ATCGCTTGAA CCTCGTAGGA GGAGTTTGCA GTGAGCTGAA ATTGTGCCAC TGCACTCTAG 21720CCTGGGCAAC AGAGTGAGAC TCTGTCTCAA AAAATAAATA AATAAAAAGA GAAAAAAGTG 21780TTGCCTGCAG GCCGGGCACA GTGGCTCACG CCTGTAATCC CAACACTTTG GGAGGCCGAG 21840ATGGGCAGAT CACCTGAGGT CAGGAGTGCA AGAACAGCCT GGCCAACATG GTGAAACCCC 21900ATCTCTACTA AAAATACAAA AGTTAGCTGG GTGTGTACAT GTAGTCTCAG CTACTTGGGA 21960AGCTGAGGCA GGAGAATCTC TTCAACCGGG GAGGTGGAGG TTGCGATGAG CTGAGATCAC 22020GCCACCACAC TCCATCCAGC CTGGGTGACA GAGTGAGACT CCATCTCAAA GCAAAAAAAG 22080AAACATAGGT GGGACCCTTG GTGTGTCCTT AGGGCATGAT GGTTGACGTA TACTGCTGGT 22140CCTGTCATGT AAAAGAAAAC GAGCCGACTC TGTGTCTACT CGAGAAAGCA CTGCATATAT 22200CAGCCACAGT CAATACCTCG CTTCTGCAGG GACGGTGGCT GCCAGAGTGG GAGGCTTTGG 22260TAGCACCCAT GTCGTGGAAT CACAATGTTG TCGATAGCTC TGGGGTCTTG TACAAAATGC 22320CAGATCCTCC CATTTGGTTT CCTTATGGGA AGGATCGCAG TACTATAATA CATGGGCTTG 22380TGCAAGGGAT CATTATACCC TTTTCTCTTT TTTTGCTTTT CTTTGAGACA GACTTTCACT 22440CTCGTCACCC AGGCTGGAGT GCAATGGCGC GATCTTGGCT CACTGCAACC TCCACCTCCT 22500GGGTTCAAGT GATTTTCCTG GCTCAGCCTT CTGACTAGCT GGGATTACAC ATGCCCGCCA 22560CCAGGCCTGA CTTATTTTTG TATTTTTACT AGAGACAGGG TTTCACCAAG TTGGTCAGGC 22620TGGTCTTGAA CTCCTGACCT CAGGTGATCC ACCCACCTCG GCCTCCCAAA GTGTTGGGAT 22680TTCAGGCATA AGCCACCAGG CCCAGCCTTT CTTTCTTTTT AAAATTAATC TTTGTTTAAA 22740AATACTCTCA TTTTTTATTT AATTGTAGCA CTCCTAGATC CCGAAAGCAG ATACACTCTT 22800GTTATGGGTC TGATTCTTTT CATTGCTTCA CGCCTTAGAG GATATTGTCC AATACTGGAT 22860AAAAGTTTAC TCAGGTCTAC TTCCACTTTA ACGGGCATGG CTGAATATCT CTTCCACTTG 22920GCTGTTTGTT TATAATGAAC TGACAAACAT ACAAATTTTC TTGAGTTCTG TGAGACATTC 22980TAGTAAATCA TCTAACCTGA AGAGCAGGTT GTGAGAACCC CTGATTTAGA AAGCCCAGTG 23040GTCATAAATA TAAGTGGCTC TGGACTGCCT CCCGGGGTCT GAAGTGTGGG CAGTCGGTTA 23100GGATTCAGCC CTTGTAATTT GTAGGATCTG ACACACACTC CAGGAAGGCA GTGTCAGAAT 23160TTACCTCTAT TATATTGGAC ACCCAGTTAG CGTTTCGAGA ATTGGTTGCT CCTATAGAAA 23220AATACCAAAT ATTTTATGTC AGGGGAGTGA AAGAAAAAAC AAAAACCCGG CCCGGCGCGG 23280TGGCTCACGC CTGTCATCCC AGCACTTTGG GAGGCCGAGA CGCGCGGATC ACGAGGTCAG 23340GAGATCGAGA CCATCCTGGC TAACACCGTG AAACCCCATC TCTACTAAAA ATACAAAAAT 23400TAGCCGCGCG TGGTGGCGCC CGCCTCTAGT CCCAGCTACT CGGCAGGCTG ACGCAGGAGA 23460ATCGCGTCAA CCCGGGAGGC GGAGCTTCCA GTGAGCCCAG ATCGCGCCAC CCCACTCCAG 23520CCTGGGCGAC AGAGCGAGAC TCCGTCTCAA AAAAAAAAAA CAAAAAAAAA AAACAAAAAA 23580AAAAAACCCA TACACTTThA GGAAAGCAAC TGACAGCATT TGTTACCAGT GATAAAATTT 23640GAGCTTTGAA GTAACAATAA CAATTTTCCC ATTGTGCCCG GCCCAACAAA AAAAAAAGAA 23700TTTTGCCATT CTGAAAGGCT TCCCAGTACT TTCTGATGAC CTTGACGGTG ATATTAACAA 23760ATAACTTTTT TTTTTTTTTT TTGAGATGG GTCTTCCTCT GTCACCCAGC CTGGACTGCA 23820GTGGTTCAAT CTCAGCTCAC TGCAACCTCC GCCTCCCAGG TTCAAGCGAT TCTCCTGCCT 23880CAACGTCCCA AGTCGCTGGA CTACAGGTGT GCGCCACCAC GTCCACATAA TTTTTCTATT 23940TTTAGTAGAG ATGCGGTTTC ACCATGTTGC CCAGACTGGT CTCAAACTCG TGACCTCAGG 24000CGACCCGCCC ACCTCGGCCT CCCAAAGCTC GGAGCCCTTG CTGGGATTAG AGGTATGAGC 24060CGCTGCACCT GGCCTCTTCT CCTTCTGTTT TGCAGTCATG CAATGACCAT GTCTTACATT 24120TCCAACCAGA AAAAAAGGTT ACTCTAACAA TCTTTATCCT GTTTTTCCCA GAGTAGACAT 24180TATGAAGATT AAAAAAATTT CAAAGTGTTT TGAATATAAT AAACTATGCT ATACACACAA 24240CATTTTGGTG ACTAGAAATA CAACTTTATT GTTTGTTGTT TGTTGAGACA GGGCCCTGCT 24300CTGTCTCCCA GGCTGGCTGG CACAATCATG GCTCACTACA GTCTTGAACT CCTGGGCTTA 24360AGCGATCCTC CCACCTCAGC CTCCAGAGTA GCTCCCACTG CAAACGAGCA CCACCACGCC 24420TGGCTAATAT TTGTATTTTT TGTAGAGATG GGGTTTCACC ATGTTGCCCA GACTGGTCTC 24480AAACTCCTGG GCTCAAGCAA TGCTCCTGCC TCGCCCTCCC AAAGTGCTGG GATCACAACT 24540ATGAGCCACT CCACCCCGCT CAGTTTCTCT TGTTTTAAGC CGCTTCATTT GTGGTACTTC 24600TTACAGCAGT CCCAGGAAAC TCACCAACTG CAGAACATCA AAATTGTTTT TCTTCAGCAA 24660AAGGAGAAGC AcTTGTGGTT CGCACCAGCT TTTCCTGTGC TCACTTCTGC ATGGCCGCAC 24720CTTTGCCCGA CACGAGTGCA CAGCAGGCTO TGGGGGAGCA ACTGCTTGAG TCAGGCCTCC 24780ACTTGTGCCC TATCCCCACC TGCTTTGCTG GACACCCCTG TTTGGGGGGC ACCCACTGCT 24840GCCCCAGACA CCAAGCAAGC ACCAGCTGTC TCCAAAACTT ACAGTCACTG TCTTGGCCCG 24900TTTTGTGCTG CTGTAACAGA ATGCCACACA CTGGGTAATT TAATACAGAA CAGAAATTTA 24960TTTCCTCAAA GTTTTCGACG CTGGGAAGTC CAAGAGCAAG CGGCCATCAG GTCAGGGCCT 25020GGTCTCTGCT TCCACGATGC CACCTTGACC ACCGTGTCCT CACGTGGTCA GAGAGAGCCC 25080ACTCCCAGGA GCCCTTTTAA TAGAGCAOAA CACTCGCTCG CTGCGCTTAA GTTTCCAACA 25140CGTGAACTTC GCAGCTGACA CATTCAGATC ATAGCACTCA CTCTAGGCAG ACTGTCTGAT 25200GTGGTTTTAA AATACGTTCA CAGACTGGCC GGGCACTGTA GCTCACGTCT GTAATCCCAA 25260CAGTTTGGGA GGCCAAGGTG GGTCGATCAC CTGAGGTCAG GAGTTCAAGA CCAGCCTCAC 25320CAACATGGTG AAACCCCATC TCTACTAAAA ATACAAAATT AGCCAGGTGG TGCATGCCTG 25380TAATCCCAGC TACTCGGCAG GCCGAGGCTG GAGAATCCCT TGAATCCAGG AGGTGGAGG 25440TACAGTGACT CGAGATCATG CCATTGCACT CCAGCCTGGG CAACAAGAGC GAAACTCTGT 25500CTCAAAAAAT AAAATAAAAT AAAATACATT CACAAGCCCG GCCACTGTGG CTCACGCCTC 25560TAATCCCAGC TACTTGGGAG ACTGAGGCAG GAGAATCGCT TATAACCTGC GAGGTGGAGG 25620TTGCAGTGAG CTGAGATCAC ACCGCTACAC TCTACCTTGG GCAACAACAG TGAAACTCCG 25680TCTCAAAAAA GTAAAATAAG CCCCTGCAGG CATGGTGGCC CACACCTGTA ATCCCAGCAC 25740TTTAGGAGGC CAAGGCGGTC GGATCACGAG GTCAGGAGTT CGAGACCAGC CTGGCCAACA 25800TGATGAAACC CCGTCTCTAC TAGCCTAGCC AACATOGGGA AACCCTGTCT CTACTAAAAA 25860TACAAAAATT AGCCGGGCAT GGTGGTGCGT GCCTGTAATC CCAGCTACTC AGCAGCCTGA 25920GGCAGGAGAA TCGCTTGAAC CCAGGAACCA GAGGGTGCAG TGAGCCAAGA TTGCGCCGCT 25980CCTCTCTAGC CTGGGCGACA GAGCCAGACT CCATCTCTAA ATAAATAAAT AAAATAAGAA 26040AATAPAATAT GTTCACAAAT CCTTTGACAT TCCTCACCTC AAAGCTGCA ACCCAACTCC 26100CTCCTAAGCA TGAGTCTTCT CAGTGACTCA CTTCTAACAG CAGAACTTAC ATGGTTCCCC 26160ACACCCAGAG GACATTGGGT TCCTCCCAAT ATCCCCCCAC CCACCGACCC CCACCCAGCT 26220CGCTCCCTTT GGGTCCCCCA GACCCATGTT TCAAGGACAC TCAGGCAGCC CCTGGATGTC 26280CATCTGGTAA GGAATGAAGG CCTCCTGCCT GCAGCCTCGG GAGGGAGCAT TCTCAGAAGA 26340GGATGCCCCA CCTCCTGCCC ACCCTTCACA TGGCCAGGAC CTCGTCCAAC GTCCTGACTG 26400CAACATCATG AGAGACTCCG AGCCAGAAAC CCCCAGGTTT TGTACTCCTG ACTTATCGGA 26460ACTGACAGAT AATGTTCGTT GTTAATTAAC GGGTGACTTG TCACACACAA TAGGTCACTA 26520AACAGCTCTG TCTGGCCTCC CAGGAGGAGC CTCCCTTTCC TTTTCTTCAT GGGAAAAGTG 26580CGATCAGTTT GTGAAGGAAT GTCCGCCCCC ACTTGATGCC AGAGGCTCCA CATGGTGACT 26640GTCATAAACT CCATCTGCCC TCAGTGCCTT CCCAGCACCC GGCCTGCGAT CAGCTTGCTC 26700TTGCGGCAGC CCAAGGCCCA CGTGTGTTTG TGTCTGCTGT CTCTGTCTGC GTGCCCATGC 26760ATGCCCAGGG TACAGGGATG CCATATACAA ATTCTTTCAA TGTTGTATGT GGCATGTGTG 26820TGTCTGTATG CCCAGGATAC AGGGATGCTA TATACAAACT CTGTTTTTTC GTTTTTTTTT 26880TTTTGAGACA CACTCTTGCT GTTTCGCCCA GGCCGGACTG CAGTGGCGCT ATCTCGGCTG 26940ACTGCAAGCT CCACCTCCCC GGTTCACGCC ATCCTCCTGC CTCAGCCTCC TGAGTAGCTG 27000GAACTACAGG CGCCCGCCAC CACACCCGGC TAATTTTTTG TATTTTTAGT AGAGACGGGG 27060TTTCACCATG TTAGCCAGGA TGGTCTTGAT CTCCTGACCT CGTGATCCAC CCGCCTCACC 27120CTCCCAAAGT GCTGGGATTA CACGCATGAG CCACCACGCC TGGCCTACAA ACTCTTTCTT 27180TTTTTTTTTT TTTTTTTTCA GATGGAGTCT CACTGTCTTC CAGGCTCGAG TGCACTGATG 27240CGATCTCAGC TCACTGCAAG CTCCACCTCC CGGGTTCATG CCATTCTCCT GCCTCAGCCT 27300CCCAAGTAGC TGGGACTACA GGCACACACC ACCACGCCCA GCTAATTTTT TCTGTTTTTA 27360GCAGAGATGG GCTTTCACCA TGTTAGCCAG GATGGTCTCG ATCTCCTCAC CTCGTCATCC 27420GCCCCCCTCG CCCTCCCAAA GTGCTGGCAT TACAGCCGTG AGCCACTGCG CCCACCCTGC 27480AAACTCTTTC AATGTCTTTC TTTTCTCTCT CCTGCCATCT TCTCCCTTGC ACATTTCTTT 27540TGTCTCTACG TCTTCCCCAG CTGAGTCCGA GGTCCTGACT TGCCCACGCT CCCTGGACTG 27600GAGGAGAGGT GATAGCAAGA GCTCCTTCAA CCCCAGGAAT GCCACCAGGG CTGCCCCGGG 27660AGAGGAGGAA GCTGGGTCTC TCGGCGTTGT GGGGACCAGA CACCCTTCTA AGACATGGAC 27720TCAGCACAGA AAGTCTACAC ATCCACTACA AACACATCTC CCTCCTAACA GGGGGCCCCT 27780GGGCACCCCA AGTGGCTGTT TGGTGGGACA GGCATGTCCA TCAGTCAGAA TATCTTTATT 27840TTTTATTTTT TATTTTVTAT TTTTGAGAGA GTTTCACTGG AGTGCAATGC CACGATCTCA 27900GCTCCCTACA ACCTCCGCCT CCCAGGTTCA AGCGATTCTC CTCCCTCAGC CTGCCACGTA 27960GCTGGGATTA CAGGTGTGAG CCACCACACC CAGCTAATTT TTTTTTTTTT TTTTTGAGAT 28020GCAGTCTCGA GGCTCTGTCQ CCCAGGCTGG AGTGCAGAGG CGCGATCTCA GCTCACTGAA 28080AGCTCCOCCT CCTGGGTTCA CGCCATTCTC CTGCCTCAGC CTCCCGAGTA GCTGGGATTA 28140CAGGCATGAG CCACCGCGCC CGGCCAATTT TGTATTTTTA GTAGAGACAG GGTTTCACCA 28200TGTTGGTCAG GCTGGTCTTG AACTCCTGAC CTCAGGTGAT CCACCTCCCT CGGCCTCCCA 28260AACTGCTGGC ATTACAGCCC TGAGCCACCA CGCCCAGCCC AGAATGTCTT CTTACTTTTT 28320ATTACTCTGT CCCCCATCCT GGGTCCAGAC CTGTGACCGT GAACAACCGG CTGCCCAGCG 28380GTGAATGGGG TGAGTGGGGT GAGTCCACAG AACAGTGGGG TGCACCCCCA GGGGTCTCGT 28440AGCACCTGCC CCCAGGPCAG GAAGTCCCAC AGCCTAGAGG CTCCAGCCTC AGATG~ATAC 28500ATATGTAGGC CCTGCCCTTT CCTCCTGACC GGCGGGCCAC AGACTCCTCA ACAACACCAA 28560GCCCCTGAGG AGGCCTCCGC CCTCAGGGAC GGCAGGGGAG CCCCCGCCAG CCCCACCCAC 28620AGCAGCGGGC CCTGCCACCC CCCACCCTCA CACCTCACCC CTTGGATTCC AGAGAGCAAA 28680GTGGGCTTGT GTGTAGTTTA CATGCTCATA TCTTAAAATC ACCGTTGTCA ATAGAACAAT 28740TCATAATAAT GATGATAAAA TAAGATTTAT AACCAGCTTC AGTCTGGAGA TACACACAGA 28800GCAGATCTTC ACTCCCAGAC AGGGAGCCCG CAGCTGCCCC CGACCCCACA GGTGCAGGAC 28860ACACACAGAC AGTTCAACCA TGTCTTAAAC ACACAGGTGT TTATTTAATT GTTCATTTGA 28920TTGAATTTTT AAGTTCACTT TACTACGTGG ATGAGATGGG TGCATATTAC AGTAGGCTTT 28980CGCTATGAGC GCTGCCACCA TGAGGAATAT CCCAGCCCTC AGTTCTGCTT CCCTTTCTGA 29040GTCCCACAAA AGCCAGATGT GGACAGCCTT GGGTTCCCAT CCCAGCTGGC TGCTCCTTCT 29100GGGGCTGTCT TGGTGGGGAG AGGGAGATGG GGCAGTGGGT CCCTGCTGAC CCCTGAGCCC 29160TGCAGGGGGT AGGATCCTCC CGTGGTCCCT GGGTGTGGCT CTGGAAGACA CTGGCAGTGC 29220CCGGCCAAGG CCTCCCGCAG GATGGAAGTT GAGGGCCCTG GCTCTGGGTC CTAACAGAAC 29280TCACCCGCCC CCTTCACACT TTACAGCAAG GGGCCAGGCA GCAGCTTTGG CATGGGGCTT 29340CCGTGGAGAA GTGGGCGATG CTGCAGTGGT ACAAAGACAG CCTCCCCCAC CGCCATCCTC 29400CAGCTGACCG TCCTCCAAGC CCAGCACTGG GCGTCCAAGG GAAAGAAGCA ACTCACCCCA 29460GAGGGTGTGG GCAGGAGAGG CCTGGACTCA GGCCTCCACC CACAGCCCCC TCTGCGTCCC 29520AAGTGGGAAG GGTGTTGGGG CTGGCTTGGG AACCTTACCC GCTGCCCTTC CAACACCTGG 29580ATCTGTGGGC AGCGGTCCCA CAAAATCCCC CTTGGGGCTC CCTGAGGAGG ACTTGTGGCT 29640GCCGCTTCCA CCACGGCAGA GGGCACAGGA GGGGCCAGCA CTCCAAAGGG CTCTAGGGTG 29700GCTCTTTCAA GGACATCTGC AAAGCCCTGG TOGOGAGGOG CCTGGGCCAG AGGCTCTTTG 29760GAACTCTTGC ACTTCTGAGT GGGGGACTGT CCATGCTGCC CACAACCTCT AGACCATOCA 29820GCCTGCTCAT GGGTCCCTGG CAGAGAATGC CCACTCCCCA CCACACTCAG GGCAGGCCCC 29880CAACTGCAGG CTTCCAGGAA GGCCCAGGGT GTCCACCTCA CGCCAGGTGG TCTCAGAGGA 29940CCCCTGTGCA ACCACATTAA GGAAAGCTGC AGCCCCCACC CACCCCCCTG CCAGTTCAAC 30000AAGCACCGGC TGCACACGCA CGCTCCCAGG CACCATCACC CCCCTCCCCC GTCGCCCCTC 30060CCTCACGGGG AGCCCCTTCC CCCTGGAAAG ACAGCAGGTA CTGTAGCCTC GCCTGCTGGC 30120CAGGGGCGCC GGCTCAGAGG ACCTGCCCTG ACCTGCACGT CCTGACCAGA CAGCCCAGCG 30180TAAGGACCCG CGATCCCACG CCACCGCCCT GGGTTTACCA CGGTCACCAC CACCTCTCTC 30240ACAGGGCCCC CGGGGCACCC AGCCCCCCCC GGCCTGGTGT CTCCACCCAG GGACCGCGTC 30300TCACGCCCGG CGGCTCCTGC AGGGGAACCC GTGCTCAGCG ACTCACCACG AGGACAGGGC 30360AGGGCGGCTG AGTGCGGAAG AGAAGCATGA AGCTGGGGGC GGGGGTGGGG GAGGAGGAAC 30420AAAAAGTTGCA TCTAGACAGA GGTGAACGAA ACAAAACCAA AACCCGAACG TGTTCCGTCG 30480CAGGATCGGC GCCGCCCGTC CCCGGCCCTT AGCCCGACAT CTCTTCTCGC TGCTCCTTGT 30540TCCTGCCCAC CTCGGCCGCG TGCAGCTCCT GCAGCACAGG GGGCGGGAGG GCCTGACGGC 30600GGGGGTGGCT TCCGCCGACT CCGGGAACCC CCAGGCGCGC AGGCCGTGGC GCCCTGGCAC 30660CCGCCCGGCC TCATCCGGGC TGGCCTTCGG CAGGACCCTG ACTGAGTTGA GGGCGCGGGA 30720GCACCGGGGA GGCGCAGAGC AAGGCCAGGG ACCAAGGACG GGTTTCCTGG GAGCTGGCTG 30780GGCCCCGCTT CTAGCTCGTA CCGCAGCCGA GCTTCCTTCA GGGCACTTTC AATATAATGA 30840ATTTAGCCAT CTATTACTGC GGCTAGTTAC TGTCCCGCCA GGACCACACT CTGGACCTGC 30900CTCGTGCGCT GCTGGGGACG CCCAGTAAAC ACGGGAGGAG CCCCCGACCC CCACCCCAGC 30960TCAGCGCCTC GGAGTCCCCC GCCCCGCTCT GCGCCCCTCC GACCTCCGCC CTAGCCCCGC 31020CCCCGCCCAG TGCCCCGCCC CCTGCCTGCT GCTAGCCCTG CCCCCGCCCC GGCCCCTGCC 31080CGCTCCGAGC TCCGCCCTCG CCCCGCCCCG GCCCCTGCCC GCTCCGAGCT CCGCCCTCGC 31140CCCGCCCCCC GCCCAGTGCC CCGCCCCCTG CCTGCTGCTA GCCCTGCCCC CGCCCCGGCC 31200CCTGCCCGCT CCGAGCTCCG CCCCGGCCCC GCCCCGGCCC CTGCCCGCTC CGAGCTCCGC 31260CCTGGCCCCG CCCCCGCCCA GTCCCCCGCC CCCTGACTGC TGCTAGCCCT GCCCCCGCCC 31320CGGCCCCTGC CCGCTCCGAG CTCCCCCCCG GCCCCGCCCC GGCCCCTGCC CCCTCCGAGC 31380TCCCCCCCGC CCCCGCCCCG GCCCCTGCCC GCTCCGAGCT TCGCCCCGCC CCCGCCCCGG 31440CCCCTGCCCG CTCCCAGCTC CGCCCCGGCC CCCCCCCCGC ACCTTCTCGC GCAGCCGCTC 31500GCGCAGTGCG GCCAGGTGTG CCTCGCGGAT CTCCTTGCTG AGCTCCATCT TGTAGTTGAG 31560CTTCTCCTCC CCCTGGCGGC TGAAGTTGTT ATTCTCCTCC AGCGCCTTGT GCAGCACCTC 31620GCGCTCGTCC TCGCCCCCCT CCGCCACCTG CTTCACCACC TCCGCCTCCT CCCTCTGTCC 31680GGGGCCGCCG GGCCCGCGTG AGCGGCAACC CCCCGCCCTG CCCCGCCGCA CTCCTCCCTG 31740CTCTCCGCCT CCCCCCCACC GCCCGCTCGC CTCACCTGGC GCCTCCACCT GCCCAGGCCT 31800CGGTGGGCCC CGGGACCCCC GGGCGCTCCC CTGGCAACCC TCGCCTGCCA TCCGCCCTGT 31860GCTCGGGGCA CGGCCACGGG GTCGCGATCC GCCGCCCCCG CCCCCGTCCC TGCCTCGCGC 31920GCGGGTCCCG CGCTCCTGGC TGCGCCCAGG GCCCCCGCCA TACCCTGCCC CCACTCCACA 31980CCCTGCCCTG CGCGTCTGCC CCTCCAAGGA CCAGCAGCAA GAAACCCTAA ACTTCTGCCC 32040GGTCTCTGAG CTTTGTCTCT TCCTCGGACA TCCCCCCACT GAGCAGAGTA CCTGCTTGTT 32100ACACACCGGC TTCCCACCTC CCAATTAGGT GCCCAGGAGC GGAGGGTCCC CAGGGATGCT 32160GGGGGAGGGG CCGGCTGGTG ACCCCTGGGA GGAGAGCGGG GCAGCAGGAC CCGCACCCAC 32220ATGCCAGTCC CTACTAGTCA GCCCTGTGAA CCCTCGTCTC TGGCCTCACC GGGAACGGAA 32280CGGAGCCGCT TCCCCTGCCC AATGCGTTGC CCTCCAGGGT CGCACCCCCA AAAGCACATT 32340TTTATCTCTG TTTCAGTCTC AGAGGGCCTG GTGGGAGGGG AGGCTGCAGG GAGGGGACCT 32400GCAGCCCACA CCCACCTCTC CCAGGGCCCC TCCGCCCTCC AGCAAGCCTC ACGCTCTTCA 32460CACATGAGCC CCTTCCTCCA GCTTCCCTGT CTGGGAGAGG GATGCCCCAC CCGACGTCCC 32520CAGGGCCCAT CTGGGGACCA CCCCCTAGCA TCCTGCTGGC CCTGACAAGG GTGCCTCCCA 32580CCCTCACCAG AGGCTCCTCC TCCTTCCAGO TGGCCGCCTC GGAACCCTTC CTCCTCTCCA 32640TCCCTTTCTT TTTTTGTTCT TGTTTGTTTT TTGAAATGGA GTCTCACCCT GTCGCCCGGG 32700CTGAGGAGTG CAGTGGCGCA GTCTCGGCTC ACTGCATCCT CCACTTTCTTG CGTTCAAGCA 32760ATTCCCCTGC CTCAGACTCC CTAGTAGGTG GGATTACAGG TGTGCACCAC CACACCTCCC 32820TAATTTTGTA TTTTTAGTAC AGATGGGCTT TCACCATCTT GGCCAGGCTG ATCTTGAACT 32880TCCAACCTCA AGTGATCTGC CTGCCTCACC TTCCCAAAGT TCTCGCATTA CACCCGTGAG 32940CCACCACACC CGGCCTCTCC CCATCCCATT CTTATCTCTC AGAAAGAGGC CCAGGGACCC 33000ACAGCCCCTC CTGCTCCAGG CCAAGGCACT GACCAACCCT GTCCGGGAGC ACCCTGCTTC 33060TTGCAGGCCC TGTCCCCGTG GGCCGCCTCC GTTGAAACTC CTGGGGGGTG GGGGATGGAG 33120GACTCCTTGC CTTCCTCCGC TCCTCGGCTG CCTCCAGCCG CTTTTGCAGC TCCTCCAGGG 33180AGGTGTCCTT CTTCTTGGGT GGGGAGOAGA GCATAGGGCT CTCTGOGGAC ACGTCAGAAG 33240GGGACTTGAG GATGACCTCG AAGCTCTGGC CTGAGGCCCG CTTGTCCAGC TGCTTCACCT 33300CCATGTCTCC AGGGCAAGAC CAGACTAGAG CTTCAGAGGC CCGGCCAGGG CATGGCGTGG 33360GCTGAGCGGG ATGCTCCCAG CACACATCCA ACCCCAGGGC TGGGCGAGAG CCGGTGCCTG 33420CTCCCGCAGG AATCCCAGGC TTCAGCCCCC AGGATGGGCC CCTTCCCCCT AGAACCTCCC 33480TCTCCAGAGG CAGCCAGGAC GGGAGTTCAG AGAGACTGCC GCAGCCCGGG GGAAAAGGTG 33540AGGTGGGCAG GCACCGCAGG GAAGGGCAGC CGGCAGCCAG GCACTCACCC CCGTACTGGT 33600AGACGGTATT GGGGTGCGGC TGTGTGTAGA AGCAGGAGCA GATGAGCGAC AGCACCGACA 33660GCTCCTTCAT CTTCTCCTTG TAGGCTGTGG GCACAAGGCT GGGCTGAGCA AGCACCACTG 33720GGGCCTGCCC ACCIGGGCCC CCGTTTTCCC TCCCCATGGC TGCCTCTATC ATGTCTCTGT 33780GAGACACGGA GCTGCCCAGC ACGCTCTCTT GTGTGTCTCC ACACCCCCGG CCCCTTCGTC 33840TCTCCAGCTC TCPCGCTTCC AGACGTCCGC ACTGTCTCCG TGGTGTGTCC CCTGCCTTCT 33900GTCTCTCTCG CCCTCTGCCT CTCCCCGCTT TTCCTCTCTC TCGGCATTAA TGTCTGTCTC 33960ATCTTCCACA CTGACTTGTT TCTCCATCCT TCTCCTGCCT GCTGTGGTCT GAATGTTTCC 34020ATTACCCAAA ACTCATGTGT TGAAATCGTA ACCCCAAGGT GCCCCTGTGC GGAGGTGAGG 34080CATTCGGAGG GAATTAGGCC ATGAGGATAG AGCCCTCCTA AGTGGCCCCA CAGTGGGGCT 34140TCAGAGAACT CCCTCACCTT CCATCATGTG AGGACACAGC CACAAGACGC CACCCGTCTA 34200TGTACCAGGA GGCGACACCT CTCCAGGCAC CGACTCTGCC GGCACCTTGA TCCTGGACTT 34260TCTGGCCTCC AGAGCGATGG CAAATAAGTT CCTGTCGTCT ATAAACCACT CAGTCTCAGG 34320TACCTGCCCA GACTGACAAA GTGGCTACCC CTGCCTGTCT CGGTCTCTGT TTACCTTCTG 34380TGTGTCTGAC TCTGTCACTG TCATTGTATC TTTCTGTGTC TCTGGGCGTA GCCCCTGACT 34440CTGTCTTTCT CCCTGAGTGC ATCTTTCTGT GATTCCTTGT CACTGTGTGT CTTTCTGACT 34500CTTACCTCCC TCTGTCCCGC TACTTCTCTC TCCCCTCCTC CTCCTTCCCA CTCCTCGCCA 34560GCTCAAGCAG GCAAGATTTA CTCATGACGG GACCAGCACA GATGCAAACC CTCTGTGGGC 34620AGGACTTTCT TGGGCTGTAA ACCTGGATGA AGCCCTCACA CCCTCCTTTT TCCTTCCCAA 34680TGATTGTGTG GTCACCTTGA GATGAAACCA GGCCCTCTCC AGGCACATGC TCTCTGTCTA 34740TCTAGGGCTG GGCTTGGGCC ACTGATGCCA CCAAGGAGCA AGGGAGGGAA GCTGTCCCTT 34800CAGCACCACA GCCAGCCCTC TTGCCCATTC AGGTCAATCA AGTGCCCACC AGCCAGTCTC 34860CCTGCTGCCC AACCCAAACC AGAAGCAAGC CGGGCTCCTG TGGCCCTGTG CCCTGTCAGG 34920GGAAGAGGAA GGCGCCTGCT CTCACAGTGA AAATAATTA GCTCTTTTGC TCTATTCAGG 34980GCGAACCTCA TTCCTAAGCA GACACGCTGG CCCGGTTTCT CACTAGTGCT CGATAATCCT 35040TTTGGCTGGG TGCAGTGGCT CATTTAACTG TAATCCCAGC ACTTTGGGAG GCCAAGGCAG 35100GTGGAACACC TGAGCTCAGG AGTTTGAGAC CAGCCTGACC AACATGGTGA AACCCGATCT 35160CTACTAAAAA TATAAAAATT AGCCAGGCGT GGTGGCAGGC ACCTGTAATC CTAGCTACTT 35220GGGAGGCTGA GGCAGGAGAA TCGCTTGAAC CTGCGAGGCG GAGGTTGCAG TGAGCCGAGG 35280TCGCGCCATC GCACTCCAGC CTGGGTGACA GTGTGAGACT CCGTCTCAAA ACAGAAAGAA 35340AAAGAGAGAG AGGAAGAAAG GAAGGAGGGA GGGACGGAGG AAAAGAAGAA AGGAAAGGAA 35400AGGAAGACAG ACAAGGCACA AGTAATCAAG CCTTTCATGG TGACCTGGGT CTTCTCGGTGA 35460CAGTGCAGAG AATGGTCTGT CCTGACTTAA ATTTCCTCGT GACCTACACT TTTCBGGACA 35520GAGCAGCACA GACCCCAAGA GcGTGTAACG AGCAGCAGAA AGCAATCCCA GGCTGGGCAG 35580GCCCGTGCGA GAGCCTTTCG GGGAAGGAAT GAGACTTTGA GCCGGGAAGC CACGCAAACC 35640TACCTGTCTT GGTCATTGTC TTCAGGCAGG GAGATGGAGG GGCACCAGGT GGCGGAGCCT 35700CACAGOCOAC TTTGGTCTGA CTTGTCAAGT TTTCTTTTTT TCTTTTTGAG ATGGAGTCTT 35760GCACTGTTGC CCAGGCTGCA GTGCAGTGGT GCGATCTCGG CTCACCGCAA GCTCCGCCTC 35820CTGGGTTCAC ACCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACCAC AGGCACCGCC 35880ACCACACCCA GCTAATTTTT TGTATTTTTA GTACAGACGG GGTTTCACTA TATTAGOCAG 35940GATAGTCTCG ATCTCCTGAC CTCGTGATCC GCCCGCCTCG ACCTCCCAAA GTGCTGGGAT 36000TACAGGTGTG AGCCACTGTG CCTGGCCTAC TTTATTTTTT AGAAACAGGA CTGTGCTCTG 36060TTGCCCATGC TGGAGTGTAG GGTGCAGCTG TGCGGTTCAC TGCAGCCTTG AACTTCTGGG 36120CTTGACGGAT CCTGCCATCT TAGCAGCTGG GACTACAGOT GCATGCCACC ACACCAGTTT 36180TCTTTTTTTT TTTATCTCTG CTCACTGCAA TTCCGCCTCC TGGGTTCTAG CGATTCTCCT 36240GCCTCAGCCT CCCAAGTAGC AGGGATTACA CGCACATGCC ACCACACCCG GCTAATTTTT 36300GTATTTTTAG TAGAGACAGG GTTTCACTAT GTTGGTCAGC CTGGTCTTGA GCCACCGCGC 36360CCGCCCGGCC TACACACCAG CTTAAAAAAA AGAAAAAAAT AGCTGGGCGT GGTGGCTCAT 36420CCCTGTAATC CCAGCACTTT GGCAGGCTGA GGCAGGCAGA TCACCTGAGG TCAGGAGTTC 36480AAGACCAACC TGGCCAACAT GGCGAAACCC TGTCTCTACT ACAAATATAA AAATCAGCCA 36540GGCGTGGTGG CGGGCTCCTC TAATTCCAGC TACTTGGGAG GCTGAGGCAG GAGAATCACT 36600TGAACCCGGG AGGTGGAGGT TGAAGTGAGC CAAGATCGAG CTACTGCACT CCAGCCTGGC 36660AGCAAGACTC CCGTCTCAAA AAAAAAAAAA AAATTTGTAG TGGTATGGAG GCCGGGCATG 36720GTGGCTCACG CCTGTAATCC CAGAACTTTG AGCGGCCAAG GCGGGCAGAT CATGAGGTCA 36780GGAGTTCGAG ACCAGCCTGA CCAACATGAT CAAACCCTGT CTCTACTAAA AATAACAAAA 36840ATTAGCCAGG CATGGTGGCG GGCACGTGTA GTCCCAGCTA CTCGGGAGAC TGAGACGGGA 36900GAATCGCTTG AACCCAGGAG GCAGAGGTTG CAGTGAGCTG AGATCACGCC ACTGCACTCC 36960AGCCTGGGTG ACAGAGTGAG ACTCTGTCTC AAAAACAAAC ACAAACAAAC ATATATATAT 37020ATACATGTAT ATATATAATA TATATATACC TATATATACA CGTGTATATA TATAATATAT 37080ATACGTATAT ATACACGTGT ATATATAATA TATATACGTA TATATGTATA TATTAATATA 37140TATACGTATA TATACACGTG TATATATTAA TATATATACG TATATATACA CGTGTGTATA 37200TATTAATATA TATACGTATA TATGTGTGTG TGTGTATATA TATATGTATA TATATATATA 37260TATATACATA TATATATACA GAGAGAGAGA GAGTAGTGAT AGGTCTTGCT GTCTTGTCCA 37320CGCTGATCTT GAACTCCCGG CCTCAAGAGA CCCTCCCACC TCACCCTCCC AAAGCACTAC 37380GATTATAGGT GTAAGCCACA CTACCTAGCC TATTATGAAT TAATCTTAAA CAACAGGATG 37440TGATCAGGGA GTTAGAGGGT CTGCCAGCCA TGTGTTCCAC AGCACCAGGT CAGGAGACAT 37500TGGGGACATT TAGAGGAGCT GAAGAGGTGG CCAACCCTGT GCTCAGGACG ACGGGGGACG 37560GAGAGAGCAA GAGGGAGTTT GGGCTCGGGC AGAACGTACC TGGGTCCTGA GAGGATAAGA 37620AGGTAGGCAC TTGGCCCCTC CAGGCCTGAC TCTGCCAGCA ACCAGCTCCC TATCAGCAGA 37680CTCCAGGCCC CTACCCTTCA GCTCATCCTT CCTTATCACA CATCCAAAAC TCTGAATGTG 37740GCCGGGCGCA GTGGCTCACG CCTGTAATCC CACAACTTTG GGAGGCTGAG CCAGCAGGAT 37800CGCTTGAGAA CAAGAGTTTG AGACCAGCCT AGGCAACATG GTGAAACCCC ATCTCTACTA 37860AAAATATAAA AATTAGCTGG GTGTGGTGGC ACATGCCTGT TGCCCCAGCT ACTCAGGAGG 37920CTGAGGCAGG AGAATCACTT GAGCCTGGAA GGCGGAAGTT GTAGTGAGCA GAGATTGTGC 37980CACTGCGTTC CAGCCTGGGC AACACAGCGA GACTCTGTCT CAAAAAACAA AAACTGGAAT 38040GTGTTTACCA TAAAGGCCAG AAAATGTGAT TAACAGCTGC TCAAAGCCCC TGTCTGCCCT 38100AAGCCTGAAA TTTTCACCGA AAAAAAGATC TGTAGCCTCA TACAGAGGAA GGACAAACAC 38160CAGGGAGGCT CTCTTCCAGT TTGCTTCACC TCAGCAAGCA GACGGCTGGC AGCAATTTGG 38220GGGCAGGTGT GAGCACCTCC ATCATCAGGA AAGAAGGGGC ACGGTGGGGA CGCAGGTCAG 38280ACCTCTCACA CGTCTTGGCT CTGCCCAGGA GACACGTGTC CAACTGAGAG GTGAGGAACT 38340GGGTTCTGCA GCTGCAGACA CAGGTGCGGC TCAGCATCTG ATGGCCACGG AGACCCCCTG 38400GCTTGGCTTC TCCCAGCTGG TGGCCCATGA GGAGCTTCTA TCCCAAGAGA CTGTCCCTCA 38460AGGAGCAAGT GGGACCAGGT ACCCACAGGA CGGAGCCTGG GAGTGAGGCC TGCCCTGTGG 38520TCTGGCTACA GGGAGGAAGG GCAGATTGGA GGGGGCAGGA CAGCAGGTCA GGAATTGGCC 38S80AACTCTGGAG AGAGCAAGCA AGGGGAAGTC TGCGCACAGG GCAGGGCTGC TCAGGGGCGA 38640GGCAGGGCAT TGGACCAGTA TTTTCAGAGC TGGTGAGGCT TAAAGAGCAT GTCTACTGCC 38700TCTTATTACA GAGAGAGGAT GCCGAGGCCC AGACCCATCC AGCCCACCTC TCCACAGACA 38760CAGCTCGTGC CAGGGAAGCC CCTCCCAGAG CCTCAAGGCA TTGCTCCCTC TCTCTCTCTC 38820TTTTTGTTTT TTTGGAGACG GAGTCTCACT CTGTCTCCCA GGCTGGAGTG CAGTGGTACA 38880ATCTCGGCTC ACGGCAAGCT CCGCCTCCCG GATTCACGCC ATTCTCCTGC CTCACCCTCC 38940CGAATAGCTG GGACTACAGG CGCCCGCCAC CACGCCCACC TAATTTTTTG TATTTTTAGT 39000AGAGACGGGG TTTCACTGTG TTAGCCAGGA TGGTCTCGAT CTCCTGACCT TGTGATCCGC 39060CCGTCTCAGC CTCCCAAAGT GCTGGGATTA CAGGTGTGAG CCACCGCGCC TGGACTTTTT 39120TTTTTTTTTA AGACGGGGTC TCACTCTGTC ACCCAGCCTG GAGTGCAGTG GCGCGATGTC 39180GCCTCACTGC AACCTCTGCC TCCCCAGTTC AAGTGATTCT CCTGCCTCAG CCTCCCAAGT 39240AGCTAGAATT ACACGCACAT GCCACCATGC CCAGCTAATT TTCTGTATTT TTAGTAGAGA 39300TGAGGTTTCA CCATGTTGGC CAGGCTGGTC TTGAACTCCT GACCTCCGGT GATCTGCCCA 39360CCTCAGCCTC CCAAAGTGCT GGCATGACAG GCGTGAGCCC CCGCGCCTGG CCCCCCGCAG 39420TCCTGGGATT ACAGGCGTGA GCCCCCCCGC CCGGCCCCTC CCTCTCTTTG ACTCCCTTCT 39480TTCTCACCCC CCCCTCCCCA CCATCCTTCC CCTTCACTGA CTTCAGGGAG TTAAAAACAA 39540TTCTCGCAGT GAGCTGGGCT TGTTTTGTCT CCCTGCTTCT CTTTGTACTA AACATTAGAT 39600ACCGAGGAAA TGCGGATTGG CCTTTGGATG ATTCATCAGC ACCAGTCACA AAAAGGCACC 39660AGGTTCGCCT CAACCAGCAG GCTATAGTAG TGCCCGCTCC CAGGGTCACA CCTCACGCCC 39720ACCCCTCCCG CCCTCCAGGT GCATGGT(CC CACTCCCAGG GTCACACCTC ACGCCCACCC 39780CTCCCCCCGT CCAGGTGGAT GGTGCCCACT CCCAGGGTCA CACCTCACGC CCACCCCTCC 39840CCTCCCCCAG GTGGATGGTG CCCACTCCCA GGGTCACACC TCACGCCCGC CCCTCCCACC 39900CACCCGCGTG GATGGTGCCC GCTCCCAGGG TCACACCTGA CGCCCACCCG GGTGCATGGT 39960GCCCGCTCCC AGGGTCACAC CTCACGCCCA CCCCTCCCGC CCGCCCGGCT GGATGGTGCC 40020CCCTCCCACG GTCACACCTC ACGCCCACCC CTCCCGCCGT CCAGGTGGAT GGTGCCCACT 40080CCCAGGGTCA CACCTCACGC CCACCCCTCC CGCCGCCCAG GTGGATGGTC CCCACTCCCA 40140GCCTCACACC TCACACCCAC CCCTCCCGCC CACCCGGGTG GATGCCCTTA TCAGCTCTCC 40200TTCTCCTTCT CTTTCGTCTT CTTCGTCTTC CTCCTCTTCT TTCTTCTTTT TTTTTTTTTT 40260TAGAAAGAGT TTCTACTCTT GCTGCCCACG CTGCAGTGCA ATCGCACAAT CTCAGCTCAC 40320TGCAACCTCC CTCTCCCCGG GTCAACCAAT TATCCTGCCT CAGTCTCCCA GATTGCTGGG 40380ATCACAGGAG TGTGTCACCA CACCTGGCTA ATTTTGTACT TTTAGCAGAG AGGGGGGATT 40440TCACCATGTT CGCCAGCCTA CTCTCCAACT CTTGACCTCA CTTTATCCAC CGGCCTCAGC 40500CTCTCAAAGT GCTCCGATTA CAGGCATGAG CCACCCTATC TGCCTCACTT CTACAGACGA 40560GGAATGAAGC CTCAGAGAGG GCAAGCATTC CACCCAGCAT CACACAGAGT GCCGGGTGAG 40620AGCCCAGTCA TGAGCCTGGG CCTCACTGCA GGCTCCTGTT GGGAGCTCGC CGAGGTGGGG 40680GATCTGTCCA GAACTGAGAG GCCAGGGGAC CACAGTGGCC TCTGACCCCT GGACGGCCCT 40740GGAGGCTCCT GCCCGCTCCC CCCGGGGGCA CATGGAGGTC ACTGTCACCC AGCCTGCTTC 40800TCATGGTGCC AGGACCACAG CATGGCAGGA GCCACCAGCC GATTTGCCTT TCCCTGGGCA 40860GGAAACTCAG AAATGTCCCT ACCACAGTCA GGCTGCTTGA CGTGCGCTGA GCACTCATCT 40920CTTAGCAGGC AAGCGGCCAA GCACCTTTCC TGAAATATTG AGGCCTCAGA ACAAGCCCCA 40980GGAGAGGTGC CAGCACCGTC ATCTCTACCC AGATAAGGAG ACCCACGTCC TGAGAGGTTA 41040GCCAGCTCGG ACAACACCAC ACAGCTGGAG GAGGTCAGAC TCTGGGTTCC AGAAGGAGAA 41100TGTGAGCAGA GGCCACAAAA GAGCGAGGAG CCAGTCCCCA GATGCCGAGA TGCCCTCGCC 41160CTCCCAGCTC AGCCCCAGCA ACCGAGCCCA TGGGGACGGA CCGTCAGGGA AAGGCTGTCA 41220GGAAGGGCAG GAGGCGGCCC TGGAGAGGAC GGCGCTGCCC TCACGGGCAG GAGGGGAGTC 41280CCCTCCGCTG AGAGCCCCCC CACCCCCAGT ATCCCCGGGG GTGTCCAGGA GGAGGCGGAG 41340GGAGGAAGCG CAGATGGACA GGACTCCCAG ATAGGGTGGG GAGGTGTGGC CGGTGACACA 41400CACGGTCCCC TCCTGCCAGG TGCTGAACTC ACCTGGAGCC TCCAACCCCG TGCGGCCTGA 41460CGGGCGGGGT CAGGTCGCCC ACGCGTGGGT GGGCCCAGTT CTGCGCCCCG GGCCAAGGCG 41520CCCGAGTTCA ACCAGTCACC TCGCCAGAGG GACCGCCGCG ACCTCTCCCG GGGGCGTAAG 41580AAAAGGTGCG AGGGACTGCG GCTCCTGAAC CGGGGCGGCG ATGGCAAGCA GGTGCGGCCC 41640TTCGTCCTGT CCTCCCAAAC GTCGAGTGAA AAACCAAGCG GCTTCTGCGG CCTCGCGGCG 41700CACCAGACCO TTTCGGGAAG GGCGGGCCCA GCGTCCTCGC GCCCGAGGTC GCCCGGCAGC 41760TCCCCTGCGT CCAGAATCCG CCCCCCGCCC GGGCCTGCGC CCGCCCCTCC GCCTGAGCTC 41820CGCGCGGCAC GGGCCGGGAG GCCCGGGTGG GCGCTACCTT CGAAGCCGGT GGGTCCGCCC 41880CGCGGGAGGT CCAGGGGCGG GAGGGGCGGA GCCCTCTGGT CTCCGCAGGG TTTGGCGATC 41940GCAGTCGCCC CTCCCCCATC CAGACCCCGC GGCGCAAAGG GCAGTGCCTT TTCTGGCCAG 42000AGCAGGTGGC GCGGGCGTCG CAAAGGGTGG TCCCCGAGGC CGCAGCGCTG TGCGGGGAGG 42060GCGCGGTCCC CCTCACTCCG GGCTCCGCCG TGTCTGGCCC GCCCCCCTCC TTCAGCGCCC 42120CCTCCAGCCC CTGTGCTGCA CTGGCGCGGG GAGCGCCGGG TTCCCGGCTG GGGCTTTGGC 42180AGAGGGTCCC ACCCTCTCCC CGCCTCCCCA CGAAGGCTCT GGCGGACCCA GATCTCGGGT 42240CGCCGGACGC CCCAGGGACC CCGCCCGCAC ATCGCGAGCG CGCCCACCCG GTCGCGAGCC 42300CACGCCCGGG TCTGGGACCC ACCCTGCGGC AGTCGCGCCC TCCGTCGCAC GCTGCTCCCC 42360CAGGGGCGAG GCGCCCCCGC CCGACGTCCC GGTCCCGAGC GCTCCCCGCC GCGGCGCCTC 42420GCAGCCCAGC GCCCCACCAG CCCCGCCGGC GCCGCAGACC CCAGCCTCGG GCGGGTCGGG 42480CCCAGGCTTG CAACGCGCAG GGTAGGAGAA GGGAAATTGG CGTCCGCTGC CGGCCGCTGC 42540CCCAGGCGAG GCCAGACGAG GCCTCTGCTC AGATCCCGCC GCCCCACAAA GCCCGTGGCC 42600CCGGAGCCTA CCGGAAATGG TGCTCGCCAT GGTGCTGGCG GCGCTTGGGC CTGCGGAGGC 42660TGGAGAGGCG CAAGTGGCGG CCGGAGCTGC AGACGGCTGG TGCTGCAGTG CCGGGGAGGG 42720GAGGGGAGAG GAGTGGAGCG AGCGAGGGCG GGCGGGAGGC GGGCGCGGCG GGAGAGAGAG 42780AGGGAGGGAG ACAGAGOGAG AGAGAGAGAG GGTTGGGGGA AGGAGCGGGG GOAGGAGOGA 42840GGGAGGGTTG GGGGAAGGAG AGAGAGAGAG AGAGAGACTG CGGGGGCGGG GGAAGGAGGG 42900AGGGAGGAAG GGAGGGAGGA AGAGAGAGAG GAGCAAGCGC CTGGCTGCGG AAGGGGCCGC 42960GGCTCTCAGG GGGAGAGGGC GGAGGAGGGG GGCTACCCGA ACTGCAACAA GACCCCCCAC 43020CCTCCAACCG CTCACAGCGG GACAGCTGCT TCTCCAACTT GGCTTTGTGA GGCCTGAGAG 43080TGGGGTGGGG GTGGAGATGA GCCCCCATTC CCCAGGGCAG GCGGGGCAGG GGCAATGCCG 43140GAGGAGCAGG TCCCACCCAT GGGGTGGGGC CGCAGAGCTC TTCGCCGCCA AGGCCGCTGT 43200AGGCTGGGCT GGCGCCAACA GGGTCCAGGT CTGTGCCTGC CATCGGAGAG GATGCCACAG 43260CCACAGGGGT GGGCGCTGGC CTGGAGGCCT CCAAGGGGCA TCTCCTGTGA GCCCAGGGGA 43320TGGGCAGCAT CTGAGCGGAG AAGAGTGAAA GTGGAGGAGT GAGGCCAGAA CAAAGGCTTT 43380GCCCTGAAAC AGGTGGTTTC CCGCCTGGGC TCAGACCTTC ACTCACTGTG TGGCCCAGGC 43440CAAGGGCAAG CGTCTGACCT CGCTGGGCCT TTGTTTCTCA GGGGTAAGAT GAAACAATGA 43500TGCCCCCAGA CGATGGAGAG GAGGGGTGCC AGCGTTGTGC GCACTTAGTG AGTCGGCGGC 43560AACCTATCCT GCCTCCCCCT CTCCTCATAA CTCCCAAAGG GAAACCCTGG TAGCCAAACG 43620GAGCGTCTTT GCCATTGCAG GCATGAAGCC ACCGAGGCAG GCACAAAACT CCTTTGCCCT 43680ACAAGCAACT AAGTCATAGG GCCAGGACCA AAACCCTGAA AACCTCAGGA GACTTGCAGA 43740GCCATGAGCC TGGCTCAGCA ACACAAAAGC CAGGGGCAAG CCTCAGCTCT AGCAGTGCGC 43800TGGGAGCACC CAAGGCCAGT CACATCCTAG GGTCGCCTGG AGAGTCCTGA CCCCTGACGT 43860GCAAGCCGGC ATCATCCCCG GGACTGTGAG TCTGCTGGGG CTGATGCCCA GGAATGTCAC 43920ATTGTGTGGC CCAGAGGTAC CCTTAAGACT GGAGGATCAC CAGGCGGGCC CTCACCTCAT 43980CACAGCAGCC CTTTAAAAGC AGTTTCCTTT GCCTGGTTGA AGAAATCGGA GGGATCAAAC 44040CAAAGAAGGT TTTCTCTTGT TGAGATGAGG GGGCCACGTG GCAAGGATCT CAGAACTCCT 44100CCCAGCCAAC AGCCAGCAAG ACAACAAGAC CTTAACTGCA AGGAAGTGAG TTCTGCCAAC 44160AAGAAGAGAA TGGGCTTGGA GGCAGGTTTG ACCCCAGGGC CTCCACACAA GAACTGAGCC 44220CAACTGCCCA CTTGGTTTCA GCCTTGGCTT ACTAAGAATT AGGAGGTAAT GAATGAGAGT 44280TGTTTTAAGC TGTTGGTTTT CTGGTGATTT GCTATGAAGC CATATCAAAC TAATACTACAC 44340ACACAGGTGT TGGCCCCTGC GCCATTCCTA G(AAGCCAGC TCTGCGAAGG AGGAAGAAG 44400GCAGAGAGGC ACACAGAGCT GCCCACCACA GCAGCTGTGT CCTCCCTCTT GGCCACCACA 44460CTAGCAGTTG GGCATGGTCA GCATCCTTCA CGCACACTCC AGCCCCGGGT CCTGGACCTC 44520AGGTGCTAGG GATCAAGACA AGTAGCCCTC TCTGGCACCT CCACAGTCTT CTCATGTGGG 44580TGGGGTAGGA CCCACCCAGT CAGGCTCAGA GCACCGCAAT GCCTCACACT CATTGTGACT 44640CTGGCCAGGC CCTCTCTGAG CCTCTGTGTC CTCATGTCGA GCACAGGGAC CAGGTGTGTG 44700GAAGCCCGTG CCATAGTCCC AGGAACACAC TAGATGTCCA CAGTGTCCAC TAGCAGGAAC 44760ACACAACAGG GCTACTGACT GTCAGCACCT AGGCAGGCAC ACGCAATGGG GTACTGACTG 44820TCAGCCATAC TCACTCTCAG CGTGCTAGCA GCCATACACA ACAGCTCTAC TGACACCACA 44880CTAGCACGCA CATOCCATAG GTGTACTGAC TCTCAGTGCA CTGGCAGGCA CACGCAATAG 44940GAGTAATGAC AGCATGCTGG CAGGCACACA ATAGCTGTAC TGACTGTTTG CCCCAATATA 45000GTGCCAGGTC TTGGAGCAGA TTTTGACTTC TCACCAAGAT CAAATGCAGA AAGTCCACGA 45060GCATTTCAAA GATGTTTTTC ACATGCACAT TAGTGCTAGT TAAAAAAATG TTTTGACTGC 45120GTGCAGTGGC TCACAACTGT AATCCCAACA CTTTGGGGGG CCGAGGTCGG CACATCACCT 45180GAGGTCAGGA GTTTGAGACC AGCCTGGCCA ACATGGTGAA ACCCCATCTA CCCTAAAAAT 45240ACAAAAATTA GCCAGGTGTC GTGGCAGGTG CCTGTAATCT CAGCTACTTT GGAGGCTGAA 45300GCAGCAGAAT CACTTGAATC CAGGAGGCAG AGGTTGCAGT GAGCCGAGAT CCCACCACTG 45360CACTCCAGCC TGGGCAACAA TATCAAGACT CCACCTCAAA AAAAAAAATG TTTTTCATAA 45420AGTGTGACTT TTATCAGACC TCTGCATTCT TGAAATTAAC TCTGGCTTGG CTGGGCGTGC 45480TGGCCCACAC CTGTAATCTT AACACTTTGG GAGCCTGAGG TGGGCAGATC ACGAGGTCAG 45540GAGTTCAAGA CCAGCCTGAC CAACATGATG AAACCCCATC TCTACTAAAA ATACAAAAAT 45600TAGCCGGGCG TGGTGGCATC CACCTGTAAT CCCAGCTACT CAGGAGGCTC AGOCAGGAGA 45660ATCGCTTGAA CCCAGGAGGT CGAGGTTGCA GGGAGCCGAG ATCGCACCAC TCTATTCCAG 45720CCTGGGCGAC AGAGCAACAC TCTCTCTCAA AAAAAAAAAA GAAAGAAAGA AATTAACTCT 45780GGCTCCTAGA AGCAGCCCTA TATCTCAGCA GGACACTCAG TCATTCAACA GACATCTGTC 45840AAGCACCTGC TGTATGCTGG AGCTGTGGGT ACGTCAGCAA TTAGAGGAAG AGGCCAGGGG 45900TACAGGAGTT CCTGACCACC CCAGGCCAGC ACGCTCCTAT AGCAGCTGGC AAGCAGCAGA 45960TGACTCAGAC TTCAGCTCAG TCCACAGGAC ACCCTTTTCT GGCCACTGCT CTCACGAGAT 46020GAGATGTGTG GCTGCAAAAG GTAAACTCCT GGCTCCTGAG CAGGCTCTGG CCAATCTGCT 46080CAACGCTCTG TGCCTCACTT TCTCACCCAG AAAGTGTGGA CAATGAGAGG ACTTATCTGG 46140CTGGGCGCGG TGGCTCACGC CTGTAATCCC AGCACTTTGG GAGGCCGAGG CGGGTGGATC 46200ACCTGAGGTC AGGAGTTCAA GACCTGCCTG GCCAACACGG TCAAACTCCA TCTCTACTAA 46260AAATATAAAA AATTAGCCGG GCTTAGTGGT CCACACCTGT AATCCCAGCT ACTTGAGAGG 46320CTGAGGCAGG AGAATCACTT GAACCCAGGA GGTGGAGGTT GCAGTGAGCC AAGATTGTGC 46380CACTGCACTC CAGCCTGGGC AAAAAGCCAA AACTCTGTCT CAAAGAAAAA AGAATCATGG 46440CAGAAGGTGA AGTCTATGTT AGTCCCAGTT CCCAGGTCGT ACATGGCGGC AGGAGAAACA 46500GAGAGAGAAG GGGAAACTGC CACTTTTAAA CCATCGGGTC TCCTGAGCAC TCACTGTCAG 46560AACAGCCTGG AGGAAACTCA CCGCATGATC CAACCACCTC CCTCCAGGTC CCTCCCTCCA 46620CACGTGGGGA TTACAATTCG AGGTGAGACT TGGGTGGAGA CACAGAGCCG AACCATATCA 46680GCATGTATGG GGGGCACTCA AACTTGTGCT TGGTGCCCAT TCATTCAACG AGTCTGTCTG 46740GCTGGTCTCC TCATCTTCAA CTCCCTGCCG AGTCTCAGAT AGGCACCCTG CAGTTCCTTC 46800ACCACAACAG GCACATGGGG CTGGGTGCCA GTGAGTGCTG GGGCTTCTCC GAGCACTATC 46860TCACACCCAG GAGCGTGGGC ACGCATGGCA TTCGCATGTG CCGTCAGTGG ACATTAAACA 46920CAGCCATGAA GAAGCCACGA AGAAGTGCTG CCTGCCGGCC GTGCGCGGTC ACGCAGCGCC 46980AACTCCCTCC TGCGGCCTTC TGGGGCCTTC TGGGGCATGG GAGCTGGGGC CGCCTGAGAC 47040AAACATCCGT CACGCTGGGC TGACCCCACA GAACGGTGCG GGCCTCGCTC TTGCAGTCAG 47100CCCTGCTGCC AGCCAGTGCC GGGTGCTGGG GACTCAGGGA GGCCCGCCGG GACCACTGCG 47160GGACAGTGAG CCGAGCAGAA GCTGGAACGC AGCACAGGAA GGAGAGGGGG CGGTCAGGGC 47220TCTCAGGAGC CGGGTCCTGG GCAAGGCGCA GCCGTTTTCA AATTTTCAGG AAAGCGGTCG 47280GCTCACACTC GAGCAGTAAA AAGATGCCTC TGGGGAGGAG GCCCGTGCAG CTCTCCGGGC 47340AATGGTGGTG GCTCGGCCTA GAGAGGCGGT AGTGGAACGC AGACCCTGGT GGGGGAATGA 47400CATCAAGGGA GGAGACGGGC GGGACCCCAG ATTTCTGCCT GTGGGCGATG GAAGTGAGGT 47460TCACTGGCCA GCGGAGCCGG ACACAGAACG CGCAAAACGC CGTGTAGGCC TGGAGGACCC 47520GAACAGCAGG CGCACCCCCT CCGCGGGGCA ACAGTTTCCG CCGGGAGCAC AAAGCAACGG 47580ACCGGAAGTG GGGGGCGGAA GTGCACTGGG CTCAGCGCCG ACTGCGCGCC TCTGCCCGCG 47640AAAACTCTGA GCTGGCTGAC AGCTGGGGAC CGGTGGCGGC CCTCGACTGG AGTCGGTTCA 47700GTTCCTCAGG GACCCCGGTT CTGGAAGGTT CCCCCCCGAG ACAAGTGAGC AGTGAGTCGC 47760AGTGACCCTA CAACTGGTTC TTTTACCCCA GCCGCTCCTA GGCGCGTTGC GCTTTTTTCGA 47820AACTACACCT CCCCGCAGGC CCCAAGCCCC CCTCGCGGCC GCCCGTCGGC GGATTGGCCG 47880CGCTCCATTT TGGGACCTGT AGTTTCCTGC GCTCGTGGCG CTGGCGCCGC GGCGTTGGCT 47940CAGCCCTTGA CCGGGGCTGG AGGGAAGGGC CGACATTCAG TGTGTCCGCG TCTGTTCTGT 48000TAGTCCCAGT TCCCGGGCGG GATTGAOGCT TAGAGAAGTT GAGTGATTTG CTGACGGCTG 48060CACGGGTTGG CATCCCGGCA TGCTCTTTCG CTACTTTGGC TGCATCTGGT TGCCCACCCG 48120GGCGCATGGG CAATGGACTC CAGCCAGCCA GGAGGGCAGA GGGCTGGAGA CGCAGGCCCG 48180GAGGTTCAGA CCCTCCGCTC TGACGTTGCG CCTGGTGAGG CCGGGAGGCC TGCCGCTTCC 48240CTCTTCAGCC CTCACGCTCT TGTGGAAGTC GCGGAATTAC TGCAGGCGGA ACTTGCAGCA 48300CTGTGGGCGT CTTTTCCAGA GAAGGACGGA GTTGTGGGCC GCGAGCATAA CGCAAGCCCC 48360AGCCACTTCG CATCTTCGCC CCGCCAGCTC CTCCAGATCC GATATACCAG GGTTGCTCTC 48420CAACCCTCTC COCAGGAGOG ACTGATGGAA ACGCCTGGGA AAGTAGCCCG GTACCCACAA 48480AGGCTGTCTA CAAACAGAGT CTTACTGTCT TTCCCAGGTC TGTGCCATAG GGATTCTCGA 48540AGAGAACAGC GTTGTGTCCC AGTGCACATG CTCGCATCCC TTACCAGGAG TGCCCGAGAC 48600CCTAAGATGT TCGGAGTGGT TTTTTCGCAC AGACCCGAAT AGCCTGCCCC TCAGCCACGC 48660TCTGTGCCCT TCTCACAACA GGCTCATATG CCCAAGATAG TCCTGAATGG TGTGACCGTA 48720GACTTCCCTT TCCAGCCCTA CAAATGCCAA CAGGAGTACA TGACCAAGGT CCTGGAATGT 48780CTGCACCAGG TAGAGCACAG GCCCCGAGGA AAGCACTGCG GGTGGGTGGA GCTTCAGCCA 48840GGACGGGGTG TGCTTCCCTC TCCCGGCCCA TTCCAGCCAG GCCCCTCCGG GCCAGAGGCA 48900GCGTCTGTCA TAAAAAGGGC TGCTGTTCCA GGTGGGGTCA GAGAGAGGAT TGACAAGTAA 48960AAACGATCGT CCTTTGAAGG GGGCCGGCCC CTCCACACCT GTGGGTATTT CTCATCAGGC 49020GGGACCACAG ACTGAGAAAA TGAATAAGAC ACAGAGACAA AGTATAGAGA GAAAAGTGGG 49080CCCAGGGGAC CGGCGCTCAG CATACAGAGG ACCTGCACCG GCACCAGTCT CTGAGTTTCC 49140TCAGTATTCA TTAATTACTA TTTTCACTAT CTCAGCAAGA GGAATGCGGC AGGACAGCAA 49200GGTGATAGTG GGGAGAAGGT CAGCAAGAAA ACGTGAGCAA AGGAATCTGG GTCACAAATA 49260AGTTCAAGGG AAGGTACTAT GCCTGGATGT GCACGTAGGC TAGTTTTATG CTTTTCTCCA 49320CCCAAACATC TCGGTGGAGT AAAGAGTAAC AGACCACCAT TGCTGCCAAT ATGTCTCGCC 49380TCCTGCCACA GGGCGGCTTT TCTCCTATCT CAGAATTGAA CAAATGTACA ATCGGGTTTT 49440ATACCGAAAC ATTCAGTTCC CAGGGGCAGG CAGGAGACAG TGGCCTTCCT CTATCTCGAC 49500TGCAAGAGGC TTTCCTCTTT TACTAATCCT CACCACAGAC CCTTCACGGG TGTTGGGCTG 49560GGGGACTGTC ACGTCTTTCC CATCCCACGA GGCCATATTT CACACTATCA CATGGAGAGA 49620AACCTTGGGC AATACCCGGC TTTCCAGGGC AGACGTCCCT GCGGCTTTCC GCAGTGCATC 49680GTGCCCCTGC TTTATCGAGA CTGGAGAATG GCGATGACTT TTACCAAGCA TACTGCCTGT 49740AAACATATTC TTAACAAGGC ATGTTCTGCA CAGCTCTAGA TCCCTTAAAC CTTGATTCCA 49800TACAACACAT GTTTCTGTGA GCTCAAGGCT GCGGCAAAGT TACACATTAA CAGCATCTTA 49860GGGCAAAGCA ATTGTTCAGG GTACAGGTCA AAATCGAGTG TGTTATGTCT TCCCTTTCTA 49920CATAGACACA GTAACAGTCT CATCTCTCTT TTCCCTACAG TCCTTGAGGG TGACAGACTT 49980AGGAGTGCCT TCGGGGCCTC TCTGAGGAGC AGCTGATATT CACGGGTCAG GAGGAAGCAT 50040TTCCATTAGA GGCGCAGCCG CTCGCCAGCC TCACTTGGAA GGTCTTTGAA CCTCGGGGGT 50100GCAGCGAGGT GGCAGTGGTG CAGGTTGCCT TCTCCTGGGT TCCTTGAGCT GCCCTCTTGT 50160ACCCGCCTCA CACCCTTCCC CTCCCCGAGT TTCCTGCTCA GGTTCCCGTC TGAGAGCTTG 50220TATGTAGGAC GTCAGATACG ACAGCATAAA TGTTTGGATC CAGAAACGCA GAACAGTTTC 50280CTATTTTGAG ACTTGACACC TAATTAGTCA TCTTACTATT TAAGCTGAAA AATAGTGTCG 50340TGTTTTGGCT AACGTTCTGC AAATCGTTTG CTAATGGCGG CTGAGTTGCT TCACGCCCTT 50400TAGGGCAACA GTGGGACTTG CCTGTGGACT TCTCCGCGGT CCCACAGGGC TCTCGCCACC 50460TGGCAGTGGC CTCTGCATCT CCAAAGAGCT GCCCGCTGGC TGCCGAAGCT TGTCTCAGGG 50520CAGCTTGTGT GGCCTCGCCT CTTCCTGGCT TCCCCGTAAC CCTTGCTCCG AACTCCGTTC 50580AGAAGGTGAA TGGCATCCTG CAGAGCCCTA CGGGTACAGG GAAGACGCTG TGCCTGCTGT 50640GCACCACGCT GGCCTGGCGA GAACACCTCC GAGACGGCAT CTCTCCCCGC AACATTGCCG 50700AGAGGGCGCA AGGAGAGCTT TTCCCGGATC GGGCCTTGTC ATCCTGGGGC AACGCTGCTG 50760CTGCTGCTGG AGACCCCATA GGTGACCCTA GTTCCCAGGC CTCTCCTGGC CTCCTGTGGG 50820GATGCTTGGC AAGGGATGGC GCTGAGGGTG CGCTGGGCCC ATGGGGACTC CTGCCGTCTC 50880TCAAGCAGAA CTCAAGGAGA ATTTTTTAGC TGCTGTATAA TTTCTCGCCA TCGTGGGTGT 50940AAACCTAGGG TTGGGCTTTT TTGCTGAATT AGCGCACCGC AGATGCCCAC TTCACCCATT 51000TTTGATAAAC CAGTATCTGG GGTCTCAGAT TCTTGGCTGT CTGCAGGGCC GAGTTAGCCG 52060AATGCCACCT GCCTTTGATA CGTGAGAACG TTGTCTGAGA ACCGTGACTT CTGTGCTTGC 51120TTGTGTCTGG TCAGCTTGCT ACACOGACAT CCCAAAGATT ATTTACGCCT CCAGGACCCA 51180CTCGCAACTC ACACAGGTCA TCAACGAGCT TCGGAACACC TCCTACCGGT GGGTCAGACG 51240AGTTTACACC TGTCTCGGGG TCCTCAAGAG AACCACCTTG GCATGGTGCT GAGTCCACAG 51300CCCCATGCTG TGCTGTGGTG GAGGGTGGTG GTCTTTCTAG ACGCTCCCCC CAAGTGTGCA 51360GAGCGCTGGT GCCCAGGGGT GGGGTGCGGC CTGGGCTCCC TCCAATGCCC ATTACTTGTG 51420AGGAAGCAGC TTTGCATCTG TGTCCTGACC TTGGGCGGGC GTCCTGAGCT CCTCGCAGGT 51480GCTGTTGTAG CACCTGTGCA GTAGGTCAGG GCTGGCCCCC AGTGCAGCTT TGCACATCAA 51540GTAGGAGGAG GCCCTGCTGC TTGTCAGAGC CCAGCAGAGT CTTGGTGTTC TGTCGGGTTC 51600CTGTGGCCCG ACCAGTGGCA GGGTGCTGTG GAAGCTGTCG AATCTCCTCC CTCTGTCCAG 51660TACCCCCGCT CGTCTTCTAG CTCCCTCCTA CGCCCGGGCC ACGTTTCAGT TATGCTCACT 51720TCCTCTGACC GCCGAGGCTC CTGCGTGTCT CCAPACAGCT CACGCTGCAG GGCCACGCTC 51780TGGGTGTTCC AGACAGCTCC TCCTCGACCC ACGGTGCTCT CTCCCACCAG GCCTAACGTG 51840TCTGTGCTGG GCTCCCGGGA GCAGCTGTGC ATCCATCCTG ACGTCAAGAA ACAAGAGAGT 51900AACCATCTAC AGGTAGGCTC CTGGGCTCCC GCTCCGGCTC AGTGTCCGAC AGGCGAGTFGC 51960TGCTGGGTGT CCAGAGCCCC AGGCTCCGCT CCCGCTGGGC TAGGGTTTGA AGTTCACTCG 52020GGGACTGCAC GGGAGGACCT GGTGGGGGTC GGCACTGGCT TCGGTCCTTT CTTCGCCCTO 52080CTTCACCTGC GCACTCTGCC CTTCCTCCCA CAGATCCACT TGTGCCGTAA GAAGGTCGCA 52140AGTCGCTCCT GTCATTTCTA CAACAACGTA GAAGCTACAA GCACCTGGGT CCGACCACCG 52200TCCCCTTGGA CTCTGTCCAG CCTCTCAGGC TCGAGCTCAG TGGTGTCACA GCCTGGTTGT 52260GCTTGCCCGG TGGGGCC3GCC AGTGCGGCCA TGTACCTGGG CCCTGTCTTC TGACTCGGGG 52320CCACCCATGT TAGACTTCTG TGTGGAAGAG CTCACACACT GGTCTGACAC ACCCAGCCGG 52380CAAGACTGCC TCTGGCTGGT GCCTGGGCCC TTGGATTTTG GGAACGCTCC CTCCATTTCC 52440TGATGAGACG GTCTCCCTGC ACCTAACCTG CTGGTGCAAA CAGTAGGGGT TTTGCTGAAC 52500ACCGGCTTTC TCTTCGGGA CTTTGTTGCT TGCCCACCAG CAGGTGCTCC AGTGACCGGC 52560CCTCATACCA TCTTGGGAGG GTGTCCTGGA AGCCGTCTCT GGCCTCCCGC GACCCTGCCC 52620CGTGTGTCTT TTTCCTGTGC TGACCTTGCT GCGGAAAATT ATGGCCCTGA GTCTGACTCC 52680ACGCTGAGTC CTGTCGGTCC AACACCGGAT GCCTTGGCGC CTCTTCTGGA GACGCGATGT 52740GAGTGACAGG AGCCGCCCGG GGCAGCTTGC CCTCTGACTG CACGTGGCCA CAGCCTGTGA 52800GCGCCGGGGG TCCTTCTCCA CCCACGTGGC TGCCCCTCGG GTATCTCAAG GGCTTCTGGG 52860GCTCATCACG GGGTCCTAGA GACAGTGGCA GGGTGCACCC CCGTTGGCTC CCCTTACACT 52920TTCTGTGACC TCAGGCTGGC ATCTGTCCAG TCGGCGCGGT CTGTGCTTCT GTGGGATCAG 52980GGTTCCCTCT GTTTCCTCCC TCAGTTGGGG CTCAAGCCTC AGCTGAGGTG GCCCCGGACC 53040ACTCAGAACG CATCGGCGGT CCTGTGGGCT GCTTTCTGCA CTCACGTTTC CTGAGTGCTC 53100AGTCTGCCAG GACTGAGGAC CCTGAAGCTG CTCTTGTATT TAGGGCGGCG CTCCCCTGCC 53160AGAGACTGAG CCAGGTGGTC CCGCATGACC CACTACCAGC CGTTTCTGGG CCCTGGCCCT 53220TGGAGGGACA GGGTGGGCGG AACATGGGCC TGCAGGGAGG CTCCCGCTTA CTGGAGGCAT 53280GTGCTGTGTT GCTGGAGACA TCCTCTGTGT TGCTTCTTGT TCGCTGTCCT TTTTGGTCTG 53310GTGGCACCAA GCACCCTCAG TCATCTTGAT GTGTGGTTGT CCAGGCCTTT TTGTTGGTCC 53400TAAGAAGGGG CTCTCCCTTT GTGCCCCCAG CTTCCCTGAC AGGACCTGCC GGCTCGTCCC 534G0GGTCATGCCT GCAGGACGTG ACTCTGGCAC GGGGGGTTGG GCAGATGTGC TGATGGAAAT 53520TCTCAAGCAG GCGTCATTTC CGAGGTCCTC ACCTGGATTT CCAGGACACG AGTGCCTGCT 53580GGGTGTCCCC AGTCCCATGC ACCGGGGCTC CTTGGGATAG CATGCAACGC TGAGCATGGG 53640CCTGGCCGCC CGTGGTCCTG GACAAGGGCA GTGCCCCGGT GGCTGCTGGG CCTGGGACCT 53700GGTGGGGACG CTGGCCCTGG TACCTGGTCG GGATGCTGGG CCTCGGACCT GGTGGGCAGG 53760CCTCTCACTG CCTCCTGGTG CTGCTTCCGT CTGTGTTAGG CCTCTGGGTA TTGGCGCCCC 53820CATCTGTCTC CTCCTCCACG CCTGTGGACT CAGACCAGGA AGACACAGCC CAGCCCCTGC 53880CTGTCCCCCT TGGCTTCCCC TCTCACTGCC CGACCTGGCG GGAGGTTGCC TAGCCGTGAA 53940CCTTCGCACC CTGTCTGCCA CCCGACACCC TGTCAGGGGG TGTCTGCAGC ACCTGCACCC 54000GCCTGAGCAT CTTCAGAGTG GGCTGCAGCT CCTGGAGGGC TCTGAGAGGA AGGGAGGCAG 54060GTATTTTGGG CGAATGAGGA GACACCTGGA GAGCTGGCAC CCTTCCTGGC CTGCGTCCTG 54120TGAGCACTCT GGTTGGGGAC AGCAAGCTTG GGGTCAGCCT GGGGCACAGC CTCTGGCACC 54180CCCCCGCCCC TCGTGCCCCT TCCCCTCCCA GCTCCTGTCC TCCCCCCGCC CTCAGCTCTC 54240CGCCAGGCAA GGTTTGGCAA GTGCCGCTGT GCGGCAGTGC CTGCTGATTG GCTGGTCTCT 54300TCCTATGGTC CTGCCCAGGG GTGTGCTTTT CCTCCCCTGC CTTCCCTGCT ATCCCTGGGA 54360GTATCTGGGG TTGGGTCATC GCTGGTGTGT GTGAGTGTGT GTGTGTGTGT ATGTGCACGT 54420GTCCATATGT GTGCCCTTCT GGCCTCTGCA CCTGAGTCCT GGCCCTCGGG GGCCCTCCCA 54480CCTCCTGGGG ACAGGCACAA AGCACCCATG ATGGAGTCCG GAGCTGGCGG AGGCCCCATT 54540GCCCCACGTG GCTGCCCTGT GACTCTGGGG TGCTTGTTAG AAGAGGTATC TGGTTCTGTC 54600TGTGTTAAG CAACTCCCTA AGGAATTCTT GTGGTTCCAG TTTGGGGGGC CTGTACTGTA 54660GAGCCAAGGG AGGGGCAGGA CATCCCCCAG ACTCTGACTT CTGAAGCCTT TTCTGCCCGG 54720GGCCTCTCCG CCAGTACAGG CAGTGTCCTT TCCCACGGCT GCCATGCTGC AGAGCGGAGT 54780GGGCCACTGT TTAGCCCAGG AAAACCTGGC TCTCCCTTAG CTGGAAGTTC TGGGCCTGTT 54840GTGGTTGGCA GGGAAGCTGA GTGACGGTGC TAATCACAGG GGCACCTGCA GGGGTTTGTG 54900GGAGATGCCT CTGTGGGTTG GGGCGATAGG CTGAGGGGCT GTTCTTCCCT GCCCTGAGGA 54960GGGCTGAGTG TAGCCGCCAC TCCTCTCCTG TCTTGGGCTG TCTCGGAGAG GATGCGTAGA 55020ACCCTCGGCA TCCTGCTGGC CTCCCTCTGC TCCACCCTGA ACCTCAGGCC TTCTGGGGCC 55080AGACCAGGAT TCCCTCAGGA TCACTCGGGT GGGGGCCTCT CTTGGGCACC TGAGACCCTC 55140AGTGGGTGCT TTGTGGCGCG TTCACGGTTG GTGGGGGACG CCCAGCCCTG CCCGCCGTGT 55200AGGAGCCGTT CTGTCCTGGG CATCCCCCTG TGGTCTGGGA CTTAGTGGAC CCTGAGGGTG 55260TGTGTTTACC CCTGCCTCAC ACCTGCAGAA AAAAGCCTGG AGCAGGAGCT GGCCAGCCCC 55320ATCCTGGACA TTGAGGACTT GGTCAAGAGC GGAACCAAGC ACAGGTGAGA CCCCTCAGTG 55380AGGCCACGAC CACTGTCCTT CCATGGCCCA GCTCTCCTGT GACCTGTGGA GGCCCGGATA 55440TATTTCTTCA CTTTTCTTTG TTCCTTTTTA AATTATGAAA CTAACCACCA TTCAGTACGA 55500AAAAGTTTAA GCAGCTCTGA GGAAGATAGA GTAAAAAATT GTCTCCCTCT TCCCTGGCCC 55560TCAGCCATCC CCGGTGGCCA CCGTGGAGTG TGGACGGAGC CCTGCAGGCC TGTGTCTGTG 55620CGGAAGCACG CGCAGTTTTG TCTGCACAGA CTGTCCTGCA GTTGGCTGTT TTCACTCAGC 55680GTTCTCGCTA TAGCTTCCCA TGCTGGTCCT GGCAGCTCGG CCTTGTTCTT TTGAGGACAC 55740CAGATGTCTC CTATGTCTAC CTCTTACAGC TTCAGAGATT CAAGTTATAA TAAAGCTCTT 55800CTTATATTGA GGGGGAAACC TCCCTCCCCC TTTTTTTTGA AACAGGGTCT CGCTCTGCTA 55860CCCAGGCTGC AGTGCAGTGT CACAGTCTTG GCTCACTGCA GCCTCAGCCT CCCAGCCTCA 55920AGCGATTTTC CCACCTCAGC CTCCCAAGTA GCCGGGACTG CAGGCACGCA CCACCATGCC 55980TCCTTAATTT TTGTATTTTT TGTACAGACA GGGTCTCACT CTGTTGCTCA GGCCAGTCTC 56040CTGAGCTCGA GAGTTCCACC TGCCTTCGCC TCCCAAAGTG CTGGGATTAC ACGCGTGAGA 56100CCCCATGCCT GGCCAGCTCT TTTTTTTTTT TTTTTTTTTT TTGAGACGGA CTCTCGCTCT 56160GTCGCCCAGG CTGGAGTGCA GTGGTGCCAT CTCGGCTCAC TGCAAGCTCC GCCTCCCGAG 56220TTCACGCCAT TCTCCTGCCT CACCCTCCCC AGTAGCTGCG ACTACAGCTG CCCGCCACCA 56280CCTCTGGCTA ATTTTCTGTA TTTTTAGTAG ACACCGGCTT TCACCCTCTT AGCCAGGATG 56340GTCTCCATCT TCTGACCTTG TGATCCGCCC ACCTCGGCCT CCCAAAGTGC TGGGATTACA 56400GGACTGAGCC ACCGCGCCCG GCCCAGCTCT GCTTTTTCTT AGTGGTTCTG CGTTGTGTTT 56460GTTTCTATCC AGGAATAGGG TTGGTTTTAC TTTTCCATCG AGTTTTTAAA GAGACGACGA 56520TTTACATGGT CCGAAACTCA CGAGGACTCC CCATCCCTTC GTCGCAAACT CACATGGACT 56580CCCCATCCCT TGGTCAGAAA CTCACCTCGA CTCCCATCCA TCCCAGGCAG CAGCTTCCCA 56640CCTGGGCCCT ACGTGCAGCA TGAGGCCTCC TTCCGGGTCA GAAGACATGG CGGCCTCGGG 56700GCACCGTCCC CTGCATGGGG TGCTCACACG ATCTTCTCCT CTCTCCTTCC CAGGGTGTGC 56760CCTTACTACC TGTCCCGGAA CCTCAAGCAG CAAGCCGACA TCATATTCAT GCCGTACAAT 56820TACTTCTTGG ATGCCAAGGT GGGGGCTCAG TCCTGTAGCT GACGACTCCT GATGTCAGG 56880GGTGTCCCTG GGCTTGGGAA CAGCTGTCCG AGCCTTTGCT GCTTCAGGCC CTTAGATCAG 56940CAGGCCTGGG TGGGAGGACT CACCTCTGTC ACTGGGCAGG GGCTCAACCT GGCCACACAC 57000ACTTCTGAGC AGCCCCACGC CACAGCTCAG TTTTCTGAGC AGTCTGGGAG CGCGCAGGCT 57060GGTGGGAGTG ACGAGAGACC TCCAGGCTGT GGTCCATAGG CCAGTCCCCG CTCTTGATCC 57120TGACAGCTCA GGTTCTCTCC TTCACGTCAG GCCATGGOAG GCACCGAGAA CACAGGAACC 57180CCACTGACTC CCCTCTTCCC AGCGCGTGCC CGGCCCCACA CTCACTCCCC CTCCCAGCAT 57240GTGCCCGGCT TCACACTCAC TCCCCTCTTC CCAGTGCATG CCCGCCCCCA CACTCACTCC 57300CCCCACAGCA TGTGCCCGGC CTGACACTCA CTCCCCTCCT CCCAGTGTGT GCCCAGCCCC 57360ACTCCCTTCC GGCCCGTGTG CCCAGCCCCA CGCTCACTCC CCCCCCCAGC ATGTCCCCGG 57420CCCCACACTC AACTCCCCTC CTCCCAGTGT GTGCCCGGCC CTGCTCCCCT CCTCCCCATG 57480TGCCCTGCTT TTCTGCCCCA CACTTTTTAC TTAGTGCAGG TGGGATCACA CGCCACGGGT 57540CAATGGTTTG TGTGTTCACG TGACCATGGC CTGCTGACGT TTCCAGATCC CGTCGTTGGT 57600TCGCTCATTC TCGGGGTGTA TATTTATTGA GAGCTCATCA TGCTGGGTGC TATTCCAGGC 57660ATAGCAAGAC TPGGCTTCACT CACATGGAGC TTTGATTCTA GTGGTGGGGA CAGGTGGACA 57720GCAAAAGAGT AAGCACCTGA GCTGACGATA CrGAAGGGAA ATAGAGGAGA GGGAGGAGGC 57780OGAGACCOAG CCAAGCGGGC CCAAGTGCGA TGTCGGCGGG AGGTGGGGAA TGCTGGTGGG 57840TCTGAGGGGA GCCTCAGCAG GTGCAGCAGA GCAAGGGAAG AGGTGAGTGG GGGCGGCTGG 57900GGGGCCGACT CCTGGGAAGC TGTAGCAGAA CCCCACAGAG AGCTGGTGAG GTTTGCCGTG 57960GTTGTGGGTG ACTCGGTGCT TTGAGCCCTG GCTGCCCCTG GGAACCATCT GGAGAGCTTC 58020TAACCCAACC AGGCCCCTCC CTGGGACAGT TATATCACAG CTGGTAAGCC GAGTCTAACA 58080CTTTCACGGA AACGCAGAAG ATCTAAAACA GCAAGATGAC CGTGAAGAAG AACAGAGCTG 58140GAGGACTCAC CTCGCTGGTT TCAAGACTCC TCTAAAGCTG CAGGAGTGGA GGTGGAGATG 58200GCCCAGCTCA GGCACAGGCC TGCAGGCCAT GGAGAAGGCA GCAAGCTCAA GCTGACCCAC 58260ACGCATGTGG TCATTGTTTT TTTTTTCAGT TGGAATCTCA CTCTGTCACC CACGTTGGAG 58320TGCAGTGGCA CCATCTCGGC TCACTGCAGC CCCCGCCCCT AGGTTCTAGC GATTCTCCCA 58380CATCAGCCTC CCGAGTAGCT GOGATTACAG GCGTGCGCCA CCATGCCTGG CCCTTGGTGA 58440TTGTTTTTTG ACAAACATGC CAATTTAATT GAGAGAGGAA ATGAAGGTTG ATTTCTGGTT 58500TTCTGAAAAA ATGGTGCTAA GAACAGCTGG ATATCTGTTC GGAAAACAGT GAATCTTAAC 58560TCTTGTTTTA CCCTGTATAA ACCTAAATGT AAAAGCTAAA CTAAAAGTTA TAGAAAGGAA 58620CATGGGGGAG GTCTTTGCAA CTTTCGGGTA GGCAGAGATT TCTTAGTATG GATACACAAG 58680GCACTAGCCA TGAAGAAAAA CATTAAAATT TAGACTTCAC CAAAATTTAA AGCTTCAACT 58740CTGTGGAAGA GTTGAGAAAA TGAAAAAGCA GTTAAAGAAA GGGAGAAAAT ACTTCTTTCA 58800AAGGACTTAA AAAATTTTTT CAGCCCTCCT CTGATTTGAA AGGACCTTTG ACCAGAGTAT 58860GTAAAATTCT CCCATAACTA AGCAAACAAC CCACTTAACC ACTGGGAAGG GATCTGGACA 58920GACGTTTCAC CAAGATGGGT GGAATGGCCA GTTAACCACT GGGAGAGCAT CCGGACAGAC 58980GTTTCGCCAA GATGGGTGGA ATGGCCAGTT AACCACTGGG AGAGCATPCCC GACAGACGTT 59040TCGCCAAGAT GGGTGGAATG GCCAGTTAAC CACTGGCAGA GCATCCGGAC AGACGTTTCG 59100CCAAGATGGG TGGAATGGCC AGTTAACCAC TGGGAGAGCA TCCGGACAGA CGTTTCGCCA 59160AGATGGGTGG AATGGCCAGT TAACCACTGG GAGAGCATCC OGACAGACOT TTCGCCAAGA 59220TGGGTGGAAT GGCCAGTTAA CCACTGGGAG AGCArCCGGA CAGACGTTTC GCCAAGATGG 59280GTGGAATGGC CAGTTAACCA CTGGGAGAGC ATCCGGACAG ACGTTTCGCC AAGATGGGTG 59340GAATGGCCAG TTAACCACTG GGAGAGCATC CGGACAGACG TTTCGCCAAG ATGGGTGGAA 59400TGGCCAGTTA ACCACTGGGA GAGCATCCGG ACAGACGTTT CGCCAAGATG GGTGGAATGG 59460CCAGTTAACC ACTOGGAGAG CATCCGGACA GACGTTTCGC CAAGATGGGT GGAATGGCCA 59520GTTAACCACT GOGAGACCAT CCGGACAGAC GTTTCACCAA GGTGGATGGA ATGACCAGTT 59580GAGCACATGG AAAGTCGCCC AGCATCTCCA GTCATAGGAG AAGGCAGATT AAAGCCACGG 59640GGAGCCGACA CTGTGGTCCC ACTGGCATGG CTGAAATTCA GAAGCCCTGA GTGTGGCATG 59700AGGATGTGGA ACAGCTGGAT CTCATCCATC GCTCTGAAGT TGTGTAGCCA CTCCACAAAC 59760CTGTGGCAAA CAGCCCAGCC GCGAGAAGGG AAGACGTGTT CAAAGATTCA TATGTGGCCA 59820GCCTCAGTGG CTCACGCCTG TAATCCCACA ACTTTAGGGG CCAAGGCTGG GGGATCCCTT 59880AAGCCCAGCA GTTTGACACC AGCCTAGGCA ACATACCGAG ACCCCATCTC AAAAAAAAAA 59940AAAAAGAAAA AAGAAAAGAC TTCAGTCTCC AGGTTTACCA CAGTTTTGTT TGCAGTTGCC 60000AAAACTGGGA AGCAGCCCGC GTGAGCCCAT CCACACGTGA ATGGACAGAC CGTGGTACCC 60060GAACACTAAC AGCAGCCACG GGCGTGGACT GTGGTCACAC AGCAGCAGGG AGCCGATGAG 60120TCTCGGACAT GCTAACCCAG AGAGGCCCAT TGAGGAGGAC CTACTGTTTT TTGTGTTT~I7T60180 GTTTTTTGTT TTGAAATGGA GTCTCGCTCT GTGGTCCAGG CTGCAGTCCA GTOCTGTGGT60240 CTTGGCTCAC TGCAGCTTCC GCCTCTTGGG TTCAAACAGT TCTCCTGCCT CACCCTTCCG60300 AGTAGCTGCG ACTACAGGCA CCCGCCACCA CACCCGGCTA ATTTTTGTAT TTTCAGTAGA60360 GACGGCACTT CGCCATGTTG GCCAGGCTGG TCCCAAACTC CTGACCTTGT CATCCACTCA60420 CTTTGGCCTC CCAAAGTGCT GAGGTTGCAC GCATGAACCA CCCCACCCGG CTCGACCTAC60480 TGTTTTATTC CATTTATGTG ACACTCTATT AATAGAAAAO GCAGGCGTGG GGCTGGTGGT60540 TATATGGTGC ACATAACTGC CAGAACTCAC TACACTTAAA ATGAACATCT TAATGTGTGA60600 AATTTTTTTT TTTGAGACGG GGTCTTGCTC TGTCACCCAG GCTAGAGTGC AGTCGTCCGA60660 TCTCCACTCA CTGCAAGCTC TGCCTCCTGG GTTCACGCCA TTCTCCTGCC TCAGCCTCCC60720 GACTAGCTGG GACTACAGGC GCCCGCCACC ACGCCTGGCT AATTTTTTTT TTTTTTTTGT60780 ATTTTTAGTA CAGACGGGGT TTACAGTGT TCGCCAGGCT CGTCTCGATC TCCTGACCTC60840 GTGATCCGCC TGCCTCGGCC TCCGAAAGTG CTGGGCTTGC AGGCGTGACC CACCATCCCC60900 GGCCAATGTG TGAAAATTTA AAAGTACCAA AGCTGGACCC CACCCCAGAT TGCTCCCATG60960 ACACTCTGTG GGTGGGACCT GGGAGTTGGG TTTTGTTTTG TTTTGTTTTG TTTTTGAGAT61020 GAAGTCTCAC TCTGTCGCCT AGGCTCGAGT GCAGTGACAC AATCTCGGCT CACATTAACC61080 TCTGCCTCCC AGATGAAAGC GATTCTCCTG CCTCAGCCTT CTGAGTAGCT GCGATTACAG61140 GCACACACCA CCACCCCCTG CTAATTTTTG TATTTTAGT AGAGACGGGG TTTTACCATG61200 TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CGTGATCCGC CCGCCTCCGC CTCCCAAAGT61260 GCTGGGATTA CAGGCGTGAG CCACCGCGCC TGGCTGGGAG TTGGGTTTGT AAATCTCCCT61320 CAGTGGGGCT GGGGCAGGGA ACTCCTGCGT CTGCGTCTTC CTCCCTCCTC TCGTCTGTGG61380 CTTCCTGACT GCGGTGGCCG GGGGCTCCCA GGGCATCGTG GCCGTCTGTC TTCCTCACCG61440 TGGCACGTGC CTTTCCATGC TCTGCAGGAG CGTCTCCCGG TATGGCGAAC TGCTGGTTAG61500 GGTGGGGCGG TGTTGCCAGG TCATCCAGCT CTGGCCTCTG CTCTCGACAT CGCCGGCGCT61560 GTTGCTCATC TGCGCTTGTC ATCTTCGATG CCTGCTGCAC ATGTCTTGGC TTCCCTCTTT61620 CCCGGCCTCT GTGAGCTCCA GCGCTGCGTC CCTTCTCTTC CTCCTGTAGA CCCGCAGAGC61680 ACACAACATT GACCTGAAGG GGACAGTCGT GATCTTTGAC GAAGCTCACA ACGTGGTGAG61740 TCTCCGCTGG CCTCCTAAAC ACCTCCTATT GCTTCTGGCC TTTTTGTCAA GAGCCACGCA61800 AACCTTTCTC GAGGGGCTCT GGCCAAACTC CTGAAGCCCT AGGTCCCCAG GACTGGGGAC61860 TGAGCACACC AGGAGCTTCT GCCACCCCCT CCCGCCCTGA TCCGATCCCT CTCCTCGGGC61920 TOGAGACTOG CCAGCTGGGC CAGGGACCTG CCCGTCAGGC GCAGGGCCCC CACACGCCGC61980 TCACCAGACC CTTTCCCTCC AGCCAGCTCG GGGTCAGCCT GGGCCAGGGC TGTCTCCTCT62040 GCCCTCGGCA GCAGCACGCT TGTGGTCTTG CCTOCACTOT CTCTGCCCTT CCGGCCACAT62100 GGCTTGAGAC TGAGGCAGGA GAATCGCTTG AACCTTGGAG GCAGAGGCTG CAGTGAGCCA62160 GGATCACACC ACTGCATTCC ACCCTGGGTG ACAAAGCGGG ATTCTGTGTC AAAAAAAAAA62220 ATGTTGACTG GGCGCGCTAG CTCATGCCTA TAATCCCAGC ACTTTGGGAG GCTGAGGTGG62280 GCGGATCACG ACGTCAACAG ATCAAGACCA TCCTGGCCAA CATAGTGAAA CACCGTCTCT62340 ACTAAAAATA CAAAAAAATT AGCTGGGCGT GGTGGCGTGT GCCTATAGTC CCAGCTACTC62400 ACGAGGCTGA GGCAGGAGAA TCACTCGAAC CCAGGAGGTA GACGTTGCAA TGAGCCAAGA62460 TCACACCACT GTACTCCAGC CTCGTGACAG AGCAAGACTC CGTCTCAAAA AAAATAAAAT62520 CAAAAAGAAT AATTGGCAAT TCCAGTGAAA TAATTGTTTG TTTGTTTGTT GAGACAGGGT62580 CTCCTTCTGT CGTCCACGCT GGAGTTCAGT GGTATGATCT TGGCCCACTG CAACCTCCAC62640 CTCCTGGGCT CAAGCCATCC TCCCACCTCA GCCTPCCCGAG TAGCCGGGAC TACAGOTOCA62700 CACCACCACG CCCGGCTAAT TTTTGTATTT TTTCTAGAGG CGGGGTTTCC CAGCGITGCC62760 CAGGCTGGTC TTGAACCCCT GAGCTCAAGT GATCTGCCCA CCTTGGCCTC CCAAAGTGCT62820 GGGATTACAG GTGTGAGCCA CCGCGCCCGG CCTGAAACAA TCGTTTCTAA ATATTGGTGT62880 GGGCCACACA GTCATGTTTG GACCTACTTG TGGCCTTTTA CAGACCCCAG GCCAACCCTT62940 TGGGAACTTG GCTGTCAGCC TCCTGTGCCT TCTGCACCCC CACCCCATTT CTGCTTTCTG63000 GAACCCCCGA TCCTGTCCTG TTCTGTGGTC ATTCGGGTGT GCTTGGGCTC TAGGAGAAGA63060 TGTGTGAACA ATCGGCATCC TTTGACCTGA CTCCCCATGA CCTGGCTTCA GGACTGGACG63120 TCATAGACCA CCTCCTGGAG GACCAGACCA AGGCAGCGCA GCAGGGTGAG CCCCACCCGG63180 AGTTCAGCGC GCACTCCCCC AGCCCAGGTG CGTTCATAGC CACACTGCTT GGTCCTGAGG63240 CCTGCGCTGC TGCAGGGTGA GCCCCACCCG GAGTTCAGCA CGGACTCCCC CAGCCCAGGT63300 GCGTTCATAG CCAGGCTGCT TGGTCCTGAG GCCCGTGCTA CTGCAGTGGG CAGCCTGCCC63360 TGTGGCTGTG TGTGGTCGGC CTGGGCACCA TCTATTCAGG CTGGCACTGC AGGGCATCCG63420 CTTCTCTCAG AGGCTTCTTG GGTGTGAATT CTTCAGGGTC CTGTAGCCTG TGGAAGGCCT63480 GGTATTGTTC AGTAGTTCTG GTATTTTCCA AAGACCTATG TCTTCTCCCA GCCAGTATCA63540 ACTTCGCCTC TACTCTGTAA AACTGGAAAA CTCTACTTTG TGAAGCTGAG TTGGGAGCAT63600 CGCTTGAGGC CAGGAGTTTG AGACCAGCCT GGGCAACATG GCGGAACCTC GCCCCTCCCA63660 AAAAATTAGC CAGGTGTGGT GGTGTGCTCC TGTGGTCCAA GCTTTTCTGG AGGCCGAAGT63720 GGGAGGCGTG CTTGAGCCTG GGAGGCAGAG CTTCCGGTGC CCCAGATGAC TCCACTGCAC63780 TCCAGCCTGG GCGGCAGAGT GACGCCATCT CAAAAAAAAA AAAAAGGAAA ACTAAATATA63840 TTCACTGTAA CGGCATTTTG CATCTTThAA TGACCCACAA ATCTGGCATG CATCAGCTGC63900 TCTGCCTGTA CGTTCCTTCC CAGTGTTTGT CCAGAGGTGT ATTTCCACAC AGCGCTAGTC63960 ACCGCATATG TGCAAAACGT GGAAACCCTT CATGGATGTT CTCACTTGGT CTATATTTTC64020 TTTCTTTTTT TTTTTTTTGA GATGGACTTT CACTTTTGTT GCCCAGCCTG CAGTGCAATG64080 GCGCGATCTT GGCTCACTCC AACCTCCGCC TCCTGGGTTC AAGCAATTCT CCTGCCTCAG64140 CCTCCCAAGT AGCTCCGATC ACAGGCGTGC ACCACCACGC CCAGCTAATT TTGTATTTTT64200 AGTAGAGATG CTTTCTCCGT GTTCGCCACG CTGGTCTCGA ACTCCTGACC TCACGTGATC64260 CACCCGCTTC GGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCCCCAC GCCCCGCGTT64320 TGTCCATATT TTCTACATGG CTTCTGTAAA CAGCTGACTA GGAGTCTGTG TGAATATCTT64380 CATAGGTTCT GCTGTGACAC TACTTGCTCG TGACCATCTC CAGGTCTAAA CAGCATCACC64440 TTCCCCCATT TTCCTTTAAA ATCGCACATG TGGACGCACA CCACGGGGAC CCTGGACCCT64500 GGGGAGCCCC GTCCTCACCC TTCTCACCAG GATGGCTGCT TGGTAGAGAG TGAGTTTGCA64560 AAGTTGGCAT TTCTTTAGTA CAGAAGTTAT CAGGTGTTCT GGCTTTAGAA TCCCTTTATA64620 TATATATATA TATACATATA TTTAAGTGAC AGGGTCTCAC TCTGTTCCCC ACGCTGGAAT64680 GTGGTGGTAC AATCAAAGTT CCCTGTAGCC TCGCCCTCCT GCGCTCATGG CATCTTCCCG64740 TCTCAGCGTC TTAAACCCCC GGCACCACAG GTGTGCACCA CTCCCACCCG CTCTCAAGAT64800 TGCCACGCAG GGACTTCCAG TGGGGGAAOG GGTTCCTGGG ACTTTGAACG CTCCACCTCC64860 CTCCTCTCCA CAGTCCCCCA ACCCCACCTC TCTAACGGGG TGGACGCCCC CCTCTTTCCA64920 TCCTTCGCTT GCCGCAGCCT GGGGAGAGTC ACAGGTCTCC TTCCCTCATC TCGGCAGCTC64980 CCATTTCATC GCTTACATAA CGTGGGAGAA ACATCCACCC ACCCCCAGGC CTGTGTGAAC65040 ATCACCACGC GGCCTTCTCC ACTCTTCAGT TTTGTTAGTT ACTTGATGTG CAGGGCTTTT65100 TGTTCTAACT ACTOGGOQAC GTGTGGTGGG GTGGGCTTCT GCCATCTCAT TCAGGACCAG65160 AACTTCAGTT TTCATCCCTA TCTGTTCCCC CACCCCTTTG GAGATGGGGT CTCACTCTGT65220 CACCCACGCT GGAGAGCGGT GCTCCCATCA CGGCTCACTG CAGCCTCCAC CTCCTCCAGC65280 CTCCACCTCT TGGGCTCAAG TGATCCTCCT GCCTCGCCCT CCCAAGCTCC TGGGACTACA65340 GGCGTGTGCC ACTGTGCTTG GCAGGGTCCA TTCTTTTCCT CACACTTTAT TTATTGAAGA65400 GCCCAGGCCG TTTACCCTGC AGAGTCGGAA TCTGTACAGG AGGGGCAGCC ACACGAGTTC65460 CCCGGTTTAC TCTGAACTTA GGTGGCTTGA GGGCCCCAGT TAGACTGCGG CCACCGTTTG65520 CCGGGCTCCA GATGGGACGT CCTTTCTATC AGAAGGCTCA CAGTATCTCC TTTCCCGTTT65580 CTTCCCATGT GAACATTGTT GCTGCTGAAC ACCTGAATAT GTTAATCACT GGCGGCTTGC65640 AAGATGGCAG TGTGCTAATT CCATCATCTA GTCAGTTACC AGGAATAACT TAGGACCACG65700 CCCTGCACCA TATCAGCTAT GTGGTGATCC CATTCACACA GGAAAGGTGC GACAAATGCT65760 GGGGGTGGGC CGGGTGTGCT GTCTCACACC TGTCATCCCA GCACTTTGGG AGGCCCAGGC65820 AGGCGGATCA CGAGGTCAGA GATTGAGACC ATCCTGGCCA ACACGGTGAA ACCCCGTCTC65880 TACTAAAAAT ACAAAAAAAT TAGCCAGGTG TGGTGGTGCA TCCTTCTAAT CCCAGOTACT65940 TGGGAGGCTG AGOCAGGAGA ATCATTGAA CCCAGGACGC GGAGGTTGCA GTGAGCCGAG66000 ATCGCACCAT TGCACTCCAG CCTCGCAACA GAGCGAGACT CCGTCTCAAA AATCAATCAG66060 TCAATCAAGT GTCATCACTG AATGTTTGTG TGTGAACGTG GGGATTGGTC CTGCCCCATG66120 CTCCCTCCTG AATCTCACTC CTGACCTCAG TTGCTGCACC TTGAGGTGTT TTCTGTGGGC66180 TCTTGTGTCC TGACCCCGGC GGTTGTGGCC TCTGCTGTCT GGGAGTCAGG ATTTTTCACA66240 CTCATGTCCT GCTCCAGACC TGGAATCAGC CAAGTCTCCA AGAAGCCCTG CTTCTTTTC66300 CTGCAAGACG GTATTTCAAG ACCCGCCGTG CGGCACCGGG TTGGTCATGG TTACTGGGTT66360 GGTCGTTGTG ACTGGGTGTT TCGTGGAGA TACAGCCATA CGCACAGGTG TGTTCACAAA66420 TGTTAATTCT AAAGGTCAAA CACCCGGCCA GGCATAAGGG CTCAGCGGTA ATCCCAGCAC66480 TTTGGGAGAC CAAGACTGGT GGATCACCTG AGGTCAGGAG TTTAAGACCA GCCTGAGCAA66540 CAGGGTGAAA CCCCATCTCT ACTAAAAATG CGAAAATTAG CCGGGCATGG TGGCGCACAC66600 CTATAGTCCC ACCTAGTCGG GAGACAGACA CGAGAATTGC TTGAACCTCG GACATGGAGG66660 TTGCAGTGAG CAGAGATGGC GCTGCTGCAC CCCTGCCTGG GTGACAGAGT GACACCCTGT66720 CTCAAAAATG AATAGATAAA TAAAGATAAA ACACCTGCTC CTCTTGGTGT CTCCAGTTTG66780 GATTTGGCCT GTGTAGCCTC TTCCTTCCCC TGTTGGTGGA TTTGGCCTGC ACGGATTCTG66840 TGTGGCCTCT TCCTTCCCCT GTTGGTGGAT TTGGCCTGCA CGGATTCTGT GTGGCCTCTT66900 CCTTCCCCTG TTGGTGGATT TCGCCPGCAC GGATTCTGTG TGGCCTCTTC CTTCCCCTCT66960 TGGTGGATTT GGCCTGCACG GATTCTGTGT GGCCTCTTCC TTCCCCTGTT GCTGGATTTG67020 GCCTGCACGG ATTCTGTCTG CCCTCTTCCT TCCCCTGTTG GTGGATTTCG CCTGCACGGA67080 TTCTGTGTGG CCTCTTCCTT CCCATGTTGG TGGATTTGGC CTGCATGGAT TCTGTGTGGC67140 CTCTTCCTTT CCATGTTGGT GTCCTTTTTT CCATGCCAGG AATCCTGGTT CTCAAGGGCG67200 GGGTTGTTGG CACGAGCGTG ATGCAGACTG CCTTTGCTGC CTTTCTCTTG CCCAGGGCTG67260 AACATGGAGC TGGAAGACAT TGCAAAGCTG AAGAGTAAGT GTTGCCCTCC CCGCCTCCTT67320 GCAGCTGGGT GGGGCCTCCT CCTTGCGAGG AGGTGGGTGA CACCTCCTCG ACCCACAGTG67380 ATCCTGCTGC GCCTGGAGGG GGCCATCGAT GCTGTTGAGC TGCCTGGAGA CGACAGCGGT67440 GTCACCAAGC CAGGGAGGTG AGAGGCGGGG AGCCAGCCCC TTCACTGCAG GCCCAGCCTA67500 GAGCTAGAAA CGGGCCATGG TGCAGTCCTG GGCTGTCACA TCACGAGTGA GGCCTGTTTT67560 CAGCCCTGTT TTCCCTTTTT GAGACCTGGG AGGAGCACCT GCTTTGCATG ATCTGGTTGC67620 TGAGATGTTG AGAGGAGCAG CACACACTCC CACGGGACAG CACACAGCCC CCCACGGAAC67680 GGCACACACA CCCATGGAAC AGCACACACA CTCCCACGAA CACCACACAC ACTCCCACGA67740 ACAGCACACA CACTCCCACG GAACACCACA CACACCCACG GAACGGCACA CACACCCACG67800 GAACAGCACA CACACTCCCA CGGAACAGCA CACACACCCA CGGAACGGCA CACACTCCCA67860 CGGAACAGCA CACTCTCCCA CGGAACAGCA CACTCTCCCA CGGAACAGCA CACACACTCC67920 CACGGAACAG CACACACACC CACGCAACGG CACACACTCC CACGGAACAG CAGACTCTCC67980 CACGGAACAG CACACACACT CCCACAGACA GCACACACAC ACCCACGGAA CAGCACACTC68040 TCCCACGCGG GGCCGCTGGG TTTCCTCCAG TTTCTCCTCC TCCAGGCCTT TCCCTCCACC68100 CTGGTCCAGT CCGTCATTTG AGCACAGCTG CCTGTTACAA CGAGACCTTC TTCTTAGCAC68160 GATGAGTGTC CCAGCCACCA CCTCTTTTGG ACTCCGGGAG GCCTGGAACG TTCTGAACCC68220 TCCGTGGGGC TCCAGTCTTC TCCGCAGCCA GGGCAGCAGG GTTTGCTCTC TGTCCTGCAG68280 GCAGATGACG AGTCAGGGCT GGGGCCTGTG TGGGGGCTCT CCTGAGCGCG CAGCCGCCGA68340 GGTGGAGCGT GTTCTGCCTC AGCGCCGACC TGGTCGGGGG AATCCCAGTT GCTTCCACCT68400 GCACCCACTG TCCTCACCCT AATCCTCAAG GCTCTGGCCT GGCTCCTCCG CCACCCTGCA68460 CCCTCAGGGT CCCCTCCTCT AGCTTCTGCT CCCCCATCAC TGTCACTCTC CAAAGCTTTG68520 GGGACTCTGC CCAGAGCCAC CGCCTCCCAC AAGCCCCTGA CAACCTCTTG ACCACCCCCT68580 AGTGACCCCA TCCCTCCCCT CTGACGGCGG CCCCTGCTCT CAGGCGGCTT CTTTTCCTCG68640 GTGCTCTTCT CGTCCTGGCC AGGCCTCCTC TCCCCACCTG GAGGCTCCTG AGGGCCGACG68700 CCTCTCACCT CCAATGCTGG CGTCCCCTGG AGGGCTGAAT TTGTTTCCGA GGGAAGGAAA68760 CTTCCACAGT TGTTGCCTTC AGTTCCAAAG CTGCAGCCTG ATTTCCCCCT CCAGGCTCGA68820 GCCTGTTTTC TTCTCGGCAG CTACATCTTT GACCAGTGTC GTCCCCCCTC AGGCCCGAGC68880 CTGCCTTCTT CTCCTCAGTT CCCAAAGCTG CAGTCTGGTC CCCCCGCCAG GCTCGAGCCT68940 GCCTTCTTCT CCTCGGCAGC TACATCTTTG AGCTGTTTGC TGAAGCCCAG ATCACGTTTC69000 AGACCAAGGG CTGCATCCTG GACTCGCTCG ACCAGATCAT CCAGCACCTG GCAGGACGTG69060 AGTGCTGGCA CGGGGTCTTT GGTGCGGGCA AATGTGGCGT AGGGGGTGCA GCAGGCCTCC69120 ATCTTGGCAG TCAGGGCTCC CCTGGCCGTC ACCTGGCCGT CAGCAGGAAC AGGCCCACAG69180 AACCTCATCT TCTGATCGGG GCGTGCAGGC GTTAGTGCCA CTTGCCAGCT GCCGTAGAGC69240 CTGTCCCAGT TCTGCACCTG GCGGCTTCCT CCTACAGCCT CATCCCATTA TTCTGCTTTT69300 GAGAAAGAGC AGCCCAAGGC CCTAGCTCGC TTGTGGGGCC TCTGGCTTCT CCACACCACC69360 CCGAGTTCTG CTTCTCAGAG TTGTGGGGTC CAGAGGCTTT GCCCAGAGGC CGTGTCCCCA69420 TGGGCTGCTC TGGTTTGAGA CGCCGGGCCC AGCGGGGTCT CTCCTCTGCT GCGCTCCCGG69480 GTGCTGGGGA GGGTGGCTTT TGCTGCTTCA ACCCTTAGGC GACCATAGAG CCTCTTTTCA69540 AGTCCCACTG ACCCCCTTGG AGACTCTGTC CCTGCCTGCC TTCTCTCCTG GCTGCTGGGA69600 AGAGCAGGCG AACTGCCCGC CCTGAATGGA TGCTGCGCTC CACCCTGGGC CCCCCATTGG69660 GCAGGAGATG GAGCTTGGCA GTCGGGCTGA GCGGGCTCAT GCTGGAAGGG CCGGGGCTGG69720 GGTCGGGGCC TCCCCTGCCT GCAGTGTGGG TGTCAGCGCC CTGCTGCCCT CCAGGTGCTG69780 GAGTGTTCAC CAACACGGCC GGACTGCAGA AGCTGGCCGA CATTATCCAG GTGGGGCCTG69840 CTCCTCTGTG GCATCTCCTT CCCTGATGGA AGCCGGGCGG CTGCCTTCTC CTGCTGTATT69900 AGTTAACTGA TTCTAGACTT GGGGATGGGA GAAAGGCCCC TACACCACCT GTTTCTGATT69960 CCCAAACTCT CGGCTCCTTT CCACTGCCCT AAACCCACAC TGGGCCTCCT GCAGGGATGG70020 CCGAGGACGA GGTCTGGTGG CACATGCCCA CCGTOATGCT GGTGAGGGAG GACGCAAACC70080 ACAGTGCGGG CCGGGGAGCC GCTCCTGCCC TGTCCGGGCC CTCAGGCCAG GGGGGACCCA70140 CTGCTGGCAG CCCCAGCAGC CCCAGCTGCA CGCAGATGAA GAGCTCTGGA CACACGCGGC70200 TTCCTGAACA GCTTCTCCAG GGACAGACAA ATGGGGACCC TCCAGCTTCC CGGCAGGGG70260 GTCCCTGGGA GCCCATCATT GGGGGTGCGA CCCTCGCCCC CTTCTCATTG GCCCCGTCCT70320 GTCCTGCAAT GCCCGTCCCA TGTGAGGTCT GCTTCTCCCT CCATGCCTAT GGCAGCACCT70380 GCTTTCCCTC CCGTAGAGGT GCTTGTCCGG TTTGTGGAGG GCACGCCCCA TTTTGGGTGC70440 TCTGGGCACC TTGCCTCTCC GGGGCCTCGC TGGCTTTTTT ACAAGCAGAC TCAGAAGTCC70500 CTGACTGGGG AAGCCAAGGC ACAGGTGGCT GTGTGCAGCC CTGTGAGGCC TCCTCTCTGC70560 TGCCCACGCT GTACCTGCTC GCCACACGAG ATCATGGCAG GGTTACCCAG GCCTGCCCAC70620 CGCTATGACA GCTTCATGAG TGTCCATCTG GCCTGTGGGC TGCTTGAGCT CGCGGAGGCC70680 GCAGAAGAAC CCTCGGATGC ATGGCTGGCC TGTGCATGCT GCTGGCCATG GACCTCCAGA70740 TCCCGGAACA AGCAGCCACT GCCTTCTCCT TCACAGACGC ACCTCTCACC CGGCGCCAGA70800 CCTGGGCAGG GACCAGOTOG GGTCGGCACA GGGTGGTGGG GCCCAGGCTC AGCCCTCCCT70860 CCACTGTGCC CGTCTCTGTC GCCAGTGACG CCACAGCCTG TGTCTTCTCT CTGCGGTAGC70920 TGCGGCTGGA AGGACAGUAC TGCCTTGTCC TCCCAACTCC TCCCCAAAGG CACGGTGGGC70980 ATCCCAGGCC CAGACCCCTC TGTCTGTGGC TCCTGCCTGC CAAGGGCTGC TGTGCTGTCC71040 CGCATGGAGT GTGGTTGGCT CTTCAAGCAG GAOGCCGTGC ACCTATCAGG CCGACCTGCT71100 TCCATGTCCC TGATGGGTCA CTGCAAAGCA CCTCCAGCAC ATGGCCAGGC GAGGTAGCCC71160 TGCAGCCCAG GGCCTGGAGG GCAGGTGTGA GCTGGCCCGG GCCTGTCCCT CCCTGGAATA71220 CAGCTTCCCA GGCTCCCACT TATGGAGAAG TCTCCTCCAC ACTATGGAAC TGAATCCTAG71280 AATGTGGCTT CTGAGGTTCC TACACTCGAA CTGAATCCTG GAATGCGGCT TCCAAGGCTT71340 CCAGCTATGG AGAAGACTCC ACACTCTGGA ACCGAATCCT GGAACGCGGC CTCCCAGGCC71400 CCCAGCTATG GAGAAGACTC CACACTCTGG AACCGAATCC GGGAACGCGG CCTCCCAGGC71460 CCCCAGCTAT GGAGAAGACT CCACACTCTG GAACCGGATC CTGGAACGCG GCCTCCCAGC71520 CTCCCACTTA AGGAGAAGTC TCCACACTCT GGAACCGGAT CCTGGAACGT GGCCTCCCAG71580 GCCCCCACTT AAGGAGAAGA CTCCACACTC TGGAACCGAA TCCTGCACAC TCCATCGGTT71640 TGGAATTTCC TTTGGCTGCT GCTCTAAGTA GCCGCTGGTG GATGACTCAG CTTCTGCCAG71700 CCCTCGGGTG CCTGGAGGAT GAGGGACTGC ACACAGTGCT CACCCGCGTT GGCTCCTGAG71760 CCCCTGCAGG TGTGCGCGGT GCCCATAGGG CTGCTGCTGG GTTGGGCCTG CAGCCCTGAG71820 TCACAGGTGA CCCTGGGGGC AGAGTGGGGC CAGTGGCCCC AGGAAGAGGA TGTGGGATGC71880 ACAGCTCACC TGGAGGCGAA CTCCAGGCAG GGTCAGGCCG TGTGCTCGGA AGTCAGGGCT71940 TAGCTGGAGG CAAACTCTGG GCAGTGCTGG CCCGTGTTGG GGAACCAGTT GCCCCTGGGC72000 CCCCGTGAGA CTGCTCGGTC CTCATCCCTC TCTGCCTGAG GCCGGAGCTG CCCTGGCCTG72060 AGGCACAGGG GGATTTGTGG TGGTCTTTTT TTCAGAAACG GTCTCGCTTT GTCACCCCGG72120 CTGGACTGCA GGGCCTTGAT CACAGCTCAC TGCACCCTCA ACCTCCTGGG CCCAAGTGAT72180 CCTCTTCCCT CAGCCACCCG AGGAGCTGTG AACACAGGTG TGCACCACCG CACTCAGCTA72240 ATTTTTAAAA TTTTTTTGTA GAGATGAGGT CTTGCCATGT TTCCCAGGCT CGTCTCAAAC72300 TCCTGGGCTC AGGCAGTCTG CCCGCCTTGG CCTCCCAAAG TGCTGGGATT ACAGGCAAGA72360 GCTTCCATGC CTGCCCAGCA GAACGCTTTT CGAACGAAGC TGTTTCCTGA GGCAGACTCA72420 GCCCTGCTCA TGGCAGCCAC CAGCGTGCGC GTCAACTTGT TCTGTTACTT CCATCCCCGT72480 GGGCCAAATG CTTTTGGTAA ACACAAGGCC CTGTGTTTAG CTGTCTTGAC AGPQAAAATG72540 GCTGGGAAGG AAGGAAGGAA CGGAAGCAAA TTTCTCTCTC CTTCTGTGCC TACCCAGGCA72600 CGTGCACATG CATGCACAGT ACGCACACAC GCACGCACGC CTGCACAAAT CCACGCATCT72660 TGCCAAGTCT CTGTGTTCCA GCCGTGGTGT CTGCCCCCCG GTGTTCTCTA GTTCGGCTTC72720 TCCGCATTTC TGTGAATGAT TCCCGCTTCT TGGTGTTCCC AGCAGAACTC CCTCAAGTCT72780 GCGGCCGGGC TCTGACCCCG GTGGCTTGCC TGACATGGCC ACATTGCTGA CCCTGTTGGG72840 GGCTTTGCCT TCCTGTTCTC GCCCTTTTTG GCTCGTTTTC CAGGAACGGT CCTCACGCGC72900 TCCTCTCCTA GTGCAGGCAT CATTCCTTTC CCATTGATTT GCAGGCTTCT CTGTAACTTC72960 TGAGCATCCC ATATACATAT ACTCTCTGTA ACTTCTGAGG ATCCCATATA CATATTCTCT73020 CTCTAAGTTC TCAGCATCCC ATATACATAT TCTCTCTCTA AGTTCTGAGC ATCCCATGCC73080 GACATACATA TTCTTTCCTT CrCTCATGCT GGTCATTTTT TCCATTTTCA TCACAGGTTT73140 GGTGAACACA TGTTTCCTTG TCAGATTTTT GTTCTGAGCT TGTCCCTCCC CACCAAGATG73200 CTAAACCGGG TCTTGTGTAT TCTCCAAACT CCACTCTAGA GTCACGGAGC TTTGTGTCTG73260 GGCCTCCATG CCTTCTGACG TCACCTGTGG GGGTGTGAAA GGCACACTCT ACCTTGATTT73320 TTCCCAGCAC CCCACACCGC TGGTTCTGTG CGCTGACCGA GCGGCTCGCC TTCCCCCAAC73380 TCCACTGGGC ACCTGCCACA CTTTTCCTCA TGTTTTTGTT CACTGTGGTT TTGTCGTAAG73440 TCCTGGTGTT CCCCTGAACC AATTTCTTTT TGTTTGTTTT TGAGACAGAG TTTTGCTCTT73500 GTTGCCCAGG CTGGAGTGCA GTGCCGCGAT CTCGOCTCAC TGCAACCTCC CCCTCCCCGG73560 TTCACCCCAT TCTCCTGCCT CACCCTCCCA AATACCTGCG ATTATACGCA CCTGCCACCA73620 CCCCTGCCTA ATTTTTTGTA TTTTTACTAG AGACGACGTT TCACCGTGTT AGCCAGGATG73680 GTCTCCATCT CCTCACCTCG TGATCCCCCT CCCAAAGTCC TGGGATTACA GGCATGAGCC73740 ACCGTGCCCA GCCTGATATT TTTAGTAGAA ATGGGGTTTT GCCATGTTGG CCAGGCTGCT73800 CTCGAACTCC TGACCTCAGG TGATCCTCTC ACCTTGGCCT CCCAGAGTGC TGGGATTACG73860 GGTGTGAGCC ACCACGCCCG GCCTCTTGTT CTTTTGAAAC CTGCCCTCAC GTTTTTTCCA73920 TAGTGCATCT TGGAGTCAGC GTGTCTACTT CCTGTAAAAA TCTTACTGTG ATTTTGACTA73980 GAATGTGTTG AATTCCTGTT TTTTTTTTGA GTCAGGGTCT CTCTGTTGCC CAGGCTGGAG74040 TGCAGTGGCA CCATCACAGC TCACTGCAGC CTCAACCTCC TGGGCTCAGG GGATCCTCTC74100 AGCTCAACCT CCCAAGTAGC TGGGACCACA GCCACATGCC ACCATGCCCG GCTAGGTTTT74160 TTTTTTTTTT TTTTTCGTCA ACACCCTGCC GTTGCACCAT GTTGCCCAGG CTGGTCTCGA74220 ACTCCTGGCT TCGGGCAGTT TGCTCCTCTC AGCCTCCCGC AGTCCTGGGA TTACAGGCCT74280 GACCCACTGC ACTAGGCCAT GTTGAATTTC TAGATTAATT TGCCGCCCTC AGGGGCACAG74340 ACAOGACGGC TGGGCCAGTT CGCGGGAGGA GAGGCCCCTC GGGCTGCCGC ATTTTCAGTG74400 CATGGAGATG GCCTATGTTG GCGGAACACA GACCTCACCG GGGCTCCCTG CAGGGAGGAC74460 AAAGGGTCAG GCAGGTGCCA GCTCCTGTCC ATTGCCCTGG GGCTCCATGA TGGCAGGGGC74520 CGGTGAACCG ATGACCCCTG GCTCTCCTGT GACCTTCTGT GTATCCGCCT GATGCTGCAC74580 AAAGTCGGGT GGCCTCAGGC TCCTGACGGG GCTGCACTTC CTCTGCCTTT CACATTGTGT74640 TCAGTGTGGA CCCCTCCGAG GGCAGCCCTG GTTCCCCAGC AGGCCTGGGG GCCTTACAGT74700 CCTATAAGGT AGGGGCCACC TCCAGGAGGC AGGTGGAGGG CAGCCCTTGT TCCCCGGCAG74760 GGCTGGGOGC CTTACAGTCC TATAAGGTGC GGGCCACCTC CAGGAGGCAG GTGCCGCTGG74820 GGGTCTTCTG GTCCTAAAAC GTAAGGGGCT GCCCCCAGGA CATGGGCGGG GCCTCCACAC74880 TCCTGGTCCT GTCCCCTCCA GGTGCACATC CATCCTGATC CTCCTCACCG GAGGACCGCT74940 CACCGGTCTG ATGCCTGGAG CACCACTGCA GCCACAAAGC GACGTACAGA CCTGGGCCCA75000 CACGCTCCCC GCCCGCCCCG GTGCAGTGCC CGGCACCACC ATGCCACAGG CTAGGCACAT75060 GCCCAGCCGT GGATCTCCTG CCCCCATGGC CCTGGCCACC TTCTCCATAT CCAGGCCAAT75120 CCAGAGCATT CTCCTCACTG TCCCTCTGAA GATTGGAGTT ACTCAGAGAC GVAGGAGATG75180 GCCTGATGGC ACCGTGACCT GCCCAGAGTC ACCTGGTTGG TCCTGGCAGA GCCACAGCCC75240 AGCCAGGCCT CCCTGCTCGC ACACGCTCGT TTATGCCGAG GCCGTCAGCA CAGAGCCTCC75300 ACAGTGAGGC ACGGCTCTGC CTGCTGCCTC CACGCACCGC CTGGCCGGGC CAAGCCTCAC75360 GGTCACATCT CAACGCGGCC CGCCTGGCCC TGTTGTCCGA AGCCCCTGCT GCGCTCAGCC75420 CCGAGGCCCC ACGTGCCTTC TTGGCTTCCT GTGCTCCGTG GCGTcTTCGA GTCGCTGCTG75480 CCGGGGACCC TGTGTGGATG GGGTCTGTGA GTGTGCCCTC GGCTCCGTGT CCGGAGCCCT75540 GTGGTTCTTG GCGTGTATCT GGCCCCACCC CCACTCCCTG GTGTCCAGCG TGCGGCTTCA75600 CGGCTCCAGC TGCGGGACCT GCTGCCCCTC CCTTGTCCTC CACTGCGGCC TTCCCTCTGG75660 GCTTGGTTCC TCCCTCTCTG GAACATTCTT TCTCAGCTGC TGTCCCACCC ATGGTGGCAT75720 CACGTCCCCC TGGCTGAACC AGCCCTTGTG CGGTTGCTGT GCTTGGGTCT GCCTCGCCGA75780 GCCGGAAGCG AAGGGCTGGG AGGGCGTCAG GGTGGCGTGG CTTGACCCCC GCTCGGTGAT75840 GGTCCTGCAG CAAGGCCTCT CCCAGCAGGA AGCGTCCATC CCGGGGGGAG GCCGGCGCCC75900 CTCACGCAGT TGGGGTTGCG GGAGGCAGTG CGTGCCTGAG GCAGCCGGTG CACAGATTCC75960 AAGGGCCTGG AATCTGTTTG TTCCATTGAC CTCTGATGTC ACTTCACTTC TCAGAAGCAC76020 CCACTCCCTG CACTGGGCGT TTGTAGGAAA TGAGCTCCTG GAGGAGGGGG TGGGGAAGTT76080 CCCCCATTGC AGGGCACACT CAGCCCCAGG AAGGAAACGT GCCTCGTCCC TGCTGACTCC76140 GAATCGCAGT CAGAGTCGTT CTGCTTCTGC CGTGTTGAAT TCCCGGCATC CGCCATCCAG76200 ACTCAGCCTC CTCCCCAGGC CACGGCCGCC GTGCCCAGTC GGTCAAGCCC TTCTACGAAC76260 TTCCTTTGAG CTGGCCCCCT TGTTCACTGC TGACGCCACT CACAGCCTTG TGCACGTGTC76320 CTGCTTCCAG GCAGAGCTGG GAACTCGCAC CCCGTCTTCT GCACGCGGCC GTGGAATGTC76380 GGGATGCCGG CCCTTCCTTC CCGTGTGCTC TTGGCGGGGT GGGCTTCTTG CCCTGAGCCG76440 CATGTCACAG TTTCTGCAGA AGTTTAGGGT TGGAGTGGCC TGACCTCTCT GCAGGTGTCC76500 CCAGCCTCTC CCTGGGGTCT GCCTCCTACT CCCAGGACCC CCTGTCCCCC AGACGGGCCC76560 CAAGCTGGCA CGCTCACACT CAGGCCAGCC TCCTTTGTTC TGACTTCTGC ACAGTGGGCC76620 TGGGTGGCTG CCCGCGGCTC CCTTGCTTCA TGCCAGTGGC TGGAGAGGGT GATGGGCAGA76680 GAGGCAGGTG GTCAGGCCCC CAGTCCCGTC CTCACACTCT GTGCCCTCTG CCGCCCCCCG76740 CCCCACAGGG AAGCTCCTGA GCTACTGGTG CTTCAGTCCC GGCCACAGCA TGCACCAGCT76800 GGTCCGCCAG GGCGTCCGCT CCCTCATCCT TACCAGCGGC ACGCTGGCCC CCGTGTCCTC76860 CTTTGCTCTG GACATGCAGA TGTACCGCCC ACCCCTGCCA GCCCCTGAGC ACCCGTGACA76920 CCTCTGACAT CAGCGCGGTG GAAGTGGTGG GGGTCCCCAT GAGCCGCGTG CTCGGGGTCT76980 CCGGCCTCGA GGGCTAAAGC GCTGCTGGTG CACTTCCCCA CTGTCTGCTC CCTCTGGCCA77040 CGCTCAGCCC TTTCCCAGTC TGCCTGGAGA ACCCACACAT CATCGACAAG CACCAGATCT77100 GGGTGGCGGT CGTCCCCAGA GGCCCCGATG GACCCCAGTT GAGCTCCGCC TTTGACAGAC77160 GGTGACGGCC TGTCCCTGGG CCCTGCTGGG GTUGGAGGTG GCGCAGCACT CAGGCCTGAG77220 GCCCTCACCA GTGGCCTCTC CGGCTCTAGG TTTTCCGAGG AGTGCTTATC CTCCCTGGCG77280 AACGCTCTGG CTGACTGCCC TGAATGCCCC AGCTGTGCGC ATCCTCGATC CTGGACCCCT77340 GCTCCCAAGA GCTGGTAGGC ACCCCTCCAC ACATCCTGCC CCTCCCTTGA CCCCGGCCCC77400 TGCACTTCCA GGCAACATCG CCCCCGTGGT GCCCTATGCG CTCCTGATCT TCTTCCCTTC77460 CTATCCTGTC ATGGAGAAGA GCCTGGAGTT CTGGCGGGTG CGTCTCCCCT GTGTTCTCGG77520 CGGGGTGGGT UAGGGCAGGG CTGGAGCATG AAGCAGGCAG TGGTCACAGC TCCTGCTTGC77580 CCTCATCGGA TCGGCGGCGT GACCAGGOCT ACCGTGTCCC TGCCTCTTCC TCCCACAGGC77640 CCGCGACTTG GCCAGGAAGA TGGAGGCGCT GAAGCCGCTC TTTGTGGAGC CCAGGAGCAA77700 AGGCAGCTTC TCCCAGGTCG CCACTTGGCC GGGGCTCTGG CCCTGCTGCC CCCTCGTGCC77760 TCCCCTGCCT CTCACACCTT CCCCAAGGCT GACCACTGGC CCTGACCATG GGCTCCGGCG77820 GCTCCCGCTG CCTCTTCAGG GCTCCTGCGT TTCCTTCCTG GCCCTGAGTG TTGCCTCTTA77880 TCTTACAAAG CCCCCAGCAC CCGGTCGGTG TCCTAACAGT GGCCCTCCTG TCTGAGTAGC77940 CCTAGTCGGC CACCCTGGCC CTGGGGTTCC CCGTGTTTTC TGGGAAGCAC TGAGCAGGCG78000 TGGGGTCAGC CTGGGATCCG TGCCAGGAAG AAGCTTCCAG AACCCGATTG GCCTTCCTGG78060 CTAGGACGAT CCTTCATCTT GGAGCATGAG ACCTGGGTCT CCCTCATGGG GGACCAACGC78120 CCTGGGGGGG CGCTCCAGGC TCAGCCTCAC CAACTTTCCT TCCAGACCAT CACTGCTTAC78180 TATGCAAGGG TTGCCGCCCC TGGGTCCACC GGCGCCACCT TCCTGGCGGT CTGCCCGGGC78240 AAGGTGAGCT CTCCAGGGCC CTCTGCCCTG ACCTGGTTGC CTGTTCCCTG GTOGGTCCTT78300 ATGGCTCCCC AGCAGACTCT GCGCCCTGGG GGCTGCCCGG TCCCCTCCTT GGGTCCCACG78360 AGAGCGACTG CTGGCCCTGC TCGCAGCGTG TCCTGCTCTG GGCCTGGGCA GGCAGGATGG78420 GAGTTTCCTG GCCACAAGAG TTGGAGGTCG CGTCTGGOAC CTGTGGACCC CAAGTGGGGT78480 CCTCACCCAC AGATGGAGCT TCCTCCCACC CCTGGTTGGG GACGGAGCCT CCGCGAAGGT78540 GGCTGGGCTG GGTGTGGGCA CCACGGAGAG GAGCCCCCAC GGCCCCAGGC AGCTCCCTGG78600 TGTCTCCCCT AGGCCAGCGA GGGGCTGGAC TTCTCAGACA CGAATGGCCG TGGTGTGATT78660 GTCACGGGCC TCCCGTACCC CCCACCCATG CACCCCCCCG TTGTCCTCAA GATGCAGTTC78720 CTGGATCAGA TGAAGGCCCA GCGTGGGCCT GGGCGCCAGG TGAGTTACAC CAGGGTGGGG78780 CTGGGGTAAG GCGGTCTGGT GACTGAGCCC CCGCCCCGTG GCCAAGGGAC CCCCCGTGAC78840 CGAGCCGCCT CGCCGCACAG TTCCTCTCTG GGCAGGAGTG GTACCGGCAG CAGGCGTCCA78900 GGGCTGTGAA CCAGGCCATC CGCCGAGTGA TCCGGCACCG CCACGACTAC GGAGCTGTCT78960 TCCTCTGTGA CCACAGGTGC GTCCAGTCCG GTGGCACGCG CGGCGCCACG GGACACGCCC79020 ACACCCCACT GGGCCCCTGG ACTCTCCTTC CCCACATGAG GCCCCGTCTC CTCCAGAGCC79080 TCTCCGGCTA CTCGGGGTCA GCGTGGCGCC CCTGCAGCAG ATGAGGGTCT TCACTTCGGT79140 GAACTGAACC CTTGAAGCGG CTGTGGGCAG GOCACCAGOG CTATGGCCAC CCCCCAGGTT79200 CGCCTTTGCC GACGCAAGAG CCCAACTGCC CTCCTGGGTG CGTCCCCACG TCAGGGTGTA79260 TGACAACTTT GGCCATGTCA TCCGAGACGT GGCCCAGTTC TTCCGTGTTG CCGAGCGAAC79320 TGTGAGTTCC TCCCCAGGGA GCGGATGAGG GTGTTGTCCC CAGAGGAGCC AGAAATGGGT79380 CCACCCACCC CCATGGTTCT GCAGATGCCA GCGCCGGCCC CCCGGGCTAC AGCACCCAGT79440 GTGCGTGGAG AAGATGCTGT CAGCGAGGCC AACTCGCCTG GCCCCTTCTT CTCCACCAGG79500 AAAGCTAACA CTCTGCACCT GCATGTCCCC AGCCTGAAGC AGAGGTCCTC AGGTGCGGAC79560 GGGCAGCGCT GGGTGGGCGG TGTGGGGGTG GCGGAGCGGG CGGCGTGGGG CGGGCAGCAC79620 CAGGCGCCCA GGGCGGAGGC GACTCACCTG GCTTTGTGCG CTTCCCCTCC CACCTCCAAA79680 GGCTGCCTCT CCCTCCTAGG GCAGGGCCCC CACGGGCTGC AACCCTCCCC TACAGGCAGA79740 GAACGCCCCA GGCAAGGATG CCCCCCGAGG CTGAGACTCC CCCCAATAGC AGGGAGGACA79800 CCCACAGGCA GGACCCCAAG TGCTGGCACT CTCCCCCAAC AGGGGCTTTG CCACAGGCAG79860 GGACCCCAGC TGGGGCCCCC CGTGGGCTTC ACTGCGCACT CGGGTGCCCC TGCAGGGTCA79920 CCAGCTGCCG GGGACCCCGA GAGTAGCCTG TGTGTCGAGT ATGAGCAGGA GCCAGTTCCT79980 GCCCGGCAGA GGCCCAGGGG GCTGCTGGCC GCCCTGGAGC ACAGCGAACA GCGGGCGGGG80040 AGCCCTGGCG AGGAGCAGGT ACAGTTCCAG GGCCTTGGGA TGGACACAGA CCCTCTGTCT80100 CCTGAGGCCA ACCCGACCCC GCCCATCTGG CCTCAGGCAC CTCCCCACAC ACCCCTGTAA80160 ATCCCCTCCC GGCAGGCAG GCOGGCAAGC GGGCGGGCGA TCCCAGCTGC CTGCCTGTCT80220 CTGGCTCCTC CACCCCACCT CACCCACAGG CTGCTGGCTC CCAGGTG~TG CATGCCCTGG80280 CCCTCCGCGG GTGCCCCCCA CATCACTTTG GTTCTCTGGC GGGTCAGCTT GGCTCAGTGC80340 ACTCAAGGTC GGCTCCCCCT GCCACTGGCT GCGCTTCAGG CTGGCCTTTC TCCAGGAATG80400 TCCTGCGGGT CGAACCCAGG TTCCTTCTTC CTTGGGGCCT TTTGCCCCAG AAGCCCATAA80460 TTCCTCAGGC CAACCCCAAA TTTTCTCCCT CCTTCCTCCT GGGAGCCATT CCCCTCTTCC80520 TCCCCATCCC TCCCCTTCA~ GCCCCTCGAG TGACCTCCAG CTGCAGCCAC CACGCACCTG80580 TGTCCCCTTC CTGCCAGCCC CTCGCTGTGG TCGGACTGTC TTCCCTGCAC CTCCTCTTAC80640 AAGTCACCAC CTGCCAGCCT CATGAGCCGC TGGTGTCACT TOCACACCAC CAAGTTGTGG80700 CACTGTCACC GGGGTGTGCT GTGCCCCCCT CCCCCGACCT CCATCTTGGC TCAGGGCTCC80760 TTGGGACCAT CTTCCCTCTG CGTCCACGTC CTTTGGGACC CCAGAGTGTG TGGTTGGCCT80820 CTGTGTGTGG TTGTGAGCTC TGTCCTCCTC AGGCCCACAC CTGCTCCACC CTGTCCCTCC80880 TCTCTGACAA GAGGCCGGCA GAAGAACCGC GAGCAGGGAG GAAGAAGATC CCGCTGGTCA80940 CCCACCCGGT GCGTGAGCTG TCCCTGCACC TGTGCCGACC ACCATAGACA CGCATGGGAA81000 CGCAGCCGTG GGTGCCCCCA GCCACGGCTG GTCCCGATGG GACCAGGGAA TCCACCCCCA81060 GGAGCTGATG TCCAGGGCAG CTGTGATGCT GACGGCCAGG GGCTCAAGTC TGTCGTTTCT81120 TCTGCACGGG CTCATGAGT CCCAGCTGGA ATCAGGCCCC ACCCTTGGGC AGGTTTGGCA81180 TGGGGCCTGC AGCACTGGGC TTGGCCCTGG CATTTCCCTC AAGTGTGGAT GCACACCTGC81240 CTCATGTGAG CGACACAGCC CATTCCTAGC CTTGGATCAA AGAACGGAGT TATAGCCGGA81300 GCCAGGAAGC CCCCTGCCTG CTGGAAAACC CCAAGTGTGG CGGCCTTTGT CCATGTCCCT81360 TGGCTTCTGG CIAACAACTGG GTCGTGCCCA GGCACGGCTG CTGCCATCAG GAAGTCGGTG81420 CCTGCTGAGG GGCCTGGGCT GGCGAGGCCC TGGGTGGCGA GTGCCTGGGC CGCCCCTGCC81480 TTGCTTTCCA CGTTTCCGTG TTGGTCTGGG GTGTGTAGAG AGATGGGCAC TGCTCATCCG81540 GAAGCCCCTC CTTGTGCGCT GCCATCCTGG GAGCCTCAGC CGCATCCGCT GTGGGCCAGG81600 CGGCTTCAGG GACCAGGAGA GAGACGCCCC ATGCACGACC CCTGGCTTGA GGCAGAGCCA81660 ATCTACCCTT TGCCCATTCA CTCCTCTCAC TTCCCTCCCA GCCTCTCACT GTGTCACCTC81720 AGACGGGCCC AGCCCCACAG CTTTCTTCCC GCAGCCCCTC CCTATGTCCA TCCACCCAGC81780 CAGTTTCTCA GGCAGCAGCC CCACCTCGGC AGTCACTGTC CCAGGGAACG CTCAATGTTC81840 CAAGGAAGGC TCTGCAGCCC CAGGGACCAG ATGATGAGCC TCGCCCTGAT GGAGCCTCGG81900 GCCTGTGTCC TGCAGGAGGA GCCCGTGGCT GGTGCACACA CGGACAGGGC CAAGCTCTTC81960 ATGGTGGCCG TGAAGCAGGA GTrGAGCCAA GCCAACTTTG CCACCTTCAC CCAGGCCCTG82020 CAGGACTACA AGGGTTCCGA TGACTTCGCC GCCCTGGCCC CCTGTCTCGG CCCCCTCTTT82080 GCTGAGGACC CCAAGAAGCA CAACCTGCTC CAAGCTGCCC TCGCTTGCAG AGGCCACCCA82140 CCCTGAGGGC AGTGCTGCCG CCGCGTGTGG GGTGGGGGCC ATCTGGGTCC AAGGTGGTCT82200 CTGTTCTCTPA GAGAAAAAGC CGCAGATGGG GACAGACGCC CCTTCCTCTA CAGGCTTCTA82260 CCAGTTTGTC CGGCCCCACC ATAAGCAGCA GTTTGAGGAG GTCTGTATCC AGCTGACAGG82320 ACCAGGCTGT GGCTATCGGC CTGAGCACAC CATTCCCCGA AGCCAGCGGG CACAGCCGGT82380 CCTGCACCCC ACTGGTAAAT GGGGCCCCA5 GTCGGACCCT CAGACTCCTC CGTOGAAGGC82440 AGTGTGGGCC AGAGTCCTGG GCTGCTTCGG CTCGGCATCC TCGGGCCCTC CTTGGCCCCG82500 CCTCTCTCTT CCCCTATGGc~ AGTGATCGCC GCCTCCACCT CCACCACCAG CACCAGCAGC82560 ACCACCTCCA CCTTCACCAC CACCACCTCC ACCACCACCA CCTCCACCAC CTCCACCTCC82620 ACCACCTCCA CCACCTCCAC CACCTCCACC ACCACCACCA CCTCCACCAC CACCACCACC82680 ACCACCTCCA CCACCACCAC CACCACCACC ACCTCCACCT CCACCACCTC CACCACCACC82740 TCCACCTCCA CCACCACCAC CACCTCCACC TCCACCACCT CCACCTCCAC CTCCACCACC82800 ACCACCTCCA CCACCACCAC CACCACCTCC ACCTCCACCA GCAGCAGCAT CACTTGTTGG82860 CGAGACCCTG TGCAACTCCA TCCACAGCCC TGTCCCTGCC ATACCCCCGA CCCCTAAGCA82920 CAGCCCTGTC CAACTGCCAC ACGTCCCCTG CCTCCCATGC ATGGTCCTCG GGGGTCAACT82980 GCACACGCCA GGGTCCTAGG CTCCTAGACC CCT~TCCTCC CTCTTTCTGC CTCTGTTTGG83040 GGTGGAGTCC AAGTCTCCAG AGGCCGAAGC ATCTCTGTTC GTQTGTTM~T GAACACCCCC83100 TACAGACTTC CCCTAGTTCA CCCAGGGGGG AACCTAGCCT GTTGGGACCA CCCCACATCC83160 CTTCTGGGCT TGGTACTCAC TGGGATATCC TCATGCCTCC ACCCAGCCTA CGGCTCTGAG83220 CTCCTGAGTG GCGCTTTGGC CTGCCCGCCA CTGTTCCAGC CCCCATCCAG CAGCCTGGTG83280 TCTCCTCTGA TGCCCCCAGC ACCCACCCGT GTACCTGCCT GGGTTTTCCC CCCCTGGTCT83340 GACGTCGGTG AGGCCTCGCC TCCCTACCCA GCCCTGCCCC CCCACCCCAG GGAACTTTCC83400 ACATGCTCCC GACCAGCTTT GTGGCTCTAC ATCTCTTCAT CAGGAAGAAC GGCGCCGGAT83460 CCCAAGCTGA CCGTGTCCAC GGCTGCACCC CAGCAGCTGG ACCCCCAAGA GCACCTGAAC83520 CAGCGCAGGC CCCACCTGTC GCCCAGGCCA CCCCCAACAG GTAGCTGACT CCTGAACCGT83580 GTGCAGCCTA CGACTTGGTC CCTCCCTCAC TCGCTTCACC AGGCTAACTC TTGAGTGTGC83640 CCGCGGCTGC CCCTGTGGGC AGCCATCTCA TCGTGGGCAC TGCTCCCGGT TCTGCACCCC83700 GCAGTTGTCC TGAGCAGCTC TCCAGGAGTT CCTGGAGCAA GGGCGGGCAG GGCGGTGGGA83760 CTCTCAGTCC TCCACCCCAG CGCCACTCTG AGCCATGCTA CTCCCACACC AGCAGACCCT83820 GGCAGCCAAC CACAGTGGGG GTCTGGAGTG CCCAGAGCAG GGAAGCACGG CCAGCACGCC83880 GTGAGCGCCT ACCTGGCTGA TGCCCGCACG GCCCTGGGGT CCGCGGGCTG TAGCCAACTC83940 TTGGCAGCGC TGACAGCCTA TAAGCAAGAC GACGACCTCG ACAACGTGCT GGCTGTGTTG84000 GCCGCCCTCA CCACTGCAAA CCCAGACGAC TTCCCCCTCC TGCACACCAA CTGGCCCTGG84060 CCTGGGGAAC AGCCGGTGGG GTGGGGGGCA GGGGACAAPA TGGGGGCTGT GCCGGGTCTG84120 ATTGAACCTC CCCGCAGGGT TCAGCATGTT TGTGCGTCCA CACCACAAGC AGCGCTTCTC84180 ACAGACGTGC ACAGACCTGA CCGGCCGGCC CTACCCCGGC ATGGAGCCAC CGCGACCCCA84240 GGAGGAGAGG CTIGCCGTCC CTCCTCTGCT TACCCACAGG GCTCCCCAAC CAGGTAGGGC84300 ACCTGCCTGG CTGCTCCTGG CACCCCCCCA ACCGCACGCA GCCCTGGGAG TGAGCAGCXA84360 AGCCCCAGGC CCCCCTCAGA CTCAACTCTC TGTCTCCAGG CCCCTCACCG TCCGACAAGA84420 CCCGGAAGAC CCAGAGCAAG ATCTCCTCCT TCCTTAGACA GAGGCCAGCA GCGACTGTGG84480 GCGCGCGCGG TGAGCATGCA GCTCCCAGCC ACTCCTCAGG ACCTCCCCAC GGGCCTGCAG84540 CATCTCAGTG GGGTGAGCCT CATGGGAGAG ACATCGCTGG GCAGCAGGCC ACGCGAGCTC84600 CGGCCGGGCC CCTCTCAGCA GGCTGTGTGT CCCAGGGCTG TGGGGCAGAG GACGTGGTGC84660 CCTTCCAGTG CCCTGCCTGT GACTTCCAGC GCTGCCAAGC CTGCTGGCAA CGGCACCTTC84720 AGGTTGGTGC CTGCCCACTA CAGTTCCTCC TGCGTGTAGC CCCAGCTGAT CGGCTGAGGG84780 GGAAAGGGCA CCCCCTTGTC CTGGTGGCAA CGCCTCCCAG ACGTGTGCAG TGGGCCGGTT84840 GTCTCACAGC CCTCTAGGAT GTGCCCAGCC TGCCACACCC CCTCCAGGAA GCAGACCCTC84900 ATGCAGGTCT TCTGGCCACA GCCCCAGTCA GTGCCCACCG AGGCCCCCAG CACACCCAAC84960 GTGCCTTGAT CACCTGCCTG TCCAGCTCTG GTGCGCCAAC AACCCACCCA ACAGAATAGG85020 CCACCCCATG CCACCCGGCT TGGCCCGCTC CACCCCTCAG CCAGGCGCGG CCCATGGTTG85080 GTCCCTGCGG TCGGACCGGA TCTGCGCCTG CCTCTCAGAA GCCCTCAGCT ACCTTGGGGT85140 CTGGGGTGCG TTTCTGGGAA AGTGCTTCCC CAGAACTTCC CTGGCTCCTG GCCTGTGAGT85200 GGTGCCACAG GGGCACCCCA GCTGAGCCCC TCACCGGGAA GGAGGAGACC CCCCTGGGCA85260 CGTGTCCACT TTTAATCAGG GGACAGGGCT CTCTAATAAA GCTGCTGGCA GTGCCCAGCA85320 CGGTGTCTTC GTGCCCTCGG CTTGGTGGTC CCAGTTGAGG GACAGGGAGT TGGCAGAGGC85380 CCCTCCCAGC CTGCCATGTG ACACTGTACT TCCTCCACGG TGGGCTCAGC CCTCCCCTCA85440 TCCTCACAGC CCCAGCCAAG CTGCAGTTGG TAGGGGATCC ACCGACACAC CAGGCTGCCT85500 GGGCTGGTCT CTGGGTTGGG AGCTGCCCCA GGTGCTGAGG AGCCCAGCTC CCTGGCTGGT85560 GACGCCCCTC CCAGAACCAC CCTTGGACTC ACCTCTGGGG AGGCATGGTA CCACGTGGGT85620 GAGGGGGGCT CCCTGGGGAG CGAGGGGTTC CTATGGGGCG TGGCCAGGCT GGCCCAGCCC85680 TCTCCCCGCC CATATATGTA GGGCAGCAGC AGGATGGGCT TCTGGACTTG GGCGGCCCCT85740 CCGCAGGCGG ACCGGGCGCA AAGGAGGTGG CATGTCGGTC AGGCACAGCA GGGTCCTCTG85800 TCCGCGCTGA GCCGCGCTCT CCCTGCTCCA GCAAGGACCA TGAGGGCGCT GGAGGGGCCA85860 GGCCTGTCGC TGCTGTGCCT GGTGTTGGCG CTGCCTGCCC TGCTGCCGGT CCCCGCTGTA85920 CGCGGAGTGC CAGAAACACC CACCTACCCC TGGCGGGACG CAGAGACAGC GGAGCGGCTG85980 GTCTGTGCCC AGTGCCCCCC ACGCACCTTT GTCCAGCGCC CGTGCCGCCG AGACAGCCCC86040 ACCACCTGTG GCCCGTGTCC ACCGCGCCAC TACACGCAGT TCTGGAACTA CCTGGAGCGC86100 TGCCGCTACT CCAACGTCCT CTGCGCGCAG CGTGAGGAGG AGGCACGGGC TTGCCACGCC86160 ACCCACAACC GCGCCTGCCG CTGCCGCACC GGCTTCTTCG CGCACGCTCG TTTCTGCTTG86220 GACCACOCAT CGTGTCCACC TGGTGCCGGC GTGATTGCCC CGGGTGAGAG CTGGGCGAGG86280 GCAGCGGCCC CCAGGAGTGG TGGCCGGAGG TGTGGCAGGG GTCAGGTTGC TGCTCCCAGC86340 CTTCCACCCT GAGCTAGGAC ACCAGTTCCC CTGACCCTGT TCTTCCCTCC TGGCTGCAGG86400 CACCCCCAGC CAGAACACGC AGTGCCAGCC GTGCCCCCCA GGCACCTTCT CACCCACCAG86460 TTCCAGCTCA GAGCAGTGCC ACCCCCACCG CAACTGCACG GCCCTCGGCC TGGCCCTCAA86520 TGTGCCAGGC TCTTCCTCCC.ATGACACCCT GTGCACCAGC TGCACTGGCT TCCCCCTCAG86580 CACCAGGGTA CCAGCTGAGC CAcAGGCCTC AGCGGGCAGC ACACTGCAGG CCAGGCCCAC86640 TTGTGCCCTC ACTCCTGCCC CTGCACGTGC ATCTAGCCTG AGGCATGCCA GCTGGCTCTG86700 GGAAGGGGCC ACAGTGGATT TGAGGGGTCA GCGGTCCCTC CACTAGATCC CCACCAACTC86760 TGCCCTCTCA GGGGTGGCTG AGAATTTGGA TCTGAGCCAG CCCACAGCCT CCCCTGGCGA86820 GCTCTGGCAA AGTGGGCAGC AATCTCCTAA CTGCCCGAGG GGAAGGTGGC TCGCTCCTCT86880 GACACGCAGA AACCGACGCC TGATCGTAAC TCTCCTAACT GCCTGAGAGG AAGGTGGCTG86940 CCTCCTCTGA CATGGGGAAA CCGACGCCCA ATGTTAACCA CTGTTGAGAA GTCACAGGGG87000 GAAGTGACCC CCTTAACATC AAGTCAGGTC COGTCCATCT GCAGGTCCCA ACTCCCCCCT87060 TCCGATGCCC CAGGAGCCCC AAGCCCTTGC CTCGGCCCCC TTGCCTCTTG CAGCCAAGGT87120 CCGACTGGCC ACTCCTGCCC CCTAGGCCTT TCCTCCAGCT CTCTGACCGA AGGCTCCTGC87180 CCCTTCTCCA GTCCCCATCG TTGCACTGCC CTCTCCAGCA CGGCTCACTG CACAGGGATT87240 TCTCTCTCCT GCAAACCCCC CGAGTCGGGC CCAGAAAGCA CGGTACCTGG CAGCCCCCGC87300 CAGTGTGTGT GGGTGAAATG ATCGGACCGC TGCCTCCCCA CCCCACTGCA GGAGCTGACC87360 AGTGTGAGCC TGCCGTCATC GACTTTGTCC CTTTCCACGA CATCTCCATC AAGAGCCTGC87420 AGCGGCTCCT GCAGGCCCTC GAGGCCCCGG AGGGCTGGCG TCCGACACCA ACGCCGGGCC87480 GCGCGGCCTT GCACCTGAAG CTGCGTCGGC CGCTCACGGA GCTCCTGGGG GCGCAGGACG87540 GGGCCCTCCT GGTGCCGCTG CTGCAGGCGC TGCGCGTGCC CAGGATGCCC GGGCTCGAGC87600 GGACCGTCCG TCAGCGCTTC CTCCCTGTGC ACTGATCCTG CCCCCCTCTT ATTTATTCTA87660 CATCCTTGCC ACCCCACTTG CACTGAAAGA GCCTTTTTTT TAAATAGAAC AAATGAGCTT87720 TCTTAAACCT TATTTTTATA AAGCTTTTTC ATAAAACTGG TTCTAGTTGC ACAGCTACTG87780 CGAGGGCAGC CGGGGACACC TGAGCCGCCC GCTGTGCCCA GATCCCTCAG GCTGCCTGCC87840 ATCAGAACTG CTGCCCCGGC CTTCCCCTAC CTCAGACACA CCCTCCCTGG GAGGATCAGT87900 GGGGAGTGCC ACCTCTGCCC CCAGTGCCTC TGCCACCTCG CAGGGGCCCC TGAAGCTCAC87960 CCAGGGTCAG GGCCTGGGAG CCTATCATTG CTGGAAGAAC AGGATCGGGC TCAGCCCAGC88020 CCTAGTCGCC GGGGCCCACA CTAACCCCCC ACTTATGAAT TCCTCCCACT CCCAACTCAC88080 AGGGGATTTC CCGACAGGGC ACCTGCCAAA GACCTCCTCC AGGCCTCCCA TGCTTCCCGG88140 GAAGTGAAGC TTCTCCCCCT CTGGCGCACG CTCTGAAGCC TCCCGATGCA CCCAGAGCAA88200 CCAGGGGGCT GCACCAGCCA CTCGCCTCCC CAGCACGGCC AGGTTCCCGG GGCTGGAGGT88260 CCCCCCCAGG TCCTCGGAAC CAACCTGCAG AACACACACA GGGTCCCCTG GAGAGGACGC88320 CGGGACTTCC AGGGCCCGAC TCCTGTGAGT CACACCCCCG CAGCTGCTGC GCCACCCCCA88380 CCCTGACTCA TGCCCCTTCC CAGCAGCTCC TCCCAGGACC CCATGTCCTT CCCACATCCG88440 CAGGAACGGA GTGCCTGGAC TCTCCAGGCC CACCTGGGGA CCCCCTCACC TGCCCACCAG88500 CCCCTGACCA GCCCAGTAAC ACCATCACCC TGTCCAACAG CCAGGAGCCT CCACCCTCCA88560 GGAGGCAAGG GATGGACAGA GCCACACTCG CCGTCTTTAT TTTGCACTCA CCCTGGGTGA88620 CACTCGGCAG GCCGCTCCTC CCCACAGCCA GACTGAGGAA GAACACAGCA CTCGGCAGGC88680 CCAGTGGGGT CCGTGCAGCG AGGACCCCAG GACCAGCCTT ACTCCCGAGC AGGCGACACA88740 GGGCCCCACA GAGAACCCCT CCGGGACGTT CTCTCCTGGC TGCGGGAGGG CTCTCGACCC88800 CCACAAACAC TCCCCAACTT GCGGGGCTGC GGCATAAAAA CAGCCACTCC CAGCACGCCC88860 CCTCAGCTTT TTGCATCAGT CAGCTCCCTC CCGGGGGATT AGGGTGAGGT GAAGCCAGGC88920 CCAGGCGTGG GGTATAGGTC TTCCCCCGCA GGCCTCAGCC CTGTCCCGAG GCTGCATCAC88980 AATCCAGGGC CCCCGCTGGC CTTTGGGAAC ATGCCCTGGG TCTTCCTCAA GGCAAGATCA89040 GCCCCAGACC ACTTCCGGGG TCACGGGGTC ACACOCCAGA AGCCAGATGG CAGCCATGGC89100 TGACGGGCCT CCTCCTCGAT GGGGCGGAGA CAGCCACGGG GTCTCCCGAG GGTCCCACAG89160 GGCTGTCCTC ATGCAGCCCA AGCCAGCCTG AGCACTGGAG CCCCAATTCC CAACCAGGTC89220 TCCCTCAGAC CCCCCAGAAA GGGCCTCGAA AGGCCGCCGC TGCGCCCTGT GGAAAGGCTG89280 CCGCTGCAGG GCCTGGGCCA GCCGGGCTGC CAGACTCCCC TCCAAAGCCT CCGGATCCCT89340 ACGCTTTTCC AGACATAGAG GAAAGTTTGT CTTCGAGAAA ACAAAGTAAA TAGAAGAACC89400 CCAAAGCAAA GCAAACCCAC CcCCCAGATC AGCAGCATGG GAGCCAACAG GAGGCCACTC89460 CTCCAGCACC AGGOGACCAG CCGTCCCGAC GGCAGCCCGG CTGCGCCTAC GTGATGTCCC89520 TCTGCCGCGG CGGCCGGTGC ACATTCCGCA CGACACACTT CACCATCCAC TCGATGCCCT89580 CGCGCACCCC TTTGCTGTGA AGACACCOOG TGTGACGCGG GGGGTCTCGG TCCCCAAAGC89640 CCCCGCAGGT GCAGCCCCCA CTCACCCTGT GAGGGCCGAG CAGGCCTGGG TCAGGCAATC89700 GCGCCTGCCG ATCTTGCTGG TGCAGTCGCT GAAGGCCGTC TTGATGTCAG GGATTGAGAG89760 GCACGTCTGG GGGAGGTAAG GCCGTGAGGA GCAGCCCCCA CGTCTGGCCC TGTCCTGCCT89820 GTGGGCCCGG GACTCTCAGA AGGGCGTATG CCCTTCACCC CAGGGAAACA GCCAGAGCTC89880 CACCAGGGTC CCAGTGTCTC CCACAGAGAC CACAGCAGTG AGGACCCTGT GCTCAGCCCG89940 AGGCTGAACA TGGCTGGTAG TGCCTGAGAC AAACTAGACG TCCACACGGC TCCAAGGAGT90000 CCACCCCCCA TCCCCTCCCT GGGGGACACC CTGAGCCCCG AGGTGGGGCG CTGAGGACTG90060 AGGCCTCCTG GGCAGTGGCG GAGGCAGGTC CCAGGGGCCC ACACAGCCGG GGATGATGGA90120 GAGGTGGGAG CCCTGCATCA GTGATGGGGG CAGTCTGCAG TCATGGTGGC TTCTGCTCAC90180 AACCACCTGC CCAGTCTTCA AAAAGCAGCC CTCCCCTCCC CTTTTCCTCC GAGGGGAGAC90240 CCCTGCCCCG TACCAGATGT CCCTCTTGTC GGCTGAGATT GTAGGGGAGG CCAGCCTTAC90300 AGGCTGGGGG CAACAGAGCC ACCCCAGAGA AGGCACGAAG TGAAGATTCA CCCGGCCCTC90360 TGGACGCCCG GCTGCTTCTC TGCAAAGCCA CTCCAAGAGA ACAGCTACAA CTCAGCCTGG90420 CCAGTCCTCC CGGGGGCAGT CGCACCTCAG AGGGGTCTTG AGGGGCTGCC CTGGGGGTGG90480 GGCTGGCACA CATGCCACCT CCAAGGCTAG CAGGAACAGG TAAGGCTCAG AGCTCACTCC90540 CACCAGGGCC CCAGCATCAC TTCTTTCACC TCTGAGTTTC ACCTGGCTCT CCCCACAGCT90600 TGGCCACACA CTCCTGAGAC ACGCCCGCCC TCCTGGGGAG AGGTCCCCTG CATACCAGGA90660 AGAGGCCTCT GGGCGCCTGC CCTGAGGTGG GAGAACCTCC AGGGCTGGCA GCAGCAGGTC90720 TGGAGAGGAA CCAAGCTTGG GAAGCTGCTG GGGGCAGGGC AGGCCTTGAG AATGGCTCTG90780 TACCCCCTGG GCAGTCACTG GGCCTGGGGT GTCTGGGTGC ACACCTACTC CCCTTGCTGT90840 GGGGGAGGCT GGGGACTCGG GAAGCTGCTG CGGGAGGCAG GGGTGCGGCT CACCTCCACA90900 TCCTGCTTGT TGGCCAGCAC CAACACCGCG ACACCOCACA GCCCCTCCCT GGTCACCACC90960 TTCTCTGGGG AGCGCAGGAG AGGCAGCGCC TCACACCCAG CATCCTGCCT CTGACTGCCC91020 ACGGGCCCAC AGGCGTGGAC ACTGTGACAG CCACTCCCTC TGCCCCCCCC CCGTCACCCA91080 CTAGGCAGGA GCACTTCTGA CCAGACACTG AGCCTGCCCC AGGCACAGAG CTGCCCAAGC91140 TGGACCTGCC CCCACTCACC ATCCATCCCT CCCAGACCAG CCAGGCCGCA CTCACCAAAC91200 GCCTGCTTGG ACTCAGCCAG CCTCTCCTCG TCGGTGGAGT CAATGACGTA GATGACGCCG91260 TCACACTCCG CATAATACTG GGAGGAAGCA CCACGAGTTG GGGCTCAGTC CCCACCCTGC91320 CAACGGCCAG CAGAGCCAGG CCTGTGTCAT GGCCACAGTG AGGGGCTCAC ATGAGGAACG91380 GGCAAGAGGG CAGCCCCCAA CTGCAAGACC CTTCTGGGAT GCATTCTGGG GTTGCGCGGA91440 GATCTGGTGG AGGTGTCCCC AGACGCTCCT CCTGAGAACC TGCCGGCAAC CTTTCGCCTG91500 ATGGTGGCCA AAGGTGAAAG ACAGGGATTG GGCCAGGCGT GGTGGCTCAC ACTTATTATC91560 CCAACACTTT GGGAGGCAGA ACCAGGAGGA TCACCTGAGC CCACTTCACG GCCAACCTGG91620 GCAACACAGT GAGACTCCOT CTGTACAAAA GCTThTGGTA ATGTGCGCCT GCAGTCCTAG91680 CTACTCGGGA GGCTGAGGTG GGAGGATGGC TTGAGCCTGG GAGGTTGAGG CTGTAGTGAG91740 CTCTGATCAC ACCACTGCAC TCCAGCCTGC GTGAGAATGA GAGACCCTGT CTCAAAAAAA91800 AGATAGGGTT TGGGGGCTGG AGGAACCTAG ACCACAGCCT GGCCCGTTGA GGGAGTGCAC91860 CTGTGGGGCT CTGTGCCAGC ACCTCGCACA GGGAGGGAGT GTGGCCATGC GGATAAGACT91920 GACCAGCACC ATCTACGAAG CGAGCCTTCC CTGCCAGGAC AGGGCCAGAG TCACTGAGCT91980 CAGACCTCTG CAGCCTGGGC TGGTCAGTCC TGGGCTCGCT CGCAACACTC CTGGGCAAGA92040 CAGGGCACAG CCCCTGCAGC CTCAGGTACA AGTGCTGAGC CCTGGACCAG ATGAGTGCAC92100 CTCTATCTCA ATCAGAAAAA AACACAGCAA ACTCCGCGTC CACGTGGAGC AGACAACAGC92160 TCACATTTGC CACTTTGCCT CCAGGCTGTG CCAGCTCTCC TGTCCAGGCA TGAGTGCCCA92220 GAGACCTAGA ACTGGATGCT GACCAGGTAG GACAAGCTGG TGGTCAGTGT GTTAAGACAC92280 ACACACCCGA GAGCATGAGA AGCCAGGAGG CACAGCCCAA CTCTCCGAAA TCCTTAGGGT92340 GTCTGAGCAG GGAGTACCAG ACAACCCCAT CCCAGTGCCA GACAAGCTTG TGCACCTGCA92400 CTTCCCACAG AGGAGAGAAG CCTGTGCACC TGCACTTCCC ACAGTGGAAA GGAGGAGGCC92460 CAAGCCCAGG CCCCCCCACC CCCAGGAACT TCCCACAGTG GAGAGGAGGC CCAAGGCCAG92520 CCGCCCTCCA GGCTTCTGCA GGTAGCGAGG CCCCCCCACC CCCAGGAACT TCTCTGGCCT92580 ACAGACAGGT CCCACACAGA GGCCGCCAAC CCCTCAAGGG ACCCTGCAGT GPGCCGGCTG92640 TCTGCTGCTG ACACAAGGGA GCAGGCGGAC CCTAAGGTGG AGACCTCTGT GCCACGAGGG92700 GCGGCTCTGT CGAGCCTGCA CCAACCCCAG TGAGACAATC TCCACCTGGC TCCTGGGGCT92760 TCTGAGCAGG GTGGCAGAAG GTTCATGTCC AACCGCGTCC TCGACCATGG GACCACGTGG92820 CCAGACCCAC CCATCACACC TACCAGGCAC AAGGTGCACA GCCCAGCAGG GCCGCAGTGG92880 ACGGGAGCGA CACCTCAGGG CTCAGTGCCG CCAGGACCCA GAGCCCCACG CCCCAGTGGA92940 GGCGTCACAG CAGTGGTCAT TGTGGGGTCC CCCACAAGCA GGGGGAAGAG CCAGGTGTCC93000 CAGCGTGCCT CCTtGCTGCC CACCTGACCC CAGTGGAGCA GTCAGAGCCA CTGTGGGTCT93060 CAGTTTTTCT CCCCAGCACC AATGGGAGCT CCCCAACTGC AAAGTGCCAG CCAGCCTGAG93120 AGACTACTGT TACAGCAAAG AACCCAGGAG CTGAGGTCCT GGCACATCCC ACACATGTGG93180 ACACCAACCC AGGGTCCAGC CCCAGGACGA GGCCAATTCG CAATGACCCC CCTTTCTGTG93240 GTGCTGGCTC TGCACAAGGA TGCAGGATAC AGGAACCAGG GTGCCAGCAC GGGCCTCCCT93300 TCCGGTCCCT CCCACTGACC TAGCCGGGTC CCTCCAGCTG ATCCTCCCAG CTCTGAGCTC93360 AGCAGCGTCA GGGGTCCCGG CCACTAGAGC AGCACATACT CAGCAGACAC GCTGAATGAC93420 GAGCCACAGC TGCCTCATCG GCATGACTTG CACCTCATGT CTAGGAGACC CTGGTGOGCA93480 GGAGATGGGC CTGCCATCCC ACAGCTGTCC CACAGCTGGG GACCCAGGGA GCCACTCGCC93540 CCACCACCGT CGTGTCTGGA GAAGGGCTCA GACTCCCACG AAGTCGCACC CCAGCAGAAG93600 TGGTAGTGAA TTCGCAGCGC ACTCAAGGAA GGGCTCTGCA CCCCCAAGAC CAGCAGCAAC93660 GATGGGCTAC AGTGGCCCCC TTAAGTCTCC CTCTTCCACT TTCCCCTTAA GAGAGGCCCT93720 CAGGACCTTG GAGGAACCCC TCTCCAACGT GGAAGTGTGG GTCCACATAG GGCTGCAGCT93780 GTGGCCAGTG CAGGCATCTC TGGCCCCACT CTATTCTTCC TTCATGTTGG ACAACACTGC93840 ACCAGCAGAT GGTCTCATTT TGGTTTCTGT GGGACCCACT TTGGCTGCAA AGACCCACAC93900 TGCCAGCTCA CACCTGCCCA GGGCAGCCCA CACTGGGGAC CCACCAGGCC ATGGTGTGAA93960 GTCCCGGCCA GCCTCGCCCC ACATGGCACA CCATAGCCAG TTCTCCTCCA GGGCTCCCTG94020 CTCGGCCAAC CACAGCTCTC CGGATCCTGC TGCCTGACTC GACCTCTCCT CTCCCGTCCT94080 CCCTGCCTTC CTGGTGCCGA CCCCCAGTGT GCATCCTGTA CCTCGACCTG TCTCAGCATC94140 TCTGCCTGAG ACACCGGCCT GTGACAAGAT CATCATCATC TGTGTCACTC CCCAAGCATG94200 CTGCGCACTC GACACACAGG CCCTGACTCA ACTTGTCCTC TCTGACTTCA GTGGTCCTAC94260 AGCATCTATC AGAGATCACT TGGCCATGGG AGAAATGTCT TCTTGGCTAG AAGTCACAGC94320 AGGAGGGGAC ACTTTCCGCG CGCCTAGGAA AGGGGAACTA GGATCAAAAA AGAGATCAGG94380 ACCTGGCCAC TCAGCTCTAG AGATGGCATC AGGGCAGCCA AGGCACTGGG GACACCCCAC94440 ACCCACTGTG CCAGCCTAGG GCAGGGAGCC CGAGCAAGCC ACAGGCTCTG CCCTCCTCAG94500 TGCTGGACTC AGTGCCTGGC CCAGGCTGAG AAGGACATAA ACTCCAGCCTTCGCGGTGTG94560 GGGAAGGGGC ACCACACTGG GATCTCAGAA ATGCCCAAAA CCTCTGTCAA AATAGGACAC94620 TGCCGCTGTG AGACCCTGAG GAGTCTTCTG GTGATCATGG AAGAACAAAT CTTAAGCTAG94680 AACTGAAGGA ACCTCATCAG GGCACAGGCA GCCATCCTGC CCTCCCCACA TCTGGTCTTT94740 GCCATTTCTG TGTCCTGTGG TGGTCAGCAG CAAGGTCTCT GAGCCGAAAG GAGGCACTCA94800 CTTTCGAGGA GTGCAGGGTC CCCAGGTCCC CACACTTTGT CTTGTCCTGA CTGAGAAAGA94860 AACAGACTGC CCTGACCTCT CTGACTTGCC CAGCGAGGTT GCCCTTAGGC TCAAACCCAA94920 CCCAGGGTTT GAACATTCCC AGACACTTGT AAGATGTTTA GGTTGTTAAC ATAATCTTCA94980 GGTTTCAAAA CATTCAAAGA AACTAGCCCC AGCCCTGAAC CCAGATCCCC CCCCGCTTCA95040 CGCATGACCA GTGAACACGC CCTTCTCTCA CTGGTCACCT GAGCATGCCG CACTCTGTCA95100 ACAGGTTCCC CTAATACATG CTCTCATCTG ATCGCCTTGG CATTTAGTGA TTCTTTCCCT95160 GGAATTCTCC ACTGGCCCCA TCGCAGGGAA CTCCCAAGTG GGAAACTCCC CTACCACCAC95220 TTTTGGGGCA ACTTCAGCTA AGGGTTCAGC TGGGACAAAA CAGGGAGCCA CTCGGGAACC95280 TGGGACAGGA CCAGAGAGAA AACCCGAGGG ACAGAGTGGG TAAGGAAAGC TGCTGAGGAA95340 GCGCCCAAAG GGCACTCTGG AAAGAAGTGG CACTGGAGGG CTGGGGTGGG GGTGGTCCTG95400 GCCAGGGAGT CTTACCTTGT CCCACAAAGA CTGCAGCTCT TCCTGCCCTC CTAAGTCCCA95460 GAACATGAGC CGAGCCTTTC CGACATCCAC AGTGCCGACT GGGGAGAGGA GGAAACAGGC95520 AAGGCTCATG ACCTTGGTCC TCGACACACC CAGTCCCAGC TCTCCCAGGG GATGGGGCAA95580 ACCATGCTGG TGCCACTCAA ATGAGACTTG ACAGGGGCCC GACAGGGCTG TGGCCACGGG95640 CCAGCTGGAC TGTGAATATC ACGGCATCCT CAAGGCCCCA AACCCACAGC CTGCTATTGA95700 GACCCTTACT GTTTAGGCCC ACGGTGGTGG TGATTTTGGA TAGACTCATC CCCTTGTAGT95760 TCTTGTTAAA TCGGGTTTTC GACTGCTCCA GGAAGGTCTG ACGAGAGAGG CAGAGGCGAA95820 ACACATCAAG GAGGGGCTAT ACTGGCTTCC AAATATCCTT ACTCAGGTCT GTTCTTTAAA95880 AGACAGAAAC AGAAACAGAG CAACACTCTG CTCTTCAGGA GGCTGGTGGT GACTATCCTG95940 CCGTCTCAGG TGAAATTTGG CTTCCGTCTG CGTAGTGAAC GTGCAGCTGA CAGCACAAAA96000 CCGAAGGGGG CGCCGCCAGG CCGTGGGAAA GGTGCGCGCA AGGGCGTGGG CACTCACCGT96060 CTTCCCAGCA TTGTCCAGGC CCAGGATCAG GATGCAGTAC TCGTCCTTCT GAAACATGTA96120 CTTGTACAAG CCCGACAGCA GCGTGTACAT CCTGCCCTGG GCACCCCAAC ATAGGTCAGT96180 GTGCAGCCAG AAAGCACCTC CCCTCCCCCG GGCTTCTCCA CGGTGGTCAG TGGCGCCCCA96240 CGTCCAGCCG ACCGCTCAGG ACGAGAGCCT GGGGGCCATT CCCGACTCCT CGTCCCTCTC96300 CCACCCCGTC CCTCTGTAAC TTCTCCCAGG TCAGCCGCCA CTGTGTCCTG CTCACAGCAA96360 TGACTGCGAC CTCTCCGCAT ACACATCGGT TCCGGCCCCT CCCCTGCTCG CGGGACTACC96420 CAGCCGGGTG TTCACAGTGA GCTCAGCCGC GCTCCCGCCC TCCCCCGAGG CTTCGCTCCC96480 ACGCTTCACG CGCGCGGAAC CGGCAACACA CTCGCTGCAG CCCCGCCTGC GCCACGGCAC96540 CCTCGAGCGC CAGCCCCGCG CCCCACCCGG GAGCACCGAG CCACCGGCGC GCTCCCCAGC96600 AGCCCCTGCA GGCGCCGCGT AGGGACGCCC CATCACCCCA TTTCTTAAAA CGGGGACGGC96660 CCTGGGGGGA CCGGACTACA GGGCGGGTGA GCAGCGCCCC GGCTGCTCCT GGAGTGCACC96720 TGGAGGCGCC GCCCGGCTGG CAGGGAACGA CTGCGAACCA AGAACCTCGG TCGCGGCCCC96780 CGGCTACGTC CGCCCCAAGC CGCCGCCGCC AGCTCTGAGC CTCCCCGACA AGCAGCCAAA96840 GCTGGCTCCT CTCACACCCG CGTCCCACCT CGAGTCCTGG GCCGCCCCTC GGGCCTCGCG96900 CCTCACCCCA CAGCCTGCGC CCTACCTGCG TCCGCCGCCC CCTCGGAGCC GCTGCTGCTG96960 ACCCCCGCTG ACCTCCGCTG ACCCCGCGCT AACCCCGCGC GGCGCCTGAC GGGACGCCGG97020 CCGGCCTCAG GGAATGAGCT GAACCGCGTC CCAGCGGCCT CCGCGCTCCG CTTCCCGGCT97080 GCCCCCGCCC GCCAAGCACT TCCGGAAGCG GCGGCGCTCG GGAGGAAGTG CCGATCGGCT97140 GCTGGGGCGA AAAGGGGGCG CCGGGCCGCT CTACCCGGTG AGGCCGGCGG GCTCTCTGTG97200 GCTGCGGCTG GGAAACCGCG CGGAGGAGGT GCCCGGCCGG CGACCAGGTG GCCGCGGTTT97260 GCCGGGACGC GCCCCTGGCC AGACAGAAGA GACGCCGGGC GGGGGGGCGC GGCCCGCCTG97320 GAAGGGGCGG GGCGCGGCGG GTGGGCTCGG CGGAGGCTGA GCCGGCGGGG CGCCCCGCGG97380 CGAACGGGCT CCGCACTGAC GCGGGACCCC GCTACCGGCG AGCCCACGCC GGCTCGGAAG97440 GGAAGCGCGG ACCCTGAGCG GGGGTACCCG GGCTGCGACC TCTGCCCTCG GAGCTGTGCC97500 TCTGAGCCCG TGTCTCCCCG AGGGAAAGGG GACGTGCCCG TGCCCGTGCC CGCCCTCAGC97560 CTGTGGCGTC GGTCCCGAGA CGCGGOGCTC AGCTGGCTTC TCTTCTTGCA GCCCTGGTCC97620 AGCCCCTCCC TCTCTCAGCA TGGACCAGGA GAGCCTGCAG TCGGCCTTGC AGACCTACCG97680 TGCGCAGCTG CAGCAGGTGG AGCTGGCCTT GGGCGCCGGC CTGGATTCGT CTGAGCAGGC97740 TGACCTGCGC CAGCTGCAGG GGGACCTGAA CGAGCTCATC GAGCTCACCG AGGCCAGCCT97800 GGTGTCTGTC AGGAAGAGCA GGTTGTTGGC CGCGCTGGAC GAAGAGCGCC CGGGCCGCCA97860 GGAAGATGCT GAGTACCAGG CTTTCCGGGA CGCCATCACT GAGGCGGTGG AGGCACCAGC97920 AGCGGCCCGT GGGTCCCGAT CAGAGACCCT TCCTAAAGCA GAGGCGGGGC CAGAATCTGC97980 GGCAGGTGGG CACGAGGAGG AAGAGGGAGA GGACGAGGAA GAGCTGAGTG GGACAAAGGT98040 CAGCGCGCCC TACTACAGCT CCTGGGGCAC TCTGGAGTAT CACAACGCCA TGGTGGTGGG98100 AACGGAAGAG GCGGAGGATG GCTCGGCGGG TGTCCGTGTG CTTTACCTGT ACCCCACTCA98160 CAAGTCTCTG AAGCCGTGCC CGTTCTTCCT GGAGGGAAAG TGCCCCTTTA ACCAGAACTG98220 CAGGTAAAGC CCTTTGTTGT CAGATGCCAA CCTTAGGGGC GTAAGGGGCA CGCACACACG98280 GTCGGGTCAG GATCGCCCCT CCCTTTGCTT TGCAGTTTTG TCTCAGCTTC CTGGGGCAGG98340 CGTGCTTTCA CAGCTGTGTC TGTGTTCAGG CGTCTACGTC TTCCTTCTGG GGTGAATCAA98400 GAAGCATGGA AGGACGCCAG GCGCGGTGGC TCACGCCTGT AATCCCAGCA CTTTAGGAAG98460 CCGAGGCGGG CACATCACCT GAGGTCAGGA GTTCAAGACC ACGCTGGTCA ACATGGTGAA98520 ACCCCATCTC CTTAAAAACA CAAAAATGAA CCGGTCGTGG TGGCGCGCAC CTGTGGTCCT98580 GGCTACTCAG GAGGCTGAGG CACGACAATT GGTTGAACCC AGGAGGCCGA GTTTGCAGTG98640 AGTGCACATG CAGCCACTGT ACTGCACCCC GGTGCAGCAGT GCAAGGCTTA TGTGGAAGAG98700 AGTAGGTCTC CAGCCTATCG TCAGTTTTTT TTTGGTGGTT GTTTPAATTT TTTTTGAGAC98760 AGGGTCTTAC TTTGTCAACC AGGCTGGAGT GCAGTGGCAT AGTCCTGGCT CACTGCAGCC98820 TGGACCTCCT GGGCTCAACC GATCCTCCTG CCTcAGCCCC CCTACGAGCT CGGCTACAGA98880 CTCACGCTAC TACACCCACC TAATTTTTAT ATTACTATAA TTTTTTATCT TTTTTTTGAG98940 ACGGAGTCTT GTTCTGTTGC CCAGGCTCGA GTGCACTGGC GTGATCTCGG CTCACTGCAA99000 CCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCACCC TCCCGAGTAG CTGGGACTAC99060 AGGCGCCCGC CACCATGTCT GGCTAATTTT CTGTATTTTT AGTACAGACG GGGTTTCACC99120 ATGTTAGCCA GGATGGTCTC AATCTCCTGA CCTCCTCATC CGCCCACCTT GGCCTCCCAA99180 AGTCCTGGCA TGACAAGCCT CACCCACCGC CCCTGGCCTT TTTTTTTTGG AGACACAGTT99240 TCACTCTCCT CACCCAGGCT GGAOTGTAGT CGCGCAATCT CAGCTTACCG CAACCTCTGT99300 CTCCCGCGTT GAAGTAATTC TCTACCTCAG CGTCCAGAGT AGCTGGCATT ACAGGCGCCC99360 GCCACCACAC TCGGCTAATT TTTTCTATTT TTAGTAGAGT CGGAGATTCA CCATCTTGGC99420 CAGGCTCGTC TTGAACTCCT GACCTCGTGA TCCACCCACC TTCGCCTCCC AAACTGCTGG99480 GATCACAGCC GTGAGCCACT GCGCCTGCCC CTGTTGTTAG TTTTATTCTC TAGAGTTCAA99540 CTTTTAAATT TTACTTTCAT GGAGATTTTC AAACATACCC CAAATTAGAG AGTTTAGCAT99600 AATCACCGCC CACGGTCCAT CATCCAATGT CCTCATTTAT TAATATTTTC CCAGTCTCAT99660 TTTGTCTGTT CTCCCTGCCC TATTTTTTTC TTTCCTGGGC CATTTTAAAC CAAATTCCAG99720 AAGTTACTGC TTTTTTCCAA TTATGAATAC TTCATAGTTG CATCTCTAAT CTAACTGATT99780 AGGAAATTAC TTAAAAACTA ACTTTTTGCA AGTCCAAGTC CGATGTGAGG ACAAAAAAGA99840 GTAACTTCTG TGTCATAATA GGTAACACAT TTAATGGTAA TACCTCTTCC ATATTCAAAT99900 ATGAACAATT ATTACTGTAA TGTCTCTATT TCCCTAAGCG CATAGCTTTA TTTTTCCTCC99960 TTTTTACTTT TCTCTTAGAA GAAATATTTA CCAAGCCTTC TAGTAGGTAA TTTTCTTTTT100020 TAGCCAATAC TTCAGGCTGA CCGTGTAACC ATCCCTAGTT CTAGTTCTAC TTCTTTGAAT100080 GTCTTCCTTT TTTTTTTTTT TTGAAACAGC GTCTTCCTGC TCTGTCACCC ACGCTGGAG100140 GCAGTGGCAC AATCTCGGCT CACTGCAATC TCCGCCTCCC TGGCCCAACC CArCCTCCCA100200 CCTCAGCCTC CCTAATAGCT CATACTACAA GTCTGCACTG CCACGCCCAG CTAATTTTTC100260 TATTTTTTGT AGAGACGGCA TTTCACCATA TTACCCAGCT CTCGAATTCC TGATCCCTTT100320 GATOAGAGAT CTGACACATC CCTGTGGTGC TCCCTCTGGA CCAGGCACTG CTCCAAGGGT100380 TTCATATACT TTCATTCATC TGTGCAACAG CCCTGTAGGT AGGCCCTGCA GTCACAGCAT100440 CTGACAGAGG AGGAAACAGG AGTAGAAGAA GTGAGTGGTC CAGGGCTTCA AGGCTCAGAG100500 GGCTCCAGTT GCCCCCAGCC CTCGTTCCGT CCCCTGCTCC ACCCAGTGCT GCTTGCCATG100560 TCGGCATCAG GCCTGATCTG AAAGCTTCCC GAGCATCTTA CAGACGTCCA CCTTGCCACC100620 ATTCAGGACT GATAAGTTCT CTTGGATTTG CGTTGGACCT TTTTTTTTTT TTTAAGATGG100680 AGTTTCACTG TTGTTGCCCA GGCTACAGTA CAATGGCACG ACCTCCACCT CCTGGGTTCA100740 AGCGATTCTC CTGCCTCAGC CTCCCAAGTA GCTGGGATTA CAGGCGCCTG TCACCACGTG100800 GTGCCCAGCT AATTTTTATA TTTTTAGTAG AGGCAGGGTT TCACCGTGTT GGCCAGGCTG100860 GTCTCGAACC CTTGACCTCA GGTGATCCCG CCTTGGTTTC CCAAAGTGCT OGGATTACAG100920 GCATGACCCA CCACACCCGG CCCAGGATTT CTTTATATAT TCTGGATATC ATCCCTTATG100980 AAGTATATAG TTTGCAGATA TTTGCTCCCA TTGTTTGGGT TGTCTTTTCA CTTGATATAG101040 TGTCCTTTGA TGCACAAACA TTTTAAATTT TGATGCAGTG CAATTTATTG TTTCTTTATT101100 GCCTATGTTT TTGTCATCAG GTTTAAGAAA CCACCTCATC CATAGTTATG AGGATTTTCA101160 CCTATGTTTT CTTCTAAGAG TTCTGTAGTT TTAGCTGTTA AATTTAGGTC TTTGATCCAT101220 TTTGAGTTAA TTTTTGTATA TGTTATTAGG TGAGGCTCCA CTTTATTCTT TTGCATGTGG101280 ATTTCCAGTT TTCCCAGCAC CATTTGTTPA AAAGACTGCT TTTTCTCCAC TGAATGGTCT101340 TGGCACTTTT GTCCAAAATC AATTGGCAAT ATATGTAAGG GTTTATTTCT GAGCTCTCTC101400 TCCTGTTCCA TTGGTGTATA TGTGCCAGTA CCACACTGTT CTGATTATTA TAGCTTTGTG101460 ATAAGTTTTA AACTCAGGAA GTGGTAGTTA TTCACCATTT GCTCCTCTTT TTCAAGTTTG101520 TTTTGTTTCT GGATCCTTTG CAATTTCATA TGAATTTTAG GATCGGCTTG TCCAATTCTC101580 CATAAAAGAC AGTTTGAATT TTGATATGGA TTGCATAGAA TGTGTACATC TGTTTGGGGC101640 ACATTGTCAT CTTTACAATA TTAAGCCTTC TGGCTGGGTC TGGTGGCTGA CGCCTGTAAT101700 CCCAGTACTT TGGGAGGCTG ACGCGGGCAT ATCACTTGAG GTCAGGAGTT CAAGACCAGC101760 CTGGCCAACG TGGTCAAACC CCGTCTCTAC TAAAAATAAA AAACAAATTA GTCGGAGGTG101820 GTGCACACCT GTAATCCCAG CTACAGGAGA GGGTGAGGCA GGAGAATCGC TTCAACCTGG101880 GAGGAGGAGG TTGCAGTGAG CTGAGATCAT GCCACTGCAC TCCAGCCTGG GTAACAGAGG101940 GAGACTCCAT CTTAAACAAC AACAATAACA GAAGAAAAAA ACAGTATTAA GTCTTCCAAT102000 TCATGAATGA AGGATCTGTC CATTTATTTA CGTCTTTAAT TTCTTTCAAC AGTATTTTGT102060 ACTGTTCAAG TCTTGCACAT TCTTGGTTAA ATAAGTATTA TTTTTGATGC TTCTCTAAGG102120 AATTGTTTTT CTTTTCCTTT TTTTTTTTGA GACAGAGTCT TGCTCTGTCA CCCAGGCTGG102180 AGTGCAGTGG CACAATCTTG GCTCACTGCA ACCTCTGCCT CCCGGGTTCA AGCAATTCTT102240 CTGCTCAGCC TCCCAAGTAG CTGGGATCAC AGGTGCCTGC CACCACACCC AGCTAATTTT102300 TTTTTTTGAG ATGGAGTCTT GCTCTGTTGC CCAGGCTCGA GTGAACTGGC CCAATCTTGG102360 CTCACTGCAA GCTCCACCTC CCGGGTTCAC ACCATTCTTC CGCCTCAGCC TCCTGAGTCG102420 CTGGGAATAC AGGTGCCTGC CACCACGCCC AGCTAATTTT TTGTATTTTT AGTAGAGATG102480 GGGTTTCACC ATGTAGCCAG GATGGTCTCG AACTCTTGAC CTCAGGTGAT CTGCCTGCCT102540 CGGCCTCCCA AAGTGCTGGG ATTACAGATG TGAGCCACTG TGCCCGGCTC GAGTTGTTTT102600 CCTTAGTTAC ATTTTCACCC TGTTTGTTCC TACTATATAG AAATACAAGC TGGGCACCGT102660 CGCTCACGCC TGTAATCCCA GCACTTTGGG AGGCCAACGC GGGTGGATCA CCTGTGGTCA102720 GGAGTTCGAG ACCAGCCTCC CCAACATGCT CAAATCCACC CTCTATTAAA AATACAAAAA102780 TTAGTCTGGC ATGGTGGCAC GTGCCTGTAA TCCCATCTAC TCAGCAGGCT GAGGCAAGAG102840 AATTGCTTGA ACCTCCCAGC CGGAGGTTGC ACTCAGCTGA GATCGCGCCA TTGCACTCCA102900 GCTTGGGGAA CAAGAGTGAG ACTTCATCTC AAAAAAAAAA AAAAAGAAAT ACAGTGGATT102960 TTTTTATCTT AATCCTGTAT TGATTGCTGA ATTGGTTTAT TACTCCTAAT AGGATTTTTT103020 ATGCACTATT TAGGATTTTC GATATATACA ATCATATATA TTCAATATAT ACAATTAATA103080 TATATGTGAA TAGAGATAAT TGTAGTCTTT GTTTCTAGTT TGCATCGCAT TTATTTCTTT103140 TTCTTGCTTA ACTGCCTTAG CTAGAACTTC AAGTACGATG TTGAATAAAA GTGACTAGAG103200 CGGGCCGCCG GTCGTGGCTC ACACCTGTGT TCCCAGCACT TTGGCAGGTG GAAGTGGGCA103260 GATCACTTGA GATCAGCAGT TTGAGACCAG CCTGGCCAAC ACGGCGAAAC CCCATCTCTA103320 CTAAAAATAC AAAAATTAGC TGGGTCAGGT GATGTCCACC TGTAGTCCCA GCTACTTGAG103380 AGGGTGAGAC ATGAGAATTG CTTCAACCTG GGGGCCGGAG GTTGCAGTGA CCCAAGATCA103440 TGCCACTCCA CTCCAGCCTG CACCACAGAG CAAGAACCCT GTCTTTAAAA AAAAAAAAAA103500 AAAACTGGCT AGAACAAACA TCTTTATCTT GTTCCTGATC TTAGGTGGAA AACTTTTTTG103560 TTCCTGATAT TAGGTGGAAA ACTTTTAGTC TTTCACTGTT GAATATGATG TTACTTGTAG103620 GTTTTCTGTA GATTCCCTTT ATCGAGTTGA GGAAATTCTC TTATATTCAT AGTGTGTTGA103680 GTGTTTTTTA TCATGAAAGG CTCTTGATTT TTTTTTTAAA GATAGGGTCT TGTTCTGTCA103740 CCCAGGCTGG ACGGCAGTGG CATGATCATG GCTCACTGCA ACCTCGAATT CCTCGGCTCA103800 GGGGATCCTC CTACTTCATC CTCCTGAGTA CCTCAGACTA CAGCCATGAG CCACCATGCC103860 CAGCTAATTT TTTAATTTTT CTGTAGAGGT AGGGTCCTGC TTTCCTGCCC AGGCTGGTCT103920 TAAACTCCAG GGCTCAAGCA ATCCTGCCTC AGCCTCCCAA AGTGCTGACA TTACACGCCT103980 GAGTCACTGC ACTCCACCCA GCTGTGTGGG ATTTTTCAAA TGCTTTTTTC CTTTACATGA104040 TCATGTGTCG TTTTTTTCCT TTCATTTTCT TAATCTGGTA TATTGATTTT CGTATGTTCA104100 ACCATCCTTG AATTCCTCAG ATAAAGCACG CATATTCATG GCGTATTATC TCTTTATTAT104160 TATTTTTTTT GTAGAGATGA GATTTCACTC TGTTGCCCAA GCTGGTCTCA AACTCCTGGG104220 CTAAAGTGAT CCTCCTGCCT CAGCCTCCGA AAGCGCTGGG ATTATAGGCA TGAGCCACTT104280 GGCCCTATCT TTTTTCTTTT TCTTTTTTTT TTTTTTTTCA GACAGACTCT CACTCTGTCG104340 CCGGGCTGGA GTGAGTGGCG CGATCTCGGC TCACTGCAAC CTCCATCTCC CGGGTTCAAG104400 CAATTCTCCT CCCTCAGCCT CCTGAGTAGC TGGGACTACA GGTGCCCGCC ACTATGCCCA104460 GCTAATTTTT TGTGTTTTTA GTTGAGACGG TGTTTTGCCA TGTTGGACAG GCTGGTCTTG104520 CACTCCTGAC CTCGTGATTC ACCCACCTTG GCCTCCCGAA GTGCTGGGAT TACAGGCATG104580 AGCCACCGCA GCGAGCCTTA TCTTTTTAAC AGTTAAAAGT TTAAGGCCTT ATCATGTAAT104640 AACATTGCTG GATTTCATTT GCTGCTGTTT TGTTGAGAAT ATTTCCATAA GTATTGATAA104700 GGCATATTGG TCTGTAGTTT TCTTTTCTTC GCATGTCTTT GTATACCTTT CATGCCAGCA104760 TAATATTGGC CTCATAGAAT GAGTTAGGAA GTATTCTTTA TATTATGGGA AGAGGTAAAA104820 AGGGATTGGT GTTAATTCTT CTTCAAATCT TTGATAGAAT TCAACAGTGA AGTCATATA104880 ACAATCATAT ATATAGAGAG AGAGAGAGAG AGAGATGGAC TTTTCTTTTC TTGGAAGTTT104940 ATTGACTATT GATTCAATTT CCTTATTGAA ATTGACTTTT CTTTTTGGAA GCTAAAATGT105000 ATAACTGTAG TGAAAGTTTC TGAACTTTTC TTTCATTGGA AGTTTTTTGA CTACTGATTC105060 TTTATTTGTT ATAGGTCTAT TCAGATTTTC TGTTTCTTCT TGAGTCAGTT TGGTCTCGCT105120 CTGTCCCCCA GGCTGGAGTG CAGTGGTGCC ATCTTGGCTC ACTGCAACTT CTACCTCCCG105180 AGTTCAAGTG ATTCTCCCAC CTCAGCCTCC CCAGTATCTC GGACTACAGG CGCACGCCAG105240 CATACCTGGC TAATTTTTGT ATTTTTAGTA GGAACACCAT TTCACCATGT TGGCCAGGCT105300 GGTCTCGAAC TCCTGACCTC AGGTGATCCA CCCGCCTCGG CCTCACAAAG TGCTGGGACT105360 ACAGACATAA GCCACCGCGT CCAGCCTTGA GTCAGTTTAG ATAGTTTGCA TGCATGTTTC105420 TAGGAATTTG TCCATTTTGT TTATGTTATC TAATCTGTTA CCATACAATT GTTCATAGTA105480 TCCTTTTATA GCCCTAGTTA TTTCTGTAAG ATCAGTAGTA ATAGCTCCAC TTTCTCTCTT105540 GGTTTTAGCA ATTTGAGTCA TCTCTTTTCT TCTTCTTTTT TTTTTTTTGA CATGGAGTCT105600 CACTGTGTCA CCCAGGCTGG AGTGCAGTGG CATGATCTTG GCTCACTGCA ACCCCTGCCT105660 CCCACGTTCA AGCAATTCTG CCTTAGCCTC CTGAGTAGCT GGGATTACAG GTGTCAGCCA105720 CCACACCCAG CTAGTTTTGT TTTGTFTTTT TGTTTTTGAG ACGGAGTCTG TTTCTGTCTC105780 CCAGGCTGGA GTGCAGTGGT GCAATCTCAC TCATTGCAAC CTGCGACTCC CAGATTCCAG105840 CAATTCTPCCT GCCTCAGCCT CCCGAGTAGC TGGAACTATA GGCGTGCACCACCACGCCTG 105900 GCTGATTTTT ATATTTTTAG TAGAGATGGG ATTTCACCAT GTTGGCCAGGCTGGTCTTGG 105960 ACTCCCTACC TGAGGTGATC CGCCCACCTT GGCCTCCCAA AGTGCTGGGATTATAGGCAT 106020 GAGCCACCAT GCCCAGCCAG TTTTTGTATT TTTAGTAGAG ATGCGGTTTCTCCCTGTCGG 106080 CCAGGCTGGT CTTGAAATCC TGACCTCAGG TTATCCACCA GCCTTGGCCTCCGAAAGTGC 106140 TAGGATTACA GGCATGAGCC ACCACGCATG GCCTGTCTTT TCTTCTTGGTCATTTTCGCT 106200 AAAGGTTTGT CAATTTTGTT GATCTTTTTT CTTGCTGATC TCTATTGTTTTCCCATTCTG 106260 TTTCATTTAT TTCCATTTTA ACCTTTGTTT CCTTTTTTCT GCTGGTTTGGGTTTAATTTG 106320 CTCTTTTTTT CCCCTAATTT TTCAAGGTAT ACAGTTAAGT TATTGATTTGAGATCTCTTT 106380 TTTCTTTTCT TTTTTTTTTT TTTTTTTTTT TTTGGTTGCT GTTGAGATGGAGTCTCCCTC 106440 TGTCACCCAG ACTGGAGTGC AGTGGCATGA TCTCAGCTCA CTGCAGCCTCCGCCGCCCAG 106500 GCGATTCTCC TGCCTCAGCC TCCTGAGTAG ACGTTTCCCG GCCAAGGTGTTTCTTTTTGA 106560 ATGTAAGCAT TTACAGCTAC AGATTTCCCT CTAAACACTG CTTTCACTGCATTCCATAAG 106620 ATTGTTTTTT GTTGTTTTTT GTTGTTGTTT TGTTGTTTGA GACACAGTCTCACTCTGTTG 106680 CCGTTTGGAG AGCAGCGATG CGATCATAGC TCTGTAGCCT TGACCTCCTGGACTCAATCA 106740 GTCCTCCTGC CTCAGCCTCC CAAGTAGCTG GGACTACAGG TGTACACCACTGCACCTAAC 106800 TAATTTCTTT TATAAGTTTT TGCAGAGCCC AGGCACAGTG GCTCACACCTGTAATCCCAC 106860 CACTTTGGCA GGCCAAGGTG GGTGGATCAC CTAAGGTCAG GAGTTCGAGACCAGCCTGGC 106920 CGACAGGGAG AAACCCCATC TCTACTAAAA ATACAAAAAT TAGCTGGGCGTGGTGCCAGG 106980 TGCCTGTAAT CCCAGCTACT CAGGAGGCTG AGGCACCAGA ATCGCTTGAACCTGGGACGC 107040 AGAGGTTGCA GTGAGCCAGC ATCACACCAT TGCACTCCAG CCTCGGTAACAAAAGCAAAA 107100 CTCCATCTCA AGAAAAGAAA AAAAAAAGTT TTTGCAGAGA CAGCGTATCACTTTGTTCCC 107160 CAGGCTCGTC TCAAACTCCT GACTTCAAGG AGTCCTACTC CCTCAGCCTCCCAAACTCCT 107220 GAGATTATGG GCAAGAGCCA CCGCACCCTG CCACTTGGCT GTTTTGTTCTGTTGTATTTC 107280 CATTTTCATT GATCTCAAGA CATCCTAATC TCCCTTTTGT TTTTTTGTTCCACTTACTGC 107340 TTATTCAAGA GTGTCTTTAT TTCTGCATAT TTGTAAATTT TCCAAAAAACTTTTTCTTTC 107400 TTTTTTTTTT GAGAAAGGCT CTTGCTCTGT CGCCCAGGCT GGAGAATGGTGGTGCACAAT 107460 CTTGCCTCAC TGCAACCTCT GCCTCCCGGG TTCAAGTCAT CCTCCCACCTCAGCCTTCCC 107520 AGTAGCTGGG ATTACAGGCA CACACCACCA CACCTGCCTA ATTTTTGTATTTTAGTCTTA 107580 ACGTGCTGGT CAGACTCGTC TCGAATTCCT GACCTCAGGT CATCTCCCCGCCTTGCCCTC 107640 CCAAAGCACT CGGATTACAG GCCTCAAACA CCATCCCCAC CCCCCAATTTTTTTTTTTTA 107700 ATAGACACAA GCTCTCACTC AAGCCCAGGC TGGTCTTGAA CTCCTGAGCTCAAGCTGTCA 107760 TCCCTCCTCC GCCTCCCAAG GTGCTGAGAT TACAGGTGTC AGTCACAGTACCTGGCCTTC 107820 TTTCAACACT TTAAAAATGC CATCTTGGCT GGGCACGCTC GCTCACCCCTGTAATCCCAG 107880 CACTTTGGCA GGCCGAGGTG GGCAGATCAC GAGCTCAGGA GATCAAGACCACCCTGGCTA 107940 ACATGGTCAA ACCCTGTCTC TACTAAAAAT ACAAAAAATT AACCAGGTCTGGTGGCACGT 108000 GCCTGTACTC CCACCTACTC CGGAACCTGA AGCAGGACAA TGGCGTGAACCCGGGAGGTG 108060 GAGCTTGCAG TGAGCTCAGA TCACACCACT GTACTCCAGC CTGGGCAACAGTCCGAGACT 108120 CCGTCTCAAA AAAAAAAAAA AAAATGTCAT CTCACTGCCT TCTGGTCCAATACTTTCTGA 108180 TGAGAAATTC GCTGTTAATC TTATTGACCA ACATTTATAT ATTCACTAGTCACTTGTCTC 108240 TTGCTCTTTT AGCACATTCT CTATCTTTGG GTTTCAGCAG TTTGATTATAATGTATCAGT 108300 GTGGATCCCT CAATTTATAA GCTACTTGGA GTTCATTGGA CTTCTTGGATCTGTAAATTC 108360 ATGTCTTTCA TTAAATTTGC AAAOTTTCAG CTACTATTCT TTGCATCTTGAAATACTAGT 108420 TTTGTTTCTT TCTGTCTGTT TGCCGCTTAT GGAACTTTAT GCATACATTGATGTGCTTCA 108480 TGGTGTAGCA CAGGTCCCTT GGGCTCTAGG CATTTTTCTT TGTTCTTTTTTTCTTTCTGC 108540 TCCTCATTTT GCATAAATTC AGCTGACCTG TCCTCAAGTT CACTGTTTCTTTCTTCTTCC 108600 TTCTCAAATC TGCTGTTGAA ACTTCTGGTG AAATTTTCAC TACAGTTACTGTACTTTTTA 108660 CCTCCAAAGT TTCTATTTGG TTTCTTTCTG TAGTAATTAT CACTTTACTAGTATTCTCTA 108720 TTTGGTTACA CATGGTTCTT TTGTTTTCCT TTAGTTCATT ATCCATGGTTTCCTTTATTT 108780 TTAAATTTCT TTTTATTTAG TTATTAATTT TTTTTTTTTT TGAAOCGGGGTTTCACTCTT 108840 GTCACCCACG CTCGCAGGCA ACGTCACAAT CTTCGCTCAC TACAACCTCCGCCTCCTGGG 108900 TTCAAGTGAT TCTCCTGCCT CAGCCTCCCA AGTAGCTGGG ATTATAGCCATGTGCCACCA 108960 CACCCACCTA ATTTTTGGTA TTTTTAGTAG AAACTGGGTT TCACCACATTGGCCAGACTG 109020 GTCTTAAACT ACTAACCTCA GGTGATCTGT CCGCCTCAGC CTCCCAAAATGCTGGGATTA 109080 CAGATCTGAG CCACTGTGCC CAGCCTCTPT TTTTAGTGTA TTTAAGGTAATTGATTGAAA 109140 GTTTTTCTCT AGTCATTCAA ATGTCTAGGC TTCCTCAGGA ACAGTTTCTATTAATTTCTT 109200 TATTTTTAAA AAATTTTTTT TAATTTTCTT TTTTTTTTAG ATGGAGTCTCACTCTATAGC 109260 CTACCCTGGA GTGCAATGCC TTGATCTTGG CTCACTGCAA CCTCTCCCTCCTGGGTTCAA 109320 GCGATTCTCC TGCTTCAGCC TCCTGAGTAG CTGGGACTATAGGTGCGTCAC CACCACCCCT 109380 GGCTAATTTT TTGTATTTTC AGTAGAGACATGGTTTTGCC GTGTTAGCCA GGATGGTCTC 109440 GATCTCGTGA CCTCATCATC CTCCTCCCTCGGCCTCCCAA AGTGCTGGAA TTACAGGTGT 109500 GAGCCACCGC GCCCAGCCTA TTTTTTATTTTTTGAGACAA ACTCTCCCTC TCTCACCCAG 109560 GCTGTACTGC AGTGGCACAA CCCTGGCACACTCCAGCCTT AACCGTCCAG GCTTAAGTGA 109620 GTCTCCCACC TTAGTCTCCT GAGTAGCTAGAACTACAAGC ATGTGCCACC ATGCCTGGCT 109680 GGTTGTGTTG TTACTGTTTT AGACACACOGTCTTGCTACA TTTCTCTGAC TGGTCTTGAA 109740 CTCCTGGGCT CAAGCAGTCA TCCCACCTTGGCCTCCCAAG GTGTTGAGAT TACAGGTGTG 109800 AGCCACCGCA CCCGGCCTGT TAATTTCTTTATTTCCGGTG AATCGGCCAC ACTTTCTTGT 109860 TTCTTTGCAT GCCTTGTAAT TTTTTGTTGAAACCTGCACA ATTTGAAGAT GATAATGTGG 109920 TTACTTTGAA AATCAGATCC TCCGCCCTCTGCAGGGTTCA TTGTTGCTGT TTGTTGTGGA 109980 TTGTCGTTTC TCGTTTGTTT AGTTACTTTCCTGACCTTTT TAAATAAAGA CTATATTCTG 110040 TCAGGGGTGC TTGTTTCTGT TCTTTTAGCTTAGTGGTTAG CTTGTGCTTT GAAAGAGAT 110100 TCTTTAAATA TCTAGTCGCA AAAAGGATAAAGAGGCCGGG CGCAGTGGCT CACGCCTGTA 110160 ATGCTAGGAC TTTGGGAAGT GGAGGCGGGTGGATCACTTG AGGTCAGGAG TTTAAGATCA 110220 GCCTGGCCAG TATGGTGAAA CCCTGTCTCTACTAAAAAWA CAAAAATTAA CCGGGCATGG 110280 TGGCACCTGC CTGTAGTCCC AGCTACTGGGAAGACTGAGG CAGGAGAATC GCTTCAATCC 110340 AGGCGGCGCA GGTTGCAGTG AGCTGAGATTGCGCCATTGC ACTCCAGCCT GGGCAACAGA 110400 GCGAGACTCT GTCTCAAATA AAAAAAAAAAAAAAAGGATA AAGAGTGTCT TCCATCCTTT 110460 CCAGGTTGCC TCTGTACTGG GGCAAGTCCTTCAGTGTCCG CCAGGCTGTT CACCCCTTTT 110520 CCTCAGCCTT TACTTCTCGC TCCCATGGAGCCTAAGGATG AACCAGACGT GAAAGTTGAG 110580 GGCCTCCTCA GGTGTTTCTG AGCCCCTGTCTAGCCCCAGC TGTGTGCATG GCCTTCTGGA 110640 TTTCCAACCA TGAACAGGAG CTTTCCAAAGCCCTTAGACC TTCATGTAGC TCTTTTCCCA 110700 GCCTCTTCCT TCCTAGGCTT TTCTGTCAGCTCTTTGCCCA TCTGTTGTTG TCCCTCCCCC 110760 ACAACTTCAG GTAGTATCTA CCTGTAAATGCCTTCAGGCC ACGCGCGGTG GCTCATACCT 110820 GTTATCCCAG CACTTTGGGA GCCCGAGGCGGGTGAATTCC TTCACGTCAG GAGTTCGAGA 110880 CCAGCCTGGC CAACATGGTG AAGCCCCGTCTCTAGTAPAA ATACAAAAAT TAGCTGGGCG 110940 TGGTGCGTCC CTGTAATCTC AGCTACTCGGGAGGCTGAAG CAGGAGAATT GCTTGAGCCT 111000 GCGAGGCGGA GGTTGCACTC ACCTGAGATCGTGCCATTGC ACTCCACCCT CGGCGACACA 111060 GTGAOACTCC ATCTCGGGCA AAAAAAAAAAAAAAAAATGC CATCAACACC ACGACCCTGG 111120 AGGCTGCCCC ACCCCTCAGA GAGTTCGAGGGCGTGAAACA AAGGCAAGCC CTTCACCGAC 111180 ACACTAGAAA CATCCAAATG CATAAGCAGGATTCCTTGAG AAAAGCTCTG TATCATCCCT 111240 TCTGACACCA GCAAGCCACA TCAGAAATACAGGTTGCCTT CCCCATGGCT ACATGTGAGC 111300 TGGTAGTAGT GGCTGAGCAG AAATAGCCCAGCTCTCCTCC TCAAATTTAG CAGGGTCTTA 111360 CTTCATTGAG CAGTCATCTG GTTCCTAGACACCAGAGTTA CAGAAAAGTT TATTGGGACG 111420 TTTTGACAGT TTAATAGAAA AAAGTTTATTGTGACAGTTT TGACACCTGA ATAGAAAAAA 111480 GTTTACTGTC ACAOTTTTGA CAGCAGAATAGTTGCTTTGC TGCACACACG GATCTTTGGA 111540 CCTGCCAACT CCATCATTTT GGTGATATCCAGCTCTGTTG CTCAATTTTT AGCTATGCTG 111600 TTTTAAGTTA TTTTCTTAGT CGTTGCTCTAGAGATGACAA TGTGCATCTT TAACTTACCA 111660 CAATGTACTT CACATTATTA CTAACTTAACACTTAAAGTA CAGCATTTTT TTTTTTATCG 111720 ACTTTCACTC TGTCACCCAG GCTGGAGTCCAATGGTGTGA TCTCGGCTCA CTCCAACCTC 111780 CGCCTCCCAG CTTCACGCCA TTCTCCTGCCTCAGCCTCCT GAGTAGCTGG GACPACAGGC 111840 ACCCCCACCA CACCCGGCTA ATTTTGTATTTTTAGTAGAG ATGACCTTTC ACCATQTTGG 111900 TCAGCCTGGT CTCGAACTCC TGACCTCACGTGATCCGCCC ATCTTGGCCT CCCAAAGTGC 111960 TCGGATTACA CGTGTGACCC ACTGCACTCAGCCTAACTAT CGCAACCTGT CTATAACATA 112020 GATCTACTTC COTTOTACTA TCACATAGTTCCCCCTCCAT TTTCCTATAG CACAGTCCCA 112080 ACCTCCCTTT TCCTCTGACA TAGTTCCATCCTCCCTCCTC CTATGACGTC CTCCCTTCTC 112140 CTCTGGCATA CCTCCATCCT CCCTTCTCCTATGACACAGC TCCATCCTCC CTTCTCCTCT 112200 GACACAGCTC CATCCTCCCT TCTCCTATGACACACCTCCA TCCTCCCTTC TCCTCTGACA 112260 TACCTCCATC CTCCCTTCTC CTATGTCATAGCTCCATCCT CCCTTCTCCT CTGACACAGC 112320 TCCATCCTCC CTTCTCCTCT GGCATAGCTCCATCCTCCCT TCTCCTATGA CACAGCTCCA 112380 TCCTCCCTTC TCCTATCACA CAGCTCCATCCTCCCTTCTC CTATGACACA GCTCCATCCT 112440 CCCTTCTCCT ATGACACAGC TCCATCCTCCCTTCTCCTCT GGCATAGCTC CATCCTCCCT 112500 TCTCCTCTCA CATAGCTCCA TCCTCCCTTCTCCTCTGACA TAGCTCCATC CTCCCTTCTC 112560 CTCTGACATA GCTCCATCCT CCCTTCTCCTCTGACATAGC TCCATCCTCC CTTCTCCTCT 112620 GACATAGCTC CATCCTCCCT TCTCCTCTGACATAGTTCCA TCCTCCCTTG TCCTCTGACA 112680 TAGCTCCATC CTCCCTTCTC CTCTGACATACCTCCATCCC CTCTTCTCCT TCATGTATTA 112740 TTGCCATATA TACATTTATG TATGTTATAACTTCAGCTCT TCAGCGTTAT AATTATTGCT 112800 TCAAAAGTAT TTTCAAAGAA GTTGCCTGCAGGCAGTGGCT TATGCCTTTA ACTCCAGCAC 112860 TTTTCGGGCC TGACGTGGGC AGATCGCCTGAGCCAGGCAG TTGGAGACCA GCC2TGGGCAA 112920 CATGACGAAA CCCATCTCCACCAAAATTAC AAAAAATTAG TCTGGCATGG TGCCACGCGC 112980 CTCTAGTCCC AGCTATTTGGGGGAGGATCC CAGCTAAGGT GGGAGGATCA CTTGAGCCTG 113040 GGAAGTCAAG GCTGCAGTCAGCTGACATTC TGCCACTGCA CTCCAGCCTG GGTGCAGATC 113100 TTATCTCAGA AGTAAAGGCACTAGGAATGC TGGCTTTTAT CTCTAATCCC ACCACTTTGG 113160 CAGCCTGAGG TCAGTCGATCACCCGAGCTC AGGAGTTTAA GACCACCCTG GCCAACATGC 113220 TCAAACCCCG TCTCTACTAAAAATACAAAA AGTAGCCGGG TCTGGTGGTG GGTGTCTGTA 113280 ATCCCAGCTA CTCGGGAGGCTGAGGCAACA GAATCGCTTG AACCTGGGAA GCGGAGGTTG 113340 CAGTGAGCAA GATCCCACCACTGCATTACA GCCTAGATGA CAGAGCGAGA CTCTGCCTAA 113400 AAAAAAAAAA AAAAAGAAAAGAAAAGAAAT TAAGATCTAG ACACTGTCGT TCATGCCTCT 113460 AATCCCAAAG CCTTCGCAGGCCAAGGCAGG AGGATCACTT GACGCCAGGA GTTCAACACC 113520 AGCCTGCGCA ACATAGCGAGACTCCATCTC TATTTAAAAA AGAAAGAAAT TCAAAGAGAA 113580 AAAAAGTATA CTTGTTTTTTTGTATCATCC ATATTTTACC TTTCTTTTTT TTGCCCCTTT 113640 TTCTTTCCTG TGAATTTGAGTTACTGTCTA GTGTCATTTC CTTTTAGTCT GAAGAACTTC 113700 ATTTAGAATT TTTTTTTTTTTTTCAGACAA AGTCTCACTG TGTTGCCCAG GCTCCACTGC 113760 AATGGTGCAG TCTCAGATCACTGCAACCTC TGCCTCCCTG GTTAGAGTGA TTTTCCTGCC 113820 TCAGCCTCCC AACTACCTGAGACTGCAGGC ACCTGCCACC ACCCCCAGCC AATTTTTTTG 113880 GTATTTTTAG TAGAGACAGGGTTTCACTAT GTTGGCCAGG CTCGTCTCGA ATTCATGACC 113940 TCATGATCTG CCTGTCCTGGCCTCCCAAAA TCCPGGGATT ACCATGACCC ACCACGCCCA 114000 CCCCATTTAC AATTTCTTTTTTTTTPTTTT TTTTGAGATG GGGTCTCGCT CTTGTTTCCC 114060 ACGCTGCAGT GCAGTGGCACGATCTCGGCT CACTGCGACC TCCGCCTCCC GGGTTCACGC 114120 CATTCTCCTG CCTCAGCCTCCCCAGTAGCT GOCATTACAG GCGCCTGCCA CCACGCCCAC 114180 CTAATTTTTT GTATTTTTAGGAGAGATGGG GTTTCACCAT GTTAGCCAGG ATGGTCTTGA 114240 TCTCCTCACC TCGTGATCCGCCCGCCTTGG CCTCCCAAAC TGCTGGGATT ACAGGCGTGA 114300 GCCACCGCGC CCGGCTAGAATTTCTTGTAG GACAGGCTTG CTAGCAACCA ATTCAGTCTT 114360 TATTTGGGAA TGTCTTTATTTCAGCTTCAT TTTTTGAAGG ATAGTTTAGC TGGCTATACA 114420 ATTATTAATT GATCATTCTTTTCAGTGTTT AAAAGTGTCA TCATGCTACC TTCTGGGTTC 114480 CATTGTTTCT GATGAGAAGTCATCTGTCAA ATTGTCCCTT TGTACTTGAA GAATTATCTT 114540 TTTTTCTCTT GATGTTTTCAACATTTTCTC TTTGTCTTTG GCCTTTAGTA GTTTGTGATG 114600 TATCTAGGTG TGGATCTCTTGGTGTGCATC GTATTTGGGC TTCAGTAACC CTCTTAGATT 114660 CATACATTAA TGTTTTGTTTTCTTTTACCA AATTTGGACA CTTTTTACTC ATCATTTCAA 114720 CAAATTTTTT TCCTGCCCCTCTCTCATCTC CTTTTGGGAG TACCACTGCA TCTATGTTCG 114780 TGTGCGTTCT CTA.114793

[0090] The present invention also relates to a portion of SEQ ID NO: 3which comprises 5′ regulatory regions, exons, introns and 3′non-translated regions which comprise the human NHL gene of the presentinvention. Such regulatory sequence may be found within the variousregions of this 115 kb fragment. The 5′ portion of SEQ ID NO: 1 beginsat nucleotide 47095 of SEQ ID NO: 3, the initiating ATG of human NHL isfrom nucleotide 48687-48689 of SEQ ID NO: 3, the termination ‘TAG’ codonis from nucleotide 84855-84857, while the 3′ terminus of SEQ ID NO: 1 asdisclosed herein (GCAGTGCCC) corresponds to nucleotides 85308-85316. Tothis end, one preferred aspect of the invention is an isolated genomicfragment or fragments which comprise from about nucleotide 470000 toabout nucleotide 85500 of SEQ ID NO: 3), which comprises the portion ofthe genomic clone encoding the mRNA transcript responsible for human NHL(see FIG. 5A-B). The genomic sequence encoding NHL contains 35 exons(FIG. 5A). An especially preferred aspect of the invention is a humangenomic fragment or fragments which comprise from about nucleotide 47095to about nucleotide 85316 of SEQ ID NO: 3As noted in regard to SEQ IDNO: 1, the present invention also relates to DNA vectors and recombinanthosts which comprise at least a portion of SEQ ID NO: 3. Portions of the115 kb genomic fragment may be housed in multiple vector/hosts so as tooptimize handling of the DNA sequences within SEQ ID NO: 3. Therefore,the present invention relates to the isolated genomic sequence which setforth as SEQ ID NO: 3, a region of SEQ ID NO: 3 which contains thecoding and non-coding region of human NHL, as well as cis-actingsequences within SEQ ID NO: 3 which effect regulation of transcriptionof one or more of the genes localized within this 115 kb human genomicfragment, including regulatory regions effecting levels of NHL,M68/DcR3, SCLIP and ARP. As noted above, this region of chromosome 20(20q13.3) is associated with tumor growth. Therefore, an aspect of thisinvention also comprises, as one example, the use of one or moreregulatory regions of this 115 kb genomic sequence as a target toantagonize the effect of a transcriptional factor(s) which normallyupregulate expression of a gene which has a caustic role in tumorgrowth. Alternatively, compounds may be selected which interacts with aspecific cis-acting sequence to upregulate a gene within this region,where upregulation results in a decrease in tumor growth.

[0091] The present invention is also directed to methods of screeningfor compounds which modulate the expression of DNA or RNA encoding a NHLprotein Compounds which modulate these activities may be DNA, RNA,peptides, proteins, or non-proteinaceous organic molecules. Compoundsmay modulate by increasing or attenuating the expression of DNA or RNAencoding NHL, or the function of the NHL-based protein. Compounds thatmodulate the expression of DNA or RNA encoding NHL or the biologicalfunction thereof may be detected by a variety of assays. The assay maybe a simple “yes/no” assay to determine whether there is a change inexpression or function. The assay may be made quantitative by comparingthe expression or function of a test sample with the levels ofexpression or function in a standard sample. Kits containing NHL,antibodies to NHL, or modified NHL may be prepared by known methods forsuch uses.

[0092] The DNA molecules, RNA molecules, recombinant protein andantibodies of the present invention may be used to screen and measurelevels of NHL. The recombinant proteins, DNA molecules, RNA moleculesand antibodies lend themselves to the formulation of kits suitable forthe detection and typing of NHL. Such a kit would comprise acompartmentalized carrier suitable to hold in close confinement at leastone container. The carrier would further comprise reagents such asrecombinant NHL or anti-NHL antibodies suitable for detecting NHL. Thecarrier may also contain a means for detection such as labeled antigenor enzyme substrates or the like.

[0093] The assays described above can be carried out with cells thathave been transiently or stably transfected with NHL. The expressionvector may be introduced into host cells via any one of a number oftechniques including but not limited to transformation, transfection,protoplast fusion, and electroporation. Transfection is meant to includeany method known in the art for introducing NHL into the test cells. Forexample, transfection includes calcium phosphate or calcium chloridemediated transfection, lipofection, infection with a retroviralconstruct containing NHL, and electroporation. The expressionvector-containing cells are individually analyzed to determine whetherthey produce NHL protein. Identification of NHL expressing cells may bedone by several means, including but not limited to immunologicalreactivity with anti-NHL antibodies, labeled ligand binding, thepresence of host cell-associated NHL activity.

[0094] The specificity of binding of compounds showing affinity for NHLis shown by measuring the affinity of the compounds for recombinantcells expressing NHL. Expression of human NHL and screening forcompounds that bind to NHL or that inhibit the binding of a known,radiolabeled ligand of NHL provides an effective method for the rapidselection of compounds with high affinity for NHL. Such ligands need notnecessarily be radiolabeled but can also be nonisotopic compounds thatcan be used to displace hound radiolabeled compounds or that can be usedas activators in functional assays. Compounds identified by the abovemethod are likely to be agonists or antagonists of NHL and may bepeptides, proteins, or non-proteinaceous organic molecules.

[0095] Accordingly, the present invention is directed to methods forscreening for compounds which modulate the expression of DNA or RNAencoding a NHL protein as well as compounds which effect the function ofthe NHL protein. Methods for identifying agonists and antagonists ofother receptors are well known in the art and, can be adapted toidentify agonists and antagonists of NHL. For example, Cascieri et al.(1992, Molec. Pharmacol. 41:1096-1099) describe a method for identifyingsubstances that inhibit agonist binding to rat neurokinin receptors andthus are potential agonists or antagonists of neurokinin receptors. Themethod involves transfecting COS cells with expression vectorscontaining rat neurokinin receptors, allowing the transfected cells togrow for a time sufficient to allow the neurokinin receptors to beexpressed, harvesting the transfected cells and resuspending the cellsin assay buffer containing a known radioactively labeled agonist of theneurokinin receptors either in the presence or the absence of thesubstance, and then measuring the binding of the radioactively labeledknown agonist of the neurokinin receptor to the neurokinin receptor. Ifthe amount of binding of the known agonist is less in the presence ofthe substance than in the absence of the substance, then the substanceis a potential agonist or antagonist of the neurokinin receptor. Wherebinding of the substance such as an agonist or antagonist to ismeasured, such binding can be measured by employing a labeled substanceor agonist. The substance or agonist can be labeled in any convenientmanner known to the art, e.g., radioactively, fluorescently,enzymatically.

[0096] Therefore, the present invention-includes assays by whichmodulators of NHL are identified. As noted above, methods foridentifying agonists and antagonists are known in the art and can beadapted to identify compounds which effect in vivo levels of NHL.Accordingly, the present invention includes a method for determiningwhether a substance is a potential modulator of mammalian NHL levelsthat comprises:

[0097] (a) providing test cells by transfecting cells with an expressionvector that directs the expression of NHL in the cells;

[0098] (b) exposing the test cells to the substance;

[0099] (c) measuring the amount of binding of the substance to NHL;

[0100] (d) comparing the amount of binding of the substance to NHL inthe test cells with the amount of binding of the substance to controlcells that have not been transfected with NHL or a portion thereof;wherein if the amount of binding of the substance is greater in the testcells as compared to the control cells, the substance is capable ofbinding to NHL.

[0101] The conditions under which step (b) of the method is practicedarc conditions that are typically used in the art for the study ofprotein-ligand interactions: e.g., physiological pH; salt conditionssuch as those represented by such commonly used buffers as PBS or intissue culture media; a temperature of about 4° C. to about 55° C.

[0102] The assays described above can be carried out with cells thathave been transiently or stably transfected with NHL. Transfection ismeant to include any method known in the art for introducing NHL intothe test cells. For example, transfection includes calcium phosphate orcalcium chloride mediated transfection, lipofection, infection with aretroviral construct containing NHL, and electroporation.

[0103] Where binding of the substance or agonist to NHL is measured,such binding can be measured by employing a labeled substance oragonist. The substance or agonist can be labeled in any convenientmanner known to the art, e.g., radioactively, fluorescently,enzymatically.

[0104] Therefore, the specificity of binding of compounds havingaffinity for NHL shown by measuring the affinity of the compounds forrecombinant cells expressing the cloned receptor or for membranes fromthese cells. Expression of the cloned receptor and screening forcompounds that bind to NHL or that inhibit the binding of a known,radiolabeled ligand of NHL to these cells provides an effective methodfor the rapid selection of compounds with high affinity for NHL. Suchligands need not necessarily be radiolabeled but can also be nonisotopiccompounds that can be used to displace bound radiolabeled compounds orthat can be used as activators in functional assays. It is also possibleto construct assays wherein compounds are tested for an ability tomodulate helicase activity in an in vitro- or in vivo- based assay.Compounds identified by the above method again are likely to be agonistsor antagonists of NHL and may be peptides, proteins, ornon-proteinaceous organic molecules. As noted elsewhere in thisspecification, compounds may modulate by increasing or attenuating theexpression of DNA or RNA encoding NHL, or by acting as an agonist orantagonist of the NHL receptor protein. Again, these compounds thatmodulate the expression of DNA or RNA encoding NHL or the biologicalfunction thereof may be detected by a variety of assays. The assay maybe a simple “yes/no” assay to determine whether there is a change inexpression or function. The assay may be made quantitative by comparingthe expression or function of a test sample with the levels ofexpression or function in a standard sample.

[0105] Expression of NHL. DNA may also be performed using in vitroproduced synthetic mRNA. Synthetic mRNA can be efficiently translated invarious cell-free systems, including but not limited to wheat germextracts and reticulocyte extracts, as well as efficiently translated incell based systems, including but not limited to microinjection intofrog oocytes, with microinjection into frog oocytcs being preferred.

[0106] Following expression of NHL in a host cell, NHL protein may berecovered to provide NHL protein in active form. Several NHL proteinpurification procedures are available and suitable for use. RecombinantNHL protein may be purified from cell lysates and extracts by variouscombinations of, or individual application of salt fractionation, ionexchange chromatography, size exclusion chromatography, hydroxylapatiteadsorption chromatography and hydrophobic interaction chromatography. Inaddition, recombinant NHL protein can be separated from other cellularproteins by use of an immunoaffinity column made with monoclonal orpolyclonal antibodies specific for full-length NHL protein, orpolypeptide fragments of NHL protein.

[0107] Polyclonal or monoclonal antibodies may be raised against NHL ora synthetic peptide (usually from about 9 to about 25 amino acids inlength) from a portion of NHL disclosed in SEQ ID NO: 2. Monospecificantibodies to NHL are purified from mammalian antisera containingantibodies reactive against NHL or are prepared as monoclonal antibodiesreactive with NHL using the technique of Kohler and Milstein (1975,Nature 256: 495-497). Monospecific antibody as used herein is defined asa single antibody species or multiple antibody species with homogenousbinding characteristics for NHL. Homogenous binding as used hereinrefers to the ability of the antibody species to bind to a specificantigen or epitope, such as those associated with NHL, as describedabove. Human NHL-specific antibodies arc raised by immunizing animalssuch as mice, rats, guinea pigs, rabbits, goats, horses and the like,with an appropriate concentration of NHL protein or a synthetic peptidegenerated from a portion of NHL with or without an immune adjuvant.

[0108] Preimmune serum is collected prior to the first immunization.Each animal receives between about 0.1 mg and about 1000 mg of NHLprotein associated with an acceptable immune adjuvant. Such acceptableadjuvants include, but are not limited to, Freund's complete, Freund'sincomplete, alum-precipitate, water in oil emulsion containingCorynebacterium parvum and tRNA. The initial immunization consists ofNHL protein or peptide fragment thereof in, preferably, Freund'scomplete adjuvant at multiple sites either subcutaneously (SC),intraperitoneally (IP) or both. Each animal is bled at regularintervals, preferably weekly, to determine antibody titer. The animalsmay or may not receive booster injections following the initialimmunization. Those animals receiving booster injections are generallygiven an equal amount of NHL in Freund's incomplete adjuvant by the sameroute. Booster injections are given at about three week intervals untilmaximal titers are obtained. At about 7 days after each boosterimmunization or about weekly after a single immunization, the animalsare bled, the serum collected, and aliquots are stored at about −20° C.

[0109] Monoclonal antibodies (mAb) reactive with NHL are prepared byimmunizing inbred mice, preferably Balb/c, with NHL protein. The miceare immunized by the IP or SC route with about 1 mg to about 100 mg,preferably about 10 mg, of NHL protein in about 0.5 ml buffer or salineincorporated in an equal volume of an acceptable adjuvant, as discussedabove. Freund's complete adjuvant is preferred. The mice receive aninitial immunization on day 0 and are rested for about 3 to about 30weeks. Immunized mice are given one or more booster immunizations ofabout 1 to about 100 mg of NHL in a buffer solution such as phosphatebuffered saline by the intravenous (IV) route. Lymphocytes, fromantibody positive mice, preferably splenic lymphocytes, are obtained byremoving spleens from immunized mice by standard procedures known in theart. Hybridoma cells are produced by mixing the splenic lymphocytes withan appropriate fusion partner, preferably myeloma cells, underconditions which will allow the formation of stable hybridomas. Fusionpartners may include, but are not limited to: mouse myelotnas P3/NSI/Ag4-1; MPC-11; S-1194 and Sp 2/0, with Sp 2/0 being preferred. Theantibody producing cells and myeloma cells are fused in polyethyleneglycol, about 1000 mol. wt., at concentrations from about 30% to about50% Fused hybridoma cells are selected by growth in hypoxanthine,thymidine and aminopterin supplemented Dulbecco's Modified Eagles Medium(DMEM) by procedures known in the art. Supernatant fluids are collectedform growth positive wells on about days 14, 18, and 21 and are screenedfor antibody production by an immunoassay such as solid phaseimmunoradioassay (SPIRA) using NHL as the antigen. The culture fluidsare also tested in the Ouchterlony precipitation assay to determine theisotype of the mAb. Hybridoma cells from antibody positive wells arecloned by a technique such as the soft agar technique of MacPherson,1973, Soft Agar Techniques, in Tissue Culture Methods and Applications,Kruse and Paterson, Eds., Academic Press.

[0110] Monoclonal antibodies are produced in vivo by injection ofpristine primed Balb/c mice, approximately 0.5 ml per mouse, with about2×10⁶ to about 6×10⁶ hybridoma cells about 4 days after priming. Ascitesfluid is collected at approximately 8-12 days after cell transfer andthe monoclonal antibodies are purified by techniques known in the art.

[0111] In vitro production of anti NHL mAb is carried out by growing thehybridoma in DMEM containing about 2% fetal calf serum to obtainsufficient quantities of the specific mAb. The mAb are purified bytechniques known in the art.

[0112] Antibody titers of ascites or hybridoma culture fluids aredetermined by various serological or immunological assays which include,but are not limited to, precipitation, passive agglutination,enzyme-linked immunosorbent antibody (ELISA) technique andradioimmunoassay (RIA) techniques. Similar assays are used to detect thepresence of NHL in body fluids or tissue and cell extracts.

[0113] It is readily apparent to those skilled in the art that the abovedescribed methods for producing monospecific antibodies may be utilizedto produce antibodies specific for NHL peptide fragments, or arespective full-length NHL.

[0114] NHL antibody affinity columns are made, for example, by addingthe antibodies to Affigel-10 (Biorad), a gel support which ispre-activated with N-hydroxysuccinimide esters such that the antibodiesform covalent linkages with the agarose gel bead support. The antibodiesare then coupled to the gel via amide bonds with the spacer arm. Theremaining activated esters are then quenched with 1M ethanolamine HCl(pH 8). The column is washed with water followed by 0.23 M glycine HCl(pH 2.6) to remove any non-conjugated antibody or extraneous protein.The column is then equilibrated in phosphate buffered saline (pH 7.3)and the cell culture supernatants or cell extracts containingfull-length NHL or NHL protein fragments are slowly passed through thecolumn. The column is then washed with phosphate buffered saline untilthe optical density (A₂₈₀) falls to background, then the protein iseluted with 0.23 M glycine-HCl (pH 2.6). The purified NHL protein isthen dialyzed against phosphate buffered saline.

[0115] Pharmaceutically useful compositions comprising modulators of NHLmay be formulated according to known methods such as by the admixture ofa pharmaceutically acceptable carrier. Examples of such carriers andmethods of formulation may be found in Remington's PharmaceuticalSciences. To form a pharmaceutically acceptable composition suitable foreffective administration, such compositions will contain an effectiveamount of the protein, DNA, RNA, modified NHL, or either NHL agonists orantagonists including tyrosine kinase activators or inhibitors.

[0116] Therapeutic or diagnostic compositions of the invention areadministered to an individual in amounts sufficient to treat or diagnosedisorders. The effective amount may vary according to a variety offactors such as the individual's condition, weight, sex and age. Otherfactors include the mode of administration.

[0117] The pharmaceutical compositions may be provided to the individualby a variety of routes such as subcutaneous, topical, oral andintramuscular.

[0118] The term “chemical derivative” describes a molecule that containsadditional chemical moieties which are not normally a part of the basemolecule. Such moieties may improve the solubility, half-life,absorption, etc. of the base molecule. Alternatively the moieties mayattenuate undesirable side effects of the base molecule or decrease thetoxicity of the base molecule. Examples of such moieties are describedin a variety of texts, such as Remington's Pharmaceutical Sciences.

[0119] Compounds identified according to the methods disclosed hereinmay be used alone at appropriate dosages. Alternatively,co-administration or sequential administration of other agents may bedesirable.

[0120] The present invention also has the objective of providingsuitable topical, oral, systemic and parenteral pharmaceuticalformulations for use in the novel methods of treatment of the presentinvention. The compositions containing compounds identified according tothis invention as the active ingredient can be administered in a widevariety of therapeutic dosage forms in conventional vehicles foradministration. For example, the compounds can be administered in suchoral dosage forms as tablets, capsules (each including timed release andsustained release formulations), pills, powders, granules, elixirs,tinctures, solutions, suspensions, syrups and emulsions, or byinjection. Likewise, they may also be administered in intravenous (bothbolus and infusion), intraperitoneal, subcutaneous, topical with orwithout occlusion, or intramuscular form, all using forms well known tothose of ordinary skill in the pharmaceutical arts.

[0121] Advantageously, compounds of the present invention may beadministered in a single daily dose, or the total daily dosage may beadministered in divided doses of two, three or four times dailyFurthermore, compounds for the present invention can be administered inintranasal form via topical use of suitable intranasal vehicles, or viatransdermal routes, using those forms of transdermal skin patches wellknown to those of ordinary skill in that art. To be administered in theform of a transdermal delivery system, the dosage administration will,of course, be continuous rather than intermittent throughout the dosageregimen.

[0122] For combination treatment with more than one active agent, wherethe active agents are in separate dosage formulations, the active agentscan be administered concurrently, or they each can be administered atseparately staggered times.

[0123] The dosage regimen utilizing the compounds of the presentinvention is selected in accordance with a variety of factors includingtype, species, age, weight, sex and medical condition of the patient;the severity of the condition to be treated; the route ofadministration; the renal, hepatic and cardiovascular function of thepatient; and the particular compound thereof employed. A physician orveterinarian of ordinary skill can readily determine and prescribe theeffective amount of the drug required to prevent, counter or arrest theprogress of the condition. Optimal precision in achieving concentrationsof drug within the range that yields efficacy without toxicity requiresa regimen based on the kinetics of the drug's availability to targetsites. This involves a consideration of the distribution, equilibrium,and elimination of a drug.

[0124] The present invention also relates to a non-human transgenicanimal which is useful for studying the ability of a variety ofcompounds to act as modulators of NHL, or any alternative functional NHLin vivo by providing cells for culture, in vitro. In reference to thetransgenic animals of this invention, reference is made to transgenesand genes. As used herein, a transgene is a genetic construct includinga gene. The transgene is integrated into one or more chromosomes in thecells in an animal by methods known in the art. Once integrated, thetransgene is carried in at least one place in the chromosomes of atransgenic animal. Of course, a gene is a nucleotide sequence thatencodes a protein, such as one or a combination of the cDNA clonesdescribed herein. The gene and/or transgene may also include geneticregulatory elements and/or structural elements known in the art. A typeof target cell for transgene introduction is the embryonic stem cell(ES). ES cells can be obtained from pre-implantation embryos cultured invitro and fused with embryos (Evans et al., 1981, Nature 292:154-156;Bradley et al., 1984, Nature 309:255-258; Gossler et al., 1986, Proc.Natl. Acad. Sci USA 83:9065-9069; and Robertson et al., 1986 Nature322:445-448). Transgenes can be efficiently introduced into the ES cellsby a variety of standard techniques such as DNA transfection,microinjection, or by retrovirus-mediated transduction. The resultanttransformed ES cells can thereafter be combined with blastocysts from anon-human animal. The introduced ES cells thereafter colonize the embryoand contribute to the germ line of the resulting chimeric animal(Jaenisch, 1988, Science 240: 1468-1474). It will also be within thepurview of the skilled artisan to produce transgenic or knock-outinvertebrate animals (e.g., C. elegans) which express the NHL transgenein a wild type background as well in C. elegatis mutants knocked out forone or both of the NHL subunits. These organisms will be helpful infurther determining the dominant negative effect of NHL as well asselecting from compounds which modulate this effect.

[0125] The present invention also relates to a non-human transgenicanimal which is heterozygous for a functional NHL gene native to thatanimal. As used herein, functional is used to describe a gene or proteinthat, when present in a cell or in vitro system, performs normally as ifin a native or unaltered condition or environment. The animal of thisaspect of the invention is useful for the study of the retinal specificexpression or activity of NHL in an animal having only one functionalcopy of the gene. The animal is also useful for studying the ability ofa variety of compounds to act as modulators of NHL activity orexpression in vivo or, by providing cells for culture, in vitro. It isreiterated that as used herein, a modulator is a compound that causes achange in the expression or activity of NHL, or causes a change in theeffect of the interaction of NHL with its ligand(s), or otherprotein(s). In an embodiment of this aspect, the animal is used in amethod for the preparation of a further animal which lacks a functionalnative NHL gene. In another embodiment, the animal of this aspect isused in a method to prepare an animal which expresses a non-native NHLgene in the absence of the expression of a native NHL gene. Inparticular embodiments the non-human animal is a mouse. In furtherembodiments the non-native NHL is a wild-type human NHL which isdisclosed herein, or any other biologically equivalent form of human NHLgene as also disclosed herein.

[0126] In reference to the transgenic animals of this invention,reference is made to transgenes and genes. As used herein, a transgeneis a genetic construct including a gene. The transgene is integratedinto one or more chromosomes in the cells in an animal by methods knownin the art Once integrated, the transgene is carried in at least oneplace in the chromosomes of a transgenic animal. Of course, a gene is anucleotide sequence that encodes a protein, such as human or mouse NHL.The gene and/or transgene may also include genetic regulatory elementsand/or structural elements known in the art.

[0127] Another aspect of the invention is a non-human animal embryodeficient for native NHL expression. This embryo is useful in studyingthe effects of the lack of NHL on the developing animal. In particularembodiments the animal is a mouse. The animal embryo is also useful as asource of cells lacking a functional native NHL gene. The cells areuseful in in vitro culture studies in the absence of NHL.

[0128] An aspect of this invention is a method to obtain an animal inwhich the cells lack a functional gene NHL native to the animal. Themethod includes providing a gene for an altered form of the NHL genenative to the animal in the form of a transgene and targeting thetransgene into a chromosome of the animal at the place of the native NHLgene. The transgene can be introduced into the embryonic stem cells by avariety of methods known in the art, including electroporation,microinjection, and lipofection. Cells carrying the transgene can thenbe injected into blastocysts which are then implanted intopseudopregnant animals. In alternate embodiments, the transgene-targetedembryonic stem cells can be coincubated with fertilized eggs or morulaefollowed by implantation into females. After gestation, the animalsobtained are chimeric founder transgenic animals. The founder animalscan be used in further embodiments to cross with wild-type animals toproduce F1 animals heterozygous for the altered NHL gene. In furtherembodiments, these heterozygous animals can be interbred to obtain thenon-viable transgenic embryos whose somatic and germ cells arehomozygous for the altered NHL gene and thereby lack a functional NHLgene. In other embodiments, the heterozygous animals can be used toproduce cells lines. In preferred embodiments, the animals are mice.

[0129] A further aspect of the present invention is a transgenicnon-human animal which expresses a non-native NHL on a native NHL nullbackground. In particular embodiments, the null background is generatedby producing an animal with an altered native NHL gene that isnon-functional, i.e. a knockout. The animal can be heterozygous (i.e.,having a different allelic representation of a gene on each of a pair ofchromosomes of a diploid genome) or homozygous (i.e., having the samerepresentation of a gene on each of a pair of chromosomes of a diploidgenome) for the altered NHL gene and can be hemizygous (i.e., having agene represented on only one of a pair of chromosomes of a diploidgenome) or homozygous for the non-native NHL gene. In preferredembodiments, the animal is a mouse In particular embodiments thenon-native NHL gene can be a wild-type or mutant allele including thosemutant alleles associated with a disease. In further embodiments, thenon-native NHL is a human NHL. In a further embodiment the non-nativeNHL gene is operably linked to a promoter As used herein, operablylinked is used to denote a functional connection between two elementswhose orientation relevant to one another can vary. In this particularcase, it is understood in the art that a promoter can be operably linkedto the coding sequence of a gene to direct the expression of the codingsequence while placed at various distances from the coding sequence in agenetic construct.

[0130] An aspect of this invention is a method of producing transgenicanimals having a transgene including a non-native NHL gene on a nativeNHL null background. The method includes providing transgenic animals ofthis invention whose cells are heterozygous for a native gene encoding afunctional NHL protein and an altered native NHL gene. These animals arecrossed with transgenic animals of this invention that are hemizygousfor a transgene including a non-native NHL gene to obtain animals thatare both heterozygous for an altered native NHL gene and hemizygous fora non-native NHL gene. The latter animals are interbred to obtainanimals that are homozygous or hemizygous for the non-native NHL and arehomozygous for the altered native NHL gene. In particular embodiments,cell lines are produced from any of the animals produced in the steps ofthe method.

[0131] The transgenic animals and cells of this invention are useful inthe determination of the in vivo function of a non-native NHL in thecentral nervous system and in other tissues of an animal. The animalsare also useful in studying the tissue and temporal specific expressionpatterns of a non-native NHL throughout the animals. The animals arealso useful in determining the ability for various forms of wild-typeand mutant alleles of a non-native NHL to rescue the native NHL nulldeficiency. The animals are also useful for identifying and studying theability of a variety of compounds to act as modulators of the expressionor activity of a non-native NHL in vivo, or by providing cells forculture, for in vitro studies.

[0132] As used herein, a “targeted gene” or “Knockout” (KO) is a DNAsequence introduced into the germline of a non-human animal by way ofhuman intervention, including but not limited to, the methods describedherein. The targeted genes of the invention include nucleic acidsequences which are designed to specifically alter cognate endogenousalleles. An altered NHL gene should not fully encode the same NHL asnative to the host animal, and its expression product can be altered toa minor or great degree, or absent altogether. In cases where it isuseful to express a non-native NHL gene in a transgenic animal in theabsence of a native NHL gene we prefer that the altered NHL gene inducea null lethal knockout phenotype in the animal. However a more modestlymodified NHL gene can also be useful and is within the scope of thepresent invention.

[0133] A type of target cell for transgene introduction is the embryonicstem cell (ES). ES cells can be obtained from pre-implantation embryoscultured in vitro and fused with embryos (Evans et al., 1981, Nature292:154-156; Bradley et al., 1984, Nature 309:255-258; Gossler et al.,1986, Proc. Natl. Acad. Sci. USA 83:9065-9069; and Robertson et al.,1986 Nature 322:445-448). Transgenes can be efficiently introduced intothe ES cells by a variety of standard techniques such as DNAtransfection, microinjection, or by retrovirus-mediated transduction.The resultant transformed ES cells can thereafter be combined withblastocysts from a non-human animal. The introduced ES cells thereaftercolonize the embryo and contribute to the germ line of the resultingchimeric animal (Jaenisch, 1988, Science 240: 1468-1474).

[0134] The methods for evaluating the targeted recombination events aswell as the resulting knockout mice are readily available and known inthe art. Such methods include, but are not limited to DNA (Southern)hybridization to detect the targeted allele, polymerase chain reaction(PCR), polyacrylamide gel electrophoresis (PAGE) and Western blots todetect DNA, RNA and protein.

[0135] The following examples are provided to illustrate the presentinvention without, however, limiting the same hereto.

EXAMPLE 1 Characterization of DNA Molecules Encoding NHL

[0136] M68/DcR3 identification—The human osteoprotegerin (OPG) sequence(Acc. # U94332), which is a member of the TNFR-related family, was usedto searched Genbank using the programs TBLASTN and TFASTX3 to identifynovel gene family members. Two EST sequences (GenBank Acc. # AA155701and AA025672) were identified that showed sequence similarities to thecysteine repeats of the OPG sequence. These EST sequences were then usedto identify additional EST sequences, which formed a single EST cluster(GenBank Acc. #s aa577603, aa603704, aa613366, aa158406, w67560,aa325843, aa155646, aa025673, aa514270, m91489). Two clones were furthercharacterized, which were derived from colon tumor and germ cell tumorlibraries (Research Genetics, Inc). DNA sequence analysis revealed twoalternatively spliced forms of the 5′-end UTR of M68/DcR3. The M68/DcR3open reading frame was confirmed by sequence analysis of clones obtainedby PCR cloning from a normal human cDNA library (Clontech).

[0137] M68/DcR3 BAC identification and sequencing—To further delineatethe gene structure of M68/DcR3, genomic DNA was obtained using a human“Down to the Well”™ genomic bacterial artificial chromosome (BAC)library (Genome Systems, Inc.) according to the manufacturer's protocol.Two sets of PCR primers, C68.36F:

[0138] 5′-CACAGGTTCAGCATGTTTGTGCGTC-3′ (SEQ ID NO: 4) and C68.275R:

[0139] 5′-CACAGTCCCTGCTGGCCTCTGTCTA-3′ (SEQ ID NO: 5), and E68.715F:

[0140] 5′-CAGGACATCTCCATCAAGAGGCTGC-3′ (SEQ ID NO: 6) and E68.972R:

[0141] 5′-AATAAGAGGGGGCCAGGATCAGTGC-3′ (SEQ ID NO: 7), were used tocarry out PCR reactions to identify positive wells that contained thefull-length M68/DcR3 gene. The PCR conditions used were 94° C. for 9min, 35 cycles of (94° C., 30 sec., 68° C. 3 min.) followed by 72° C.for 10 min. Two positive BAC clones were identified and characterized byrestriction digestion and BAC-end sequence analyses, of which hbm168 wasselected for shotgun sequencing.

[0142] A shot-gun library for BAC hbm168 was constructed using aconventional strategy. Briefly, two 150-ml bacterial cultures werecombined and purified using a modified protocol of the plasmid-Maxi kit(QIAGEN) followed by CsCl gradient purification. After butanolextraction and isopropanol precipitation, BAC DNA was nebulizied at 10psi for 60 seconds to generate randomly sheared fragments. Followingethanol precipitation, the fragments were end-repaired using T4polymerase (Promega) and BstXI adaptors (Invitrogen) were ligatedovernight. Removal of excess, unligated adaptors and size selection wasperformed using a cDNA sizing column (Life Technologies, Inc.) togenerate genomic fragments in the size range of 1500 to 3000 bp. Adaptorligated fragments were cloned into a modified pBlueScript SK⁺ vector(Stratagene) and transformed in XL2-Blue ultracompentent cells(Stratagene). Approximately 1000 clones were isolated, plasmids werepurified using the Turbo miniprcp kits (QIAGEN), and both plasmid endswere sequenced with the BigDye terminator kits (Perkin-Elmer). Sequencedata were assembled using Phred/Phrap/Consed where single-stranded andgap regions were closed using a directed sequencing strategy.

[0143] NHL identification and sequencing—The genomic clone for the NHL,gene was obtained and sequenced. The transcript was identified throughexon prediction using GRAIL2 and sequence alignment to a contiguous 4.5kilobase region of chromosome 4 (88% sequence identity). The completeexon structure of NHL was subsequently confirmed by RT-PCR analysis. Theexon structure was confirmed by RT-PCR using polyA RNA from a humancolorectal adenocarcinoma cell line, SW480 (Clontech). Primers weredesigned based on the genomic sequence that were predicted to be exons.RT-PCR reaction were carried out with SW480 polyA RNA using standardconditions with TaqGold Enzyme at 94° C. for 12 min, 35 cycles of (94°C., 30 sec., 60 C., 30 sec., and 68° C. 2-6 min.) followed by 68° C. for7 min. Most sequence confirmation was accomplished by RT-PCR, althoughfirst junction between exon 1 and 2 was confirmed by 5′RACE andjunctions between exon 26-29 were by RCCA. The primers used were asfollows: Junction of Exons Confirmed by Primers H01/H02 hdkw (5′RACE)H02/H03 hdiy,hdiz H03-H09 hdid,hdie,hdja,hdjb H09-H13 hdja,hdie H13-H18hdje,hdjf H18-H23 hdjg,hdjh H23-H26 hdji,hdjj H26-H29 hdkv,r543(RCCA)H29-H31 hdij,hdmu,hdnd,hdne H31/H32 hdij,hdmu H32/H34hdip,hdil,hdmv,hdik,hdli H34/H35 hdng,hdnh

[0144] HDID - 5′-GTGAATGGCATCCTGGAGAG-3′; (SEQ ID NO:8) HDIE -5′-GTCTCCAGGCAGCTCAACAG-3′; (SEQ ID NO:9) HDIJ -5′-ACCCTGTCCCTCCTGTCTGA-3′; (SEQ ID NO:10) HDIY -5′-AGACCCTAAGATGTTCGGAG-3′; (SEQ ID NO:11) HDIZ -5′-GATGACCTGTGTGAGTTGCG-3′; (SEQ ID NO:12) HDJA -5′-CGCAACTCACACAGGTCATC-3′; (SEQ ID NO:13) HDJB -5′-GGAGTCAGGTCAAAGGATGC-3′; (SEQ ID NO:14) HDJC -5′-GCATCCTTTGACCTGACTCC-3′; (SEQ ID NO:15) HDJD -5′-GGTCTGAAACGTGATCTGGG-3′; (SEQ ID NO:16) HDJE -5′-CCCAGATCACGTTTCAGACC-3′; (SEQ ID NO:17) HDJF -5′-CGATGATGTGTGGGTTCTCC-3′; (SEQ ID NO:18) HDJG -5′-GGAGAACCCACACATCATCG-3′; (SEQ ID NO:19) HDJH -5′-CGTGTCTGAGAAGTCCAGCC-3′; (SEQ ID NO:20) HDJI -5′-GGCTGGACTTCTCAGACACG-3′; (SEQ ID NO:21) HDJJ -5′-ACAGCATCTTCTCCACGCAC-3′; (SEQ ID NO:22) HFMU -5′-AGTCCTCTGGCTTTGCAGTG-3′; (SEQ ID NO:23) HDKV -5′-TGTGCGTGGAGAAGATGCTG-3′; (SEQ ID NO:24) HDKW -5′-GGCTGGAAAGGGAAGTCTAC-3′; (SEQ ID NO:25) HDND -5′-TGGTTCAGGTGCTCTTGGGG-3′; (SEQ ID NO:26) HDNE -5′-CGTGAAGCAGGAGTTGAGCC-3′; (SEQ ID NO:27) HDIK -5′-ATCTTGCTCTGGGTCTTCCC-3′; (SEQ ID NO:28) HDIL -5′-CACTGCAAAGCCAGAGGACT-3′; (SEQ ID NO:29) HDIP -5′-ATAAGCAAGACGACGACCTC-3′; (SEQ ID NO:30) HDLI -5′-CTATTCTGTTGGGTGGGTTC-3′; (SEQ ID NO:31) HDMV -5′-CGTGCCTCCTGTGCTTACCC-3′; (SEQ ID NO:32) HDNG -5′-CAGACCCCAAGGTAGCTCAG-3′; (SEQ ID NO:33) HDNH -5′-GGAAGACCCAGAGCAAGATC-3′. (SEQ ID NO:34)

[0145] Amplified product were subject to direct sequencing afterpurification from an agarose gel or cloned into a TOPO PCR cloningvector (Invitrogen) for sequencing. Multiple sequence alignment of NHLto known helicases showed that NHL contains all the seven criticalhelicase domains. BLAST analysis of the predicted 1,219 amino acidsequence (see FIG. 2, SEQ ID NO: 2) reveal an approximately 26% sequenceidentity and 48% sequence similarity to the RAD3/ERCC2 gene family ofDNA helicases (see FIG. 3). Review of this sequence data shows that twopartial human cDNA clones (Acc. No. al080127 and ab029011) aredeposited. No. al080127 covers exon 25-35 while ab029011 covers exons9-35. Ab029011 starts at amino acid 240 of the full length human NHLprotein disclosed herein, but also differs at exon 35 and appears to bea fusion transcript with M68. This cDNA was isolated from brain tissue,which has been known to express rare transcripts.

EXAMPLE 2 Northern Analysis of human NHL Expression

[0146] Messenger RNA (mRNA) obtained from human brain, heart, skeletalmuscle, colon, thymus, spleen, kidney, liver, small intestine, placenta,lung, and peripheral blood leukocytes. Two μg of polyA⁺ RNA were run oneach lane a denaturing formaldehyde 1% agarose gel, and transferred to acharged-modified nylon membrane. The probe was made using a 733 bpfragment derived from 1174-1907 nt of the NHL cDNA. This fragment waslabeled via the ³²P dCTP random priming method (Ambion). Hybridizationwas carried in ExpressHyb (Clontech) according to the manufacturer'sprotocol except for the final wash, which was at 55° C. Membranes wereexposed to X-ray film with intensifying screen at −80° C. overnight. TheNorthern data is presented in FIG. 4. Note hybridization of the NHLprobe to an approximately 4.4 kb transcript. The 7.5 kb transcript maysuggest an alternative splicing of the NHL RNA.

EXAMPLE 3 Chromosomal Localization

[0147] To map the position of M68/NHL in the human genome, primersC68.36F and C68.275R, were used to carry out PCR reactions to 93 clonesof the MIT GeneBridge 4 panel (Research Genetics) and results weresubmitted to MIT for analysis. M68/DcR3 was mapped to the extremetelomere of chromosome 20, at 20q13.3, 28cR from D20S173 with a lodscore of 13. An analogous procedure was also carried out with the 83clones of the Stanford G3 radiation hybrid panel, with PCR resultssubmitted to the Stanford Genome Center for analysis. Analysis usinganother pair of PCR primers specific to NHL yielded the same result. Forfluorescence in situ (FISH) analysis, the normal human male fibroblastcell line, L136 (Coriell Cell Repository, Camden, N.J.) was arrested inmitosis with colcemid (10 μg/ml). A human chromosome 20 α-satelliteprobe (Vysis, Downers Grove, Ill.) was directly labeled with SpectrumOrange dUTP and was used to identify chromosome 20. The M68 BAC clonewas directly labeled with SpectrumGreen dUTP by nick translation(Vysis). Slides were counterstained with DAPI stain and viewed under anOlympus microscope with narrow blue and DAPI/TRITC filters. Fiftymetaphase cells were scored to verify that the M68 probe was located onthe same chromosome as the Human Chromosome 20 probe. Radiation hybridchromosomal mapping reconfirms that it is linked to M68 locus,at20q13.3.

1 38 1 4946 DNA Homo sapien CDS (828)...(4487) 1 agtcagccct gctgccagccagtgccgggt gctggggact cagggaggcc cgccgggacc 60 actgcgggac agtgagccgagcagaagctg gaacgcagga gaggaaggag agggggcggt 120 cagggctctc aggagccgggtcctgggcaa ggcgcagccg ttttcaaatt ttcaggaaag 180 cggtcggctc acactcgagcagtaaaaaga tgcctctggg gaggaggccc gtgcagctct 240 ccgggcaatg gtggtggctcggcctagaga ggcggtagtg gaacgcagac cctggtgggg 300 gaatgacatc aagggaggagacgggcggga ccccagattt ctgcctgtgg gcgatggaag 360 tgaggttcac tggccagcggagccggacac agaacgcgca aaacgccgtg taggcctgga 420 ggagccgaag agcaggcggaccccctccgc gggggaacag tttccgccgg gagcacaaag 480 caacggaccg gaagtggggggcggaagtgc agtgggctca gcgccgactg cgcgcctctg 540 cccgcgaaaa ctctgagctggctgacagct ggggacgggt ggcggccctc gactggagtc 600 ggttgagttc ctgagggaccccggttctgg aaggttcgcc gcggagacaa gtgagcagtc 660 tgtgccatag ggattctcgaagagaacagc gttgtgtccc agtgcacatg ctcgcatcgc 720 ttaccaggag tgcccgagaccctaagatgt tcggagtggt tttttcgcac agacccgaat 780 agcctgcccc tcagccacgctctgtgccct tctgagaaca ggctgat atg ccc aag 836 Met Pro Lys 1 ata gtc ctgaat ggt gtg acc gta gac ttc cct ttc cag ccc tac aaa 884 Ile Val Leu AsnGly Val Thr Val Asp Phe Pro Phe Gln Pro Tyr Lys 5 10 15 tgc caa cag gagtac atg acc aag gtc ctg gaa tgt ctg cag cag aag 932 Cys Gln Gln Glu TyrMet Thr Lys Val Leu Glu Cys Leu Gln Gln Lys 20 25 30 35 gtg aat ggc atcctg gag agc cct acg ggt aca ggg aag acg ctg tgc 980 Val Asn Gly Ile LeuGlu Ser Pro Thr Gly Thr Gly Lys Thr Leu Cys 40 45 50 ctg ctg tgc acc acgctg gcc tgg cga gaa cac ctc cga gac ggc atc 1028 Leu Leu Cys Thr Thr LeuAla Trp Arg Glu His Leu Arg Asp Gly Ile 55 60 65 tct gcc cgc aag att gccgag agg gcg caa gga gag ctt ttc ccg gat 1076 Ser Ala Arg Lys Ile Ala GluArg Ala Gln Gly Glu Leu Phe Pro Asp 70 75 80 cgg gcc ttg tca tcc tgg ggcaac gct gct gct gct gct gga gac ccc 1124 Arg Ala Leu Ser Ser Trp Gly AsnAla Ala Ala Ala Ala Gly Asp Pro 85 90 95 ata gct tgc tac acg gac atc ccaaag att att tac gcc tcc agg acc 1172 Ile Ala Cys Tyr Thr Asp Ile Pro LysIle Ile Tyr Ala Ser Arg Thr 100 105 110 115 cac tcg caa ctc aca cag gtcatc aac gag ctt cgg aac acc tcc tac 1220 His Ser Gln Leu Thr Gln Val IleAsn Glu Leu Arg Asn Thr Ser Tyr 120 125 130 cgg cct aag gtg tgt gtg ctgggc tcc cgg gag cag ctg tgc atc cat 1268 Arg Pro Lys Val Cys Val Leu GlySer Arg Glu Gln Leu Cys Ile His 135 140 145 cct gag gtg aag aaa caa gagagt aac cat cta cag atc cac ttg tgc 1316 Pro Glu Val Lys Lys Gln Glu SerAsn His Leu Gln Ile His Leu Cys 150 155 160 cgt aag aag gtg gca agt cgctcc tgt cat ttc tac aac aac gta gaa 1364 Arg Lys Lys Val Ala Ser Arg SerCys His Phe Tyr Asn Asn Val Glu 165 170 175 gaa aaa agc ctg gag cag gagctg gcc agc ccc atc ctg gac att gag 1412 Glu Lys Ser Leu Glu Gln Glu LeuAla Ser Pro Ile Leu Asp Ile Glu 180 185 190 195 gac ttg gtc aag agc ggaagc aag cac agg gtg tgc cct tac tac ctg 1460 Asp Leu Val Lys Ser Gly SerLys His Arg Val Cys Pro Tyr Tyr Leu 200 205 210 tcc cgg aac ctg aag cagcaa gcc gac atc ata ttc atg ccg tac aat 1508 Ser Arg Asn Leu Lys Gln GlnAla Asp Ile Ile Phe Met Pro Tyr Asn 215 220 225 tac ttg ttg gat gcc aagagc cgc aga gca cac aac att gac ctg aag 1556 Tyr Leu Leu Asp Ala Lys SerArg Arg Ala His Asn Ile Asp Leu Lys 230 235 240 ggg aca gtc gtg atc tttgac gaa gct cac aac gtg gag aag atg tgt 1604 Gly Thr Val Val Ile Phe AspGlu Ala His Asn Val Glu Lys Met Cys 245 250 255 gaa gaa tcg gca tcc tttgac ctg act ccc cat gac ctg gct tca gga 1652 Glu Glu Ser Ala Ser Phe AspLeu Thr Pro His Asp Leu Ala Ser Gly 260 265 270 275 ctg gac gtc ata gaccag gtg ctg gag gag cag acc aag gca gcg cag 1700 Leu Asp Val Ile Asp GlnVal Leu Glu Glu Gln Thr Lys Ala Ala Gln 280 285 290 cag ggt gag ccc cacccg gag ttc agc gcg gac tcc ccc agc cca ggg 1748 Gln Gly Glu Pro His ProGlu Phe Ser Ala Asp Ser Pro Ser Pro Gly 295 300 305 ctg aac atg gag ctggaa gac att gca aag ctg aag atg atc ctg ctg 1796 Leu Asn Met Glu Leu GluAsp Ile Ala Lys Leu Lys Met Ile Leu Leu 310 315 320 cgc ctg gag ggg gccatc gat gct gtt gag ctg cct gga gac gac agc 1844 Arg Leu Glu Gly Ala IleAsp Ala Val Glu Leu Pro Gly Asp Asp Ser 325 330 335 ggt gtc acc aag ccaggg agc tac atc ttt gag ctg ttt gct gaa gcc 1892 Gly Val Thr Lys Pro GlySer Tyr Ile Phe Glu Leu Phe Ala Glu Ala 340 345 350 355 cag atc acg tttcag acc aag ggc tgc atc ctg gac tcg ctg gac cag 1940 Gln Ile Thr Phe GlnThr Lys Gly Cys Ile Leu Asp Ser Leu Asp Gln 360 365 370 atc atc cag cacctg gca gga cgt gct gga gtg ttc acc aac acg gcc 1988 Ile Ile Gln His LeuAla Gly Arg Ala Gly Val Phe Thr Asn Thr Ala 375 380 385 gga ctg cag aagctg gcg gac att atc cag att gtg ttc agt gtg gac 2036 Gly Leu Gln Lys LeuAla Asp Ile Ile Gln Ile Val Phe Ser Val Asp 390 395 400 ccc tcc gag ggcagc cct ggt tcc cca gca ggg ctg ggg gcc tta cag 2084 Pro Ser Glu Gly SerPro Gly Ser Pro Ala Gly Leu Gly Ala Leu Gln 405 410 415 tcc tat aag gtgcac atc cat cct gat gct ggt cac cgg agg acg gct 2132 Ser Tyr Lys Val HisIle His Pro Asp Ala Gly His Arg Arg Thr Ala 420 425 430 435 cag cgg tctgat gcc tgg agc acc act gca gcc aga aag cga ggg aag 2180 Gln Arg Ser AspAla Trp Ser Thr Thr Ala Ala Arg Lys Arg Gly Lys 440 445 450 gtg ctg agctac tgg tgc ttc agt ccc ggc cac agc atg cac gag ctg 2228 Val Leu Ser TyrTrp Cys Phe Ser Pro Gly His Ser Met His Glu Leu 455 460 465 gtc cgc cagggc gtc cgc tcc ctc atc ctt acc agc ggc acg ctg gcc 2276 Val Arg Gln GlyVal Arg Ser Leu Ile Leu Thr Ser Gly Thr Leu Ala 470 475 480 ccg gtg tcctcc ttt gct ctg gag atg cag atc cct ttc cca gtc tgc 2324 Pro Val Ser SerPhe Ala Leu Glu Met Gln Ile Pro Phe Pro Val Cys 485 490 495 ctg gag aaccca cac atc atc gac aag cac cag atc tgg gtg ggg gtc 2372 Leu Glu Asn ProHis Ile Ile Asp Lys His Gln Ile Trp Val Gly Val 500 505 510 515 gtc cccaga ggc ccc gat gga gcc cag ttg agc tcc gcg ttt gac aga 2420 Val Pro ArgGly Pro Asp Gly Ala Gln Leu Ser Ser Ala Phe Asp Arg 520 525 530 cgg ttttcc gag gag tgc tta tcc tcc ctg ggg aag gct ctg ggc aac 2468 Arg Phe SerGlu Glu Cys Leu Ser Ser Leu Gly Lys Ala Leu Gly Asn 535 540 545 atc gcccgc gtg gtg ccc tat ggg ctc ctg atc ttc ttc cct tcc tat 2516 Ile Ala ArgVal Val Pro Tyr Gly Leu Leu Ile Phe Phe Pro Ser Tyr 550 555 560 cct gtcatg gag aag agc ctg gag ttc tgg cgg gcc cgc gac ttg gcc 2564 Pro Val MetGlu Lys Ser Leu Glu Phe Trp Arg Ala Arg Asp Leu Ala 565 570 575 agg aagatg gag gcg ctg aag ccg ctg ttt gtg gag ccc agg agc aaa 2612 Arg Lys MetGlu Ala Leu Lys Pro Leu Phe Val Glu Pro Arg Ser Lys 580 585 590 595 ggcagc ttc tcc gag acc atc agt gct tac tat gca agg gtt gcc gcc 2660 Gly SerPhe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg Val Ala Ala 600 605 610 cctggg tcc acc ggc gcc acc ttc ctg gcg gtc tgc cgg ggc aag gcc 2708 Pro GlySer Thr Gly Ala Thr Phe Leu Ala Val Cys Arg Gly Lys Ala 615 620 625 agcgag ggg ctg gac ttc tca gac acg aat ggc cgt ggt gtg att gtc 2756 Ser GluGly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly Val Ile Val 630 635 640 acgggc ctc ccg tac ccc cca cgc atg gac ccc cgg gtt gtc ctc aag 2804 Thr GlyLeu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val Val Leu Lys 645 650 655 atgcag ttc ctg gat gag atg aag ggc cag ggt ggg gct ggg ggc cag 2852 Met GlnPhe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala Gly Gly Gln 660 665 670 675ttc ctc tct ggg cag gag tgg tac cgg cag cag gcg tcc agg gct gtg 2900 PheLeu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser Arg Ala Val 680 685 690aac cag gcc atc ggg cga gtg atc cgg cac cgc cag gac tac gga gct 2948 AsnGln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp Tyr Gly Ala 695 700 705gtc ttc ctc tgt gac cac agg ttc gcc ttt gcc gac gca aga gcc caa 2996 ValPhe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala Arg Ala Gln 710 715 720ctg ccc tcc tgg gtg cgt ccc cac gtc agg gtg tat gac aac ttt ggc 3044 LeuPro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp Asn Phe Gly 725 730 735cat gtc atc cga gac gtg gcc cag ttc ttc cgt gtt gcc gag cga act 3092 HisVal Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala Glu Arg Thr 740 745 750755 atg cca gcg ccg gcc ccc cgg gct aca gca ccc agt gtg cgt gga gaa 3140Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val Arg Gly Glu 760 765770 gat gct gtc agc gag gcc aag tcg cct ggc ccc ttc ttc tcc acc agg 3188Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe Ser Thr Arg 775 780785 aaa gct aag agt ctg gac ctg cat gtc ccc agc ctg aag cag agg tcc 3236Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys Gln Arg Ser 790 795800 tca ggg tca cca gct gcc ggg gac ccc gag agt agc ctg tgt gtg gag 3284Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu Cys Val Glu 805 810815 tat gag cag gag cca gtt cct gcc cgg cag agg ccc agg ggg ctg ctg 3332Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg Gly Leu Leu 820 825830 835 gcc gcc ctg gag cac agc gaa cag cgg gcg ggg agc cct ggc gag gag3380 Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro Gly Glu Glu 840845 850 cag gcc cac agc tgc tcc acc ctg tcc ctc ctg tct gag aag agg ccg3428 Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu Lys Arg Pro 855860 865 gca gaa gaa ccg cga gga ggg agg aag aag atc cgg ctg gtc agc cac3476 Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu Val Ser His 870875 880 ccg gag gag ccc gtg gct ggt gca cag acg gac agg gcc aag ctc ttc3524 Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala Lys Leu Phe 885890 895 atg gtg gcc gtg aag cag gag ttg agc caa gcc aac ttt gcc acc ttc3572 Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe Ala Thr Phe 900905 910 915 acc cag gcc ctg cag gac tac aag ggt tcc gat gac ttc gcc gccctg 3620 Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe Ala Ala Leu920 925 930 gcc gcc tgt ctc ggc ccc ctc ttt gct gag gac ccc aag aag cacaac 3668 Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys Lys His Asn935 940 945 ctg ctc caa ggc ttc tac cag ttt gtg cgg ccc cac cat aag cagcag 3716 Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His Lys Gln Gln950 955 960 ttt gag gag gtc tgt atc cag ctg aca gga cga ggc tgt ggc tatcgg 3764 Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys Gly Tyr Arg965 970 975 cct gag cac agc att ccc cga agg cag cgg gca cag ccg gtc ctggac 3812 Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro Val Leu Asp980 985 990 995 ccc act gga aga acg gcg ccg gat ccc aag ctg acc gtg tccacg gct 3860 Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val Ser ThrAla 1000 1005 1010 gca gcc cag cag ctg gac ccc caa gag cac ctg aac cagggc agg ccc 3908 Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln GlyArg Pro 1015 1020 1025 cac ctg tcg ccc agg cca ccc cca aca gga gac cctggc agc caa cca 3956 His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro GlySer Gln Pro 1030 1035 1040 cag tgg ggg tct gga gtg ccc aga gca ggg aagcag ggc cag cac gcc 4004 Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys GlnGly Gln His Ala 1045 1050 1055 gtg agc gcc tac ctg gct gat gcc cgc agggcc ctg ggg tcc gcg ggc 4052 Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg AlaLeu Gly Ser Ala Gly 1060 1065 1070 1075 tgt agc caa ctc ttg gca gcg ctgaca gcc tat aag caa gac gac gac 4100 Cys Ser Gln Leu Leu Ala Ala Leu ThrAla Tyr Lys Gln Asp Asp Asp 1080 1085 1090 ctc gac aag gtg ctg gct gtgttg gcc gcc ctg acc act gca aag cca 4148 Leu Asp Lys Val Leu Ala Val LeuAla Ala Leu Thr Thr Ala Lys Pro 1095 1100 1105 gag gac ttc ccc ctg ctgcac agg ttc agc atg ttt gtg cgt cca cac 4196 Glu Asp Phe Pro Leu Leu HisArg Phe Ser Met Phe Val Arg Pro His 1110 1115 1120 cac aag cag cgc ttctca cag acg tgc aca gac ctg acc ggc cgg ccc 4244 His Lys Gln Arg Phe SerGln Thr Cys Thr Asp Leu Thr Gly Arg Pro 1125 1130 1135 tac ccg ggc atggag cca ccg gga ccc cag gag gag agg ctt gcc gtg 4292 Tyr Pro Gly Met GluPro Pro Gly Pro Gln Glu Glu Arg Leu Ala Val 1140 1145 1150 1155 cct cctgtg ctt acc cac agg gct ccc caa cca ggc ccc tca cgg tcc 4340 Pro Pro ValLeu Thr His Arg Ala Pro Gln Pro Gly Pro Ser Arg Ser 1160 1165 1170 gagaag acc ggg aag acc cag agc aag atc tcg tcc ttc ctt aga cag 4388 Glu LysThr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe Leu Arg Gln 1175 1180 1185agg cca gca ggg act gtg ggg gcg ggc ggt gag gat gca ggt ccc agc 4436 ArgPro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala Gly Pro Ser 1190 11951200 cag tcc tca gga cct ccc cac ggg cct gca gca tct gag tgg ggc ctc4484 Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu Trp Gly Leu1205 1210 1215 tag gatgtgccca gcctgccaca ccgcctccag gaagcagagcgtcatgcagg 4537 * tcttctggcc agagccccag tgagtgccca cggaggcccc cagcacacccaacgtggctt 4597 gatcacctgc ctgtccagct ctggtgggcc aagaacccac ccaacagaataggccagccc 4657 atgccagccg gcttggcccg ctgcaggcct caggcaggcg gggcccatggttggtccctg 4717 cggtgggacc ggatctgggc ctgcctctga gaagccctga gctaccttggggtctggggt 4777 gggtttctgg gaaagtgctt ccccagaact tccctggctc ctggcctgtgagtggtgcca 4837 caggggcacc ccagctgagc ccctcaccgg gaaggaggag acccccgtgggcacgtgtcc 4897 acttttaatc aggggacagg gctctctaat aaagctgctg gcagtgccc4946 2 1219 PRT Homo sapien 2 Met Pro Lys Ile Val Leu Asn Gly Val ThrVal Asp Phe Pro Phe Gln 1 5 10 15 Pro Tyr Lys Cys Gln Gln Glu Tyr MetThr Lys Val Leu Glu Cys Leu 20 25 30 Gln Gln Lys Val Asn Gly Ile Leu GluSer Pro Thr Gly Thr Gly Lys 35 40 45 Thr Leu Cys Leu Leu Cys Thr Thr LeuAla Trp Arg Glu His Leu Arg 50 55 60 Asp Gly Ile Ser Ala Arg Lys Ile AlaGlu Arg Ala Gln Gly Glu Leu 65 70 75 80 Phe Pro Asp Arg Ala Leu Ser SerTrp Gly Asn Ala Ala Ala Ala Ala 85 90 95 Gly Asp Pro Ile Ala Cys Tyr ThrAsp Ile Pro Lys Ile Ile Tyr Ala 100 105 110 Ser Arg Thr His Ser Gln LeuThr Gln Val Ile Asn Glu Leu Arg Asn 115 120 125 Thr Ser Tyr Arg Pro LysVal Cys Val Leu Gly Ser Arg Glu Gln Leu 130 135 140 Cys Ile His Pro GluVal Lys Lys Gln Glu Ser Asn His Leu Gln Ile 145 150 155 160 His Leu CysArg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn 165 170 175 Asn ValGlu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu 180 185 190 AspIle Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro 195 200 205Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met 210 215220 Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile 225230 235 240 Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn ValGlu 245 250 255 Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro HisAsp Leu 260 265 270 Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu GluGln Thr Lys 275 280 285 Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe SerAla Asp Ser Pro 290 295 300 Ser Pro Gly Leu Asn Met Glu Leu Glu Asp IleAla Lys Leu Lys Met 305 310 315 320 Ile Leu Leu Arg Leu Glu Gly Ala IleAsp Ala Val Glu Leu Pro Gly 325 330 335 Asp Asp Ser Gly Val Thr Lys ProGly Ser Tyr Ile Phe Glu Leu Phe 340 345 350 Ala Glu Ala Gln Ile Thr PheGln Thr Lys Gly Cys Ile Leu Asp Ser 355 360 365 Leu Asp Gln Ile Ile GlnHis Leu Ala Gly Arg Ala Gly Val Phe Thr 370 375 380 Asn Thr Ala Gly LeuGln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe 385 390 395 400 Ser Val AspPro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly 405 410 415 Ala LeuGln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg 420 425 430 ArgThr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys 435 440 445Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met 450 455460 His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly 465470 475 480 Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile ProPhe 485 490 495 Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His GlnIle Trp 500 505 510 Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln LeuSer Ser Ala 515 520 525 Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser SerLeu Gly Lys Ala 530 535 540 Leu Gly Asn Ile Ala Arg Val Val Pro Tyr GlyLeu Leu Ile Phe Phe 545 550 555 560 Pro Ser Tyr Pro Val Met Glu Lys SerLeu Glu Phe Trp Arg Ala Arg 565 570 575 Asp Leu Ala Arg Lys Met Glu AlaLeu Lys Pro Leu Phe Val Glu Pro 580 585 590 Arg Ser Lys Gly Ser Phe SerGlu Thr Ile Ser Ala Tyr Tyr Ala Arg 595 600 605 Val Ala Ala Pro Gly SerThr Gly Ala Thr Phe Leu Ala Val Cys Arg 610 615 620 Gly Lys Ala Ser GluGly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly 625 630 635 640 Val Ile ValThr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val 645 650 655 Val LeuLys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala 660 665 670 GlyGly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser 675 680 685Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp 690 695700 Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala 705710 715 720 Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val TyrAsp 725 730 735 Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe ArgVal Ala 740 745 750 Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr AlaPro Ser Val 755 760 765 Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser ProGly Pro Phe Phe 770 775 780 Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu HisVal Pro Ser Leu Lys 785 790 795 800 Gln Arg Ser Ser Gly Ser Pro Ala AlaGly Asp Pro Glu Ser Ser Leu 805 810 815 Cys Val Glu Tyr Glu Gln Glu ProVal Pro Ala Arg Gln Arg Pro Arg 820 825 830 Gly Leu Leu Ala Ala Leu GluHis Ser Glu Gln Arg Ala Gly Ser Pro 835 840 845 Gly Glu Glu Gln Ala HisSer Cys Ser Thr Leu Ser Leu Leu Ser Glu 850 855 860 Lys Arg Pro Ala GluGlu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu 865 870 875 880 Val Ser HisPro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala 885 890 895 Lys LeuPhe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe 900 905 910 AlaThr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe 915 920 925Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys 930 935940 Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His 945950 955 960 Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg GlyCys 965 970 975 Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg AlaGln Pro 980 985 990 Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro LysLeu Thr Val 995 1000 1005 Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro GlnGlu His Leu Asn Gln 1010 1015 1020 Gly Arg Pro His Leu Ser Pro Arg ProPro Pro Thr Gly Asp Pro Gly 1025 1030 1035 1040 Ser Gln Pro Gln Trp GlySer Gly Val Pro Arg Ala Gly Lys Gln Gly 1045 1050 1055 Gln His Ala ValSer Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly 1060 1065 1070 Ser AlaGly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln 1075 1080 1085Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr 10901095 1100 Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met PheVal 1105 1110 1115 1120 Arg Pro His His Lys Gln Arg Phe Ser Gln Thr CysThr Asp Leu Thr 1125 1130 1135 Gly Arg Pro Tyr Pro Gly Met Glu Pro ProGly Pro Gln Glu Glu Arg 1140 1145 1150 Leu Ala Val Pro Pro Val Leu ThrHis Arg Ala Pro Gln Pro Gly Pro 1155 1160 1165 Ser Arg Ser Glu Lys ThrGly Lys Thr Gln Ser Lys Ile Ser Ser Phe 1170 1175 1180 Leu Arg Gln ArgPro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala 1185 1190 1195 1200 GlyPro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu 1205 12101215 Trp Gly Leu 3 114793 DNA Homo sapien 3 tgaagagctt tgaccaagaggctgtgacga ggccctacga ggactctggc tctcctcctg 60 ctaagcacac ccaggcaggtgtcctggcag atgaggacca catgcagagc ctcggccagc 120 ccaccaatgc ccggatatgcaagtgagccc agcctggacc ccccggcgag gcccagcagc 180 accagcccag gcccgaaaaccttaagaaat gaccagtgtc tgctgcttta agccaccaag 240 ctctgcggtg gtttgttaggctgcaagcat ggctaattca gaaactgcca gaaacaagca 300 ctgctgtccc cagcctgggacacacagcac cgcctctgcg tggggagagg gcacaggcta 360 agggcacaaa tgccatcccagacccggctc ttgtgtgtgg aaggggccac tgtgccatga 420 ggcagaggaa accttggcaggaccttatgc cacagcaatt taaaagagaa gaaacaggct 480 gggcgtggtg gctcatgcctataatcccag cactttggga ggccaaggtg gtggatcact 540 tgaggtcagg agttcaagaccagcctggcc aatatggtga aaccctgtct ctacgaaaaa 600 tacaaaattt aggcaggcgtggtggcgggt gcctgtaatc cctgctattc aggaggctga 660 ggcaagagat ttacttgaacccaggaggtg gaggctgctg cagtgagctg agatcatgcc 720 actgcactcc agcctgtgtgacggagtgag acttggtctc aaaaaaaaaa aaggaaacac 780 atctgactag tgtgatctcgcaaggaacat tccagacaca gtggagctag aaggttcttc 840 tccaaacaag gaatccccaggggatcaaat tgttttgcat cggccagaca tggtggctca 900 agcctgtaac cccagtgcttcgggaggctg aggtgggagg actgcttgag tccaggagtt 960 caagactagc ttgggcaacacagtgagagc ccattagcca ggcgtggtgg cacatgcctg 1020 cagtcccagc actgtactaaaaatctacac ggggccgggc atggtggcac atgcctgtag 1080 agtcccagct actcaggaggctgaggcagg acgattcctt gaacccagga ggtcacggct 1140 gccatgagcc gtgactgtgccactgcactc cagtctgtgc aacagaacga gactctgttt 1200 cgaaaaacaa aaaatcatttcatgtctcca gtttctccac tggcaaaaga ctctgtcaag 1260 gtaaaaaatg gttctgacccacagaaatct aagaaaggaa aaaatataaa aaatagaaaa 1320 tttaaaaaag agatggtctcagaataaaga ccaacctggg ctatggttgt cactcttccc 1380 tcacacctta gaaagctttctggccgcatc tggccaaagg gccaccctgc cccatcttgg 1440 atcagtgagg tgccttcgaacaagccacct gccctggagc ccgtcctgtc ttgtctgcca 1500 ccgcacgctc agtaggggaggggaagtcgc taggttttag ttcaccagtc tctggatcaa 1560 gacgtgccat aaccaagaagccccagccac acccagaccc gatgtggcca caaggggtga 1620 gctgggaagg cccaggaaaaggcgggaggc ggacgaatgg aaatgtcatt ctgtggccac 1680 agaaatgatc tcaacgttttgtaacttcct accaagaggc agtcttagct ctgcccttga 1740 accagcactt ggtgatgtcgcttgcgtcaa tcaaggcaac agaagtgagc aggaggccca 1800 ctttcctctg caactgtgggcttacggggc aaagaagtcc aggcctccag gtggaggatc 1860 acagaccggg caaagcagaggagagccacc cagccgagcc tacctgtgcc tcagactgcc 1920 tccctccaga gacccctgtggccaaggcca cccagaccag caggtccttg ccaagctgtc 1980 agctgacgac aggggttggtgaggccggcc cagaccagca gaaccacgaa ccaaccaaca 2040 gaattaaaaa taataacaactatgtcttgt cttaagccac taagttttgg atggtttctt 2100 tctttctttt tctttttttttttcggagac gcagtctcac tctgttgccc aggctggagt 2160 gcagtggcgc aatcttggctcactgcaagc tctgcccccc ggattcacgc cattcccctg 2220 cctcagcctc ctgagtaactgggactacag gtgcctgcca ttgggtgttt tcttaaacag 2280 caaaagaaaa ctgacacaatcataaacaga gcaagcaaga gaacttggca attatttcct 2340 ctctacttct cactgttcttcaaagagtta actcaagcat aagatgtgag caaattcttt 2400 taacatccta gaaaaaaagctcctactcag tgttcataaa gcaaagctaa cctacaggag 2460 ccaccttcca cagtgaccacaggaaaccaa gacagcaagt gggacaccag cctccagggc 2520 actgcgccag ccgtgcgcctgtgtctgcca ctgccctggt ccgtcactgc caccagccgg 2580 caagacaccc acagaggagagctctaagcc acaactgtgt acgaagacaa ctgtgcagga 2640 ttttattact acaacatttttgttttcttt tttttttttt tttgagactg agtctcgctc 2700 tgtcacccag gctggagtgcagtggcacaa tctcggctca ctgtaacctc catctccctg 2760 gttcaagcaa ttctcctgctgcagcctccc aactggatta caggcgcccg ccaccacgcc 2820 tggctaattt ttgtacttttagtagagatg gggtttcacc atgttggcca gactggtctc 2880 aaattcctga caagtgatccacccaccctg gcctcccaaa gtgctgggat tacaggtgtg 2940 agccactgcg cctggcccatttttgtttat caataaaaat gtacttaatg ttgaactctc 3000 cacatttcaa atgggtaactccagtgtcct tgatgctcct gcgacatgtt cgtgagactt 3060 ctcttgggtg tgagagtctagcatgtgggt ggtctggaca ggagggggag ggaagagtgc 3120 agagccgggc agggtaaagagaccccctag gatgtgaagg ccgccctgca tttgtcagac 3180 tgggcaacac ccactccatcagatggaccc tggtatgggc ggcaagccac ctaggtgccg 3240 aggcaagaga ccgagggcacgagctgttcc ggtgtaataa aatgcataaa ataagaatag 3300 ttatactaga tatagatcataaatatgatt atatatgaat atcattcatc attagtttgt 3360 agcaattact ctttattccaatattataat aatccttgcc taagcataac ctaggaaaaa 3420 ctaggaaatc ataacctaggaaaaactagg ccatacagag ataggagctg aggggacata 3480 gtgagaactg accagaagacaagagtgcga gccttctgtt atgcctggac agggccacca 3540 gagggctcct tggtctagcggtaacgccag catctgggaa gacgcccgtt gccaagtgga 3600 ccgtggtcta gcggtagcctcagtgtcaag gaaaaacacc cgctacttag caaaccagga 3660 aagagagtct ccctttccccgggggagttt agagaagact ctactcctcc acctcttgcg 3720 gagggcctga catcagtcaggcccgcccgc agttatccgg aggcctaacc gtctccctgt 3780 gatgctgtgc ttcagtggtcacgctcctag tccgccttca tgttccatcc tgtgcacctg 3840 gctctgcctt ctagatagcagcagcaaatt agtgaaagta ctgaaagtct ctgataagca 3900 gaaataatgg cgtaagcggtctctctctct ctctcctctc tctctgcctc agctgccagg 3960 aagggaaggg ccccctggccagtgggcacg tgacccacat gaccttacct atcactggac 4020 atggttcaca ctccttaccctgccgctttg tcttgtatcc aataaatagc gcaacctggc 4080 attcggggcc gctaccagtctccgcgtctt ggtggtagtg gtcccccagg cccagctgtc 4140 tttttctttt atctttgtcttgtgtcttta tttctacact ctctcatctc cgcatacgag 4200 gagaaaaccc accaaccctgtggggctggt ccctacaccc tggctttgta gactggagcc 4260 taggcacgac tcagctgctgtagtgaattg cgatcctcca aacccagcaa ggcacctgca 4320 ggacatctgg cccagtctcctcgttgagcc agttcacgaa aaagagactt ttctgagtga 4380 catgctaatg ggcaatatgaggactaaatg ggatggtctc caacttggac aaaccaacag 4440 taaaagccac tttgcggggaaagaaacttt tccttttttc ttttttttga gacaggatct 4500 caccctgtca cccaggctgcagtgcagtgg catgaccttg gctcactgca gcctcaacct 4560 ctctcaggct caagcaatcctcccgcctca acctcccatg cagctgggac cataggtgca 4620 tgccaccaca cccaaataatttttatattt tttgtagaga cgaggtttca ctatgttgct 4680 cgggctggtc tcaactcctgggctcaagca accctcccac ctcagcctcc caaagtgctc 4740 agattacagg caggagccaccaggcctggc caacatagga agaaatttaa atttgaattg 4800 aatattagaa gagatgaaaattcatcaaca tggaaagaca aagatcatta actaaagcca 4860 aaccagaatg gaagctgtgtgtacagtggg gtctcatgct gggaacgcga ggggcacgtg 4920 cagggctcca cggtgtggcgacgccccatg ctccctttgt gggggttcat ccagcggaac 4980 atgaggacct ggggtgcttttcaacatgta cgtgagttta ataataaaaa ggtttaagga 5040 aagaaaaatt catatgtttctatataaaca gaacatctgg aaagatctat tctaaggtgt 5100 tgacagtagg aatctctaggtagtagtaat atggcctttt tgaatttttg cttatcagta 5160 ttttctaatt ttctttttctttctaaataa ttctagctat gaaataattt tctaccatat 5220 atattttgta ataaaaatggttatatttaa ttttttaaag gctgtacaaa cttcctgata 5280 aaatggcaaa ttagacacacacatgtgggc cgggtacagt ggctcgcgcc tgtaattcca 5340 gcactttggg aggctgaggcaggcagatca cctaaggtca ggagtttgag accagcctgg 5400 ccaacatggt gaaaccccgtctctactaaa tatacaaaaa tgagctggat gtggtggcac 5460 acacctatag tgccagctacttgggaagct gaggcaggaa aattgcttca acccgggagg 5520 cagaggttgt agtgagccgagatcatgcca ctgcactcca gcctaggcaa caagagcgag 5580 actccaactc aaaaaaaaataaaaataaca cacacgtgaa taggctcctc atggaagtca 5640 tcacaacaat gcagagggaagagcttccaa agtgtaaacc cagaagcgag gagcaggagg 5700 gtgcgcgcag acgcagagagcagcaaggtg cagactgaga ggcggaggct ggccgtgggg 5760 agatgactga tgctcagtttataccccaaa tccgtaaatc tagaggcctg gcacatcaac 5820 tacctctgcc agcaggaatgagggaaagga gggcaaccaa aagatgtccc accctcaccc 5880 atccagctac ctgccatcctcagccccact ggcagaagac cctgagaggt ggaggcaggc 5940 ccctgcctac aggaccctgagagctagggg aaggcgttat cctgaactgt gtcccccgta 6000 aaattcatat gttgaaggcctcatccccag tgtgactgta tttaaagatg gggtcttcag 6060 gagataattt aaatgaggtcatataagttg gccctcatcc agtaagactt tgaccttctg 6120 gtggtttttt tttttttggagactgggtct cactctatca ctcaggttgg agtacagtgg 6180 cacgatcacg gctcactgctgtctccaact cctgggctca ggtgatcctc ctgcttcagc 6240 ctcctgagta gctgggactacaggtgctta ccaccgcacc cagctggtgg tgcattgtgt 6300 tttttgtaga gatggggttttgccatgtcg cccaggctgg tcctgaactg ggctcaagtg 6360 atctgtctcc ctcggcctcctgcagtgctg gaattacagg tatgagccac cgcgcctggc 6420 cgaccgtgac cttctaagaagtgaaagaga aagatctttc tctctccctc cctctccatc 6480 atgaggacac agcaagaagtcggccatctg caaggtagaa agcgagtcct cccaacagct 6540 gaacctggca gaccctgatcttggacttca gccttcagag ctgtaagaaa ataactctct 6600 gctgttcagg ccacgcggtctacggcagcc cgagcagact aagacacacg ccatctgggg 6660 agtcagacca gatcaggaagaaaggcctag agctcaggat actgaaggtc ccaacccggt 6720 gctggaccag accaccccggcagccgcggc cacggagtca cggctcgggt gaggtgacct 6780 ggacaccatc ccggcagccgcggccacgga gtcacggctc gggtgaggtg acctggacac 6840 catcccggca gccgcggccacggtgtcacg gctcggatga gatgactcgg acaccacccc 6900 ggcagccgcg gccacggtgtcagggctcag gtgaggagag ttggatatgg gactgggcct 6960 accccgaggc tgcttccacccagacgcctg ggtgggtgac acgaaagctg ggctcagttg 7020 ggatcagagc agcctctccccaggtcagaa atgaccctgg gctcctcaca gtagccctag 7080 ggcaccatga gaaagctacgtggacttctc tgaccaaggg tcactgctgc cacactactc 7140 attgcaggcc atgtcagggctcagctgagg agacgtggac accaccccag cagccgcggc 7200 cacggcgtcc caagggagggacttgggcac tgcctctctg ggcaagagtg gggaggtgtg 7260 gggtgggaga tgtctggaaacatcatggac acatgccggg aaaacacgga agctgtgcac 7320 caaggtgctg acaaaggaaaaaggagaatg gaggtgtgaa catccagcta gcaggtccca 7380 ctcagaaact cctgcatttccagacatggc caccagctct gtggatgaga caggggagga 7440 cagggtacct cacaccaggaacccacacag gtccatgtct tgctctgtga tcacacaaca 7500 gcctccacca ccctgacatgcaggagggag gtcaaagcct cgggtccaac aacaggctcc 7560 acagcaaggg aagaaaggcaggaaggaact cagggccagg tcctcccagg cagcagctgc 7620 ctgcacgctg tccaccaagggaggtctgac ctacaccgca caggggttgg cagtctagag 7680 tcgtcctctg tcaaacggtgagaaagtcaa aagctcatgc tcagtgatat gctaggtcag 7740 catgaagatg ccacacatgagacacagcaa ggatgagacc aacgggaaga ctgccccaga 7800 ccagagcccc agagccctctggggaggaag aataaggatg gcagcctggg actgcccggg 7860 gctgactctg cctttatttcaccccagcag aggcaggagt gacaccggct cacagcagga 7920 gcagctctgc cacctcctagcagttccacc tacgggcagc aaaacaaagc tggcagtttg 7980 ggcaaatgtt agcgtttttgccaactaaca tttgaatcgg acatctggta cagagatgag 8040 gaagaaaaca ctcacagtttcatgaagact gtcaagaaaa tcactgactc ttcacttcat 8100 ttatgaaagg ccagctctctgacatcccta ccactccctc tcacatgaga aatcacggcc 8160 tttcaggacg tggagccacgtggccatgca ggtacgggag gcctccccgc agctgcagct 8220 gggtcttctg gtccccgtgccatttctgct tttcttcgct ctctacttac acacacattt 8280 gagtccagtc tcagaagaactggaactaga aaaatcctga cacttgtccc ttactacgtt 8340 aatgccagct gtgccaaggacagcccaacc caagccccca tcagccccaa tggcaccgag 8400 gcccgagctt acccgtgaggggccaagttg gtcgtcacca acacggtctt caccccctcc 8460 acaccactgc cgtccactgcagtgtccgga gttgtcacaa ccaccacctc ctccatgtgc 8520 acactcacgt cgggagtcgccatggctcag cggaagggga cgcccaggcc agcagcgtca 8580 gtcctccagg gtcccaagtcctggaggaag caaggcaggg cacagggatg gagtcatctc 8640 cacatccaca caacatagcactcacaaagg catctctaat cagctccaaa gacccaccct 8700 tgagtcccag actgctacctcctgacaaaa acgagcggca acagaagggc tactccaggc 8760 tctggttccg agggcggtgtaagcgcactc cacccgtttt tcccactgga taagccgaaa 8820 cccttgggta gaaagcacagagccactccc tccacgtggg gctcagagca ggaggacagg 8880 aggggcctgg aattccaagcaacttccctg gacgcaggct cccggcttgc cagttcttcc 8940 gtctctcctg gcctgaactcaaagccagcc ccaatccctg aactgagttt caggtgcaga 9000 aagcactcca agaagtcctcgctggtctgt ggaacgggaa gggaaaccca ttcaagacag 9060 aaagagagga gggaaacgccctgggttttt ttgggttttt gggttttttt tgagacggag 9120 tctcgctctg tcgcccaggctggaatgcag tggcacgacc tcggctcact gcaagctcca 9180 cctcctgggt tcaagtgattctcctgcctc agcctctcca attgctggga ttacaggttt 9240 caccatgttg cccaggctggtctcaaactc ctgacctcag gtgatccact cacctcggcc 9300 tcccaaagtg ctgggattgcaggtgtgagg caccatgcct ggcctgcccc gggtttaaaa 9360 attattatta ttttgtctttcctggctttg ccttcagcaa gtccaacccc tgctaaaacc 9420 cggtgataat ggctgtcctggcccaaaaag cttggagaca ggggaatctt cctcctgact 9480 aaaggaatgg tggcccaagagtgtgggggc tccctgttgc cctctcactc tccatcccct 9540 acctagcaca gggaacacaaaagcccctgg tttccagcca gagggcaacg agcctggagt 9600 cagagtgtgg gggaggcgacaagaggagag gggagaagag aggatggcac acagctgtgt 9660 gtgagcgcct gggtcgtcccaagacagtct ctacgtggtc ctgaccctaa agggcaaagg 9720 gaagaaaact gacctacaggataggccact gcccaggtct cagatgggcc ccagtggcgc 9780 atatgggaca gatccacagtgcactggaaa gtctctaaaa taaactggcc taagaacaca 9840 gacacaggaa cggggtgcaaaatttgcagc ctgaacctaa ccaggtcgat ttcttgctat 9900 gaaaaaaaaa agtctacattctctgtgaaa cttaaaacaa gacctagagt ccatagcaca 9960 gtagtcaaag catccagaacacgatcaaac ttcctggcaa agggtagtct ggttgattct 10020 caaaggaaca aatacacaagagaagctggc tcttgaacgc agaatccaga gactttcagg 10080 tgctatcgga ccagctccaagaggaaagca aacattgtca accaagtgga aagaaaatct 10140 tggtatagaa acaggagttataaccaaaca gaaatgtgaa aattaaaaac gacaaccaaa 10200 agaaaataca caaagctgggatagtctcag ctactcggaa ggcggggctg gaggatcgtt 10260 tgagcctagg agattgaggctgcaatgagc tgtgatcaca ccaccgcact ccagtctggg 10320 caacagagtg agaactctctcaaaaaacga aaaagaaaga aagtagaaca gaagtgacca 10380 ggggctgggg gagggagtacagggagttgt tctttaatga gtacagaatt tctgtttggg 10440 atgatgaaaa gctctggaaatggacggcgg tgatggctgc acaatcactg tggctgttct 10500 gaatggtgct gaaccacacatttaaaaaca gttaaaatgg gctgggcgtg gtggctcacg 10560 cctgtaatcc cagcactttgggaggcggat cgcctgaggt caggagttcg agaccatcct 10620 ggccaacaca gtgaaatcctgtcttgacta aaaatactaa aaattagcca ggcatggtgg 10680 caggcacctg tagtcccagctacttgggag gctggggcag gagacctgct tgaacccagg 10740 aggcagaggt tgcagtgagccgagatcgtg ccactgcact ccagcctggg caacaagagc 10800 gaaactccat ctcaaaaaaaaaaaaaaaaa aaaaaaaaaa aagtttaaaa tggttaaatt 10860 ttatgttatg tatattttaccgtaataaaa acactgtaat gctactataa tagaatgact 10920 cattaggatt agatatagactagaaagtac agaatataaa aactttttaa acaaagaaaa 10980 attttcatgg ccaggcatggtgtcacacct gtaatcccag gactttggga ggccaaggca 11040 agaggaatgc ttgagctcaggggtttgaga ccagcctggg caacacagca acaccccatc 11100 tctgctaaat aaataataaaaaatagccag gcatggtggt gtgcacgcct gtagttgcag 11160 ctactctgga ggctgaggcaggaggatcac ttaagcccag gaggtcaagg ctgcagtgag 11220 ccatggttgt gccactgcgctccagcctgg gcaacagatc aagaccttgt cacaaaaaaa 11280 agaaagaaag aaaagaaaaaagaaagaaaa taaaatcttc cagaactttt aaaatcatca 11340 ttgttaatat aaaaataacatcacctgccc ctaggactgt aacaaacaag tgtgtctaag 11400 gacaggagtg ggtccaccccaacctggcac gcagtggtcc cctgcggaga gtctggccct 11460 gcactcacta agaggaggcactcatagccc agccaggcct ctgcaattat gccttcaatg 11520 ccagaactaa ctcacccaaactgaacaatc gatcacaaaa tgtgccttca ggtctcaagg 11580 ttcttgctaa atcttactcaaccgacattt tccagcatgg gaacattttt ctgaatgtct 11640 tagggagagg aagtccgcaagagaacaaaa ggtcctcagg ccaccctagc ttcttttcct 11700 ccattccaca ggctgtcttttgtctgggta tgcactggac cagggggctc tacttcttcc 11760 tacctgggca tgggtctccacacaactcca aggtaaaggg ccacaggcaa gataaagggg 11820 agaaaagaaa gctacgatttcctgggccac caatcgcaaa tggcagccag tctctgaagt 11880 aacccttgac cagagatccaaggaaccaag aaatgtaggt gatctgaaca gaggggatgg 11940 tggttaaaca ccatgaaggaaagacccatt ctcaaagaaa aggaagcaaa aagaaaccgt 12000 ggggagctgg gtaccacccgcagcaaagac cccgcacgcg ttactgacgc cagcctggcc 12060 tgggagagca gtgagtgtggcggacggtga gtggcgggga gggctgtggt aggtttaggg 12120 taagaagggg cagcgcccagagcccagaga acaccagtga gggctccaca ggaacactac 12180 tcaaagtatt cacggaacacatctaaacac aagcactaag gactaagtgc gagggacaag 12240 aaaatattcc ccgtttcctgtttcaggagg gtatcgaaaa tgagtgatgg aaggaaaatg 12300 tattgtttaa atgaggaaaaaaaattttta caaattaaga acatcctgga acatgatgag 12360 ccgtttactg tcactcaatttaaatggtgg ccatctagga cagagcgcct aaggggaaag 12420 ggggctcaca ggtgaacccctccagctgct ggtgggcaat ttcccattag ggcatcaggg 12480 tctctgaaga ctgtcttcagatgcttttta gccaggaaag ttacaatgat gaattcgttt 12540 acactggcgg aattacttcgtatttctcaa atataatgtt ttcactagca taactttgtt 12600 gttgtagact taggcttcaaaataaagaac tttaaacaaa catgaataaa aagccacttt 12660 aggccgggcg cggtggctcacacttgtaat cccagcactt tgggaggccg cggcgggtgg 12720 atcataaggt cagaagttcaaagaccagcc tgatcaatac ggtgaaaccc cgtctctact 12780 aaaaatacaa aaattagccgggcgcggtgg caggtgcctg taatctcagc tacttgggag 12840 gctgaggcag gagaatcgcttgaacctggg cagcagaggt tgcagtgagc caagatcatg 12900 ccactgcact caagcctgggtgacagagtg agactctctc ttaaaaaaaa aaagccactt 12960 taaaatttta ctcaggccaggtgtggtggc tcacgcccat aatcctagca ctttgggagg 13020 ccgaggcgag cagatcacctgaggtcagga gttagaccag cctggccaac atggtaaaac 13080 cttgtctcta ctgaaaacacaaaaattagc tgggcgtggt ggtgtgccca tgtaatccca 13140 gctactcagg aggctgaagtgagagaactg cttgaacccg ggaggcagag gctgcagtgt 13200 gccaagactg caccactacacttcagcctg ggcgacagag caagaccctg tctcagaaaa 13260 aaaaaaaatt caaaaatttggccaggcgtg gtggctcacg cctgtaatcc catcactttg 13320 gaaggccgag gcgggtggatcacctgaggt caggaattca agaccagcct ggccaccatg 13380 atgaaaccct gtctctactaaaaatacaaa aaaaaaaaaa caaattggcc gggcatggtg 13440 gcgggtgcct gtaatcccacctacttggga ggctgaggca ggagaatctc tcgaactccg 13500 gaggcagagg ttgcagcgagccaagattgt gccactgcac tccagcctag acaacagagc 13560 gagactctgt ctcaaaaaaaaaaaaattaa aattaaaaaa taaaaatttc atttaaaata 13620 ctactgatct cccgtgctgacttctcgggg tttaactctc actgaggaga cgctgctttc 13680 ataagggtaa gctcagcaggggcaactaaa gtcatttaag cagagagctg caaagaggca 13740 acagcctcac tgcaggcaggggtcctcgtc acagcttcag ggctttgcag aggattacgc 13800 aatgtacacg cacaaaactgaattccagcc tctccattgg caactgcata catacatata 13860 ttcttttttt gagacggagtctcgctctgt agcccaggtt ggactgcagt ggcccgatct 13920 cggctcaatg caagctctgcctcccgggtt caagcgattc tcttgcctca gcctcctgag 13980 tagctgggat tacaggcgcccaccaccacg cccggctaat ttttgtattt ttagtagaga 14040 cggggtttca ccatgttggccaggacagtc tcgatctcct gacctcgtga tccgcccgcc 14100 tctgcctccc aaagtgctgggattacaggc gtgagccact gagcctggcc tccaatggca 14160 actatattaa aggttcaaagcaatatgcac aaaagttacc tcacagaaaa tagtgcaagt 14220 ccttgataca atgctctttagacacagaag aagcactata gaatagagca cctcgcccta 14280 ttgccttccc aagggcgagcaccccctcct ctctccacag ctccttcttt gtttttttga 14340 gatggagtct cgctctgtcacccaggctgg agtgcaatgg caaaatcttg gctcactgca 14400 acctccgcct cccgggttgaagtgattctc ctgcctcagc ctcccgagta gctgggacta 14460 caggcaccca acacgcctagctaatttttg catttttggt agagacgggg tttcatcatg 14520 ttggccaggc tggtctcgaactcctgacct ccagtgatcc tcccaccttg acctcccata 14580 gtgctgggat tataggtgtgagccactaca cctggcctct ccacagcccc ttctgtgttg 14640 aagccaagac ccacccagctttgatcccaa ggcttgggtt ccccactagt gtgaagtgag 14700 tttccaaatt attaggtaaatcagatatga gaaaatattt tattttactt tttttttttt 14760 gagacgcaat cttgctccgtcacccaggct ggagtgcaat ggcaccatct ccactcactg 14820 caacctctgc cttctgggttcaagcaattc tcctgcctca gcctcccaac tagctgggat 14880 tacaagtgca caccaccacgcccggctaac ttttgtattt ttagtagaga cagggtttca 14940 ccgtgttagc caggctgctctcaaactcct gacctcatga tccgcccacg tcgggctccc 15000 aaagtggtgg gattacaggtgtgagccatc acacctggcc caagaaaata tttttaaact 15060 agtattcttg accggcacggtcaacactga tgtaattgaa actgttgtat ttgaagtgtt 15120 agcaaagaaa gagaattctggttcaacaga aaagtcagtc acgacttttc agtcacgcat 15180 gaattacaca gtaaccaaatagataacatg ccatgactga cgacgggccc acaacaaatc 15240 agctccgacc aacagggtccacaccaccat gggtctacac agatccaggt cccgcctgtg 15300 agcctacagt gacgcgggcccctgtggggt ggtccctgca ggtcaggtcc ctgagagtgg 15360 gtcccagtgg ggtgatccctgcgggtcgcg tccctgcgag ttgggtgcct gccgggtggc 15420 ccctgcgggt cgggtgcctgcggggtggtc cctatgggtc gcgtccctgc gggtcgggtg 15480 cctgcggggt ggcccctgggaatcgcgtcc ctgcgggtcg ggtgcctgcg gggtggcccc 15540 tggggatcgc gtccctgcgggtcgggtgcc tgcggggtgg cccctgggga tcgcgtccct 15600 gcgggtcggg tgcctgcggggtggtccttg tgggtcgcgt ccctgtgggg tggtccctgt 15660 gggtcgcgtc cctgtggggtggcccctgcg ggtcgcgtgg tggcccctgc gggtcgggtg 15720 cctgcggggt ggtccctgtgggtcgcgtcc ctgcgggtcg ggtgcctgcg gggtggtccc 15780 tgcgggtcgc acccctgcggcgtggtcccc ccgggatggg tccaccgagg aggccgctgg 15840 aggccgagcc cgcgcccgcccgcggcgcca agatggaggc aggaagcgcc gccgcccgcg 15900 cccgccaccg cccgcgccgcccgcctgacg ccgccgttgc gcctgacgcc gccgcccgcg 15960 cggccgcccc tcccccggccctcccctccc cccgccgtaa cgtcctgacg ctccgcaggg 16020 acccctgact ggacggcggcgcgtgagcgg agcgagaggc ctcgccgcgg gggggccgcg 16080 ggctcgccgg cgccgcttacctggggccgc gccgggcctg cttaggcacc cggcgggggc 16140 ggcggcgtcg ggagctgcggcggcggcggg cggcggcggc ggccgcgggc ttcgctcctt 16200 gttggggatt cggcggcggcggcggcgcgg gcgcgcgctt cctagtgacg caggcggcgg 16260 ggccgcgcac gcacggggctgggagggccg gacacttatt tggcgctcgc ggaggaggaa 16320 ggcggggccg tgaaataaggcccgacgggc cccggggcgc gtgcgcggac cgacactgtc 16380 agctcctaac gccgcaggttcctcctggtc cccgaggccc ccggtcgggc gttgcctgcc 16440 ccgcgcgggc ggccgggccgagggacgatg gtcagtggac ggacggcgcc agggagcagt 16500 gcccacgcgc ggcagggcggtaccttcagg cctccaggta cgggcgctcc tcgcccggac 16560 gctgctgtgt gtgaatgggcgcgaggggac tcccctgcgg ggcggacgcc tgaacacgag 16620 gctgtggagg aggacgctgtagggtgcgcg gactcacgcg gaacatgcca gaggctcagc 16680 cagccacggc gctcccagcgtggagggcga ggggcatccg ggagcggccg ggagggctcg 16740 gtcacccctc aagctgtcaccccagtccca caaccagcac cccgatccta tcgcagtccc 16800 acagccgaca ccccgatcccacccctgccc aacagccggc acccacccca atcccatagc 16860 taacaccccg gtcccaccgctgtcccacgg ccggcacccc gatcccaccc cagtcccgca 16920 gctggcaccc cgatcccaccccagcccaac agctggcacc caccccgatc ccaccgctgt 16980 cccacagccg gcaccccgatcccaccccag tcccgcagcc ggcaccccga tcccacagcc 17040 ggcactcacc ccgatcgcatagcatagctg ataccccgat cccaccccag tcccatagcc 17100 agcaccccga tcccaccccagtcccatagc cagcacctcg atcccataga tgacaccccg 17160 atcacgcccc agtcctatagcccgcacccc gatcccaccc gagtcccgca gccggcaccc 17220 catcccaccc atgtcccacagtcggcaccc cgatcccact cggatccggc agccagcttg 17280 gatcctgtgg ccctcctccagcccccaggg ctcatttata tgttttattg gcagaggctg 17340 gggctggctc tgttggcctctgtgctgggt ttcttcctct gcaccgcagg actggctctc 17400 ctgacctctc caggtgtcatcgaacaccct tgtgcttgct gtcacccgct gcctgtctgc 17460 aggatcccgg attccgtatcaggggaccga aattagtcgg aaaataggaa gcaggtgctc 17520 gcttggatgg aaccctgaccctgtgctcac acttgtagga ggagggctct gcaggccgcc 17580 tcccggaacg ggaggttcccaagccactgc acttcggagg ggctgtaatt agagttgcac 17640 attcattcag ttcccagtaaagtagaacgt gctccagcca gtgaggaaaa ggtgttttta 17700 aaaattagat tggccgagtgcggtggctca tgccttttac ctcaacactt tgggagacaa 17760 aggtgggagg atcacctgtggccaggagtt caagaccagc ctgggcaaca gagcctgtct 17820 ctggggaaga ataaaaaaaaaaattgagcc tttgtcagtg ctactatttt attatctggt 17880 aaatatgaga gggttcacgcggtctatgtg tgtcatttat ctgagtttgc ctatcgtcac 17940 gttttggaaa taaatgtcaataaagtcgaa gaggagtgct gaggggggcc tggggatggg 18000 agggtggcta catcatgcctgtgtgttgcg caagcccacc gaggtcggcc tggggtgagc 18060 cctggggcct gttctgcctccttcactctg gggctccaag agacaaactg ggcaacaaga 18120 gagaaactcc atctaaaaaaaaagaaaaat cacctccaag ataacttagc tttcttctgc 18180 tggcataaca aattatctcaaacttagtcg cttaaaaatg caaatttagg ctgagtgcgg 18240 aggctcacgc ccataatcctagcactttgg gaggccaagg caggattgct tgaggccagg 18300 agttcgagac caacatggccagaactgtct ctttttaaaa aatgcaaatg tgtccggcac 18360 ggtggctcac gcctataatcccagcacttt gtgaggccaa ggcgggcaga tcacgaggtc 18420 aggagataga gaccatcctggctaacactg tgaaaccccc tctctactaa aaatacaaaa 18480 aattagcctg gcgtggtggcaggcgcctgt agtcccagct actcgggagg ctgaggcagg 18540 agaatggcgt gaacccaggaagcggagctt gcagtgagcc gagatggcgc cactgcactc 18600 cagcctaggc aacagagcaagactccgtct caaaaaataa ataaataaaa ctgcaaatgt 18660 attctctaac tgttctgtaggtcggaagtc cagcccagcc tcactccgcc aaaatcaggg 18720 tgtctgcagg gccgattgcttttggagctc caggggagaa gctgttctgg cctttccagt 18780 ttctggaagc acttgagccccttgtctcgt ggcctatccc acacctgaaa gccagccaaa 18840 gccagttgag tcctcaccctgttggccccg acactgatct cctgcctccc tcatctgctg 18900 tcaaggcccc ttgtgatgacatggggccac cagctggccc agggcacctc ctgtcagagt 18960 ccgccgacca gtgaccttcattccatctgt cgctgtaatt cccctttgct tggaaccaac 19020 gttcacagat cccaggggttaggatgtgaa tatcttgggc agggctgtgg gggggctatt 19080 cttccttcta aaatatttatcatttttgtt ttggggattt ttttggtttg gttttttttg 19140 agacagagtc tcgctctgtcgcccaggttg gagtgcaatg gtgcaatctc agctcactgc 19200 aacctctgcc tccgggcagacgtgagccac tgcaccaggc ctgtttttgt ttttgtttgt 19260 tttgttttgt ttttgagatggagtctcggc cgggcgcggt ggctcacgcc tgtaatccca 19320 gcactttggg aggccgaggcgggcggatca cgaggtcagg agatcgagac catcctggct 19380 aacacggtga aaccccgtctctactaaaaa tacaaaaaat tagccgggcg tggtagcggg 19440 cgcctgtagt cccagctactcgggaggctg aggcaggaga atggcgtgaa cccgggaggc 19500 ggagcttgca gtgagccgagatcgcgccac tgcactccag cctgggcgac agagcgagac 19560 tccgtctcaa aaaaaaaaaaaaaaaaaaaa aaaaaaagag atggagtctc actttgtcac 19620 ccaggctgga gtgtagtggcgggattatag gtacgcgcca tcatgcccag ttactttttg 19680 tatttttagt agagacagggttttaccatg ttggtcagac tggtctcaaa ctcctgatct 19740 caggtaatcc acccgcctcagcctcccaaa gtgctgggat tacagacgtg agccaccgtg 19800 tctggccata tttattaactacaaagggaa agatgataat tttttttttt gagatggagt 19860 ctcactctgt cacccaggctggagtacaat agcgtgatct tggctcactg aaacctctgc 19920 ctcccaggtt caagcgattctcctgcctca gcctcccaac tagctgggat tacaggcgca 19980 cgctaccaag cccagctaatttttgtattt ttagtagaaa cggagtttca ccatgttggt 20040 gaggctggtc tcgaactcctgaccttgtga tctgcccacc tcggcctccc aaagtgctgg 20100 gattataggc atgagccactgcaaccggct gaaagatggt aattttaaag tagagaaact 20160 gggttggctg ggcatggtggcttatgcctg taagctcagc actttggaag tccaaggcaa 20220 gaggatcgct tgagtccaggagtttgagac cagcctggac aatatagcaa gaccccatct 20280 ccgcaaaagc taaaaagttagccaggtgtg gcggcacatg cctgtagtcc cagctactca 20340 ggaggctgac gtgggaggatcacttgagac caggaggtca aggctgaagt gagctgttat 20400 tgtgccactg cactcagcctgggcaacaga gcgagagtct gtctccaaag gtaaaaaaag 20460 gtccaggcac agtggctcacacctgtaatc tcagcacttt gggaggccga ggcgggcaga 20520 ttcgttgagg tcaggagttcaaaacgagcc tggctaaatg gtgaaacccc gtctctacta 20580 aaaatacaaa aaaattagccaggcatggtg acgggcgcct gtaatctcag ctacttggga 20640 gactgaggca ggagaatcatgtaaacccag gaggctgagg ttgcagcgag ccaagatcat 20700 gccactgcac ttcagcctgggcgacagagc aagactgtct caaaacaaaa caaaagaatc 20760 ttgagtcctg agttcctctaagggaaattc caggcacctc gccacccttg acaggcaaag 20820 gaacaatctg atgaggaagaagatagaaac agcttaaaca atagtctccc ggccgggggc 20880 agtggctcac gcctgtaatctgagcacttt gggaggccga ggcgggtgga tcacaaggtc 20940 aagagatcaa gaccatcctggctaacatgg tgaaaccccg tctctactaa aaatacaaaa 21000 aattagccgg gcgtggtggtgggtgcctgt agtcccagct actcgggagg ctgaggcagg 21060 agaatggcgt gaacccaggaggcggagctt tcagtgagct gagatcgcgc ctctgcactc 21120 cagcctgggc gacagagcctcgagactcca tctcaaaaaa aaaaaaaaat tagctgggtg 21180 tggtggctca cacctgtaatcccagctacg tggcaggctg aggcaggaga atcgcttgaa 21240 cctgggaggc ggaggttgtagggagctgag atcgcaccac tgcactccag cctgggcaac 21300 agagcgagac tctgtctcaaaaaaaaaaaa aaaaaacaaa aaaacaatag tctcccaagt 21360 aagtcagagt cacaaggtgttttgattccc tgtggaaact aaaatataac agcttaacat 21420 atgttcttga gttatttttcagaaacttgg acatccacca ggtggaaaat gctgagctag 21480 gaacagtggc tataatttcagccttttgag aggccaaggt ggaaggatca cttgaggcca 21540 ggagttagag accagcctggccaacatggt gaaaccccgt ctctagtaaa aatacaaata 21600 ttagctgggc atggtggtgcaacctgaaat cccagctact tgggagacct agctgggagg 21660 atcgcttgaa cctggtaggaggagtttgca gtgagctgaa attgtgccac tgcactctag 21720 cctgggcaac agagtgagactctgtctcaa aaaataaata aataaaaaga gaaaaaagtg 21780 ttgcctgcag gccgggcacagtggctcacg cctgtaatcc caacactttg ggaggccgag 21840 atgggcagat cacctgaggtcaggagtgca agaacagcct ggccaacatg gtgaaacccc 21900 atctctacta aaaatacaaaagttagctgg gtgtgtacat gtagtctcag ctacttggga 21960 agctgaggca ggagaatctcttcaaccggg gaggtggagg ttgcgatgag ctgagatcac 22020 gccaccacac tccatccagcctgggtgaca gagtgagact ccatctcaaa gcaaaaaaag 22080 aaacataggt gggacccttggtgtgtcctt agggcatgat ggttgaggta tactgctggt 22140 cctgtcatgt aaaagaaaacgagccgactc tgtgtctact ggagaaagca ctgcatatat 22200 cagccacagt caatacctcgcttctgcagg gacggtggct gccagagtgg gaggctttgg 22260 tagcacccat gtcgtggaatcacaatgttg tcgatagctc tggggtcttg tacaaaatgc 22320 cagatcctcc catttggtttccttatggga aggatcgcag tactataata catgggcttg 22380 tgcaagggat cattatacccttttctcttt ttttgctttt ctttgagaca gagtttcact 22440 ctcgtcaccc aggctggagtgcaatggcgc gatcttggct cactgcaacc tccacctcct 22500 gggttcaagt gattttcctggctcagcctt ctgagtagct gggattacac atgcccgcca 22560 ccaggcctga cttatttttgtatttttagt agagacaggg tttcaccaag ttggtcaggc 22620 tggtcttgaa ctcctgacctcaggtgatcc acccacctcg gcctcccaaa gtgttgggat 22680 ttcaggcata agccaccaggcccagccttt ctttcttttt aaaattaatc tttgtttaaa 22740 aatactctca ttttttatttaattgtagca ctcctagatc ccgaaagcag atacactctt 22800 gttatgggtc tgattcttttcattgcttca cgccttagag gatattgtcc aatactggat 22860 aaaagtttac tcaggtctacttccacttta acggggatgg ctgaatatct cttccacttg 22920 gctgtttgtt tataatgaactgacaaacat acaaattttc ttgagttctg tgagacattc 22980 tagtaaatca tctaacctgaagagcaggtt gtgagaaccc ctgatttaga aagcccagtg 23040 gtcataaata taagtggctctggactggct cccggggtct gaagtgtggg cagtcggtta 23100 ggattgagcc cttgtaatttgtaggatctg acacacactc caggaaggca gtgtcagaat 23160 ttacctgtat tatattggacacccagttag cgtttggaga attggttgct ggtatagaaa 23220 aataccaaat attttatgtcaggggagtga aagaaaaaac aaaaacccgg ccgggcgcgg 23280 tggctcacgc ctgtcatcccagcactttgg gaggccgaga cgggcggatc acgaggtcag 23340 gagatcgaga ccatcctggctaacacggtg aaaccccatc tctactaaaa atacaaaaat 23400 tagccgggcg tggtggcgcgcgcctgtagt cccagctact cgggaggctg aggcaggaga 23460 atggcgtgaa cccgggaggcggagcttgca gtgagcccag atcgcgccac cgcactccag 23520 cctgggcgac agagcgagactccgtctcaa aaaaaaaaaa caaaaaaaaa aaacaaaaaa 23580 aaaaaaccca tacactttaaggaaagcaac tgacagcatt tgttaccagt gataaaattt 23640 gagctttgaa gtaagaataacaattttgcc attgtgcccg ggccaagaaa aaaaaaagaa 23700 ttttgccatt gtgaaaggcttcccagtact ttctgatgag cttgacggtg atattaacaa 23760 ataacttttt ttttttttttttgagatggg gtcttgctct gtcacccagg ctggagtgca 23820 gtggttcaat ctcagctcactgcaacctcc gcctcccagg ttcaagcgat tctcctgcct 23880 caacgtccca agtcgctggactacaggtgt gcgccaccac gtccagataa tttttgtatt 23940 tttagtagag atggggtttcaccatgttgc ccagactggt ctcaaactcg tgacctcagg 24000 cgacccgccc acctcggcctcccaaaggtg ggaggccttg ctgggattag aggtatgagc 24060 cgctgcacct ggcctcttgtccttgtgttt tgcagtgatg caatgaccat gtcttacatt 24120 tgcaaccaga aaaaaaggttagtgtaacaa tgtttatcct gtttttccca gagtagacat 24180 tatgaagatt aaaaaaatttgaaagtgttt tgaatataat aaactatgct atacacacaa 24240 cattttggtg actagaaatacaagtttatt gtttgttgtt tgttgagaca gggccctgct 24300 ctgtctccca ggctgggtggcacaatcatg gctcactaca gtcttgaact cctgggctta 24360 agcgatcctc ccacctcagcctccagagta gctgggactg caaacgagca ccaccacgcc 24420 tggctaatat ttgtattttttgtagagatg gggtttcacc atgttgccca gactggtctc 24480 aaactcctgg gctcaagcaatgctcctgcc tcggcctccc aaagtgctgg gatcacaagt 24540 atgagccact gcacccggctgagtttctgt tgttttaagc cgcttcattt gtggtacttc 24600 ttacagcagt cccaggaaactgagcaactg cagaacatca aaattgtttt tcttcagcaa 24660 aaggagaagc acttgtggttggcaccagct tttcctgtgc tcacttctgc atggccgcac 24720 ctttgcccga cacgagtgcacagcaggctg tgggggagca actggttgag tcaggcctcc 24780 acttgtgccg tatccccacctgctttgctg gacacccctg tttggggggc acccactgct 24840 gccccagaca ccaagcaagcaccagctgtg tccaaaactt acagtcactg tcttggcccg 24900 ttttgtgctg ctgtaacagaatgccacaga ctgggtaatt taatacagaa cagaaattta 24960 tttcctcaaa gttttggaggctgggaagtc caagagcaag gggccatcag gtcagggcct 25020 ggtctctgct tccacgatggcaccttgacc accgtgtcct cacgtggtca gagagagccc 25080 actcccagga gcccttttaatagagcagaa cactgctgcg ctgcggttaa gtttccaaca 25140 cgtgaacttc ggaggtgacacattcagatc atagcagtca ctctaggcag agtgtctgat 25200 gtggttttaa aatacgttcacagactggcc gggcactgta gctcacgtct gtaatcccaa 25260 cagtttggga ggccaaggtgggtggatcac ctgaggtcag gagttcaaga ccagcctcac 25320 caacatggtg aaaccccatctctactaaaa atacaaaatt agccaggtgg tgcatgcctg 25380 taatcccagc tactcgggaggccgaggctg gagaatcgct tgaatccagg aggtggaggt 25440 tacagtgagt cgagatcatgccattgcact ccagcctggg caacaagagc gaaactctgt 25500 ctcaaaaaat aaaataaaataaaatacatt cacaaggccg ggcactgtgg ctcacgcctg 25560 taatcccagc tacttgggagactgaggcag gagaatcgct tataacctgg gaggtggagg 25620 ttgcagtgag ctgagatcacaccgctacac tctagcttgg gcaacaagag tgaaactccg 25680 tctcaaaaaa gtaaaataaggccctgcagg catggtggcc cacacctgta atcccagcac 25740 tttaggaggc caaggcggtcggatcacgag gtcaggagtt cgagaccagc ctggccaaca 25800 tgatgaaacc ccgtctctactagcctagcc aacatgggga aaccctgtct ctactaaaaa 25860 tacaaaaatt agccgggcatggtggtgcgt gcctgtaatc ccagctactc aggaggctga 25920 ggcaggagaa tcgcttgaacccaggaagca gagggtgcag tgagccaaga ttgcgccgct 25980 gctctctagc ctgggcgacagagcgagact ccatctctaa ataaataaat aaaataagaa 26040 aataaaatat gttcacaaatcctttgacat tcctcacctc aaaagctgga acccaactcc 26100 ctcctaagca tgagtcttctcagtgactca cttctaacag cagaacttac atggttcccc 26160 acacccagag gacattgggttcctcccaat atccccccac ccagcgaccc ccacccaggt 26220 cgctggcttt gggtcccccagagccatgtt tcaaggacac tcaggcagcc cctggatgtc 26280 catgtggtaa ggaatgaaggcctcctgcct gcagcctcgg gagggagcat tctcagaaga 26340 ggatgcccca cctcctgcccagccttcaga tggccaggac ctcgtccaac gtcctgactg 26400 caacatcatg agagactccgagccagaaac ccccaggttt tgtactcctg acttatggga 26460 actgacagat aatgttcgttgttaattaag gggtgacttg tcacacacaa taggtcacta 26520 aacagctctg tctggcctcccaggaggagc ctgcctttcc ttttcttcat gggaaaagtg 26580 cgatcagttt gtgaaggaatgtccgccccc acttgatgcc agaggctcca catggtgact 26640 gtcataaact ccatctgccctcagtgcctt gccagcaccc ggcctgcgat cagcttggtc 26700 ttgcgggagg ccaaggcccacgtgtgtttg tgtgtggtgt ctgtgtctgc gtgcccatgc 26760 atgcccaggg tacagggatgccatatacaa attctttcaa tgttgtatgt ggcatgtgtg 26820 tgtctgtatg cccaggatacagggatgcta tatacaaact ctgttttttc gttttttttt 26880 ttttgagaca gagtcttgctgtttcgccca ggccggactg cagtggcgct atctcggctc 26940 actgcaagct ccacctcccgggttcacgcc atcctcctgc ctcagcctcc tgagtagctg 27000 gaactacagg cgcccgccaccacacccggc taattttttg tatttttagt agagacgggg 27060 tttcaccatg ttagccaggatggtcttgat ctcctgacct cgtgatccac ccgcctcagc 27120 ctcccaaagt gctgggattacaggcatgag ccaccacgcc tggcctacaa actctttctt 27180 tttttttttt ttttttttgagatggagtct cactgtcttc caggctggag tgcagtgatg 27240 cgatctcagc tcactgcaagctccacctcc cgggttcatg ccattctcct gcctcagcct 27300 cccaagtagc tgggactacaggcacacacc accacgccca gctaattttt tgtgttttta 27360 gcagagatgg ggtttcaccatgttagccag gatggtctcg atctcctgac ctcgtgatcc 27420 gcccgcctcg gcctcccaaagtgctgggat tacaggcgtg agccactgcg cccagcctgc 27480 aaactctttc aatgtctttcttttctctct cctgccatct tctcccttgc agatttcttt 27540 tgtctctacg tcttccccagctgagtccga ggtcctgact tgcccacgct ccctggactg 27600 gaggagaggt gatagcaagagctccttcaa gcccaggaat gccaccaggg ctgccccggg 27660 agaggaggaa gctgggtctctcggggttgt ggggaccaga cacccttcta agacatggac 27720 tcagcacaga aagtctagacatccactaca aacacatctc cctcctaaca gggggcccct 27780 gggcacccca agtggctgtttggtgggaca ggcatgtcca tcagtcagaa tatctttatt 27840 ttttattttt tattttttatttttgagaga gtttcactgg agtgcaatgg cacgatctca 27900 gctccctaca acctccgcctcccaggttca agcgattctc ctgcctcagc ctgccacgta 27960 gctgggatta caggtgtgagccaccacacc cagctaattt tttttttttt tttttgagat 28020 ggagtctcga ggctctgtcgcccaggctgg agtgcagagg cgcgatctca gctcactgaa 28080 agctccgcct cctgggttcacgccattctc ctgcctcagc ctcccgagta gctgggatta 28140 caggcatgag ccaccgcgcccggccaattt tgtattttta gtagagacag ggtttcacca 28200 tgttggtcag gctggtcttgaactcctgac ctcaggtgat ccacctccct cggcctccca 28260 aagtgctggg attacaggcctgagccacca cgcccagccc agaatgtctt cttacttttt 28320 attactctgt cccccatcctgggtccagac ctgtgaccgt gaacaaccgg ctgcccaggg 28380 gtgaatgggg tgagtggggtgagtccacag aacagtgggg tgcagcccca ggggtctcgt 28440 agcacctgcc cccaggtcaggaagtcccac agcctagagg ctccagcctc agatgcatac 28500 atatgtaggc cctgccctttcctcctgagc ggcgggccac agagtcctga acaacaggaa 28560 gcccctgagg agggctccgccctgagggag ggcaggggag cccccgccag ccccacccac 28620 agcagcgggc cctgccaccccccaccctga cacctcaccc cttggattcc agagaggaaa 28680 gtgggcttgt gtgtagtttacatgctcata tcttaaaatc accgttgtca atagaacaat 28740 tcataataat gatgataaaataagatttat aaccagcttc agtctggaga tacacacaga 28800 gcagatcttc actcccagacagggagcccg cagctgcccc cgaccccaca ggtgcaggac 28860 acacacagac agttcaaccatgtcttaaac acacaggtgt ttatttaatt gttcatttga 28920 ttgaattttt aagttcactttactacgtgg atgagatggg tgcatattac agtaggcttt 28980 cgctatgagc gctgccaccatgaggaatat cccagccctc agttctgctt ccctttctga 29040 gtcccacaaa agccagatgtggacagcctt gggttcccat cccagctggc tgctccttct 29100 ggggctgtct tggtggggagagggagatgg ggcagtgggt ccctgctgac ccctgagccc 29160 tgcaggggtc aggatcctcccgtggtccct gggtgtggct ctggaagaca ctggcagtgc 29220 ccggccaagg cctcccgcaggatggaagtt gagggccctg gctctgggtc ctaagagaac 29280 tcagccgccc ccttcacactttacagcaag gggccaggca gcagctttgg gatggggctt 29340 ccgtggagaa gtgggggatgctgcagtggt acaaagacag cctcccccac cgccatcctc 29400 cagctgaccg tcctccaaggccagcactgg gcgtccaagg gaaagaagga actcagccca 29460 gagggtgtgg gcaggagaggcctggagtca ggcctccacc cacagccccc tctgggtgcc 29520 aagtgggaag ggtgttggggctggcttggg aaccttaccc gctgcccttc caacacctgg 29580 atctgtgggc agcggtcccacaaaatcccc cttggggctc cctgaggagg acttgtggct 29640 gccgcttcca ccagggcagagggcacagga ggggccagca ctccaaaggg ctctagggtg 29700 ggtctttcaa ggacatctgcaaagccctgg tggggagggg cctgggccag aggctctttg 29760 gaactcttgc acttctgagtgggggactgt ccatgctgcc cacaacctct agaccatgca 29820 gcctgctcat gggtccctggcagagaatgc ccactcccca gcagactcag ggcaggcccc 29880 caactgcagg cttccaggaaggcccagggt gtccacctca cgccaggtgg tctcagagga 29940 cccctgtgca accacattaaggaaagctgc agcccccacc cacccgcctg ccagttcaac 30000 aagcaccggc tgcacacgcaggctcccagg caccatcacc cccctccccc gtcgcccctc 30060 cctcacgggg agccccttccccctggaaag acagcaggta ctgtagcctc gcctgctggc 30120 caggggcgcc ggctcagaggacctgccctg acctgcacgt gctgaccaga cagcccagcg 30180 taaggacccg cgatcccacgccaccgccct gggtttacca cggtcaccac cacctctctc 30240 acagggcccc cgggggacccagccgcgccc ggcctggtgt ctgcaccgag ggaccgcgtc 30300 tcacgcccgg cggctcctgcaggggaagcc gtggtcagcg actcaccacg aggacagggc 30360 agggcggctg agtgcggaagagaagcatga agctgggggc gggggtgggg gaggaggaac 30420 aaaagttgca tctagacagaggtgaacgaa acaaaaccaa aacccgaacg tgttccgtcg 30480 caggatgggc gccgcccgtcccgggccctt agcccgacat ctcttctcgc tgctccttgt 30540 tcctgcgcac ctcggccgcgtgcagctcct gcaggacagg gggcgggagg gcctgagggc 30600 gggggtggct tggggcgactccgggaaccc ccaggcgcgc aggccgtggc gccctggcac 30660 ccgcccggcc tcatccgggctggccttcgg caggaccctg actgagttga gggggcggga 30720 gcaccgggga ggcgcagagcaaggccaggg accaaggacg ggtttcctgg gagctggctg 30780 ggccccgctt ctagctcgtaccggagccga gcttccttca gggcactttc aatataatga 30840 atttagccat ctattactgcggctagttac tgtcccgcca ggaccagact ctggacctgc 30900 ctcgtgcgct gctggggacgcccagtaaac acgggaggag cccccgaccc ccaccccagc 30960 tcagcgcctc ggagtccccggccccgctct gcgcccctcc gagctccgcc ctagccccgc 31020 ccccgcccag tgccccgccccctgcctgct gctagccctg cccccgcccc ggcccctgcc 31080 cgctccgagc tccgccctggccccgccccg gcccctgccc gctccgagct ccgccctggc 31140 cccgcccccc gcccagtgccccgccccctg cctgctgcta gccctgcccc cgccccggcc 31200 cctgcccgct ccgagctccgccccggcccc gccccggccc ctgcccgctc cgagctccgc 31260 cctggccccg cccccgcccagtgccccgcc ccctgactgc tgctagccct gcccccgccc 31320 cggcccctgc ccgctccgagctccgccccg gccccgcccc ggcccctgcc cgctccgagc 31380 tccgccccgg ccccgccccggcccctgccc gctccgagct tcgccccggc cccgccccgg 31440 cccctgcccg ctccgagctccgccccggcc ccgcccccgc accttctcgc gcagccgctc 31500 gcgcagtgcg gccaggtgtgcctcgcggat ctccttgctg agctccatct tgtagttgag 31560 cttctcctcc gcctggcggctgaagttgtt attctcctcc agcgccttgt gcagcacctc 31620 gcgctcgtgc tcgcgccgctccgccagctg cttcagcacc tgcgcctcct gcgtctgtgc 31680 ggggccggcg ggcgcgcgtgagcggcaacc ccgggccctg cccggccgga ctcctccctg 31740 ctctccgcct cccgcccagcgcccgctcgc ctcacctggc gcctccacct gcccaggcct 31800 cggtgggcgc cgggacccccgggcgctgcc ctgggaaccc tcgcctgcca tccggcctgt 31860 ggtcggggca gggccagggggtcgcgatcc gccgcccccg cccccgtccc tgcctcgcgc 31920 gcgggtcccg cggtcctggctgcgcccagg gcccccgcca taccctgccg ccactgcaca 31980 ccctgccctg cgcgtctgcccctccaagga ccagcagcaa gaaaccctaa acttgtgggc 32040 ggtctctgag ctttgtctcttcctcggaca tccgcccact gagcagagta gctgcttgtt 32100 acacaccggg ttcccagctcccaattaggt gcccaggagc ggagggtccc cagggatgct 32160 gggggagggg ccggctggtgacccctggga ggagagcggg gcagcaggac ccgcacccac 32220 atgccagtcc ctactagtcagccctgtgaa ccctggtctc tggcctcacc gggaagggaa 32280 cggagccgct tcccctgcccaatgcgttgg cctccagggt ggcaccccca aaaggacatt 32340 tttatctctg tttcagtctcagaggggctg gtgggagggg aggctgcagg gaggggacct 32400 ggagcccaca cccacctctcccagggcccc tccgccctcc agcaagcctc agggtcttca 32460 cacatgaggc ccttcctccagcttccctgt ctgggagagg gatgccccac ccgacgtccc 32520 cagggcccat ctggggaccaccccctagca tcctgctggc cctgacaagg gtgcctccca 32580 ccctcaccag aggctcctgctccttccagg tggccgcctc ggaacccttc ctcctctcca 32640 tccctttctt tttttgttcttgtttgtttt ttgaaatgga gtctcaccct gtcgcccggg 32700 ctgaggagtg cagtggcgcagtctcggctc actgcatcct ccacttcttg ggttcaagca 32760 attcccctgc ctcagactccctagtaggtg ggattacagg tgtgcaccac cacacctggc 32820 taattttgta tttttagtacagatggggtt tcaccatgtt ggccaggctg atcttgaact 32880 tccaacctca agtgatctgcctgcctcagc ttcccaaagt tctgggatta caggcgtgag 32940 ccaccacacc cggcctctccccatcccatt cttatctctc agaaagaggc ccagggagcc 33000 acagcccctc ctgctccaggccaaggcact gaccaagcct gtccgggagc accctgcttc 33060 ttgcaggccc tgtccccgtgggccgcctcc gttgaaactc ctggggggtg ggggatggag 33120 gactccttgc cttcctccgctcctcggctg cctccagccg cttttgcagc tcctccaggg 33180 aggtgtcctt cttcttgggtggggaggaga gcatagggct ctctggggac aggtcagaag 33240 gggacttgag gatgacctcgaagctctggc ctgaggcccg cttgtccagc tgcttcacct 33300 ccatgtctgc agggcaagaccagagtagag cttcagaggc ccggccaggg catggcgtgg 33360 gctgagcggg atgctcccagcacacatcca accccagggc tgggcgagag ggggtggctg 33420 ctcccgcagg aatcccaggcttcagccccc aggatgggcc ccttccccct agaacctccc 33480 tctccagagg cagccaggacgggagttcag agagactgcc ggaggccggg ggaaaaggtg 33540 aggtgggcag gcaccgcagggaagggcagg cggcagccag gcactcaccc ccgtactggt 33600 agacggtatt ggggtgcggctgtgtgtaga agcaggagca gatgagcgac agcaccgaca 33660 gctccttcat cttctccttgtaggctgtgg gcacaaggct gggctgagca agcaccactg 33720 gggcctgccc acctgggcccccgttttccc tccccatggc tgcctctatc atgtctctgt 33780 gagacacgga gctgcccagcacgctctctt gtgtgtctcc acaccgccgg ccccttcgtc 33840 tctccagctc tctcgcttccagacgtcggc actgtctccg tggtgtgtcc cctgccttct 33900 gtctctctcg ccctctgcctctccccgctt ttcctctctc tcggcattaa tgtctgtctc 33960 atcttccaca ctgacttgtttctccatcct tctcctgcct gctgtggtct gaatgtttcc 34020 attacccaaa actcatgtgttgaaatcgta accccaaggt gccggtgtgc ggaggtgagg 34080 cattcggagg gaattaggccatgaggatag agccctccta agtggcccca gagtggggct 34140 tcagagaact ccctcaccttccatcatgtg aggacacagc cagaagacgc cacccgtcta 34200 tgtaccagga ggcgagacctctccaggcac cgactctgcc ggcaccttga tcctggactt 34260 tctggcctcc agagcgatgggaaataagtt cctgtcgtct ataaaccact cagtctcagg 34320 tacctgccca gactgacaaagtggctaccc ctgcctgtct gggtctctgt ttaccttctg 34380 tgtgtctgac tctgtcactgtcattgtatc tttctgtgtc tctgggggta gcccctgact 34440 ctgtctttct ccctgagtgcatctttctgt gattccttgt cactgtgtgt ctttctgact 34500 cttacctccc tctgtcccgctacttctctc tcccctcctc ctccttccca ctcctcgcca 34560 gctcaagcag gcaagatttactcatgacgg gaccagcaca gatgcaaacc ctctgtgggc 34620 aggactttct tgggctgtaaacctggatga agccctcaga ccctcctttt tccttcccaa 34680 tgattgtgtg gtcaccttgagatgaaacca ggccctctcc aggcacatgc tctctgtcta 34740 tctagggctg ggcttgggccactgatgcca ccaaggagca agggagggaa gctgtccgtt 34800 cagcaccaca gccagccctcttgcccattc aggtcaatca agtgcccacc agccagtgtc 34860 cctgctgccc aacccaaaccagaagcaagc cgggctcctg tggccctgtg ccctgtcagg 34920 ggaagaggaa ggcgcctgctgtcacagtga aaataattta gctcttttgg tctattcagg 34980 gcgaacctca ttcctaagcagacacgctgg cccggtttct cactagtgct cgataatcct 35040 tttggctggg tgcagtggctcatttaactg taatcccagc actttgggag gccaaggcag 35100 gtggaacacc tgaggtcaggagtttgagac cagcctgacc aacatggtga aacccgatct 35160 ctactaaaaa tataaaaattagccaggcgt ggtggcaggc acctgtaatc ctagctactt 35220 gggaggctga ggcaggagaatcgcttgaac ctgggaggcg gaggttgcag tgagccgagg 35280 tcgcgccatc gcactccagcctgggtgaca gtgtgagact ccgtctcaaa acagaaagaa 35340 aaagagagag aggaagaaaggaaggaggga gggagggagg aaaagaagaa aggaaaggaa 35400 aggaagacag acaaggcagaagtaatcaag cctttcatgg tgagctgggt cttctggtga 35460 cagtgcagag aatggtctgtcctgacttaa atttcctggt gacctacact tttctggaca 35520 gagcagcaca gagcccaagagggtgtaagg aggagcagaa aggaatccca gggtgggcag 35580 gcccgtgcga gagcctttgggggaaggaat gagactttga gccgggaagc gaggcaaagc 35640 tacctgtctt ggtcattgtcttcagggagg gagatggagg gggaccaggt gggggagcct 35700 cacaggggac tttggtctgacttgtcaagt tttctttttt tctttttgag atggagtctt 35760 gcactgttgc ccaggctgcagtgcagtggt gcgatctcgg ctcaccgcaa gctccgcctc 35820 ctgggttcac accattctcctgcctcagcc tcccgagtag ctgggaccac aggcaccgcc 35880 accacaccca gctaattttttgtattttta gtagagacgg ggtttcacta tattagccag 35940 gatagtctcg atctcctgacctcgtgatcc gcccgcctcg acctcccaaa gtgctgggat 36000 tacaggtgtg agccactgtgcctggcctac tttatttttt agaaacagga ctgtgctctg 36060 ttgcccatgc tggagtgtagggtgcagctg tgcggttcac tgcagccttg aacttctggg 36120 cttgacggat cctgccatcttagcagctgg gactacaggt gcatgccagc acaccagttt 36180 tctttttttt tttatctctgctcactgcaa ttccgcctcc tgggttctag cgattctcct 36240 gcctcagcct cccaagtagcagggattaca cgcacatgcc accacacccg gctaattttt 36300 gtatttttag tagagacagggtttcactat gttggtcagg ctggtcttga gccaccgcgc 36360 ccgcccggcc tacacaccagcttaaaaaaa agaaaaaaat agctgggcgt ggtggctcat 36420 gcctgtaatc ccagcactttgggaggctga ggcaggcaga tcacctgagg tcaggagttc 36480 aagaccaacc tggccaacatggcgaaaccc tgtctctact acaaatataa aaatcagcca 36540 ggcgtggtgg cgggctcctctaattccagc tacttgggag gctgaggcag gagaatcact 36600 tgaacccggg aggtggaggttgaagtgagc caagatcgag ctactgcact ccagcctggg 36660 agcaagactc ccgtctcaaaaaaaaaaaaa aaatttgtag tggtatggag gccgggcatg 36720 gtggctcacg cctgtaatcccagaactttg aggggccaag gcgggcagat catgaggtca 36780 ggagttcgag accagcctgaccaacatgat gaaaccctgt ctctactaaa aataacaaaa 36840 attagccagg catggtggcgggcacgtgta gtcccagcta ctcgggagac tgagacggga 36900 gaatcgcttg aacccaggaggcagaggttg cagtgagctg agatcacgcc actgcactcc 36960 agcctgggtg acagagtgagactctgtctc aaaaacaaac acaaacaaac atatatatat 37020 atacatgtat atatataatatatatatacg tatatataca cgtgtatata tataatatat 37080 atacgtatat atacacgtgtatatataata tatatacgta tatatgtata tattaatata 37140 tatacgtata tatacacgtgtatatattaa tatatatacg tatatataca cgtgtgtata 37200 tattaatata tatacgtatatatgtgtgtg tgtgtatata tatatgtata tatatatata 37260 tatatacata tatatatacagagagagaga gagtagtgat aggtcttgct gtcttgtcca 37320 ggctgatctt gaactcccggcctcaagaga ccctcccacc tcagcctccc aaagcactag 37380 gattataggt gtaagccacagtacctagcc tattaaaaat taatgttaaa caagaggatg 37440 tgatgaggga gttagagggtgtgccagcca tgtgttccac agcagcaggt caggagacat 37500 tggggacatt tagaggagctgaagaggtgg ccaaccctgt gctcaggagg acgggggagg 37560 gagagagcaa gagggagtttgggctggggc agaacgtacc tgggtcctga gaggataaga 37620 aggtagggac ttggcccctccaggcctgac tctgccagca accagctccc tatcagcaga 37680 ctccaggccc ctacccttcagctcatcctt ccttatcaca catccaaaac tctgaatgtg 37740 gccgggcgca gtggctcacgcctgtaatcc cagaactttg ggaggctgag gcaggaggat 37800 cgcttgagaa caagagtttgagaccagcct aggcaacatg gtgaaacccc atctctacta 37860 aaaatataaa aattagctgggtgtggtggc acatgcctgt tgccccagct actcaggagg 37920 ctgaggcagg agaatcacttgagcctggaa ggcggaagtt gtagtgagca gagattgtgc 37980 cactgcgttc cagcctgggcaacacagcga gactctgtct caaaaaacaa aaactggaat 38040 gtgtttacca taaaggccagaaaatgtgat taacagctgc tcaaagcccc tgtctgccct 38100 aagcctgaaa ttttcaccgaaaaaaagatc tgtaggctca tacagaggaa ggacaaacac 38160 cagggaggct ctcttccagtttgcttcacc tcagcaagca gacggctggc agcaatttgg 38220 gggcaggtgt gagcacctgcatcatcagga aagaaggggc acggtgggga cgcaggtcag 38280 acctctcaca ggtcttggctctgcccagga gacacgtgtc caactgagag gtgaggaact 38340 gggttctgca gctgcagacacaggtgcggc tcagcatctg atggccacgg agaccccctg 38400 gcttggcttc tcccagctggtggcccatga ggagcttcta tcccaagaga ctgtccctca 38460 aggagcaagt gggaccaggtacccacagga cggagcctgg gagtgaggcc tgccctgtgg 38520 tctggctaca gggaggaagggcagattgga gggggcagga cagcaggtca ggaattggcc 38580 aactctggag agagcaagcaaggggaagtc tgcgcacagg gcagggctgg tcaggggcga 38640 ggcagggcat tggaccagtattttcagagc tggtgaggct taaagagcat gtctactgcc 38700 tcttattaca gagagaggatgccgaggccc agacccatcc aggccacctc tccacagaca 38760 cagctggtgc cagggaagcccctcccagag cctcaaggca ttgctccctc tctctctctc 38820 tttttgtttt tttggagacggagtctcact ctgtctccca ggctggagtg cagtggtaca 38880 atctcggctc acggcaagctccgcctcccg gattcacgcc attctcctgc ctcagcctcc 38940 cgaatagctg ggactacaggcgcccgccac cacgcccagc taattttttg tatttttagt 39000 agagacgggg tttcactgtgttagccagga tggtctcgat ctcctgacct tgtgatccgc 39060 ccgtctcagc ctcccaaagtgctgggatta caggtgtgag ccaccgcgcc tggacttttt 39120 ttttttttta agacggggtctcactctgtc acccaggctg gagtgcagtg gcgcgatgtc 39180 ggctcactgc aacctctgcctccccagttc aagtgattct cctgcctcag cctcccaagt 39240 agctagaatt acaggcacatgccaccatgc ccagctaatt ttctgtattt ttagtagaga 39300 tgaggtttca ccatgttggccaggctggtc ttgaactcct gacctccggt gatctgccca 39360 cctcagcctc ccaaagtgctgggatgacag gcgtgagccc ccgcgcctgg ccccccgcag 39420 tgctgggatt acaggcgtgagcccccgcgc ccggcccctc cctctctttg actcccttct 39480 ttctcaccgc cccctccccaccatccttcc ccttcactga cttcagggag ttaaaaacaa 39540 ttctcgcagt gagctgggcttgttttgtct ccctgcttct ctttgtacta aacattagat 39600 accgaggaaa tgcggattggcctttggatg attcatgagc aggagtcaga aaaaggcacc 39660 aggttggcct caagcagcagggtatagtag tgcccgctcc cagggtcaca cctcacgccc 39720 acccctcccg ccgtccaggtggatggtgcc cactcccagg gtcacacctc acgcccaccc 39780 ctcccgccgt ccaggtggatggtgcccact cccagggtca cacctcacgc ccacccctcc 39840 cgtcgcccag gtggatggtgcccactccca gggtcacacc tcacgcccgc ccctcccacc 39900 cacccgggtg gatggtgcccgctcccaggg tcacacctga cgcccacccg ggtggatggt 39960 gcccgctccc agggtcacacctcacgccca cccctcccgc ccgcccgggt ggatggtgcc 40020 cgctcccagg gtcacacctcacgcccaccc ctcccgccgt ccaggtggat ggtgcccact 40080 cccagggtca cacctcacgcccacccctcc cgccgcccag gtggatggtg cccactccca 40140 gggtcacacc tcacacccacccctcccgcc cacccgggtg gatgccctta tcagctctcc 40200 ttctccttct ctttcgtcttcttcgtcttc ctcctcttct ttcttctttt tttttttttt 40260 tagaaagagt ttctactcttgctgcccagg ctggagtgca atggcacaat ctcagctcac 40320 tgcaacctcc ctctccccgggtcaagcaat tatcctgcct cagtctccca gattgctggg 40380 atcacaggag tgtgtcaccacacctggcta attttgtact tttagcagag aggggggatt 40440 tcaccatgtt ggccaggctagtctcgaact cttgacctca gtttatccac cggcctcagc 40500 ctctcaaagt gctgggattacaggcatgag ccaccctatc tgcctcactt ctacagagga 40560 ggaatgaagg ctcagagagggcaagcattc cacccagcat cacacagagt gccgggtgag 40620 agcccagtca tgagcctgggcctgactgca ggctcctgtt gggagctcgc ggaggtgggg 40680 gatctgtcca gaactgagaggccaggggac cacagtggcc tctgacccct ggagggccct 40740 ggaggctgct gccggctccccccgggggca gatggaggtc actgtcaccc aggctgcttc 40800 tcatggtgcc aggagcacagcatggcagga gccaccagcc gatttgcctt tccctgggca 40860 ggaaactcag aaatgtggctaccacagtca ggctgcttga cgtgcggtga gcactcatct 40920 cttagcaggc aagcggccaagcacctttcc tgaaatattg aggcctcaga acaagcccca 40980 ggagaggtgc cagcaccgtcatctctaccc agataaggag acccaggtcc tgagaggtta 41040 ggcagctcgg acaacaccacacagctggag gaggtcagac tctgggttgc agaaggagaa 41100 tgtgagcaga ggccacaaaagagcgaggag ccagtgccca gatgccgaga tgccctcgcc 41160 ctcccagctc agccccaggaaccgagccca tggggaggga ccgtcaggga aaggctgtca 41220 ggaagggcag gaggcggccctggagaggac ggcgctgccc tcaggggcag gaggggagtc 41280 ccctccgctg agagcccccccacccccagt atccccgggg gtgtccagga ggaggcggag 41340 ggaggaagcg cagatggacaggactcccag atagggtggg gaggtgtggc cggtgacaca 41400 cacggtcccc tcctggcaggtgctgaagtc acctggagcc tccaagcccg tggggcctga 41460 ggggcggggt caggtcgggcacgcgtgggt gggcggagtt ctgcgccccg ggccaaggcg 41520 cccgagttga accagtcagctcgggagagg gaccgcggcg acctgtcccg ggggcgtaag 41580 aaaaggtggg agggagtgcggctcgtgaac gggggcggcg atgggaagga ggtgcggccc 41640 ttcgtcctgt cctcccaaacgtcgagtgaa aaacgaagcg ggttctgcgg cctcgcggcg 41700 gagcagagcg tttcgggaagggcgggccca gcgtcctcgc gcccgaggtc gcccggcagc 41760 tcccctgcgt ccagaatccgccccccgccc gggcctgcgc ccgcccctcc gcctgagctc 41820 cgcgcgggac gggccgggaggccggggtgg gcgctacctt cgaaggcggt gggtccgccc 41880 cgcgggaggt ggaggggcgggaggggcgga gccctctggt ctccggaggg tttggggatc 41940 gcagtcgccc ctcccccatccagaccccgc ggcgcaaagg gcagtggctt ttctggccag 42000 agcaggtggc gcgggcgtcgcaaagggtgg tccccgaggc cgcagcggtg tggggggagg 42060 gcgcggtccc cctcactccgggctccgccg tgtctggccc gcccccctcc ttcagcgccc 42120 cctccagccc ctgtgctgcactggcgcggg gagcgccggg ttcccggctg gggctttggc 42180 agagggtccc accctctccccgcctcccca cgaaggctct ggcggaccca gatctcgggt 42240 cgccggacgc cccagggaccccgcccgcac atcgcgagcg cgcccacccg gtcgcgagcc 42300 cacgcccggg tctgggagccaccctgcggc agtcgcgccc tgcgtggcac gctgctcccc 42360 caggggcgag gcgcccccgcccgacgtccc ggtcccgagc gctccccggc gcggcgcctc 42420 gcagcccagc gccccaccagccccgccggc gccgcagacc ccagcctcgg gcgggtcggg 42480 cccaggcttg caacgcgcagggtaggagaa gggaaattgg cgtccgctgc cggccgctgc 42540 cccaggcgag gccagacgaggcctctgctc agatcccgcc gccccacaaa gcccgtggcc 42600 ccggagccta ccggaaatggtgctggccat ggtgctggcg gcggttgggc ctgcggaggc 42660 tggagaggcg caagtggcggccggagctgc agacggctgg tgctgcagtg ccggggaggg 42720 gaggggagag gagtggagggagcgagggcg ggcgggaggc gggcgcggcg ggagagagag 42780 agggagggag acagagggagagagagagag ggttggggga aggagcgggg ggaggaggga 42840 gggagggttg ggggaaggagagagagagag agagagactg cgggggcggg ggaaggaggg 42900 agggaggaag ggagggaggaagagagagag gagcaagcgc ctggctgcgg aaggggccgc 42960 ggctctcagg gggagagggcggaggagggg ggctacccga actgcaacaa gaccccccac 43020 cctccaaccg ctcacagcgggacagctgct tctccaactt ggctttgtga ggcctgagag 43080 tggggtgggg gtggagatgagcccccattc cccagggcag gcggggcagg ggcaatgccg 43140 gaggagcagg tcccacccatggggtggggc cgcagagctc ttcgccgcca aggccgctgt 43200 aggctgggct ggcgccaacagggtccaggt ctgtgcctgc catcggagag gatgccacag 43260 ccacaggggt gggcgctggcctggaggcct ccaaggggca tctcctgtga gcccagggga 43320 tgggcaggat ctgagcggagaagagtgaaa gtggaggagt gaggccagaa caaaggcttt 43380 gccgtgaaag aggtggtttcccgcctgggc tcagaccttc actcactgtg tggcccaggc 43440 caagggcaag cgtctgacctcgctgggcct ttgtttctca ggggtaagat gaaacaatga 43500 tgcccccaga cgatggagaggaggggtgcc agggttgtgc gcacttagtg agtggggggc 43560 aacctatcct gcctccccctctcctcataa ctcccaaagg gaaagcctgg taggcaaacg 43620 gagcgtcttt gccattgcagggatgaagcc accgaggcag ggagaaaagt gctttgccct 43680 acaagcaact aagtcatagggccaggagca aaaccctgaa aacctcagga gacttgcaga 43740 gccatgaggc tggctcagcaacacaaaagc caggggcaag cctcagctct agcagtgcgg 43800 tgggagcacc caaggccagtcacatcctag ggtggcctgg agagtcctga cccctgacgt 43860 gcaagccggc atcatccccgggactgtgag tctggtgggg gtgatgccca ggaatgtgac 43920 attgtgtggc ccagaggtacccttaagact ggaggatcac caggcgggcc ctgacctcat 43980 cacaggagcc ctttaaaagcagtttccttt gcctggttga agaaatcgga gggatcaaac 44040 caaagaaggt tttctgttgttgagatgagg gggccacgtg gcaaggatct gagaactgct 44100 cccagccaac agccagcaagacaacaagac cttaactgca aggaagtgag ttctgccaac 44160 aagaagagaa tgggcttggaggcaggtttg accccagggc ctccacacaa gaactgagcc 44220 caactgccca cttggtttcagccttgggtt actaagaatt aggaggtaat gaatgagagt 44280 tgttttaagc tgttggttttgtggtgattt gctatgaagc catatcaaac taatatacac 44340 acagaggtgt tggcccctgggccattccta ggaagccagc tctgcgaagg aggaagaagg 44400 gcagagaggc acacagagctgcccaccaca gcagctgtgt cctccctgtt ggccaccaca 44460 gtagcagttg gggatggtcagcatccttca ggcagactcc agccccgggt gctggagctc 44520 aggtgctagg gatcaagagaagtagccctc tctgggacct ccagagtctt ctcatgtggg 44580 tggggtagga cccacccagtcaggctcaga gcaccgcaat gcctcacact cattgtgact 44640 ctggccaggc cctctctgagcctctgtgtc ctcatctgga gcacagggac caggtgtgtg 44700 gaagcccgtg gcatagtgccaggaacacag tagatgtgca cagtgtgcac tagcaggaac 44760 acacaacagg ggtactgactgtcagcacct aggcaggcac acgcaatggg gtactgactg 44820 tcagccatac tgactgtcagcgtgctagca ggcatacaca acagctgtac tgacagcaca 44880 ctagcaggca catgccataggtgtactgac tctcagtgca ctggcaggca cacgcaatag 44940 gagtaatgac agcatgctggcaggcacaca atagctgtac tgactgtttg ccccaatata 45000 gtgccaggtc ttggagcagattttgacttc tcaccaagat caaatgcaga aagtgcacga 45060 gcatttcaaa gatgtttttcacatgcacat tagtgctagt taaaaaaatg ttttgactgg 45120 gtgcagtggc tcacaactgtaatcccaaca ctttgggggg ccgaggtggg cagatcacct 45180 gaggtcagga gtttgagaccagcctggcca acatggtgaa accccatcta ccctaaaaat 45240 acaaaaatta gccaggtgtggtggcaggtg cctgtaatct cagctacttt ggaggctgaa 45300 gcaggagaat cacttgaatccaggaggcag aggttgcagt gagccgagat cccaccactg 45360 cactccagcc tgggcaacaatatcaagact ccacctcaaa aaaaaaaatg tttttcataa 45420 agtgtgactt ttatcagacctctgcattct tgaaattaac tctggcttgg ctgggcgtgg 45480 tggcccacac ctgtaatcttaacactttgg gaggctgagg tgggcagatc acgaggtcag 45540 gagttcaaga ccagcctgaccaacatgatg aaaccccatc tctactaaaa atacaaaaat 45600 tagccgggcg tggtggcatgcacctgtaat cccagctact caggaggctg aggcaggaga 45660 atcgcttgaa cccaggaggtggaggttgca gggagccgag atcgcaccac tctattccag 45720 cctgggcgac agagcaagactctgtctcaa aaaaaaaaaa gaaagaaaga aattaactct 45780 ggctcctaga aggagccctatatctcagca ggacactcag tcattcaaca gacatctgtc 45840 aagcacctgc tgtatgctggagctgtgggt acgtcagcaa ttagaggaag agggcagggg 45900 tacaggagtt cctgaccaccccaggccagc acgctcctat agcagctggc aaggagcaga 45960 tgactcagac ttcagctcagtccacaggac agccttttct ggccactgct ctcaggagat 46020 gagatgtgtg gctgcaaaaggtaaactcct ggctcctgag caggctctgg gcaatctgct 46080 caacgctctg tgcctcactttctcacccag aaagtgtgga caatgagagg acttatctgg 46140 ctgggcgcgg tggctcacgcctgtaatccc agcactttgg gaggccgagg cgggtggatc 46200 acctgaggtc aggagttcaagacctgcctg gccaacacgg tcaaactcca tctctactaa 46260 aaatataaaa aattagccgggcttagtggt gcacacctgt aatcccagct acttgagagg 46320 ctgaggcagg agaatcacttgaacccagga ggtggaggtt gcagtgagcc aagattgtgc 46380 cactgcactc cagcctgggcaaaaagccaa aactctgtct caaagaaaaa agaatcatgg 46440 cagaaggtga agtctatgttagtcccagtt cccaggtcgt acatggcggc aggagaaaga 46500 gagagagaag gggaaactgccacttttaaa ccatcgggtc tcctgagcac tcactgtcag 46560 aacagcctgg aggaaactgaccgcatgatc caaccacctc cctccaggtc cctccctcca 46620 cacgtgggga ttacaattcgaggtgagact tgggtggaga cacagagccg aaccatatca 46680 gcatgtatgg ggggcactgaaacttgtgct tggtgcccat tcattcaacg agtgtgtgtg 46740 gctggtctcc tcatcttcaactccctgccg agtctcagat aggcagcctg cagttccttc 46800 accacaacag gcacatggggctgggtgcca gtgagtgctg gggcttctcc gagcactatc 46860 tcacacccag gagcgtgggcacgcatggca ttcgcatgtg ccgtcagtgg acattaaaca 46920 cagccatgaa gaagccacgaagaagtgctg cctgccggcc gtgcgcggtc acgcagcgcc 46980 aactccctcc tggggccttctggggccttc tggggcatgg gagctggggc cgcctgagac 47040 aaacatccgt gacgctgggctgaccccaca gaacggtgcg ggcctcgctc ttggagtcag 47100 ccctgctgcc agccagtgccgggtgctggg gactcaggga ggcccgccgg gaccactgcg 47160 ggacagtgag ccgagcagaagctggaacgc aggagaggaa ggagaggggg cggtcagggc 47220 tctcaggagc cgggtcctgggcaaggcgca gccgttttca aattttcagg aaagcggtcg 47280 gctcacactc gagcagtaaaaagatgcctc tggggaggag gcccgtgcag ctctccgggc 47340 aatggtggtg gctcggcctagagaggcggt agtggaacgc agaccctggt gggggaatga 47400 catcaaggga ggagacgggcgggaccccag atttctgcct gtgggcgatg gaagtgaggt 47460 tcactggcca gcggagccggacacagaacg cgcaaaacgc cgtgtaggcc tggaggagcc 47520 gaagagcagg cggaccccctccgcggggga acagtttccg ccgggagcac aaagcaacgg 47580 accggaagtg gggggcggaagtgcagtggg ctcagcgccg actgcgcgcc tctgcccgcg 47640 aaaactctga gctggctgacagctggggac gggtggcggc cctcgactgg agtcggttga 47700 gttcctgagg gaccccggttctggaaggtt cgccgcggag acaagtgagc agtgagtcgc 47760 agtgacccta caagtggttcttttacccga gcggctcgta ggcgcgttgc ggtttttcga 47820 aactacagct cccggcaggccccaagccgc cctcggggcc gcgggtcggc ggattggccg 47880 cgctgcattt tgggacctgtagtttcctgc gctcgtggcg ctggcgccgc ggcgttggct 47940 gagcccttga ccggggctggagggaagggc cgacattcag tgtgtccgcg tctgttctgt 48000 tagtcccagt tcccgggcgggattgaggct tagagaagtt gagtgatttg ctgagggctg 48060 cacgggttgg catcccggcatgctctttcg ctactttggc tgcatctggt tgcccacccg 48120 ggcggatggg gaatggactccagccagcca ggagggcaga gggctggaga ggcagggccg 48180 gaggttcaga ccctccgctctgacgttgcg cctggtgagg ccgggagggg tgccgcttgc 48240 ctcttcagcc ctcacgctcttgtggaagtc gcggaattac tgcaggcgga acttgcagca 48300 ctgtgggcgt cttttccagagaaggacgga gttgtggggc gggaggataa ggcaaggccc 48360 agccacttcg catcttcgccccgccagctc ctcgagatgg gatataccag ggttgctctc 48420 caaccctctc cgcaggagggactgatggaa acgcctggga aagtagcccg gtacccacaa 48480 aggctgtcta caaacagagtcttactgtct ttcccaggtc tgtgccatag ggattctcga 48540 agagaacagc gttgtgtcccagtgcacatg ctcgcatcgc ttaccaggag tgcccgagac 48600 cctaagatgt tcggagtggttttttcgcac agacccgaat agcctgcccc tcagccacgc 48660 tctgtgccct tctgagaacaggctgatatg cccaagatag tcctgaatgg tgtgaccgta 48720 gacttccctt tccagccctacaaatgccaa caggagtaca tgaccaaggt cctggaatgt 48780 ctgcagcagg tagagcacaggccccgagga aaggactgcg ggtgggtgga gcttcagcca 48840 ggacggggtg tgcttccctctcccggccca ttccagccag gcccctccgg gccagaggca 48900 gcgtctgtca taaaaagggctggtgttcca ggtggggtca gagagaggat tgacaagtaa 48960 aaacgatcgt cctttgaagggggccggccc ctccacacct gtgggtattt ctcatcaggc 49020 gggacgagag actgagaaaatgaataagac acagagacaa agtatagaga gaaaagtggg 49080 cccaggggac cggcgctcagcatacagagg acctgcaccg gcaccagtct ctgagtttcc 49140 tcagtattca ttaattactattttcactat ctcagcaaga ggaatgcggc aggacagcaa 49200 ggtgatagtg gggagaaggtcagcaagaaa acgtgagcaa aggaatctgg gtcacaaata 49260 agttcaaggg aaggtactatgcctggatgt gcacgtaggc tagttttatg cttttctcca 49320 cccaaacatc tcggtggagtaaagagtaac agagcagcat tgctgccaat atgtctcgcc 49380 tcctgccaca gggcggcttttctcctatct cagaattgaa caaatgtaca atcgggtttt 49440 ataccgaaac attcagttcccaggggcagg caggagacag tggccttcct ctatctcgac 49500 tgcaagaggc tttcctcttttactaatcct cagcacagac ccttcacggg tgttgggctg 49560 ggggactgtc aggtctttcccatcccacga ggccatattt cagactatca catggagaga 49620 aaccttgggc aatacccggctttccagggc agaggtccct gcggctttcc gcagtgcatc 49680 gtgcccctgg tttatcgagactggagaatg gcgatgactt ttaccaagca tactgcctgt 49740 aaacatattg ttaacaaggcatgttctgca cagctctaga tcccttaaac cttgattcca 49800 tacaacacat gtttctgtgagctcaaggct ggggcaaagt tacagattaa cagcatctta 49860 gggcaaagca attgttcagggtacaggtca aaatggagtg tgttatgtct tccctttcta 49920 catagacaca gtaacagtctgatctctctt ttccctacag tccttgaggg tgacagactt 49980 aggagtgcct tgggggcctctctgaggagc agctgatatt cacgggtcag gaggaagcat 50040 ttccattaga ggggcagccggtggccagcc tcacttggaa ggtctttgaa cctcgggggt 50100 gcagggaggt ggcagtggtgcaggttgcct tctcctgggt tccttgaggt gccctcttgt 50160 acccggctca cacccttcccctccccgagt ttcctgctca ggttcccgtc tgagagcttg 50220 tatgtaggac gtcagataggacagcataaa tgtttggatc cagaaacgca gaacagtttc 50280 ctattttgag acttgacacctaattagtca tcttactatt taagctgaaa aatagtgtcg 50340 tgttttgggt aacgttctgcaaatcgtttg ctaatggcgg ctgagttgct tcacgccctt 50400 tagggcaaga gtgggacttgcctgtggact tctccgcggt cccacagggc tctcgccacc 50460 tggcagtggc ctctgcatctgcaaagagct gcccgctggc tgccgaagct tgtctcaggg 50520 cagcttgtgt ggcctcgcctcttcctggct tccccgtaac ccttgctccg aactccgttc 50580 agaaggtgaa tggcatcctggagagcccta cgggtacagg gaagacgctg tgcctgctgt 50640 gcaccacgct ggcctggcgagaacacctcc gagacggcat ctctgcccgc aagattgccg 50700 agagggcgca aggagagcttttcccggatc gggccttgtc atcctggggc aacgctgctg 50760 ctgctgctgg agaccccataggtgacccta gttcccaggc ctctcctggc ctcctgtggg 50820 gatggttggc aagggatggcgctgagggtg gggtgggccc atggggactc ctgccgtctc 50880 tcaagcagaa ctcaaggagaattttttagc tgctgtataa tttctcgcca tcgtgggtgt 50940 aaacctaggg ttgggcttttttgctgaatt agggcacggc agatgcccac ttcacccatt 51000 tttgataaac cagtatctggggtgtcagat tcttggctgt ctgcagggcc gagttagccg 51060 aatgccacct gcctttgatacgtgagaacg ttgtctgaga accgtgactt ctgtgcttgc 51120 ttgtgtctgg tcagcttgctacacggacat cccaaagatt atttacgcct ccaggaccca 51180 ctcgcaactc acacaggtcatcaacgagct tcggaacacc tcctaccggt gggtcagacg 51240 agtttacacc tgtctcggggtcctcaagag aaccagcttg gcatggtgct gagtccacag 51300 ccccatgctg tgctgtggtggagggtggtg gtctttctag acgctccccc gaagtgtgca 51360 gagcgctggt gcccaggggtggggtgcggc ctgggctgcc tccaatgccc attacttgtg 51420 aggaagcagc tttgcatctgtgtgctgacc ttgggcgggc gtcctgagct cctcgcaggt 51480 gctgttgtag cagctgtgcagtaggtcagg gctggccccc agtgcagctt tgcacatgaa 51540 gtaggaggag gccctgctgcttgtcagagc ccagcagagt cttggtgttc tgtcgggttc 51600 ctgtggccgg accagtggcagggtgctgtg gaagctgtcg aatctcctcc ctctgtccag 51660 tacccccgct cgtcttctagctccctccta cgcccgggcc acgtttcagt tatgctcact 51720 tcctctgacc gccgaggctcctgcgtgtct ccatacagct cacgctgcag ggccacgctg 51780 tgggtgttgg agacagctcctcctcgaccc acggtgctct ctcccaccag gcctaaggtg 51840 tgtgtgctgg gctcccgggagcagctgtgc atccatcctg aggtgaagaa acaagagagt 51900 aaccatctac aggtaggctcctgggctccc gctccggctc agtgtccgac aggcgagtgc 51960 tgctgggtgt ccagagccccaggctgcgct cccgctgggc tagggtttga agttcactgg 52020 gggactgcag gggaggacctggtgggggtg gggactggct tcggtccttt cttggccgtg 52080 cttcagctgc gcactctgcccttcctccca cagatccact tgtgccgtaa gaaggtggca 52140 agtcgctcct gtcatttctacaacaacgta gaaggtacaa gcagctgggt gggaccaggg 52200 tcgggttgga gtgtgtgcagcctctcaggg tggagctcag tggtgtcaca gcctggttgt 52260 gcttgcccgg tggggcggccagtgcggcca tgtacctggg ccctgtcttc tgactcgggg 52320 ccacccatgt tagacttctgtgtggaagag ctcacacagt ggtctgagac agccagccgg 52380 caagactgcc tctggctggtgcctggggcc ttggattttg ggaaggctcc ctccatttcc 52440 tgatgagagg gtctccctgcacctaacctg ctggtgcaaa cagtaggggt tttgctgaac 52500 accggctttc tcttcggggactttgttgct tgcccagcag caggtgctcc agtgaccggc 52560 cctcatacca tcttgggagggtgtcctgga agccgtgtct ggcctcccgc gaccctgccc 52620 cgtgtgtctt tttcctgtgctgaccttgct gcggaaaatt atggccctga gtgtgactcc 52680 aggctgagtc ctgtgggtccaacacgggat gccttggggc ctcttctgga gacgggatgt 52740 gagtgacagg agccggccggggcagcttgc cctgtgactg cacgtggcca cagcctgtga 52800 gggccggggg tgcttctccacccacgtggc tgcccctcgg gtatgtcaag ggcttctggg 52860 gctcatcacg gggtcctagagacagtggca gggtgcaccc ccgttggctg cccttacagt 52920 ttctgtgacc tgagggtggcatctgtgcag tcggcgcggt ctgtgcttct gtgggatcag 52980 ggttccctct gtttcctgcctcagttgggg ctcaagcctc aggtgaggtg gccccggagc 53040 actcagaagg catcggcggtcctgtgggct gctttctgca ctcacgtttg ctgagtgctc 53100 agtgtgccag gactgaggaccctgaagctg ctcttgtatt tagggcggcg ctcccctggc 53160 agagactgag ccaggtggtcccgcatgacc cactaccagg cgtttctggg ccctggccct 53220 tggagggaca gggtgggcggaacatgggcc tgcagggagg ctcccgctta ctggaggcat 53280 gtgctgtgtt gctggagacatcctctgtgt tgcttcttgt tcgctgtggt ttttggtctg 53340 gtggcaccaa ggaccctcagtcatcttgat gtgtggttgt ccaggccttt ttgttggtcc 53400 taagaagggg ctctgcctttgtgcccccag gttccctgac aggagctgcc ggctcgtccc 53460 ggtgatgcct gcaggacgtgactctgggac ggggggttgg gcagatgtgc tgatggaaat 53520 tctcaagcag gcgtcatttccgaggtcctc acctggattt ccaggacagg agtgcctgct 53580 gggtgtcccc agtcccatgcagcgggggtc cttgggatag catggaacgc tgagcatggg 53640 cctggccggc cgtggtcctggacaagggca gtgccccggt ggctgctggg cctgggacct 53700 ggtggggacg ctgggcctggtacctggtgg ggatgctggg cctgggacct ggtggggagg 53760 cctctgactg cctcctggtgctgcttccgt ctgtgttagg cctctgggta ttggggcccc 53820 catctgtctc ctcctccaggcctgtggact cagaccagga agacacaggc cagcccctgc 53880 ctgtccccct tggcttgggctctcactgcc cgacctggcg ggaggttgcc tagccgtgaa 53940 ccttcgcacc ctgtctgccaccggacaggc tgtgaggggg tgtctgcagc acctgcaccg 54000 gcctgagcat cttcagagtgggctgcagct cctggagggg tctgagagga agggaggcag 54060 gtattttggg cgaatgaggagacagctgga gagctggcac ccttcctggc ctgcgtcctg 54120 tgaggactct ggttggggacagcaagcttg gggtcagcct ggggcagagc ctctgggacg 54180 gccccgcccc tcgtgccccttcccctcgca gctcctgtcc tcgccccgcc ctcagctctc 54240 cgccaggcaa ggtttggcaagtgccgctgt gcggcagtgc ctgctgattg gctggtctgt 54300 tgctatggtg ctgcccaggggtgtgctttt cctcccctgc cttccctgct atccctggga 54360 gtatctgggg ttgggtcatcgctggtgtgt gtgagtgtgt gtgtgtgtgt atgtgcacgt 54420 gtgcatatgt gtgcgcttctggcctctgca gctgagtcct ggccctcggg gggcctggca 54480 cctcctgggg acaggcacaaagcagccatg atggagtcgg gagctggggg aggccccatt 54540 gccccacgtg gctgccctgtgactctgggg tgcttgttag aagaggtatc tggttctgtc 54600 tgtgtttaag caactccctaaggaattctt gtggttccag tttggggggc ctgtactgta 54660 gaggcaaggg aggggcaggacatcccccag actctgactt ctgaagcctt ttctgcccgg 54720 ggcctctccg ccagtacaggcagtgtcctt tgccagggct gccatgctgc agaggggagt 54780 gggccactgt ttagcccaggaaaacctggc tctcccttag ctggaagttc tgggcctgtt 54840 gtggttggca gggaagctgagtgacggtgc taatcacagg ggcacctgca ggggtttgtg 54900 ggagatgcct ctgtgggttggggcgatagg ctgaggggct gttcttccct gccctgagga 54960 gggctgagtg tagccgccactcctgtcctg tcttgggctg tctcggagag gatgcgtaga 55020 accctcggga tcctgctggcctccgtctgg tccaccctga acctcaggcc ttctgggggc 55080 agaggaggat tccctcaggatcactcgggt gggggcctct cttgggcacc tgagaccctc 55140 agtgggtgct ttgtggcgcgttcacggttg gtgggggacg cccagccctg cccgccgtgt 55200 aggagccgtt ctgtcctgggcatccccctg tggtctggga cttagtggac cctgagggtg 55260 tgtgtttacc cctgcctcacacctgcagaa aaaagcctgg agcaggagct ggccagcccc 55320 atcctggaca ttgaggacttggtcaagagc ggaagcaagc acaggtgaga cccctcagtg 55380 aggccacgac cactgtccttccatggccca gctctcctgt gacctgtgga ggcccggata 55440 tatttcttca cttttctttgttccttttta aattatgaaa ctaaccacca ttcagtacga 55500 aaaagtttaa gcagctctgaggaagataga gtaaaaaatt gtctccctct tccctggccc 55560 tcagccatcc ccggtggccaccgtggagtg tggacggagc cctgcaggcc tgtgtctgtg 55620 cggaagcacg cgcagttttgtctgcacaga ctgtcctgca gttggctgtt ttcactcagc 55680 gttgtgggta tagcttcccatgctggtgct ggcagctcgg ccttgttctt ttgaggacag 55740 cagatgtctc ctatgtctacctcttacagc ttcagagatt caagttataa taaagctctt 55800 cttatattga gggggaaacctccctccccc ttttttttga aacagggtct cgctctgcta 55860 cccaggctgc agtgcagtgtcacagtcttg gctcactgca gcctcagcct cccaggctca 55920 agcgattttc ccacctcagcctcccaagta gccgggactg caggcacgca ccaccatgcc 55980 tggttaattt ttgtattttttgtacagaca gggtctcact ctgttgctca ggccagtctc 56040 ctgagctcga gagttccacctgccttggcc tcccaaagtg ctgggattac aggcgtgaga 56100 ccccatgcct ggccagctcttttttttttt tttttttttt ttgagacgga gtctcgctct 56160 gtcgcccagg ctggagtgcagtggtgcgat ctcggctcac tgcaagctcc gcctcccgag 56220 ttcacgccat tctcctgcctcagcctcccg agtagctggg actacaggtg cccgccacca 56280 cgtctggcta attttctgtatttttagtag agacggggtt tcaccgtgtt agccaggatg 56340 gtctcgatct tctgaccttgtgatccgccc acctcggcct cccaaagtgc tgggattaca 56400 ggagtgagcc accgcgcccggcccagctct gctttttctt agtggttctg cgttgtgttt 56460 gtttctatcc aggaatagggttggttttac ttttccatcg agtttttaaa gagacgacga 56520 tttacatggt cggaaactcacgaggactcc ccatcccttg gtcggaaact cacatggact 56580 ccccatccct tggtcagaaactcacgtgga ctcccatcca tcccaggcag cagcttccca 56640 cctgggccct acgtgcaggatgagggctcc ttccgggtca gaagacatgg cggcctcggg 56700 gcaccgtccc ctgcatggggtgctcacagg atcttctcct ctctccttcc cagggtgtgc 56760 ccttactacc tgtcccggaacctgaagcag caagccgaca tcatattcat gccgtacaat 56820 tacttgttgg atgccaaggtgggggctcag tcctgtagct gacgactcct gatgtccagg 56880 ggtgtccctg ggcttgggaacagctgtccg agcctttgct gcttcagggc cttagatcag 56940 caggcctggg tgggaggactcacctctgtc actgggcagg ggctcaacct ggccagacac 57000 acttgtgagc agccccaggccacaggtcag ttttctgagc agtctgggag cgggcaggct 57060 ggtgggagtg aggagagacctccaggctgt ggtccatagg ccagtgcccg ctcttgatcc 57120 tgacagctca ggttctctccttcacgtcag gccatgggag gcaccgagaa cacaggaagc 57180 ccactgactc ccctcttcccagcgcgtgcc cggccccaca ctcactcccc ctcccagcat 57240 gtgcccggct tcacactcactcccctcttc ccagtgcatg cccggcccca cactcactcc 57300 ccccacagca tgtgcccggcctgacactca ctcccctcct cccagtgtgt gcccagcccc 57360 actcccttcc gccccgtgtgcccagcccca cgctcactcc ccccgccagc atgtgcccgg 57420 ccccacactc aactcccctcctcccagtgt gtgcccggcc ctgctgccct cctccccatg 57480 tgccctgctt ttgtgccccacactttttac ttagtgcagg tgggatcaca cgccacgggt 57540 caatggtttg tgtgttcacgtgacgatggc gtggtgacgt ttccagatcc cgtcgttggt 57600 tcgctcattc tcggggtgtatatttattga gagctcatca tgctgggtgc tattccaggc 57660 atagcaagac tggcttcactcacatggagc tttgattcta gtggtgggga caggtggaca 57720 gcaaaagagt aagcacgtgagctgacgata ctgaagggaa atagagcaga gggaggaggc 57780 ggagaccgag ccaagcgggcccaagtgcga tgtcggcggg aggtggggaa tgctggtggg 57840 tctgagggga gcctcagcaggtgcagcaga gcaagggaag aggtgagtgg gggcggctgg 57900 ggggccgact cctgggaagctgtagcagaa ccccacagag agctggtgag gtttgccgtg 57960 gttgtgggtg actcggtgctttgagccctg gctgcccctg ggaaccatct ggagagcttc 58020 taacccaacc aggcccctccctgggacagt tatatcacag ctggtaagcc gagtctaaca 58080 ctttcacgga aacgcagaagatctaaaaca gcaagatgac cgtgaagaag aacagagctg 58140 gaggactcac ctcgctggtttcaagactcc tctaaagctg caggagtgga ggtggagatg 58200 gcccagctca ggcacaggcctgcaggccat ggagaaggca gcaagctcaa gctgacccac 58260 acgcatgtgg tcattgttttttttttcagt tggaatctca ctctgtcacc caggttggag 58320 tgcagtggca ccatctcggctcactgcagc ccccgcccct aggttctagc gattctccca 58380 catcagcctc ccgagtagctgggattacag gcgtgcgcca ccatgcctgg cccttggtga 58440 ttgttttttg acaaacatgccaatttaatt gagagaggaa atgaaggttg atttctggtt 58500 ttctgaaaaa atggtgctaagaacagctgg atatctgttc ggaaaacagt gaatcttaac 58560 tcttgtttta ccctgtataaacctaaatgt aaaagctaaa ctaaaagtta tagaaaggaa 58620 catgggggag gtctttgcaactttggggta ggcagagatt tcttagtatg gatacacaag 58680 gcactagcca tgaagaaaaacattaaaatt tagacttcac caaaatttaa agcttcaact 58740 ctgtggaaga gttgagaaaatgaaaaagca gttaaagaaa gggagaaaat acttctttca 58800 aaggacttaa aaaattttttcagccctcct ctgatttgaa aggacctttg accagagtat 58860 gtaaaattct cccataactaagcaaacaac ccacttaacc actgggaagg gatctggaca 58920 gacgtttcac caagatgggtggaatggcca gttaaccact gggagagcat ccggacagac 58980 gtttcgccaa gatgggtggaatggccagtt aaccactggg agagcatccg gacagacgtt 59040 tcgccaagat gggtggaatggccagttaac cactgggaga gcatccggac agacgtttcg 59100 ccaagatggg tggaatggccagttaaccac tgggagagca tccggacaga cgtttcgcca 59160 agatgggtgg aatggccagttaaccactgg gagagcatcc ggacagacgt ttcgccaaga 59220 tgggtggaat ggccagttaaccactgggag agcatccgga cagacgtttc gccaagatgg 59280 gtggaatggc cagttaaccactgggagagc atccggacag acgtttcgcc aagatgggtg 59340 gaatggccag ttaaccactgggagagcatc cggacagacg tttcgccaag atgggtggaa 59400 tggccagtta accactgggagagcatccgg acagacgttt cgccaagatg ggtggaatgg 59460 ccagttaacc actgggagagcatccggaca gacgtttcgc caagatgggt ggaatggcca 59520 gttaaccact gggagagcatccggacagac gtttcaccaa ggtggatgga atgaccagtt 59580 gagcacatgg aaagtcgcccagcatctcca gtcataggag aaggcagatt aaagccacgg 59640 ggagccgaca ctgtggtcccactggcatgg ctgaaattca gaagccctga gtgtggcatg 59700 aggatgtgga acagctggatctcatccatc gctgtgaagt tgtgtagcca ctccacaaac 59760 gtgtggcaaa cagccgagccgggagaaggg aagacgtgtt caaagattca tatgtggcca 59820 ggctcagtgg ctcacgcctgtaatcccaga actttagggg ccaaggctgg gggatcgctt 59880 aagcccagga gtttgagaccagcctaggca acatagggag accccatctc aaaaaaaaaa 59940 aaaaagaaaa aagaaaagacttcagtgtgc aggtttacca gagttttgtt tgcagttgcc 60000 aaaactggga agcagcccgcgtgagcccat ccacaggtga atggacagac cgtggtaccc 60060 gaacactaac agcagccacgggcgtggact gtggtcacac agcagcaggg agccgatgag 60120 tctcggacat gctaacccagagaggcccat tgaggaggac ctactgtttt ttgtgttttt 60180 gttttttgtt ttgaaatggagtctcgctct gtggtgcagg ctggagtgca gtggtgtggt 60240 cttggctcac tgcagcttccgcctcttggg ttcaaacagt tctcctgcct cagccttccg 60300 agtagctggg actacaggcacccgccacca cacccggcta atttttgtat tttcagtaga 60360 gacggcagtt cgccatgttggccaggctgg tcccaaactc ctgaccttgt catccactca 60420 ctttggcctc ccaaagtgctgaggttgcag gcatgaacca ccgcacccgg ctggacctac 60480 tgttttattc catttatgtgacactctatt aatagaaaag gcaggggtgg ggctggtggt 60540 tatatggtgc acataactgccagaactcag tacacttaaa atgaacatct taatgtgtga 60600 aatttttttt tttgagacggggtcttgctc tgtcacccag gctagagtgc agtggtgcga 60660 tctccactca ctgcaagctctgcctcctgg gttcacgcca ttctcctgcc tcagcctccc 60720 gagtagctgg gactacaggcgcccgccacc acgcctggct aatttttttt ttttttttgt 60780 atttttagta gagacggggtttcacagtgt tcgccaggct ggtctcgatc tcctgacctc 60840 gtgatccgcc tgcctcggcctccgaaagtg ctgggcttgc aggcgtgagc caccatgccc 60900 ggccaatgtg tgaaaatttaaaagtaccaa agctggaccc caccccagat tgctcccatg 60960 acactctgtg ggtgggacctgggagttggg ttttgttttg ttttgttttg tttttgagat 61020 gaagtctcac tctgtcgcctaggctggagt gcagtgacac aatctcggct cacattaacc 61080 tctgcctccc agatgaaagcgattctcctg cctcagcctt ctgagtagct gggattacag 61140 gcacacacca ccaccccctgctaatttttg tatttttagt agagacgggg ttttaccatg 61200 ttggccaggc tggtcttgaactcctgacct cgtgatccgc ccgcctcggc ctcccaaagt 61260 gctgggatta caggcgtgagccaccgcgcc tggctgggag ttgggtttgt aaatctccct 61320 gagtggggct ggggcagggaactgctgggt ctgggtcttc ctggctcctc tggtctgtgg 61380 cttcctgact gcggtggccgggggctccca gggcatcgtg gccgtctgtc ttgctgagcg 61440 tggcacgtgc ctttccatgctgtggaggag cgtctcccgg tatggcgaac tgctggttag 61500 ggtggggcgg tgttgccaggtcatccaggt ctggcctctg ctctcgacat cgccggcgct 61560 gttgctcatc tgcgcttgtgatgttcgatg cctgctgcac atgtcttggc ttccctcttt 61620 cccggcctct gtgagctccagcgctgcgtc ccttctcttc ctcctgtaga gccgcagagc 61680 acacaacatt gacctgaaggggacagtcgt gatctttgac gaagctcaca acgtggtgag 61740 tctccgctgg cctcctaaacacctcctatt gcttctggcc tttttgtcaa gagccacgca 61800 aacctttctg gaggggctctggccaaactc ctgaagccct aggtgcccag gactggggac 61860 tgagcacacc aggagcttctgccaccccct cccgccctga tccgatgcct ctgctggggc 61920 tggagactgg ccagctgggccagggacctg cccgtcaggc gcagggcccc cacaggccgc 61980 tcaccagacc ctttccctccagccagctcg gggtcagcct gggccagggc tgtctcctct 62040 gccctcggca gcagcaggcttgtggtcttg cctgcagtgt ctctgccctt ccggccacat 62100 ggcttgagac tgaggcaggagaatcgcttg aaccttggag gcagaggctg cagtgagcca 62160 ggatcacacc actgcattccagcctgggtg acaaagcggg attctgtgtc aaaaaaaaaa 62220 atgttgactg ggcgcgctagctcatgccta taatcccagc actttgggag gctgaggtgg 62280 gcggatcacg aggtcaagagatcaagacca tcctggccaa catagtgaaa caccgtctct 62340 actaaaaata caaaaaaattagctgggcgt ggtggcgtgt gcctatagtc ccagctactc 62400 aggaggctga ggcaggagaatcactcgaac ccaggaggta gaggttgcaa tgagccaaga 62460 tcacaccact gtactccagcctggtgacag agcaagactc cgtctcaaaa aaaataaaat 62520 caaaaagaat aattggcaattccagtgaaa taattgtttg tttgtttgtt gagacagggt 62580 ctccttctgt cgtccaggctggagttcagt ggtatgatct tggcccactg caacctccac 62640 ctcctgggct caagccatcctcccacctca gcctcccgag tagccgggac tacaggtgca 62700 caccaccacg cccggctaatttttgtattt tttgtagagg cggggtttcc cagcgttgcc 62760 caggctggtc ttgaacccctgagctcaagt gatctgccca ccttggcctc ccaaagtgct 62820 gggattacag gtgtgagccaccgcgcccgg cctgaaacaa tcgtttctaa atattggtgt 62880 gggccacaca gtcatgtttggacctacttg tggcctttta cagaccccag gccaaggctt 62940 tgggaacttg gctgtcagcctcctgtgcct tctgcacccc caccccattt ctgctttctg 63000 gaacccccga tcctgtcctgttctgtggtg attcgggtgt gcttgggctc taggagaaga 63060 tgtgtgaaga atcggcatcctttgacctga ctccccatga cctggcttca ggactggacg 63120 tcatagacca ggtgctggaggagcagacca aggcagcgca gcagggtgag ccccacccgg 63180 agttcagcgc ggactcccccagcccaggtg cgttcatagc cagactgctt ggtcctgagg 63240 cctgcgctgc tgcagggtgagccccacccg gagttcagca cggactcccc cagcccaggt 63300 gcgttcatag ccaggctgcttggtcctgag gcccgtgcta ctgcagtggg cagcctgccc 63360 tgtggctgtg tgtggtcggcctgggcacca tctattcagg ctggcactgc agggcatccg 63420 cttctctcag aggcttcttgggtgtgaatt cttcagggtc ctgtagcctg tggaagggct 63480 ggtattgttc agtagttctggtattttcca aagacctatg tcttctccca gccagtatca 63540 acttggcctc tactgtgtaaaactggaaaa ctctactttg tgaagctgag ttgggagcat 63600 cgcttgaggc caggagtttgagaccagcct gggcaacatg gcggaacctc gcccctgcca 63660 aaaaattagc caggtgtggtggtgtgctcc tgtggtccaa gcttttctgg aggccgaagt 63720 gggaggcgtg cttgagcctgggaggcagag cttccggtgc cccagatgac tccactgcac 63780 tccagcctgg gcggcagagtgaggccatct caaaaaaaaa aaaaaggaaa actaaatata 63840 ttcactgtaa gggcattttgcatctttaaa tgacccacaa atctggcatg catcagctgc 63900 tctgcctgta ggttccttcccagtgtttgt ccagaggtgt atttccacac agcgctagtc 63960 acggcatatg tggaaaacgtggaaaccctt catggatgtt gtcagttggt ctatattttc 64020 tttctttttt ttttttttgagatggagttt cacttttgtt gcccaggctg gagtgcaatg 64080 gcgcgatctt ggctcactgcaacctccgcc tcctgggttc aagcaattct cctgcctcag 64140 cctcccaagt agctgggatcacaggcgtgc accaccacgc ccagctaatt ttgtattttt 64200 agtagagatg gtttctccgtgttggccagg ctggtctcga actcctgacc tcacgtgatc 64260 cacccgcttc ggcctcccaaagtgctggga ttacaggcgt gagccgccac gcccggcctt 64320 tgtccatatt ttctacatggcttctgtaaa cagctgacta ggagtctgtg tgaatatctt 64380 cataggttct gctgtgacactacttgctcg tgagcatctc caggtgtaaa cagcatcagc 64440 ttcccccatt ttcctttaaaatcgcacatg tggacggaca ccacggggac cctggaccct 64500 ggggagcccc gtcctcacccttctcaccag gatggctgct tggtagagag tgagtttgca 64560 aagttggcat ttgtttagtacagaagttat caggtgttct ggctttagaa tccctttata 64620 tatatatata tatacatatatttaagtgac agggtctcac tctgttgccc aggctggaat 64680 gtggtggtac aatcaaagttccctgtagcc tcggcctcct gggctcatgg gatcttcccg 64740 tctcagcgtc ttaaagcgccgggaccacag gtgtgcacca ctgccaccgg ctctcaagat 64800 tgccacgcag ggagttgcagtgggggaagg ggttcctggg actttgaacg ctccacctcc 64860 ctcctctcca cagtcccccaaccccacctc tctaacgggg tggacggccg cctctttcca 64920 tccttcgctt ggcgcagggtggggagagtg acaggtctcc ttccctcatc tcggcagctg 64980 ccatttcatc gcttacataacgtgggagaa acatccaccc acccccaggc ctgtgtgaac 65040 atcaccacgg ggccttctccactcttcagt tttgttagtt acttgatgtg cagggctttt 65100 tgttgtaact agtgggggacgtgtggtggg gtgggcttct gccatctcat tcaggaccag 65160 aacttcagtt ttcatccctatctgttcccc cacccctttg gagatggggt ctcactctgt 65220 cacccaggct ggagagcggtggtgccatca cggctcactg cagcctccac ctcctgcagc 65280 ctccacctct tgggctcaagtgatcctcct gcctcggcct cccaagctcc tgggactaca 65340 ggcgtgtgcc actgtgcttggcagggtcca ttcttttcct cacactttat ttattgaaga 65400 gcccaggccg tttaccctgcagagtcggaa tctgtacagg aggggcagcc acacgagttc 65460 cccggtttac tctgaacttaggtggcttga gggccccagt tagactgcgg ccaccgtttg 65520 ccgggctcca gatgggacgtcctttctatc agaaggctca cagtatctcc tttcccgttt 65580 cttcccatgt gaacattgttgctgctgaac acctgaatat gttaatcact gggggcttgc 65640 aagatggcag tgtgctaattccatcatcta gtcagttagc aggaataact taggaccacg 65700 ccctgcacca tatcagctatgtggtgatcc cattcacaca ggaaaggtgg gacaaatgct 65760 gggggtgggc cgggtgtgctgtctcacacc tgtcatccca gcactttggg aggcccaggc 65820 aggcggatca cgaggtcagagattgagacc atcctggcca acacggtgaa accccgtctc 65880 tactaaaaat acaaaaaaattagccaggtg tggtggtgca tgcttgtaat cccagctact 65940 tgggaggctg aggcaggagaatcacttgaa cccaggaggc ggaggttgca gtgagccgag 66000 atcgcaccat tgcactccagcctggcaaca gagcgagact ccgtctcaaa aatcaatcag 66060 tcaatcaagt gtcatcactgaatgtttgtg tgtgaacgtg gggattggtc ctgccccatg 66120 ctccctcctg aatctcactcctgacctcag ttgctgcacc ttgaggtgtt ttctgtgggc 66180 tcttgtgtcc tgaccccggcggttgtggcc tctgctgtct gggagtcagg atttttcaca 66240 ctcatgtcct gctccagacctggaatcagc caagtctcca agaagccctg ctttcttttc 66300 ctgcaagacg gtatttcaagacccgccgtg cggcagcggg ttggtcatgg ttactgggtt 66360 ggtcgttgtg actgggtgttttcgtggaga tacagccata cgcacaggtg tgttcacaaa 66420 tgttaattct aaaggtcaaacacccggcca ggcataaggg ctcagcggta atcccagcac 66480 tttgggagac caagactggtggatcacctg aggtcaggag tttaagacca gcctgagcaa 66540 cagggtgaaa ccccatctctactaaaaatg cgaaaattag ccgggcatgg tggcgcacac 66600 ctatagtccc agctagtcgggagacagaca cgagaattgc ttgaacctgg gacatggagg 66660 ttgcagtgag cagagatggcgctgctgcac ccctgcctgg gtgacagagt gacaccctgt 66720 ctcaaaaatg aatagataaataaagataaa acacctgctc ctcttggtgt ctccagtttg 66780 gatttggcct gtgtagcctcttccttcgcc tgttggtgga tttggcctgc acggattctg 66840 tgtggcctct tccttcccctgttggtggat ttggcctgca cggattctgt gtggcctctt 66900 ccttcccctg ttggtggatttggcctgcac ggattctgtg tggcctcttc cttcccctgt 66960 tggtggattt ggcctgcacggattctgtgt ggcctcttcc ttcccctgtt ggtggatttg 67020 gcctgcacgg attctgtgtggcctcttcct tcccctgttg gtggatttgg cctgcacgga 67080 ttctgtgtgg cctcttccttcccatgttgg tggatttggc ctgcatggat tctgtgtggc 67140 ctcttccttt ccatgttggtgtcctttttt ccatgccagg aatcctggtt ctcaagggcg 67200 gggttgttgg cacgagcgtgatgcagactg cctttgctgc ctttctcttg cccagggctg 67260 aacatggagc tggaagacattgcaaagctg aagagtaagt gttgccctcc ccgcctcctt 67320 gcagctgggt ggggcctcctccttgcgagg aggtgggtga cacctcctcg acccacagtg 67380 atcctgctgc gcctggagggggccatcgat gctgttgagc tgcctggaga cgacagcggt 67440 gtcaccaagc cagggaggtgagaggcgggg agccagcccc ttcactgcag gcccagccta 67500 gagctagaaa cgggccatggtgcagtcctg ggctgtcaca tcacgagtga ggcctgtttt 67560 caggcctgtt ttccctttttgagacctggg aggagcacct gctttgcatg atctggttgc 67620 tgagatgttg agaggagcagcacacactcc cacgggacag cacacagccc cccacggaac 67680 ggcacacaca cccatggaacagcacacaca ctcccacgaa cagcacacac actcccacga 67740 acagcacaca cactcccacggaacagcaca cacacccacg gaacggcaca cacacccacg 67800 gaacagcaca cacactcccacggaacagca cacacaccca cggaacggca cacactccca 67860 cggaacagca cactctcccacggaacagca cactctccca cggaacagca cacacactcc 67920 cacggaacag cacacacacccacggaacgg cacacactcc cacggaacag cagactctcc 67980 cacggaacag cacacacactcccacagaca gcacacacac acccacggaa cagcacactc 68040 tcccacgcgg ggccgctgggtttcctgcag tttctcctcc tccaggcctt tccctggacc 68100 ctggtccagt ccgtcatttgagcacaggtg cctgttagaa cgagaccttc ttgttaggac 68160 gatgagtgtc ccagccaccacctcttttgg actccgggag gcctggaacg ttctgaacgc 68220 tccgtggggc tccagtcttctccgcagcca gggcagcagg gtttgctgtc tgtcctgcag 68280 gcagatgagg agtcagggctggggcctgtg tgggggctct cctgagcgcg cagccgccga 68340 ggtggagcgt gttctgcctgagcgccgacc tggtcggggg aatcccagtt gcttccaggt 68400 ggagccactg tcctcagcgtaatgctcaag gctctggcct ggctcctcgg ccaccctgca 68460 ccctcagggt cccctcctgtagcttctgct gccccatcac tgtcactctc caaagctttg 68520 gggactctgc ccagagccaccgcctcccag aagcccctga caacctcttg acgaccccct 68580 agtgacccca tccctcccctctgacggcgg cccctgctct gaggcggctt cttttcctcg 68640 gtgctgttct cgtgctggccaggcctcctc tccccacctg gaggctcctg agggcggagg 68700 cctctcacct ccaatgctggcgtcccctgg agggctgaat ttgtttccga gggaaggaaa 68760 cttccacagt tgttgccttcagttccaaag ctgcagcctg atttccccct ccaggctcga 68820 gcctgttttc ttctcggcagctacatcttt gaccagtgtc gtcccccctc aggcccgagc 68880 ctgccttctt ctcctcagttcccaaagctg cagtctggtc cccccgccag gctcgagcct 68940 gccttcttct cctcggcagctacatctttg agctgtttgc tgaagcccag atcacgtttc 69000 agaccaaggg ctgcatcctggactcgctgg accagatcat ccagcacctg gcaggacgtg 69060 agtgctggca cggggtctttggtgcgggca aatgtggcgt agggggtgca gcaggcctcc 69120 atcttggcag tcagggctcccctggccgtc acctggccgt cagcaggaac aggcccacag 69180 aacctcatct tctgatcggggcgtggaggc gttagtgcca cttgccagct gccgtagagc 69240 ctgtcccagt tctgcagctggcggcttcgt cctacagcct catcccatta ttctgctttt 69300 gagaaagagc agcccaaggccctagctggc ttgtggggcc tctggcttct ccacaccacc 69360 ccgagttctg cttctcagagttgtggggtc cagaggcttt gcccagaggc ggtgtcccca 69420 tgggctgctc tggtttgagacgccgggccc agcggggtct ctcctctgct gcgctcccgg 69480 gtgctgggga gggtggcttttgctgcttca acccttaggc gaccatagag cctcttttca 69540 agtcccactg acccccttggagactctgtc cctgcctggc ttctctcctg gctgctggga 69600 agagcaggcg aactgcccgccctgaatgga tgctgcgctc caccctgggc cccccattgg 69660 gcaggagatg gagcttggcagtcgggctga gcgggctcat gctggaaggg ccggggctgg 69720 ggtcggggcc tcccctgcctgcagtgtggg tgtcagcgcc ctgctgccct ccaggtgctg 69780 gagtgttcac caacacggccggactgcaga agctggcgga cattatccag gtggggcctg 69840 ctcctctgtg gcatctccttccctgatgga agccgggcgg gtgccttctc ctgctgtatt 69900 agttaactga ttctagacttggggatggga gaaaggcccc tacaccacct gtttctgatt 69960 ggcaaactct cggctcctttccagtgccct aaacccacac tgggcctcct gcagggatgg 70020 gggaggacga ggtctggtggcacatgccca gggtgatgct ggtgagggag gacgcaaagg 70080 acagtggggg ccggggagccgctcctgccc tgtccgggcc ctcaggccag gggggaccca 70140 ctgctggcag ccccagcagccccagctgca cgcagatgaa gagctctgga cacacgcggc 70200 ttcctgaaca gcttctccagggacagacaa atggggaccc tgcaggttcc cggcaggggt 70260 gtccctggga gcccatgattgggggtgcga ccctggcccc cttctcattg gccccgtcct 70320 gtcctgcaat gcccgtcccatgtgaggtct gcttctggct ccatgcctat ggcagcacct 70380 gctttccctg gcgtagaggtgcttgtccgg tttgtggagg gcacgcccca ttttgggtgc 70440 tctgggcacg ttgcctctccggggcctcgg tggctttttt agaagcagac tcagaagtcc 70500 ctgactgggg aagccaaggcacaggtggct gtgtggagcc ctgtgaggcc tcctctgtgc 70560 tgcccacgct gtacctgctggccacacgag atcatggcag ggttaggcag ggctgcccag 70620 cgctatgaca gcttcatgagtgtccatctg gcctgtgggg tgcttgagct gggggaggcc 70680 gcagaagaac cctgggatgcatggctggcc tgtgcatgct gctgggcatg gagctgcaga 70740 tcccggaaca agcaggcactgccttctcct tcacagacgc agctctgagc gggggcgaga 70800 cctgggcagg gaccaggtggggtgggcaca gggtggtggg gcccaggctc agccctccct 70860 ccactgtggc cgtctctgtggccagtgacg ccacagcctg tgtcttctct gtgcggtagc 70920 tggggctgga aggacagcactgccttgtcc tcccaactcc tccccaaagg cacggtgggc 70980 atcccaggcc cagacccctctgtctgtggc tcctgcctgc caagggctgc tgtgctgtcc 71040 cgcatggagt gtggttggctcttcaagcag gaggccgtgc acctatcagg cggacctgct 71100 tccatgtccc tgatgggtcactgcaaagca cctccagcac atggccaggc gaggtagccc 71160 tgcagcccag ggcctggagggcaggtgtga gctggcccgg gcctgtccct ccctggaata 71220 cagcttccca ggctcccacttatggagaag tctcctccac actatggaac tgaatcctag 71280 aatgtggctt ctgaggttcctacactcgaa ctgaatcctg gaatgcggct tccaaggctt 71340 ccagctatgg agaagactccacactctgga accgaatcct ggaacgcggc ctcccaggcc 71400 cccagctatg gagaagactccacactctgg aaccgaatcc tggaacgcgg cctcccaggc 71460 ccccagctat ggagaagactccacactctg gaaccggatc ctggaacgcg gcctcccagc 71520 ctcccactta aggagaagtctccacactct ggaaccggat cctggaacgt ggcctcccag 71580 gcccccactt aaggagaagactccacactc tggaaccgaa tcctgcacac tccatcggtt 71640 tggaatttcc tttggctgctgctctaagta gccgctggtg gatgactcag cttctgccag 71700 ccctcgggtg cctggaggatgagggactgc acacagtgct cacccgcgtt ggctcctgag 71760 cccctgcagg tgtgggcggtgcccataggg ctggtgctgg gttgggcctg cagccctgag 71820 tcacaggtga ccctgggggcagagtggggc cagtggcccc aggaagagga tgtgggatgc 71880 acagctcagc tggaggcgaactccaggcag ggtcaggccg tgtgctcgga agtcagggct 71940 tagctggagg caaactctgggcagtgctgg cccgtgttgg ggaaccagtt gcccctgggc 72000 ccccgtgaga ctgctgggtcctcatccctc tctgcctgag gccggagctg ccctgggctg 72060 aggcacaggg ggatttgtggtggtgttttt ttgagaaagg gtctcgcttt gtcaccccgg 72120 ctggagtgca ggggcttgatcacagctcac tgcagcctca acctcctggg cccaagtgat 72180 cctcttgcct cagccacccgaggagctgtg aacacaggtg tgcaccaccg cactcagcta 72240 atttttaaaa tttttttgtagagatgaggt cttgccatgt ttcccaggct ggtctcaaac 72300 tcctgggctc aggcagtctgcccgccttgg cctcccaaag tgctgggatt acaggcaaga 72360 gcttccatgc ctgcccagcagaaggctttt cgaaggaagc tgtttcctga ggcagactca 72420 gccctgctca tggcagccaccagcgtgggg gtgaacttgt tctgttactt ccatccccgt 72480 gggccaaatg ctttggtaaaacacaaggcc ctgtgtttag ctgtcttgac agtgaaaatg 72540 gctgggaagg aaggaaggaacggaaggaaa tttctctctc cttctgtgcg tacccaggca 72600 cgtgcacatg catgcagagtacgcacacac gcacgcacgc ctgcacaaat ccacgcatgt 72660 tgccaagtct ctgtgttccagccgtggtgt ctgccccccg gtgttctcta gttcggcttc 72720 tccgcatttc tgtgaatgattccggcttct tggtgttccc agcagaactc cctcaagtct 72780 gcggcggggc tctgacggcggtggcttggc tgacatggcc acattgctga gcctgttggg 72840 ggctttgcgt tcctgttctggccgtttttg gctcgttttc caggaacggt cgtcacgcgc 72900 tcctctccta gtgcaggcatcattcctttc ccattgattt gcagggttct ctgtaagttc 72960 tgaggatccc atatacatatactctctgta agttctgagg atcccatata catattctct 73020 ctctaagttc tgaggatcccatatacatat tctctctcta agttctgagg atcccatgcc 73080 gacatacata ttctttccttgtctcatgct ggtcattttt tccattttca tgacaggttt 73140 ggtgaacaca tgtttccttgtcagattttt gttctgagct tgtgcctccc gaccaagatg 73200 ctaaaccggg tcttgtgtattctccaaact gcactgtaga gtgacggagc tttgtgtctg 73260 ggcctccatg ccttctgacgtcacctgtgg gggtgtgaaa ggcagactct accttgattt 73320 ttcccagcac gccacaccggtggttctgtg cgctgaccga gcggctcggc ttcccccaac 73380 tccactgggc acctgccacacttttcctca tgtttttgtt cactgtggtt ttgtcgtaag 73440 tcctggtgtt ggcctgaaccaatttctttt tgtttgtttt tgagacagag ttttgctctt 73500 gttgcccagg ctggagtgcagtggcgcgat ctcggctcac tgcaagctcc gcctcccggg 73560 ttcacgccat tctcctgcctcagcctccca aatacctggg attataggca cctgccacca 73620 cgcctggcta attttttgtatttttagtag agacgaggtt tcaccgtgtt agccaggatg 73680 gtctcgatct cctgacctcgtgatccgcct cccaaagtgc tgggattaca ggcatgagcc 73740 accgtgccca gcctgatatttttagtagaa atggggtttt gccatgttgg ccaggctggt 73800 ctcgaactcc tgacctcaggtgatcctctc accttggcct cccagagtgc tgggattacg 73860 ggtgtgagcc accacgcccggcctcttgtt cttttgaaac ctgccctgac gttttttcca 73920 tagtgcatct tggagtcagcgtgtctactt cctgtaaaaa tcttactgtg attttgacta 73980 gaatgtgttg aattcctgttttttttttga gtcagggtct ctctgttgcc caggctggag 74040 tgcagtggga ccatcacagctcactgcagc ctcaacctcc tgggctcagg ggatcctctc 74100 agctcaacct cccaagtagctgggaccaca ggcacatgcc accatgcccg gctaggtttt 74160 tttttttttt tttttggtgaacaccctggg gttgcaccat gttgcccagg ctggtctcga 74220 actcctgggt tcgggcagtttgctcctctc agcctcccgg agtgctggga ttacaggcct 74280 gagccactgc actaggccatgttgaatttc tagattaatt tggggccctc aggggcacag 74340 agaggagggc tgggccagttggcgggagga gaggcccctc gggctgccgc attttcagtg 74400 catggagatg gcctatgttgggggaacaca gagctcaccg ggggtccctg cagggaggag 74460 aaagggtcag gcaggtgccagctcctgtcc attggcctgg ggctgcatga tggcaggggc 74520 cggtgaaccg atgacccctgggtgtcctgt gaccttctgt gtatgcggct gatgctgcag 74580 aaagtcgggt ggcctcaggctcctgacggg gctgcacttc ctctgccttt cagattgtgt 74640 tcagtgtgga cccctccgagggcagccctg gttccccagc agggctgggg gccttacagt 74700 cctataaggt aggggccacctccaggaggc aggtggaggg cagcccttgt tccccggcag 74760 ggctgggggc cttacagtcctataaggtgg gggccacctc caggaggcag gtggggctgg 74820 gggtcttctg gtcctaaaaggtaaggggct gcccccagga catgggcggg gcctccacac 74880 tcctggtcct gtcccctccaggtgcacatc catcctgatg ctggtcaccg gaggacggct 74940 cagcggtctg atgcctggagcaccactgca gccagaaagc gaggtacaga cctgggccca 75000 cacgctcccc gcccgcccgggtgcagtgcc cggcaccacc atgccacagg ctaggcacat 75060 gcccagccgt ggatctcctgcccccatggg cctggccacc ttctccatat ccaggccaat 75120 ccagagcatt ctcctcactgtccctctgaa gattggagtt actgagagac gtaggagatg 75180 gcctgatggc accgtgacctgcccagagtc acctggttgg tggtggcaga gccacagccc 75240 agccaggcct ccctgctgggacacgctcgt ttatgccgag gccgtcagca cagagcctcc 75300 acagtgaggc acggctctgcctgctgcctc cacgcagcgc ctggccgggc caagcctcag 75360 ggtcacatct gaagggggcccggctggccc tgttgtccga agcccctggt gcgctcagcc 75420 ccgaggcccc acgtgccttcttggcttcct gtgctccgtg gcgtcttcga gtcggtgctg 75480 ccggggacgc tgtgtggatggggtctgtga gtgtgccctc ggctccgtgt ccggagccct 75540 gtggttcttg gggtgtatctggccccaccc ccactgcgtg gtgtccaggg tggggcttca 75600 cggctgcagc tgcgggagctgctgcccctg ccttgtgctc cagtggggcc ttgcctctgg 75660 gcttggttcg tccctctctggaacattctt tctcagctgc tgtccgaccc atggtggcat 75720 gacgtggccc tggctgaagcagcccttgtg cggttgctgt ggttgggtct gcctggccga 75780 gccggaaggg aagggctgggagggcgtcag ggtggcgtgg cttgaccccc gctcggtgat 75840 ggtcctgcag caaggcctctcccagcagga agcgtccatc ccggggggag gccggcgccc 75900 ctcacgcagt tggggttgcgggaggcagtg cgtgcctgag gcagccggtg cacagattcc 75960 aagggcctgg aatctgtttgttccattgac ctctgatgtc acttgacttc tcagaagcag 76020 ccactccctg cactgggcgtttgtaggaaa tgagctcctg gaggaggggg tggggaagtt 76080 cccccattgc agggcacactcagccccagg aaggaaacgt gcctcgtccc tgctgactcc 76140 gaatcgcagt cagagtcgttctgcttgtgc cgtgttgaat tcccggcatc cggcatccag 76200 actcagcctc ctccccaggccacggccgcc gtggccagtc ggtcaagccc ttctaggaac 76260 ttcctttgag ctggcgcccttgttcactgc tgacgccact cagaggcttg tgcacgtgtc 76320 ctgcttccag gcagagctgggaactcgcac cccgtcttct gcacgcggcc gtggaatgtc 76380 gggatgccgg cgcttccttcccgtgtgctc ttggcggggt gggcttcttg ccctgagccg 76440 catgtcacag tttctgcagaagtttagggt tggagtgggc tgacctctct gcaggtgtcc 76500 ccagcctctg cctggggtctgcctcctact cccaggaccc cctgtccccc agaggggccc 76560 caagctggca ggctcacactcagggcagcc tcctttgttc tgacttctgc acagtgggcc 76620 tgggtggctg cccgcggctcgcttgcttga tgccagtggg tggagagggt gatgggcaga 76680 gaggcaggtg gtcaggcccccagtcccgtc ctcacactct gtgccctctg ccgccccccg 76740 ccccacaggg aaggtgctgagctactggtg cttcagtccc ggccacagca tgcacgagct 76800 ggtccgccag ggcgtccgctccctcatcct taccagcggc acgctggccc cggtgtcctc 76860 ctttgctctg gagatgcagatgtacgggcc acccctgcca gggcctgagc accggtgaca 76920 cctctgacat cagcggggtggaagtggtgg gggtccccat gagccgggtg ctgggggtct 76980 cgggcctcga gggctaaaggggtgctggtg cacttcccca ctgtctgctc cctctggcca 77040 cgctcagccc tttcccagtctgcctggaga acccacacat catcgacaag caccagatct 77100 gggtgggggt cgtccccagaggccccgatg gagcccagtt gagctccgcg tttgacagac 77160 ggtgagggcc tgtccctgggccctgctggg gtgggaggtg ggggagcact gaggcctgag 77220 gccctgagca gtggcctctccggctctagg ttttccgagg agtgcttatc ctccctgggg 77280 aaggctctgg gtgagtgccctgaatgcccc agctgtgcgc atcctggatc ctggacccct 77340 gctcccaaga gctggtagggacccctgcag acatcctgcc cctgccttga ccccggcccc 77400 tgcacttcca ggcaacatcgcccgcgtggt gccctatggg ctcctgatct tcttcccttc 77460 ctatcctgtc atggagaagagcctggagtt ctggcgggtg cgtctcccct gtgttctggg 77520 cggggtgggt gagggcagggctggagcatg aagcaggcag tggtcacagc tcctgcttgc 77580 cctcatcgga tcggcggcgtgaccagggct gccgtgtccc tgcctcttcc tcccacaggc 77640 ccgcgacttg gccaggaagatggaggcgct gaagccgctg tttgtggagc ccaggagcaa 77700 aggcagcttc tccgaggtcggcacttggcc ggggctctgg gcctgctgcc ccctcgtgcc 77760 tcccctgcct ctcacagcttccccaaggct gaccactggc cctgaccatg ggctccggcg 77820 gctcccgctg cctcttcagggctcctgcgt ttccttcctg gccctgagtg ttgcctctta 77880 tcttacaaag cccccagcaccgggtgggtg tggtaacagt ggccctcctg tctgagtagc 77940 cctagtcggc caccctggccctggggttcc ccgtgttttc tgggaagcac tgagcaggcg 78000 tggggtcagc ctgggatccgtgccaggaag aagcttccag aacccgattg gccttcctgg 78060 ctaggacgat ccttcatcttggagcatgag acctgggtct ccctcatggg ggaggaaggg 78120 gctggggggg ggctccaggctcagcctcac caactttcct tccagaccat cagtgcttac 78180 tatgcaaggg ttgccgcccctgggtccacc ggcgccacct tcctggcggt ctgccggggc 78240 aaggtgagct ctccagggccctctgccctg acctggttgc ctgttccctg gtgggtgctt 78300 atggctcccc agcagactctgggccctggg ggctgcccgg tcccctcctt gggtcccacg 78360 agagcgactg ctggccctgctgggagcgtg tcctgctctg ggcctgggca ggcaggatgg 78420 gagtttcctg gccacaagagttggaggtgg cgtctgggag ctgtggaccc caagtggggt 78480 cctgacccac agatggagcttcctcccacc cctggttggg gacggagcct cggggaaggt 78540 ggctgggctg ggtgtgggcaccagggagag gagcccccac ggccccaggc agctccctgg 78600 tgtgtcccct aggccagcgaggggctggac ttctcagaca cgaatggccg tggtgtgatt 78660 gtcacgggcc tcccgtaccccccacgcatg gacccccggg ttgtcctcaa gatgcagttc 78720 ctggatgaga tgaagggccagggtggggct gggggccagg tgagttacag cagggtgggg 78780 ctggggtaag gcggtctggtgactgagccc ccgccccgtg gccaagggag cccccgtgac 78840 cgagccgcct cgccccacagttcctctctg ggcaggagtg gtaccggcag caggcgtcca 78900 gggctgtgaa ccaggccatcgggcgagtga tccggcaccg ccaggactac ggagctgtct 78960 tcctctgtga ccacaggtgcgtgcagtccg gtggcaggcg cggcgccagg ggacacgccc 79020 acaccccact gggcccctggactctccttc cccacatgag gccccgtctc ctccagagcc 79080 tctccggcta ctcggggtcagcgtggggcc cctgcagcag atgagggtct tcacttcggt 79140 gaactgaacc cttgaagcggctgtgggcag ggcagcaggg ctatggccac cccccaggtt 79200 cgcctttgcc gacgcaagagcccaactgcc ctcctgggtg cgtccccacg tcagggtgta 79260 tgacaacttt ggccatgtcatccgagacgt ggcccagttc ttccgtgttg ccgagcgaac 79320 tgtgagttcc tgcccagggaggggatgagg gtgttgtccc cagaggagcc agaaatgggt 79380 ccacccaccc ccatggttctgcagatgcca gcgccggccc cccgggctac agcacccagt 79440 gtgcgtggag aagatgctgtcagcgaggcc aagtcgcctg gccccttctt ctccaccagg 79500 aaagctaaga gtctggacctgcatgtcccc agcctgaagc agaggtcctc aggtgcggac 79560 gggcagcgct gggtgggcggtgtgggggtg gcggagcggg cggcgtgggg cgggcagcac 79620 caggcgccca gggcggaggcgactcacctg gctttgtgcg cttcccctcc cacctccaaa 79680 ggctgcctct ccctcctagggcagggcccc cacgggctgc aaccctcccc tacaggcaga 79740 gaacgcccca ggcaaggatgccccccgagg ctgagactcc ccccaatagc agggaggaca 79800 cccacaggca ggaccccaagtgctgggact ctcccccaag aggggctttg ccacaggcag 79860 ggaccccagc tggggccccccgtgggcttc actgcgcact cgggtgcccc tgcagggtca 79920 ccagctgccg gggaccccgagagtagcctg tgtgtggagt atgagcagga gccagttcct 79980 gcccggcaga ggcccagggggctgctggcc gccctggagc acagcgaaca gcgggcgggg 80040 agccctggcg aggagcaggtacagttccag ggccttggga tggacacaga ccctctgtct 80100 cctgaggcca acccgaccccgcccatctgg cctcaggcac ctccccacac acccctgtaa 80160 atcccctgcc tggcaggcaggcgggcaagc gggcggggga tcccagctgc ctggctgtct 80220 gtgggtcctc caccccacctcacccacagg ctgctggctc ccaggtggtg catgccctgg 80280 ccctccgcgg gtgccccccacatcactttg gttctctggc gggtcagctt ggctcagtgc 80340 actcaaggtc gggtgcccctgccactggct gcgcttgagg ctggcctttc tccaggaatg 80400 tgctgcgggt ggaacccaggttccttcttc cttggggcct tttgccccag aagcccataa 80460 ttcctcaggc caacccgaaattttctccct gcttcctgct gggagccatt cccctcttcc 80520 tgcccatccc tgcccttcaggcccctggag tgagctccag gtgcaggcac caggcacctg 80580 tgtccccttc ctgccagcccctcgctgtgg tcggactgtc ttccctggac ctgctcttac 80640 aagtcaccac ctgcgagcctcatgagccgc tggtgtgact tggacaggac caagttgtgg 80700 cactgtcacc ggggtgtgctgtgcccccct cccccgacct ccatcttggc tcagggctcc 80760 ttgggaccat cttccctgtgcgtccaggtg ctttgggacc ccagagtgtg tggttggggt 80820 ctgtgtgtgg ttgtgagctgtgtcctcctc aggcccacag ctgctccacc ctgtccctcc 80880 tgtctgagaa gaggccggcagaagaaccgc gaggagggag gaagaagatc cggctggtca 80940 gccacccggt gcgtgagctgtccctgcacc tgtgccgacc accatagaca cgcatgggaa 81000 cgcagccgtg ggtgcccccagccacggctg gtcccgatgg gaccagggaa tccaccccca 81060 ggagctgatg tccagggcagctgtgatgct gacggccagg ggctcaagtg tgtggtttct 81120 tctgcagggg gctcatgagtcccagctgga atcaggcccc acccttgggc aggtttggca 81180 tggggcctgc agcactgggcttggccctgg catttccctc aagtgtggat gcacacctgc 81240 ctcatgtgag ggacacagcccattcctagc cttggatcaa agaacggagt tatagccgga 81300 gccaggaagc cccctgcctgctggaaaacc ccaagtgtgg cggcctttgt ccatgtccct 81360 tggcttctgg gaagaactgggtggtgccca ggcagggctg gtgccatcag gaagtgggtg 81420 gctgctgagg ggcctgggctggcgagggcc tgggtgggga gtgcctgggc cgcccctgcc 81480 ttggtttcca cgtttccgtgttggtctggg gtgtgtagag agatgggcac tgctcatccg 81540 gaagcccctc cttgtgcgctgccatcctgg gagcctcagc cgcatccgct gtggggcagg 81600 gggcttgagg gaggaggagagagacgggcc atgcaggacc cctggcttga ggcagagcca 81660 atctaccctt tgcccattcactgctctcag ttccctgcca gcctctcact gtgtgacctc 81720 agacgggccc agccccacagctttcttccc gcagcccctc cctatgtcca tccagccagc 81780 cagtttctca ggcagcagccccacctcggc agtcactgtc ccagggaacg ctcaatgttc 81840 caaggaaggc tctgcagccccagggaccag atgatgaggc tggccctgat ggagcctcgg 81900 gcctgtgtcc tgcaggaggagcccgtggct ggtgcacaga cggacagggc caagctcttc 81960 atggtggccg tgaagcaggagttgagccaa gccaactttg ccaccttcac ccaggccctg 82020 caggactaca agggttccgatgacttcgcc gccctggccg cctgtctcgg ccccctcttt 82080 gctgaggacc ccaagaagcacaacctgctc caaggtgccc tggcttgcag aggccaccca 82140 ccctgagggc agtgctgccgccgcgtgtgg ggtgggggcc atctgggtcc aaggtggtct 82200 ctgttctcta gagaaaaaggggcagatggg gacagacgcc ccttcctcta caggcttcta 82260 ccagtttgtg cggccccaccataagcagca gtttgaggag gtctgtatcc agctgacagg 82320 acgaggctgt ggctatcggcctgagcacag cattccccga aggcagcggg cacagccggt 82380 cctggacccc actggtaaatggggccccag gtgggaccct cagactcctg cgtggaaggc 82440 agtgtgggcc agagtcctgggctgcttggg gtgggcatcc tcgggccctg cttggccccg 82500 cctctctgtt cccctatgggagtgatgggg gcctccacct ccaccaccag caccagcagc 82560 accacctcca ccttcaccaccaccacctcc accaccacca cctccaccac ctccacctcc 82620 accacctcca ccacctccaccacctccacc accaccacca cctccaccac caccaccacc 82680 accacctcca ccaccaccaccaccaccacc acctccacct ccaccacctc caccaccacc 82740 tccacctcca ccaccaccaccacctccacc tccaccacct ccacctccac ctccaccacc 82800 accacctcca ccaccaccaccaccacctcc acctccacca gcagcagcat cacttgttgg 82860 ggagaccctg tgcaactccatgcacagccc tgtccctgcc atagccccga cccctaagca 82920 cagccctgtc caactgccacacgtcccctg cctcccatgc atggtcctgg ggggtcaact 82980 gcacacgcca gggtcctagggtcctagacc cctgtcctcc ctgtttctgc ctctgtttgg 83040 ggtggagtcc aagtctccagaggcggaagc atctgtgttc gtgtgttaat gaacagcccc 83100 tacagagttc ccctagttcacccagggggg aacctagcct gttgggacga ccccagatcc 83160 cttctgggct tggtactcactgggatatcc tcatgcctgc acccagccta cggctctgag 83220 ctcctgagtg gggctttggcctgcccgcca ctgttccagc ccccatccag caggctggtg 83280 tctcctctga tgcccccagcacccaggcgt gtacctgcct gggttttccc gccctggtct 83340 gaggtgggtg aggcctggcctccctagcca gccctgcccc cccaccccag ggaactttcc 83400 agatgctccc gaccagctttgtggctctac atctcttcat caggaagaac ggcgccggat 83460 cccaagctga ccgtgtccacggctgcagcc cagcagctgg acccccaaga gcacctgaac 83520 cagggcaggc cccacctgtcgcccaggcca cccccaacag gtagctgact cctgaaccgt 83580 gtgcagccta cgacttggtgggtccctcag tggcttcacg aggctaactc ttgagtgtgg 83640 ccggggctgc ccctgtggggagccatctca tggtggggac tgctcccggt tctgcacccc 83700 gcagttgtcc tgagcagctctccaggagtt cctggaggaa gggcgggcag ggcggtggga 83760 ctctcagtcc tccaccccagcgccactctg agccatgcta ctcccacacc aggagaccct 83820 ggcagccaac cacagtgggggtctggagtg cccagagcag ggaagcaggg ccagcacgcc 83880 gtgagcgcct acctggctgatgcccgcagg gccctggggt ccgcgggctg tagccaactc 83940 ttggcagcgc tgacagcctataagcaagac gacgacctcg acaaggtgct ggctgtgttg 84000 gccgccctga ccactgcaaagccagaggac ttccccctgc tgcacagcaa gtggccctgg 84060 cgtggggaac agccggtggggtggggggca ggggacaaaa tgggggctgt gccgggtctg 84120 attgaagctc cccgcagggttcagcatgtt tgtgcgtcca caccacaagc agcgcttctc 84180 acagacgtgc acagacctgaccggccggcc ctacccgggc atggagccac cgggacccca 84240 ggaggagagg cttgccgtgcctcctgtgct tacccacagg gctccccaac caggtagggc 84300 acctgcctgg ctgctcctggcagcgcccca accgcacgca gccctgggag tgagcagcaa 84360 agccccaggc ccccctcagactcaagtctc tgtctccagg cccctcacgg tccgagaaga 84420 ccgggaagac ccagagcaagatctcgtcct tccttagaca gaggccagca gggactgtgg 84480 gggcgggcgg tgaggatgcaggtcccagcc agtcctcagg acctccccac gggcctgcag 84540 catctgagtg gggtgagcctcatgggagag acatcgctgg gcagcaggcc acgggagctc 84600 cgggcgggcc cctctcagcaggctgtgtgt gccagggctg tggggcagag gacgtggtgc 84660 ccttccagtg ccctgcctgtgacttccagc gctgccaagc ctgctggcaa cggcaccttc 84720 aggttggtgc ctggccactacagttcctgc tgggtgtagc cccaggtgat gggctgaggg 84780 ggaaagggca ggcccttgtcctggtggcaa cgcctggcag acgtgtgcag tgggccggtt 84840 gtctcacagg cctctaggatgtgcccagcc tgccacaccg cctccaggaa gcagagcgtc 84900 atgcaggtct tctggccagagccccagtga gtgcccacgg aggcccccag cacacccaac 84960 gtggcttgat cacctgcctgtccagctctg gtgggccaag aacccaccca acagaatagg 85020 ccagcccatg ccagccggcttggcccgctg caggcctcag gcaggcgggg cccatggttg 85080 gtccctgcgg tgggaccggatctgggcctg cctctgagaa gccctgagct accttggggt 85140 ctggggtggg tttctgggaaagtgcttccc cagaacttcc ctggctcctg gcctgtgagt 85200 ggtgccacag gggcaccccagctgagcccc tcaccgggaa ggaggagacc cccgtgggca 85260 cgtgtccact tttaatcaggggacagggct ctctaataaa gctgctggca gtgcccagga 85320 cggtgtcttc gtggcctgggcttggtggtg ggagttgagg gacagggagt tggcagaggc 85380 ccctcccagc ctgccatgtgacactgtact tcctccacgg tgggctcagc cctgccctca 85440 tcctcacagc cgcagccaagctgcagttgg taggggatcc accgacacac caggctgcct 85500 gggctggtct ctgggttgggagctgcccca ggtgctgagg agggcagctc cctggctggt 85560 gaggcccctc ccagaaccacccttggactg agctctgggg agggatggta ccaggtgggt 85620 gaggggggct gcctggggagggaggggttc ctatggggcg tggcgaggct ggcccagccc 85680 tctccccgcc catatatgtagggcagcagc aggatgggct tctggacttg ggcggcccct 85740 ccgcaggcgg accgggggcaaaggaggtgg catgtcggtc aggcacagca gggtcctgtg 85800 tccgcgctga gccgcgctctccctgctcca gcaaggacca tgagggcgct ggaggggcca 85860 ggcctgtcgc tgctgtgcctggtgttggcg ctgcctgccc tgctgccggt gccggctgta 85920 cgcggagtgg cagaaacacccacctacccc tggcgggacg cagagacagg ggagcggctg 85980 gtgtgtgccc agtgccccccaggcaccttt gtgcagcggc cgtgccgccg agacagcccc 86040 acgacgtgtg gcccgtgtccaccgcgccac tacacgcagt tctggaacta cctggagcgc 86100 tgccgctact gcaacgtcctctgcggggag cgtgaggagg aggcacgggc ttgccacgcc 86160 acccacaacc gcgcctgccgctgccgcacc ggcttcttcg cgcacgctgg tttctgcttg 86220 gagcacgcat cgtgtccacctggtgccggc gtgattgccc cgggtgagag ctgggcgagg 86280 ggaggggccc ccaggagtggtggccggagg tgtggcaggg gtcaggttgc tggtcccagc 86340 cttgcaccct gagctaggacaccagttccc ctgaccctgt tcttccctcc tggctgcagg 86400 cacccccagc cagaacacgcagtgccagcc gtgcccccca ggcaccttct cagccagcag 86460 ttccagctca gagcagtgccagccccaccg caactgcacg gccctgggcc tggccctcaa 86520 tgtgccaggc tcttcctcccatgacacgct gtgcaccagc tgcactggct tccccctcag 86580 caccagggta ccaggtgagccagaggcctg agggggcagc acactgcagg ccaggcccac 86640 ttgtgccctc actcctgcccctgcacgtgc atctagcctg aggcatgcca gctggctctg 86700 ggaaggggcc acagtggatttgaggggtca ggggtccctc cactagatcc ccaccaagtc 86760 tgccctctca ggggtggctgagaatttgga tctgagccag ggcacagcct cccctgggga 86820 gctctgggaa agtgggcagcaatctcctaa ctgcccgagg ggaaggtggc tggctcctct 86880 gacacggaga aaccgaggcctgatggtaac tctcctaact gcctgagagg aaggtggctg 86940 cctcctctga catggggaaaccgaggccca atgttaacca ctgttgagaa gtcacagggg 87000 gaagtgaccc ccttaacatcaagtcaggtc cggtccatct gcaggtccca actcgcccct 87060 tccgatggcc caggagccccaagcccttgc ctgggccccc ttgcctcttg cagccaaggt 87120 ccgagtggcc actcctgccccctaggcctt tgctccagct ctctgaccga aggctcctgc 87180 cccttctcca gtccccatcgttgcactgcc ctctccagca cggctcactg cacagggatt 87240 tctctctcct gcaaaccccccgagtggggc ccagaaagca gggtacctgg cagcccccgc 87300 cagtgtgtgt gggtgaaatgatcggaccgc tgcctcccca ccccactgca ggagctgagg 87360 agtgtgagcg tgccgtcatcgactttgtgg ctttccagga catctccatc aagaggctgc 87420 agcggctgct gcaggccctcgaggccccgg agggctgggg tccgacacca agggcgggcc 87480 gcgcggcctt gcagctgaagctgcgtcggc ggctcacgga gctcctgggg gcgcaggacg 87540 gggcgctgct ggtgcggctgctgcaggcgc tgcgcgtggc caggatgccc gggctggagc 87600 ggagcgtccg tgagcgcttcctccctgtgc actgatcctg gccccctctt atttattcta 87660 catccttggc accccacttgcactgaaaga ggcttttttt taaatagaag aaatgaggtt 87720 tcttaaagct tatttttataaagctttttc ataaaactgg ttgtagttgc acagctactg 87780 ggagggcagc cggggacacctgagccgccc gctgtgccca gatccctcag gctgcctgcc 87840 atcagaactg ctgcccggggcttcccctac ctcagacaga ccctccctgg gaggatcagt 87900 ggggagtgcc acctctgcccccagtggctg tggcacgtgg caggggcccc tgaagctcag 87960 cgagggtcag ggcctgggagggtatcattg ctggaagaac aggatggggc tcaggccagc 88020 cctagtcgcc ggggcccacactaacccccc acttatgaat tcctcccact cccaactcac 88080 aggggatttc ccgagaggggacctgccaaa gacctcctcc aggcctccca tgcttcccgg 88140 gaagtgaagc ttctccccctctggggcagg ctctgaagcc tcccgatgca cccagagcaa 88200 ccagggggct gcaccagccactcgcctccc cagcacggcc aggttcccgg ggctggaggt 88260 cccccccagg tcctgggaaccaacctgcag aacacacaca gggtcccctg gagaggacgc 88320 ggggacttcc agggcccgactcctgtgagt cacagccccg cagctgctgc gccaccccca 88380 ccctgactca tgccccttcccagcagctcc tcccaggacc ccatgtcctt cccacatccg 88440 caggaaggga gtgcctggactctccaggcc cacctgggga gcccctcacc tgcccaccag 88500 cccctgagca gcccagtaacaccatcaccg tgtccaacag ccaggagcct ccaccctcca 88560 ggagggaagg gatggacagagccacactcg ccgtctttat tttgcactca ccctgggtga 88620 cactgggcag gccgctcctgcccacagcca gactgaggaa gaacacagca ctcggcaggc 88680 ccagtggggt ccgtgcagggaggaccccag gaccagcctt actcccgagc aggggacaca 88740 gggccccaca gagaacccctccgggaggtt ctctcctggc tgggggaggg ctctggaccc 88800 ccacaaacac tccccaacttgcggggctgg ggcataaaaa cagccactcc cagcaggccc 88860 cctcagcttt ttgcatcagtcagctccctc ccgggggatt agggtgaggt gaagccaggc 88920 ccaggcgtgg ggtataggtcttcccccgca ggcctcagcc ctgtcccgag gctgcatcac 88980 aatccagggc ccccgctggcctttgggaac atggcctggg tcttcctcaa ggcaagatca 89040 gccccagacc acttccggggtcacggggtc acagggcaga agccagatgg cagccatggc 89100 tgacgggcct cctcctcgatggggcggaga cagccacggg gtctcccgag ggtcccacag 89160 ggctgtcctc atgcagcccaagccagcctg agcactggag ccccaattcc caaccaggtc 89220 tccctcagac cccccagaaagggcctcgaa aggccgccgc tgcgccctgt ggaaaggctg 89280 ccgctgcagg gcctgggccagccgggctgc cagactcccc tccaaagcct ccggatgcct 89340 acgcttttcc agacatagaggaaagtttgt cttcgagaaa acaaagtaaa tagaagaacc 89400 ccaaagcaaa gcaaacccaccccccagatc agcagcatgg gagccaacag gaggccactc 89460 ctccagcacc aggggaccagccgtcccgac ggcagcgcgg ctgcgcctac gtgatgtccc 89520 tctgccgcgg cggccggtgcacattccgca cgacacactt caccatccac tcgatgccct 89580 cgcgcacccc tttgctgtgaagacagcggg tgtgaggcgg ggggtctcgg tccccaaagc 89640 ccccgcaggt gcagcccccactcaccctgt gagggccgag caggcctggg tcaggcaatc 89700 gcgcctgccg atcttgctggtgcagtcgct gaaggccgtc ttgatgtcag ggattgagag 89760 gcacgtctgg gggaggtaaggccgtgagga gcagccccca cgtctggccc tgtcctgcct 89820 gtgggcccgg gactctcagaagggcgtatg cccttcaccc cagggaaaca gccagagctc 89880 caccagggtc ccagtgtctcccacagagac cacagcagtg aggaccctgt gctcagcccg 89940 aggctgaaca tggctggtagtgcctgagac aaactagacg tccacacggc tccaaggagt 90000 ccacccccca tcccctccctgggggacacc ctgagccccg aggtggggcg ctgaggactg 90060 aggcctcctg ggcagtggcggaggcaggtc ccaggggccc acacagccgg ggatgatgga 90120 gaggtgggag ccctgcatcagtgatggggg cagtctgcag tcatggtggc ttctgctcac 90180 aaccacctgc ccagtcttcaaaaagcagcc ctcccctccc cttttcctcc gaggggagac 90240 ccctgccccg taccagatgtccctcttgtc ggctgagatt gtaggggagg ccagccttac 90300 aggctggggg caacagagccaccccagaga aggcaggaag tgaagattca cccggccctc 90360 tggacgccgg gctgcttctgtgcaaagcca ctccaagaga acagctagaa ctcagcgtgg 90420 ccagtgctcc cgggggcagtggcacctcag aggggtcttg aggggctgcc ctgggggtgg 90480 ggctggcaca gatgccacctccaagggtag caggaacagg taagggtcag agctgactcc 90540 caccagggcc ccagcatcacttctttgagc tctgagtttc acctgggtgt ccccacagct 90600 tggccacaca ctcctgagacacggccgccc tcctggggag aggtgccctg catagcagga 90660 agaggcctct gggcgcctgccctgaggtgg gagaacctcc agggctggca gcagcaggtc 90720 tggagaggaa ccaagcttgggaagctgctg ggggcagggc aggccttgag aatggctctg 90780 taccccctgg gcagtcactgggcctggggt gtctgggtgc acacctactc cccttgctgt 90840 gggggaggct ggggactcgggaagctgctg cgggaggcag gggtggggct cacctccaca 90900 tcctgcttgt tggccagcaccaagacgggg acaccgcaca gcgcctcgct ggtcaccacc 90960 ttctctgggg agggcaggagaggcagcgcc tcacacccag catcctgcct ctgactgccc 91020 aggggcccac aggcgtggacactgtgacag ccactccctc tgcccccccc ccgtcaccca 91080 ctaggcagga gcacttctgaccagacactg agcctgcccc aggcacagag ctgcccaagc 91140 tggacctgcc cccactcaccatccatccct cccagagcag ccaggccgca ctcaccaaac 91200 gcctgcttgg actcagccagcctctcctcg tcggtggagt caatgacgta gatgacgccg 91260 tgacactccg cataatactgggaggaagca ccaggagttg gggctcagtc cccaccctgc 91320 caagggccag cagagccaggcctgtgtcat ggccacagtg aggggctcac atgaggaagg 91380 ggcaagaggg cagcccccaactgcaagacc cttctgggat gcattctggg gttgcgggga 91440 gatctggtgg aggtgtccccagacgctgct cctgagaacc tgccggcaac ctttggcctg 91500 atggtggcca aaggtgaaagacagggattg ggccaggcgt ggtggctcac acttattatc 91560 ccaacacttt gggaggcagaagcaggagga tcacctgagc ccacttcacg gccaacctgg 91620 gcaacacagt gagactccgtctgtacaaaa gcttatggta atgtgcgcct gcagtcctag 91680 ctactcggga ggctgaggtgggaggatggc ttgagcctgg gaggttgagg ctgtagtgag 91740 ctctgatcac accactgcactccagcctgg gtgagaatga gagaccctgt ctcaaaaaaa 91800 agatagggtt tgggggctggaggaacctag accacagcct ggcccgttga gggagtgcac 91860 ctgtggggct ctgtgccagcacctcgcaca gggagggagt gtggccatgc ggataagact 91920 gaccagcacc atctacgaagcgagccttcc ctgccaggac agggccagag tcactgagct 91980 cagacctctg cagcctgggctggtcagtcc tgggctcgct ggcaacactc ctgggcaaga 92040 cagggcacag cccctgcagcctcaggtaca agtgctgagc cctggaccag atgagtgcac 92100 ctctatctca atcagaaaaaaacacagcaa actccgcgtc cacgtggagc agacaacagc 92160 tcacatttgc cactttgcctccaggctgtg ccagctctcc tgtccaggca tgagtgccca 92220 gagacctaga actggatgctgaccaggtag gacaagctgg tggtcagtgt gttaagacac 92280 acacacccga gagcatgagaagccaggagg cacagcccaa ctctccgaaa tccttagggt 92340 gtctgagcag ggagtaccagacaaccccat cccagtgcca gacaagcttg tgcacctgca 92400 cttcccacag aggagagaagcctgtgcacc tgcacttccc acagtggaaa ggaggaggcc 92460 caaggccagg cccccccacccccaggaact tcccacagtg gagaggaggc ccaaggccag 92520 gcgccctcca gggttctgcaggtagcgagg cccccccacc cccaggaact tctctggcct 92580 acagacaggt cccacacagaggccgccaac ccctcaaggg accctgcagt gtgccggctg 92640 tctgctgctg acacaagggagcaggcggac cctaaggtgg agacctctgt ggcaggaggg 92700 gcggctctgt ggaggctgcagcaagcccag tgagagaatc tccacgtggc tcctggggct 92760 tctgagcagg gtggcagaaggttcatgtgc aaccgggtcc tggaccatgg gaccacgtgg 92820 ccagagccac ccatcacacctaccaggcac aaggtgcaca gcccagcagg gccgcagtgg 92880 acgggagcga cacctcagggctgagtgcgg gcaggaccca gagccccacg ccccagtgga 92940 ggcgtcacag cagtggtcattgtggggtgc cccacaagga gggggaagag ggaggtgtcc 93000 cagcgtggct cctggctggccagctgaccc cagtggagca gtcagaggga ctgtgggtct 93060 gagtttttct ccccagcagcaatgggagct ccccaactgc aaagtgccag ccagcctgag 93120 agactagtgt tacagcaaagaacccaggag ctgaggtcct ggcacatgcc acacatgtgg 93180 acaccaaccc agggtccagccccaggacga ggccaattcg caatgacgcc cctttctgtg 93240 gtgctggctc tgcacaaggatgcaggatac aggaaccagg gtgggagcag gggcctccct 93300 tccggtccct cccagtgacctaggggggtc cctgcagctg atcctcccag ctctgagctc 93360 agcagggtca ggggtcccggccactagagc agcacatact cagcagacac gctgaatgac 93420 gagccacagc tgcctcatgggcatgacttg cacctcatgt ctaggagacc ctggtgggca 93480 ggagatgggg ctgccatcccacagctgtcc cacagctggg gacccaggga gccactggcc 93540 ccaccacggt ggtgtctggagaagggctca gactgccagg aagtcgcacc ccagcagaag 93600 tggtagtgaa ttgggagggcactcaaggaa gggctgtgca gccccaagac cagcagcaag 93660 gatgggctac agtggcccccttaagtctcc ctcttccagt ttcgccttaa gagaggccct 93720 caggaccttg gaggaacccctctccaacgt ggaagtgtgg gtccacatag ggctgcagct 93780 gtggccagtg caggcatctctggccccact gtattcttgc ttcatgttgg agaacactgc 93840 accagcagat ggtctcattttggtttctgt gggacccact ttggctgcaa agagccacac 93900 tgccaggtca cacctgcccagggcagccca cactggggac ccaccaggcc atggtgtgaa 93960 gtcccggcca gcctggccccacatggcaca gcatagccag ttctcctcca gggctccctg 94020 ctgggccaac cacagctctgcggatcctgc tgcctgagtc gacctctcct ctcccgtcct 94080 ccctgccttc ctggtgccgacccccagtgt gcatcctgta cctcgacctg tctcagcatc 94140 tgtgcctgag acaccggcctgtgacaagat catcatcatc tgtgtcactc cccaagcatg 94200 ctgcgcactg gacacacaggccctgactca acttgtcctg tctgacttca gtggtcctac 94260 aggatctatc agagatcacttggccatggg agaaatgtct tcttggctag aagtcacagc 94320 aggaggggac actttgggggcgcctaggaa aggggaacta ggatcaaaaa agagatcagg 94380 acctgggcac tcagctctagagatggcatc agggcagcca aggcactggg gacaccccac 94440 acccactgtg ccagcctagggcagggagcc cgaggaagcc acaggctctg ccctgctcag 94500 tgctggactc agtgcctggcccaggctgag aaggagataa actgcagcct tgggggtgtg 94560 gggaaggggc accacactgggatctcagaa atgcccaaaa cctgtgtcaa aataggagac 94620 tgccgctgtg agaccctgaggagtcttctg gtgatcatgg aagaacaaat gttaagctag 94680 aactgaagga acctcatcaggggagaggca gccatcctgc cgtccccaca tctggtcttt 94740 gccatttctg tgtcctgtggtggtcagcag caaggtctct gagccgaaag gaggcactca 94800 ctttggagga gtgcagggtccccaggtccc cacactttgt cttgtcctga ctgagaaaga 94860 aacagactgc cctgacctctctgacttggc cagcgaggtt gcccttaggc tcaaacccaa 94920 gccagggttt gaacattcccagacacttgt aagatgttta ggttgttaac ataatgttca 94980 ggtttcaaaa cattgaaagaaactagcccc agccctgaac ccagatcccc cccggcttca 95040 ggcatgacca gtgaacacgcccttctctca ctggtcacct gaggatgccg cactctgtca 95100 acaggttccc ctaatacatgctctgatctg atcgccttgg catttagtga ttctttccct 95160 ggaattctcc actggccccatcgcagggaa ctcccaagtg ggaaactccc ctaccaccac 95220 ttttggggca acttcagctaagggttcagc tgggacaaaa cagggagcca ctcgggaacc 95280 tgggacagga ccagagagaaaacccgaggg acagagtggg taaggaaagc tgctgaggaa 95340 gggcccaaag ggcactctggaaagaagtgg cactggaggg ctggggtggg ggtggtcctg 95400 gccagggagt cttaccttgtcccacaaaga ctgcagctct tcctgccctc ctaagtccca 95460 gaacatgagc cgagcctttcccacatccac agtgccgact ggggagagga ggaaacaggc 95520 aaggctcatg accttggtcctcgacacacc cagtcccagc tctcccaggg gatggggcaa 95580 accatgctgg tgccactcaaatgagacttg agaggggccc gacagggctg tggccacggg 95640 ccagctggac tgtgaatatcacggcatcct caaggcccca aacccacagc ctgctattga 95700 gacccttact gtttaggcccacggtggtgg tgattttgga tagactcatc cccttgtagt 95760 tcttgttaaa tcgggttttcgactgctcca ggaaggtctg aggagagagg cagaggcgaa 95820 acacatcaag gaggggctatactggcttcc aaatatcctt actcaggtct gttctttaaa 95880 agacagaaac agaaacagagcaacactctg ctcttcagga ggctggtggt gactatcctg 95940 ccgtctcagg tgaaatttggcttccgtctg ggtagtgaac gtgcagctga cagcacaaaa 96000 ccgaaggggg cgccgccaggccgtgggaaa ggtgcgcgca agggcgtggg cactcaccgt 96060 cttcccagca ttgtccaggcccaggatcag gatgcagtac tcgtccttct gaaacatgta 96120 cttgtacaag cccgacagcagcgtgtacat cctgccctgg gcaccccaac ataggtcagt 96180 gtgcagccag aaagcacctcccctcccccg ggcttctcca cggtggtcag tggcgcccca 96240 cgtccagccg accgctcaggacgagagcct gggggccatt cccgactcct cgtccctctc 96300 ccaccccgtc cctctgtaacttctcccagg tcagccgcca ctgtgtcctg ctcacagcaa 96360 tgactgcgac ctctccgcatacacatcggt tccggcccct cccctgctcg cgggactacc 96420 cagccgggtg ttcacagtgagctcagccgc gctcccgccc tcccccgagg cttcgctccc 96480 acgcttcacg cgcgcggaacggggaacaca ctcgctgcag ccccgcctgg gccacggcac 96540 cctcgagcgc cagccccgcgccccacccgg gagcagcgag ccaccggcgc gctccccagg 96600 agcccctgca ggcgccgggtagggacgccc catcacccca tttcttaaaa cggggacggc 96660 cctgggggga gcggactacagggcgggtga gcagcggcgc ggctgctcct ggagtgcacc 96720 tggaggcggc gcgcggctggcagggaacga ctgcgaagga agaacctggg tcgcggcccc 96780 cggctacgtc cgccccaagccgccgccgcc aggtctgagg ctccccgaca agcagccaaa 96840 gctggctcct gtcacacccgcgtcccacct cgagtcctgg gccgcccctc gggcctcgcg 96900 cctcaccgca cagcctgcggcctacctgcg tccgccgcgc cctcggagcc gctgctgctg 96960 acccccgctg acctccgctgaccccgcgct aaccccgcgc ggcgcctgac gggacgcggg 97020 ccggcctcag ggaatgagctgaaccgcgtc ccagcggcct ccgcgctccg cttcccggct 97080 gcccccgcgc gccaagcacttccggaagcg gcggcgctcg ggaggaagtg ccgatcggct 97140 gctggggcga aaagggggcgccgggccgct ctagccggtg aggccggcgg gctctctgtg 97200 gctgcggctg ggaaaccgcgcggaggaggt gcccggccgg ggaccaggtg gccgcggttt 97260 gcggggacgc ggccctggccagacagaaga gacgccgggc gggggggcgc ggccggcctg 97320 gaaggcggcg ggcgcggcgggtgggctcgg cggagggtga ggcggcgggg cgccccgcgg 97380 ggaaggggct ccggagtgacgcgggacccg gctagcggcg agcccacggc ggctcggaag 97440 ggaagcgcgg agcctgagcgggggtacccg ggctgcgacc tctgcgctgg gagctgtgcc 97500 tctgagccgg tgtctccccgagggaaaggg gacgtgcccg tgcccgtgcc cgccctcagg 97560 ctgtggggtc ggtcccgagacgcggggctc agctggcttc tcttcttgca gccctggtcc 97620 agcgcctccc tctctcagcatggacgagga gagcctggag tcggccttgc agacctaccg 97680 tgcgcagctg cagcaggtggagctggcctt gggcgccggc ctggattcgt ctgagcaggc 97740 tgacctgcgc cagctgcagggggacctgaa ggagctcatc gagctcaccg aggccagcct 97800 ggtgtctgtc aggaagagcaggttgttggc cgcgctggac gaagagcgcc cgggccgcca 97860 ggaagatgct gagtaccaggctttccggga ggccatcact gaggcggtgg aggcaccagc 97920 agcggcccgt gggtccggatcagagaccgt tcctaaagca gaggcggggc cagaatctgc 97980 ggcaggtggg caggaggaggaagagggaga ggacgaggaa gagctgagtg ggacaaaggt 98040 gagcgcgccc tactacagctcctggggcac tctggagtat cacaacgcca tggtggtggg 98100 aacggaagag gcggaggatggctcggcggg tgtccgtgtg ctttacctgt accccactca 98160 caagtctctg aagccgtgcccgttcttcct ggagggaaag tgccgcttta aggagaactg 98220 caggtaaagc cctttgttgtcagatgccaa ccttaggggc gtaaggggca cgcacacagg 98280 gtcgggtcag gatcggccctccctttgctt tgcagttttg tctcagcttc ctggggcagg 98340 cgtgctttga cagctgtgtctgtgttcagg cgtctacgtc ttccttctgg ggtgaatcaa 98400 gaagcatgga aggaggccaggcgcggtggc tcacgcctgt aatcccagca ctttaggaag 98460 ccgaggcggg cagatcacctgaggtcagga gttcaagacc acgctggtca acatggtgaa 98520 accccatctc cttaaaaacacaaaaatgaa ccggtcgtgg tggcgcgcac ctgtggtcct 98580 ggctactcag gaggctgaggcaggagaatt ggttgaaccc aggaggccga gtttgcagtg 98640 agtggagatg cagccactgtactgcagccc gagcagcagt gcaaggctta tgtggaagag 98700 agtaggtctc cagcctatcgtcagtttttt tttggtggtt gttttaattt tttttgagac 98760 agggtcttac tttgtcaaccaggctggagt gcagtggcat agtcctggct cactgcagcc 98820 tggacctcct gggctcaaccgatcctcctg cctcagcccc cctaggagct gggctacaga 98880 ctcacgctac tacacccagctaatttttat attactataa ttttttatct tttttttgag 98940 acggagtctt gttctgttgcccaggctgga gtgcagtggc gtgatctcgg ctcactgcaa 99000 gctccgcctc ccgggttcacgccattctcc tgcctcagcc tcccgagtag ctgggactac 99060 aggcgcccgc caccatgtctggctaatttt ctgtattttt agtagagacg gggtttcacc 99120 atgttagcca ggatggtctcaatctcctga cctcgtgatc cgcccacctt ggcctcccaa 99180 agtgctggga tgacaagcgtgagccaccgc gcctggcctt ttttttttgg agacagagtt 99240 tcactctcct cacccaggctggagtgtagt ggcgcaatct cagcttaccg caacctctgt 99300 ctcccgggtt gaagtaattctctacctcag cgtccagagt agctggcatt acaggcgccc 99360 gccaccacac tcggctaattttttgtattt ttagtagagt cggagattca ccatcttggc 99420 caggctggtc ttgaactcctgacctcgtga tccacccacc ttggcctccc aaagtgctgg 99480 gatcacaggc gtgagccactgcgcctggcc ctgttgttag ttttattctc tagagttcaa 99540 cttttaaatt ttactttcatggagattttc aaacataccc caaattagag agtttagcat 99600 aatcaccgcc cacggtccatcatccaatgt cgtcatttat taatattttc ccagtctcat 99660 tttgtctgtt ctccctgccctatttttttc tttcctgggc cattttaaag caaattccag 99720 aagttactgg ttttttccaattatgaatac ttcatagttg catctctaat ctaactgatt 99780 aggaaattac ttaaaaagtaactttttgga agtccaagtc cgatgtgagg acaaaaaaga 99840 gtaacttctg tgtcataataggtaacacat ttaatggtaa tacctcttcc atattcaaat 99900 atgaacaatt attactgtaatgtctctatt tccctaagcg catagcttta tttttcctcc 99960 tttttacttt tctcttagaagaaatattta ccaagccttc tagtaggtaa ttttcttttt 100020 tagccaatag ttcaggctgaccgtgtaacc atccctagtt ctagttctag ttctttgaat 100080 gtcttccttt ttttttttttttgaaacagc gtcttgctgc tctgtcaccc aggctggagt 100140 gcagtggcac aatctcggctcactgcaatc tccgcctccc tggcccaagc catcctccca 100200 cctcagcctc cctaatagctgatactacaa gtgtgcactg ccacgcccag ctaatttttg 100260 tattttttgt agagacgggatttcaccata ttacccaggt ctcgaattcc tgatcccttt 100320 gatgagagat ctgacacatccctgtggtgc tccctctgga ccaggcactg ctccaagggt 100380 ttcatatact ttcattcatctgtgcaacag ccctgtaggt aggccctgca gtcacaccat 100440 ctgacagagg aggaaacaggagtagaagaa ctgagtggtc cagggcttca aggctcagag 100500 ggctccagtt gcccccagccctcgttccgt cccctgctcc acccagtgct gcttgccatg 100560 tcggcatcag gcctgatctgaaagcttccg gagcatctta cagacgtcca ccttgccacc 100620 attcaggact gataagttctcttggatttg cgttggacct tttttttttt tttaagatgg 100680 agtttcactg ttgttgcccaggctagagta caatggcacg acctccacct cctgggttca 100740 agggattctc ctgcctcagcctcccaagta gctgggatta caggcgcctg tcaccacgtg 100800 gtgcccagct aatttttatatttttagtag aggcagggtt tcaccgtgtt ggccaggctg 100860 gtctcgaacc cttgacctcaggtgatcccg ccttggtttc ccaaagtgct gggattacag 100920 gcatgagcca ccacacccggcccaggattt ctttatatat tctggatatc atcccttatg 100980 aagtatatag tttgcagatatttgctccca ttgtttgggt tgtcttttca cttgatatag 101040 tgtcctttga tgcacaaacattttaaattt tgatgcagtg caatttattg tttctttatt 101100 gcctatgttt ttgtcatcaggtttaagaaa ccacctcatc catagttatg aggattttca 101160 cctatgtttt cttctaagagttctgtagtt ttagctgtta aatttaggtc tttgatccat 101220 tttgagttaa tttttgtatatgttattagg tgagggtcca ctttattctt ttgcatgtgg 101280 atttccagtt ttcccagcaccatttgttta aaagactgct ttttctccac tgaatggtct 101340 tggcactttt gtccaaaatcaattggcaat atatgtaagg gtttatttct gagctctctc 101400 tcctgttcca ttggtgtatatgtgccagta ccacactgtt ctgattatta tagctttgtg 101460 ataagtttta aactcaggaagtggtagtta ttcaccattt gctcctcttt ttcaagtttg 101520 ttttgtttct ggatcctttgcaatttcata tgaattttag gatcggcttg tccaattctg 101580 cataaaagac agtttgaattttgatatgga ttgcatagaa tgtgtagatc tgtttggggc 101640 acattgtcat ctttacaatattaagccttc tggctgggtg tggtggctga cgcctgtaat 101700 cccagtactt tgggaggctgaggcgggcat atcacttgag gtcaggagtt caagaccagc 101760 ctggccaacg tggtgaaaccccgtctctac taaaaataaa aaacaaatta gtcggaggtg 101820 gtgcacacct gtaatcccagctacaggaga gggtgaggca ggagaatcgc ttgaacctgg 101880 gaggaggagg ttgcagtgagctgagatcat gccactgcac tccagcctgg gtaacagagg 101940 gagactccat cttaaacaacaacaataaca gaagaaaaaa acagtattaa gtcttccaat 102000 tcatgaatga aggatctgtccatttattta cgtctttaat ttctttcaac agtattttgt 102060 actgttcaag tcttgcacattcttggttaa ataagtatta tttttgatgc ttctctaagg 102120 aattgttttt cttttcctttttttttttga gacagagtct tgctctgtca cccaggctgg 102180 agtgcagtgg cacaatcttggctcactgca acctctgcct cccgggttca agcaattctt 102240 ctgctcagcc tcccaagtagctgggatcac aggtgcctgc caccacaccc agctaatttt 102300 tttttttgag atggagtcttgctctgttgc ccaggctgga gtgaagtggc ccaatcttgg 102360 ctcactgcaa gctccacctcccgggttcac accattcttc cgcctcagcc tcctgagtcg 102420 ctgggaatac aggtgcctgccaccacgccc agctaatttt ttgtattttt agtagagatg 102480 gggtttcacc atgtagccaggatggtctcg aactcttgac ctcaggtgat ctgcctgcct 102540 cggcctccca aagtgctgggattacagatg tgagccactg tgcccggctc gagttgtttt 102600 ccttagttac attttcaggctgtttgttgc tagtatatag aaatacaagc tgggcaccgt 102660 ggctcacgcc tgtaatcccagcactttggg aggccaaggc gggtggatca cctgtggtca 102720 ggagttcgag accagcctggccaacatggt gaaatccagc ctctattaaa aatacaaaaa 102780 ttagtctggc atggtggcaggtgcctgtaa tcccatctac tcaggaggct gaggcaagag 102840 aattgcttga acctgggaggcggaggttgc agtgagctga gatcgcgcca ttgcactcca 102900 gcttggggaa caagagtgagacttcatctc aaaaaaaaaa aaaaagaaat acagtggatt 102960 tttttatgtt aatcctgtattgattgctga attggtttat tagtgctaat aggatttttt 103020 atgcactatt taggattttcgatatataca atcatatata ttcaatatat acaattaata 103080 tatatgtgaa tagagataattgtagtcttt gtttctagtt tgcatggcat ttatttcttt 103140 ttcttgctta actgccttagctagaacttc aagtacgatg ttgaataaaa gtgactagag 103200 cgggccgggg gtggtggctcacacctgtgt tcccagcact ttgggaggtg gaagtgggca 103260 gatcacttga gatcagcagtttgagaccag cctggccaac acggcgaaac cccatctcta 103320 ctaaaaatac aaaaattagctgggtgaggt gatgtgcacc tgtagtccca gctacttgag 103380 agggtgagac atgagaattgcttgaacctg gggggcggag gttgcagtga gccaagatca 103440 tgccactcca ctccagcctggacgacagag caagaaccct gtctttaaaa aaaaaaaaaa 103500 aaaagtggct agaacaaacatctttatctt gttcctgatc ttaggtggaa aacttttttg 103560 ttcctgatat taggtggaaaacttttagtc tttcactgtt gaatatgatg ttacttgtag 103620 gttttctgta gattccctttatcgagttga ggaaattctc ttatattcat agtgtgttga 103680 gtgtttttta tcatgaaagggtgttgattt tttttttaaa gatagggtct tgttctgtca 103740 cccaggctgg agggcagtggcatgatcatg gctcactgca acctcgaatt cctgggctca 103800 ggggatcctc ctacttcatcctcctgagta ggtgagacta caggcatgag ccaccatgcc 103860 cagctaattt tttaatttttctgtagaggt agggtcctgc tttgctgccc aggctggtct 103920 taaactccag ggctcaagcaatcctgcctc agcctcccaa agtgctgaga ttacaggggt 103980 gagtcactgc actgcacccagctgtgtggg atttttcaaa tgcttttttc ctttagatga 104040 tcatgtgtgg tttttttcctttcattttgt taatgtggta tattgatttt cgtatgttga 104100 accatccttg aattcctcagataaagcacg catattcatg gcgtattatc tctttattat 104160 tatttttttt gtagagatgagatttcactc tgttgcccaa gctggtctca aactcctggg 104220 ctaaagtgat cctcctgcctcagcctccga aagcgctggg attataggca tgagccactt 104280 ggccctatct tttttctttttctttttttt ttttttttga gacagagtct cactctgtcg 104340 ccgggctgga gtgagtggcgcgatctcggc tcactgcaac ctccatctcc cgggttcaag 104400 caattctcct gcctcagcctcctgagtagc tgggactaca ggtgcccgcc actatgccca 104460 gctaattttt tgtgtttttagttgagacgg tgttttgcca tgttggacag gctggtcttg 104520 cactcctgac ctcgtgattcacccaccttg gcctcccgaa gtgctgggat tacaggcatg 104580 agccaccgca gcgagccttatctttttaac agttaaaagt ttaaggcctt atcatgtaat 104640 aacattgctg gatttgatttgctgctgttt tgttgagaat atttgcatct gtattgataa 104700 gggatattgg tctgtagttttcttttcttg gcatgtcttt gtatagcttt gatgccagca 104760 taatattggc ctcatagaatgagttaggaa gtattcttta tattatggga agaggtaaaa 104820 agggattggt gttaattcttcttcaaatgt ttgatagaat tcaacagtga agtgatatat 104880 acaatcatat atatagagagagagagagag agagatggac ttttcttttg ttggaagttt 104940 attgactatt gattcaatttccttattgaa attgactttt ctttttggaa gctaaaatgt 105000 ataactgtag tgaaagtttctgaacttttc tttcattgga agttttttga ctactgattc 105060 tttatttgtt ataggtctattcagattttc tgtttcttct tgagtcagtt tggtctcgct 105120 ctgtcgccca ggctggagtgcagtggtgcc atcttggctc actgcaactt ctacctcccg 105180 agttcaagtg attctcccacctcagcctcc ccagtatctc ggactacagg cgcacgccag 105240 catacctggc taatttttgtatttttagta ggaacagcat ttcaccatgt tggccaggct 105300 ggtctcgaac tcctgacctcaggtgatcca cccgcctcgg cctcacaaag tgctgggact 105360 acagacataa gccaccgcgtccagccttga gtcagtttag atagtttgca tgcatgtttc 105420 taggaatttg tccattttgtttatgttatc taatctgtta ccatacaatt gttcatagta 105480 tccttttata gccctagttatttctgtaag atcagtagta atagctccac tttctctctt 105540 ggttttagca atttgagtcatctcttttct tcttcttttt ttttttttga gatggagtct 105600 cactgtgtca cccaggctggagtgcagtgg catgatcttg gctcactgca acccctgcct 105660 cccaggttca agcaattctgccttagcctc ctgagtagct gggattacag gtgtgagcca 105720 ccacacccag ctagttttgttttgtttttt tgtttttgag acggagtctg tttctgtctc 105780 ccaggctgga gtgcagtggtgcaatctcac tcattgcaac ctccgactcc cagattccag 105840 caattctcct gcctcagcctcccgagtagc tggaactata ggcgtgcacc accacgcctg 105900 gctgattttt atatttttagtagagatggg atttcaccat gttggccagg ctggtcttgg 105960 actccctacc tgaggtgatccgcccacctt ggcctcccaa agtgctggga ttataggcat 106020 gagccaccat gcccagccagtttttgtatt tttagtagag atggggtttc tccctgtcgg 106080 ccaggctggt cttgaaatcctgacctcagg ttatccacca gccttggcct cccaaagtgc 106140 taggattaca ggcatgagccaccacgcatg gcctgtcttt tcttcttggt cattttcgct 106200 aaaggtttgt caattttgttgatctttttt gttgctgatc tctattgttt tcccattctg 106260 tttcatttat ttccattttaacctttgttt ccttttttct gctggtttgg gtttaatttg 106320 ctcttttttt cccctaatttttcaaggtat acagttaagt tattgatttg agatctcttt 106380 tttcttttct tttttttttttttttttttt tttggttgct gttgagatgg agtctccctc 106440 tgtcacccag actggagtgcagtggcatga tctcagctca ctgcagcctc cgccgcccag 106500 gcgattctcc tgcctcagcctcctgagtag acgtttcccg gccaaggtgt ttctttttga 106560 atgtaagcat ttacagctacagatttccct ctaaacactg ctttcactgc attccataag 106620 attgtttttt gttgttttttgttgttgttt tgttgtttga gacacagtct cactctgttg 106680 ccgtttggag agcagcgatgcgatcatagc tctgtagcct tgagctcctg gactcaatca 106740 gtcctcctgc ctcagcctcccaagtagctg ggactacagg tgtacaccac tgcacctaac 106800 taatttcttt tataagtttttgcagaggcc aggcacagtg gctcacacct gtaatcccag 106860 cactttggga ggccaaggtgggtggatcac ctaaggtcag gagttcgaga ccagcctggc 106920 cgacagggag aaaccccatctctactaaaa atacaaaaat tagctgggcg tggtggcagg 106980 tgcctgtaat cccagctactcaggaggctg aggcaggaga atcgcttgaa cctgggaggc 107040 agaggttgca gtgagccaggatcacaccat tgcactccag cctgggtaac aaaagcaaaa 107100 ctccatctca agaaaagaaaaaaaaaagtt tttgcagaga cagggtatca ctttgttgcc 107160 caggctggtc tcaaactcctgacttgaagg agtcctactg cctcagcctc ccaaagtgct 107220 gagattatgg gcaagagccaccgcaccctg ccacttggct gttttgttct gttgtatttc 107280 cattttcatt gatctcaagacatcctaatc tcccttttgt ttttttgttc gacttactgg 107340 ttattcaaga gtgtctttatttctgcatat ttgtaaattt tccaaaaaag tttttctttc 107400 tttttttttt gagaaagggtcttgctctgt cgcccaggct ggagaatggt ggtgcacaat 107460 cttgcctcac tgcaacctctgcctcccggg ttcaagtgat cctcccacct cagccttccc 107520 agtagctggg attacaggcacacaccacca cacctggcta atttttgtat tttagtctta 107580 acgtgctggt cagactggtctcgaattcct gacctcaggt gatctgcccg ccttggcctc 107640 ccaaagcact gggattacaggcgtgaaaca ccatgcccag cccccaattt ttttttttta 107700 atagagagaa ggtctcactcaagcccaggc tggtcttgaa ctcctgagct caagctgtca 107760 tccctcctcg gcctcccaaggtgctgagat tacaggtgtg agtcacagta cctggccttc 107820 tttcaagact ttaaaaatgccatcttggct gggcacggtg gctcacgcct gtaatcccag 107880 cactttggga ggccgaggtgggcagatcac gaggtcagga gatcaagacc accctggcta 107940 acatggtgaa accctgtctctactaaaaat acaaaaaatt aaccaggtgt ggtggcaggt 108000 gcctgtagtc ccagctactcgggaagctga agcaggagaa tggcgtgaac ccgggaggtg 108060 gagcttgcag tgagctgagatcacaccact gtactccagc ctgggcaaca gtgcgagact 108120 ccgtctcaaa aaaaaaaaaaaaaatgtcat ctcactgcct tctggtccaa tagtttctga 108180 tgagaaattg gctgttaatcttattgagga acatttatat attgactagt cacttgtctc 108240 ttgctgtttt aggagattctctatctttgg gtttcagcag tttgattata atgtatcagt 108300 gtggatccct caatttataagctacttgga gttcattgga cttcttggat gtgtaaattc 108360 atgtctttca ttaaatttgcaaagtttcag ctactattct ttgcatcttg aaatactagt 108420 tttgtttctt tctgtctgtttgccgcttat ggaactttat gcatacattg atgtgcttca 108480 tggtgtagca caggtcccttgggctctagg catttttctt tgttcttttt ttctttctgc 108540 tcctcatttt ggataaattcagctgacctg tcctcaagtt cactgtttct ttcttcttcc 108600 ttctcaaatc tgctgttgaaacttctggtg aaattttcac tacagttact gtacttttta 108660 gctccaaagt ttctatttggtttctttctg tagtaattat cactttacta gtattctcta 108720 tttggttaga catggttcttttgttttcct ttagttcatt atccatggtt tcctttattt 108780 ttaaatttct ttttatttagttattaattt tttttttttt tgaagcgggg tttcactctt 108840 gtcacccagg ctggcaggcaacgtcacaat cttggctcac tacaacctcc gcctcctggg 108900 ttcaagtgat tctcctgcctcagcctccca agtagctggg attataggca tgtgccacca 108960 cacccaccta atttttggtatttttagtag aaactgggtt tcaccacatt ggccagactg 109020 gtcttaaact actaacctcaggtgatctgt ccgcctcagc ctcccaaaat gctgggatta 109080 cagatgtgag ccactgtgcccagcctcttt ttttagtgta tttaaggtaa ttgattgaaa 109140 gtttttgtct agtcattcaaatgtctaggc ttcctcagga acagtttcta ttaatttctt 109200 tatttttaaa aaattttttttaattttctt ttttttttag atggagtctc actctatagc 109260 ctaggctgga gtgcaatggcttgatcttgg ctcactgcaa cctctgcctc ctgggttcaa 109320 gcgattctcc tgcttcagcctcctgagtag ctgggactat aggtgcgtgc caccactcct 109380 ggctaatttt ttgtattttcagtagagaca tggttttgcc gtgttagcca ggatggtctc 109440 gatctcgtga cctcatgatcctcctgcctc ggcctcccaa agtgctggaa ttacaggtgt 109500 gagccaccgc gcccagcctattttttattt tttgagacaa agtctccctc tctcacccag 109560 gctgtagtgc agtggcacaaccctggcaca ctgcagcctt aaccgtccag gcttaagtga 109620 gtctcccacc ttagtctcctgagtagctag aactacaagc atgtgccacc atgcctggct 109680 ggttgtgttg ttactgttttagacacaggg tcttgctaca tttctctgac tggtcttgaa 109740 ctcctgggct caagcagtcatcccaccttg gcctcccaag gtgttgagat tacaggtgtg 109800 agccaccgca cccggcctgttaatttcttt atttccggtg aatgggccac actttcttgt 109860 ttctttgcat gccttgtaattttttgttga aacctgcaca atttgaagat gataatgtgg 109920 ttactttgaa aatcagatcctccgccctct gcagggttca ttgttgctgt ttgttgtgga 109980 ttgtcgtttc tcgtttgtttagttactttc ctgacctttt taaataaaga ctatattctg 110040 tcaggggtgc ttgtttctgttcttttaggt tagtggttag cttgtgcttt gaaagagatt 110100 tctttaaata tctagtggcaaaaaggataa agaggccggg cgcagtggct cacgcctgta 110160 atgctaggac tttgggaagtggaggcgggt ggatcacttg aggtcaggag tttaagatca 110220 gcctggccag tatggtgaaaccctgtctct actaaaaata caaaaattaa ccgggcatgg 110280 tggcacctgc ctgtagtcccagctactggg aagactgagg caggagaatc gcttcaatcc 110340 agggggcgga ggttgcagtgagctgagatt gcgccattgc actccagcct gggcaacaga 110400 gcgagactct gtctcaaataaaaaaaaaaa aaaaaggata aagagtgtct tccatccttt 110460 ccaggttgcc tctgtactggggcaagtcct tcagtgtccg ccaggctgtt cacggctttt 110520 cctcagcctt tacttctcgctcccatggag cctaaggatg aaccagaggt gaaagttgag 110580 ggcctcctca ggtgtttctgagcccctgtc tagccccagc tgtgtgcatg gccttctgga 110640 tttccaagca tgaacaggagctttccaaag cccttagacc ttcatgtagc tcttttccca 110700 gcctcttcct tcctaggcttttctgtcagc tctttgccca tctgttgttg tccctccccc 110760 acaacttcag gtagtatctacctgtaaatg ccttcaggcc aggcgcggtg gctcatacct 110820 gttatcccag cactttgggaggccgaggcg ggtgaattgc ttgaggtcag gagttcgaga 110880 ccagcctggc caacatggtgaagccccgtc tctagtaaaa atacaaaaat tagctgggcg 110940 tggtgggtgc ctgtaatctcagctactcgg gaggctgaag caggagaatt gcttgagcct 111000 gggaggcgga ggttgcagtgagctgagatc gtgccattgc actccagcct gggcgacaga 111060 gtgagactcc atctcggggaaaaaaaaaaa aaaaaaatgc catcaacagc acgaccctgg 111120 aggctgcccc agccctgagagagttcgagg gggtgaaaca aaggcaagcc cttcagggag 111180 acactagaaa gatccaaatgcataagcagg attccttgag aaaaggtctg tatcatccct 111240 tctgacacca gcaagccacatcagaaatac aggttgcctt ccccatggct acatgtgagc 111300 tggtagtagt ggctgagcagaaatagccca gctgtcctcc tgaaatttag cagggtctta 111360 cttcattgag cagtcatctggttcgtagac accagagtta cagaaaagtt tattgggagg 111420 ttttgacagt ttaatagaaaaaagtttatt gtgacagttt tgacagctga atagaaaaaa 111480 gtttactgtg acagttttgacagcagaata gttgctttgc tggagagacg gatctttgga 111540 gctgccaact ccatcattttggtgatatcc agctctgttg ctgaattttt agctatgctg 111600 ttttaagtta ttttcttagtggttgctcta gagatgacaa tgtgcatctt taacttacca 111660 caatgtactt cagattattactaacttaac acttaaagta cagcattttt ttttttatgg 111720 agtttcactc tgtcacccaggctggagtgc aatggtgtga tctcggctca ctgcaacctc 111780 cgcctcccag gttcacgccattctcctgcc tcagcctcct gagtagctgg gactacaggc 111840 acccccacca cacccggctaattttgtatt tttagtagag atgaggtttc accatgttgg 111900 tcaggctggt ctcgaactgctgacctcagg tgatccgccc atcttggcct cccaaagtgc 111960 tgggattaca ggtgtgagcgactgcactga gcctaagtat ggcaacgtgt ctataacata 112020 gatctacttc cgttgtactatgacatagtt ccccctccat tttcctatag cacagtccca 112080 acctcccttt tcctctgacatagttccatc ctccctcctc ctatgacgtc ctcccttctc 112140 ctctggcata gctccatcctcccttctcct atgacacagc tccatcctcc cttctcctct 112200 gacacagctc catcctcccttctcctatga cacagctcca tcctcccttc tcctctgaca 112260 tagctccatc ctcccttctcctatgtcata gctccatcct cccttctcct ctgacacagc 112320 tccatcctcc cttctcctctggcatagctc catcctccct tctcctatga cacagctcca 112380 tcctcccttc tcctatgacacagctccatc ctcccttctc ctatgacaca gctccatcct 112440 cccttctcct atgacacagctccatcctcc cttctcctct ggcatagctc catcctccct 112500 tctcctctga catagctccatcctcccttc tcctctgaca tagctccatc ctcccttctc 112560 ctctgacata gctccatcctcccttctcct ctgacatagc tccatcctcc cttctcctct 112620 gacatagctc catcctcccttctcctctga catagttcca tcctcccttg tcctctgaca 112680 tagctccatc ctcccttctcctctgacata gctccatccc ctcttctcct tcatgtatta 112740 ttgccatata tacatttatgtatgttataa cttcagctct tcagcgttat aattattgct 112800 tcaaaagtat tttgaaagaagttgcctgga ggcagtggct tatgccttta actccagcac 112860 ttttgggggc tgaggtgggcagatcgcctg agccagggag ttggagacca gcctgggcaa 112920 catgacgaaa cccatctccaccaaaattac aaaaaattag tctggcatgg tggcacgcgc 112980 ctgtagtccc agctatttgggggaggatcc cagctaaggt gggaggatca cttgagcctg 113040 ggaagtcaag gctgcagtgagctgagattg tgccactgca ctccagcctg ggtgcagatc 113100 ttatctcaga agtaaagggactaggaatgg tggcttttat ctctaatccc agcactttgg 113160 gaggctgagg tgagtggatcaccggaggtc aggagtttaa gaccagcctg gccaacatgg 113220 tgaaaccccg tctctactaaaaatacaaaa agtagccggg tgtggtggtg ggtgtctgta 113280 atcccagcta ctcgggaggctgaggcaaga gaatcgcttg aacctgggaa gcggaggttg 113340 cagtgagcaa gatcgcaccactgcattaca gcctagatga cagagcgaga ctctgcctaa 113400 aaaaaaaaaa aaaaagaaaagaaaagaaat taagatctag acactgtggt tcatgcctgt 113460 aatcccaaag ccttgggaggccaaggcagg aggatcactt gaggccagga gttcaacacc 113520 agcctgggca acatagcgagactccatctc tatttaaaaa agaaagaaat tcaaagagaa 113580 aaaaagtata cttgtttttttgtatcatcc atattttacc tttctttttt ttgccccttt 113640 ttctttcctg tgaatttgagttactgtcta gtgtcatttc cttttagtct gaagaacttc 113700 atttagaatt tttttttttttttgagacaa agtctcactg tgttgcccag gctggagtgc 113760 aatggtgcag tctcagatcactgcaacctc tgcctccctg gttagagtga ttttcctgcc 113820 tcagcctccc aagtagctgagactgcaggc acctgccacc acccccagcc aatttttttg 113880 gtatttttag tagagacagggtttcactat gttggccagg ctggtctcga attcatgacc 113940 tcatgatctg cctgtcctggcctcccaaaa tgctgggatt accatgagcc accacgccca 114000 gcccatttag aatttctttttttttttttt ttttgagatg gggtctcgct cttgtttccc 114060 aggctggagt gcagtggcacgatctcggct cactgcgagc tccgcctccc gggttcacgc 114120 cattctcctg cctcagcctcccgagtagct gggattacag gcgcctgcca ccacgcccac 114180 ctaatttttt gtatttttaggagagatggg gtttcaccat gttagccagg atggtcttga 114240 tctcctgacc tcgtgatccgcccgccttgg cctcccaaag tgctgggatt acaggcgtga 114300 gccaccgcgc ccggctagaatttcttgtag gacaggcttg ctagcaacca attcagtgtt 114360 tatttgggaa tgtctttatttcagcttcat tttttgaagg atagtttagc tggctataga 114420 attattaatt gatcattcttttcagtgttt aaaagtgtca tcatgctacc ttctgggttc 114480 cattgtttct gatgagaagtcatctgtcaa attgtccctt tgtacttgaa gaattatctt 114540 tttttctctt gatgttttcaagattttctc tttgtctttg gcctttagta gtttgtgatg 114600 tatctaggtg tggatctcttggtgtgcatc gtatttgggc ttcagtaagc ctcttagatt 114660 catagattaa tgttttgttttgttttacca aatttggaga gtttttactc atcatttcaa 114720 caaatttttt tcctgcccctctctcatctc cttttgggag taccactgca tgtatgttgg 114780 tgtgcgttct cta 1147934 25 DNA Artificial Sequence oligonucleotide 4 cacaggttca gcatgtttgtgcgtc 25 5 25 DNA Artificial Sequence oligonucleotide 5 cacagtccctgctggcctct gtcta 25 6 25 DNA Artificial Sequence oligonucleotide 6caggacatct ccatcaagag gctgc 25 7 25 DNA Artificial Sequenceoligonucleotide 7 aataagaggg ggccaggatc agtgc 25 8 20 DNA ArtificialSequence oligonucleotide 8 gtgaatggca tcctggagag 20 9 20 DNA ArtificialSequence oligonucleotide 9 gtctccaggc agctcaacag 20 10 20 DNA ArtificialSequence oligonucleotide 10 accctgtccc tcctgtctga 20 11 20 DNAArtificial Sequence oligonucleotide 11 agaccctaag atgttcggag 20 12 20DNA Artificial Sequence oligonucleotide 12 gatgacctgt gtgagttgcg 20 1320 DNA Artificial Sequence oligonucleotide 13 cgcaactcac acaggtcatc 2014 20 DNA Artificial Sequence oligonucleotide 14 ggagtcaggt caaaggatgc20 15 20 DNA Artificial Sequence oligonucleotide 15 gcatcctttgacctgactcc 20 16 20 DNA Artificial Sequence oligonucleotide 16ggtctgaaac gtgatctggg 20 17 20 DNA Artificial Sequence oligonucleotide17 cccagatcac gtttcagacc 20 18 20 DNA Artificial Sequenceoligonucleotide 18 cgatgatgtg tgggttctcc 20 19 20 DNA ArtificialSequence oligonucleotide 19 ggagaaccca cacatcatcg 20 20 20 DNAArtificial Sequence oligonucleotide 20 cgtgtctgag aagtccagcc 20 21 20DNA Artificial Sequence oligonucleotide 21 ggctggactt ctcagacacg 20 2220 DNA Artificial Sequence oligonucleotide 22 acagcatctt ctccacgcac 2023 20 DNA Artificial Sequence oligonucleotide 23 agtcctctgg ctttgcagtg20 24 20 DNA Artificial Sequence oligonucleotide 24 tgtgcgtggagaagatgctg 20 25 20 DNA Artificial Sequence oligonucleotide 25ggctggaaag ggaagtctac 20 26 20 DNA Artificial Sequence oligonucleotide26 tggttcaggt gctcttgggg 20 27 20 DNA Artificial Sequenceoligonucleotide 27 cgtgaagcag gagttgagcc 20 28 20 DNA ArtificialSequence oligonucleotide 28 atcttgctct gggtcttccc 20 29 20 DNAArtificial Sequence oligonucleotide 29 cactgcaaag ccagaggact 20 30 20DNA Artificial Sequence oligonucleotide 30 ataagcaaga cgacgacctc 20 3120 DNA Artificial Sequence oligonucleotide 31 ctattctgtt gggtgggttc 2032 20 DNA Artificial Sequence oligonucleotide 32 cgtgcctcct gtgcttaccc20 33 20 DNA Artificial Sequence oligonucleotide 33 cagaccccaaggtagctcag 20 34 20 DNA Artificial Sequence oligonucleotide 34ggaagaccca gagcaagatc 20 35 780 PRT Dictyostelium discoideum 35 Met LysPhe Tyr Ile Glu Asp Leu Leu Val Tyr Phe Pro Tyr Ser Tyr 1 5 10 15 IleTyr Pro Glu Gln Tyr Ser Tyr Met Val Ala Leu Lys Arg Ser Leu 20 25 30 AspAsn Gly Gly Pro Cys Ile Leu Glu Met Pro Ser Gly Thr Gly Lys 35 40 45 ThrVal Ser Leu Leu Ser Leu Ile Ser Ser Tyr Gln Val Lys Asn Pro 50 55 60 SerIle Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile Glu Gln 65 70 75 80Ala Thr Glu Glu Ala Arg Arg Val Leu Gln Tyr Arg Asn Ser Glu Met 85 90 95Gly Glu Glu Ser Pro Lys Thr Leu Cys Met Ser Met Ser Ser Arg Arg 100 105110 Asn Leu Cys Ile Gln Pro Arg Val Ser Glu Glu Arg Asp Gly Lys Val 115120 125 Val Asp Ala Leu Cys Arg Glu Leu Thr Ser Ser Trp Asn Arg Glu Ser130 135 140 Pro Thr Ser Glu Lys Cys Lys Phe Phe Glu Asn Phe Glu Ser AsnGly 145 150 155 160 Lys Glu Ile Leu Leu Glu Gly Val Tyr Ser Leu Glu AspLeu Lys Glu 165 170 175 Tyr Gly Leu Lys His Gln Met Cys Pro Tyr Phe LeuSer Arg His Met 180 185 190 Leu Asn Phe Ala Asn Ile Val Ile Phe Ser TyrGln Tyr Leu Leu Asp 195 200 205 Pro Lys Ile Ala Ser Leu Ile Ser Ser SerPhe Pro Ser Asn Ser Ile 210 215 220 Val Val Phe Asp Glu Ala His Asn IleAsp Asn Val Cys Ile Asn Ala 225 230 235 240 Leu Ser Ile Asn Ile Asp AsnLys Leu Leu Asp Thr Ser Ser Lys Asn 245 250 255 Ile Ala Lys Ile Asn LysGln Ile Glu Asp Ile Lys Lys Val Asp Glu 260 265 270 Lys Arg Leu Lys AspGlu Tyr Gln Arg Leu Val Asn Gly Leu Ala Arg 275 280 285 Ser Gly Ser ThrArg Ala Asp Glu Thr Thr Ser Asp Pro Val Leu Pro 290 295 300 Asn Asp ValIle Gln Glu Ala Val Pro Gly Asn Ile Arg Lys Pro Ser 305 310 315 320 IlePhe Ile Ser Leu Leu Arg Arg Val Val Asp Tyr Leu Arg Glu Pro 325 330 335Asp Lys Ser Arg Leu Lys Ser Gln Met Leu Leu Ser Glu Ser Pro Leu 340 345350 Ala Phe Leu Gln Gly Leu Tyr His Ala Thr Gln Ile Ser Ser Arg Thr 355360 365 Leu Arg Phe Cys Ser Ser Arg Leu Ser Ser Leu Leu Arg Thr Leu Arg370 375 380 Ile Asn Asp Val Asn Gln Phe Ser Gly Ile Ser Leu Ile Ala AspPhe 385 390 395 400 Ala Thr Leu Val Gly Thr Tyr Asn Asn Gly Phe Leu IleIle Ile Glu 405 410 415 Pro Tyr Tyr Gln Arg Gln Asn Asn Thr Tyr Asp GlnIle Phe Gln Phe 420 425 430 Cys Cys Leu Asp Ala Ser Ile Gly Met Lys ProIle Phe Asp Lys Tyr 435 440 445 Arg Ser Val Val Ile Thr Ser Gly Thr LeuSer Pro Leu Asp Ile Tyr 450 455 460 Thr Lys Met Leu Asn Phe Arg Pro ThrVal Val Glu Arg Leu Thr Met 465 470 475 480 Ser Leu Asn Arg Asn Cys IleCys Pro Cys Ile Leu Thr Arg Gly Ser 485 490 495 Asp Gln Ile Ser Ile SerThr Lys Phe Asp Val Arg Ser Asp Thr Ala 500 505 510 Val Val Arg Asn TyrGly Ala Leu Leu Val Glu Val Ser Ala Ile Val 515 520 525 Pro Asp Gly IleIle Cys Phe Phe Thr Ser Tyr Ser Tyr Met Glu Gln 530 535 540 Ile Val SerVal Trp Asn Glu Met Gly Leu Leu Asn Asn Ile Leu Thr 545 550 555 560 AsnLys Leu Ile Phe Val Glu Thr Ser Asp Pro Ala Glu Ser Ala Leu 565 570 575Ala Leu Gln Asn Tyr Lys Lys Ala Cys Asp Ser Gly Arg Gly Ala Val 580 585590 Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile Asp Phe Asp 595600 605 Asn Gln Tyr Gly Arg Cys Val Ile Leu Tyr Gly Ile Pro Tyr Ile Asn610 615 620 Thr Glu Ser Lys Val Leu Arg Ala Arg Leu Glu Phe Leu Arg AspArg 625 630 635 640 Tyr Gln Ile Arg Glu Asn Glu Phe Leu Thr Phe Asp AlaMet Arg Thr 645 650 655 Ala Ser Gln Cys Val Gly Arg Val Ile Arg Gly LysSer Asp Tyr Gly 660 665 670 Ile Met Ile Phe Ala Asp Lys Arg Tyr Asn ArgLeu Asp Lys Arg Asn 675 680 685 Lys Leu Pro Gln Trp Ile Leu Gln Phe CysGln Pro Gln His Leu Asn 690 695 700 Leu Ser Thr Asp Met Ala Ile Ser LeuSer Lys Thr Phe Leu Arg Glu 705 710 715 720 Met Gly Gln Pro Phe Ser ArgGlu Glu Gln Leu Gly Lys Ser Leu Trp 725 730 735 Ser Leu Glu His Val GluLys Gln Ser Thr Ser Lys Pro Pro Gln Gln 740 745 750 Gln Asn Ser Ala IleAsn Ser Thr Ile Thr Thr Ser Thr Thr Thr Thr 755 760 765 Thr Thr Thr SerThr Ile Ser Glu Thr His Leu Thr 770 775 780 36 778 PRT S. cerevisiae 36Met Lys Phe Tyr Ile Asp Asp Leu Pro Val Leu Phe Pro Tyr Pro Lys 1 5 1015 Ile Tyr Pro Glu Gln Tyr Asn Tyr Met Cys Asp Ile Lys Lys Thr Leu 20 2530 Asp Val Gly Gly Asn Ser Ile Leu Glu Met Pro Ser Gly Thr Gly Lys 35 4045 Thr Val Ser Leu Leu Ser Leu Thr Ile Ala Tyr Gln Met His Tyr Pro 50 5560 Glu His Arg Lys Ile Ile Tyr Cys Ser Arg Thr Met Ser Glu Ile Glu 65 7075 80 Lys Ala Leu Val Glu Leu Glu Asn Leu Met Asp Tyr Arg Thr Lys Glu 8590 95 Leu Gly Tyr Gln Glu Asp Phe Arg Gly Leu Gly Leu Thr Ser Arg Lys100 105 110 Asn Leu Cys Leu His Pro Glu Val Ser Lys Glu Arg Lys Gly ThrVal 115 120 125 Val Asp Glu Lys Cys Arg Arg Met Thr Asn Gly Gln Ala LysArg Lys 130 135 140 Leu Glu Glu Asp Pro Glu Ala Asn Val Glu Leu Cys GluTyr His Glu 145 150 155 160 Asn Leu Tyr Asn Ile Glu Val Glu Asp Tyr LeuPro Lys Gly Val Phe 165 170 175 Ser Phe Glu Lys Leu Leu Lys Tyr Cys GluGlu Lys Thr Leu Cys Pro 180 185 190 Tyr Phe Ile Val Arg Arg Met Ile SerLeu Cys Asn Ile Ile Ile Tyr 195 200 205 Ser Tyr His Tyr Leu Leu Asp ProLys Ile Ala Glu Arg Val Ser Asn 210 215 220 Glu Val Ser Lys Asp Ser IleVal Ile Phe Asp Glu Ala His Asn Ile 225 230 235 240 Asp Asn Val Cys IleGlu Ser Leu Ser Leu Asp Leu Thr Thr Asp Ala 245 250 255 Leu Arg Arg AlaThr Arg Gly Ala Asn Ala Leu Asp Glu Arg Ile Ser 260 265 270 Glu Val ArgLys Val Asp Ser Gln Lys Leu Gln Asp Glu Tyr Glu Lys 275 280 285 Leu ValGln Gly Leu His Ser Ala Asp Ile Leu Thr Asp Gln Glu Glu 290 295 300 ProPhe Val Glu Thr Pro Val Leu Pro Gln Asp Leu Leu Thr Glu Ala 305 310 315320 Ile Pro Gly Asn Ile Arg Arg Ala Glu His Phe Val Ser Phe Leu Lys 325330 335 Arg Leu Ile Glu Tyr Leu Lys Thr Arg Met Lys Val Leu His Val Ile340 345 350 Ser Glu Thr Pro Lys Ser Phe Leu Gln His Leu Lys Gln Leu ThrPhe 355 360 365 Ile Glu Arg Lys Pro Leu Arg Phe Cys Ser Glu Arg Leu SerLeu Leu 370 375 380 Val Arg Thr Leu Glu Val Thr Glu Val Glu Asp Phe ThrAla Leu Lys 385 390 395 400 Asp Ile Ala Thr Phe Ala Thr Leu Ile Ser ThrTyr Glu Glu Gly Phe 405 410 415 Leu Leu Ile Ile Glu Pro Tyr Glu Ile GluAsn Ala Ala Val Pro Asn 420 425 430 Pro Ile Met Arg Phe Thr Cys Leu AspAla Ser Ile Ala Ile Lys Pro 435 440 445 Val Phe Glu Arg Phe Ser Ser ValIle Ile Thr Ser Gly Thr Ile Ser 450 455 460 Pro Leu Asp Met Tyr Pro ArgMet Leu Asn Phe Lys Thr Val Leu Gln 465 470 475 480 Lys Ser Tyr Ala MetThr Leu Ala Lys Lys Ser Phe Leu Pro Met Ile 485 490 495 Ile Thr Lys GlySer Asp Gln Val Ala Ile Ser Ser Arg Phe Glu Ile 500 505 510 Arg Asn AspPro Ser Ile Val Arg Asn Tyr Gly Ser Met Leu Val Glu 515 520 525 Phe AlaLys Ile Thr Pro Asp Gly Met Val Val Phe Phe Pro Ser Tyr 530 535 540 LeuTyr Met Glu Ser Ile Val Ser Met Trp Gln Thr Met Gly Ile Leu 545 550 555560 Asp Glu Val Trp Lys His Lys Leu Ile Leu Val Glu Thr Pro Asp Ala 565570 575 Gln Glu Thr Ser Leu Ala Leu Glu Thr Tyr Arg Lys Ala Cys Ser Asn580 585 590 Gly Arg Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val SerGlu 595 600 605 Gly Ile Asp Phe Asp His Gln Tyr Gly Arg Thr Val Leu MetIle Gly 610 615 620 Ile Pro Phe Gln Tyr Thr Glu Ser Arg Ile Leu Lys AlaArg Leu Glu 625 630 635 640 Phe Met Arg Glu Asn Tyr Arg Ile Arg Glu AsnAsp Phe Leu Ser Phe 645 650 655 Asp Ala Met Arg His Ala Ala Gln Cys LeuGly Arg Val Leu Arg Gly 660 665 670 Lys Asp Asp Tyr Gly Val Met Val LeuAla Asp Arg Arg Phe Ser Arg 675 680 685 Lys Arg Ser Gln Leu Pro Lys TrpIle Ala Gln Gly Leu Ser Asp Ala 690 695 700 Asp Leu Asn Leu Ser Thr AspMet Ala Ile Ser Asn Thr Lys Gln Phe 705 710 715 720 Leu Arg Thr Met AlaGln Pro Thr Asp Pro Lys Asp Gln Glu Gly Val 725 730 735 Ser Val Trp SerTyr Glu Asp Leu Ile Lys His Gln Asn Ser Arg Lys 740 745 750 Asp Gln GlyGly Phe Ile Glu Asn Glu Asn Lys Glu Gly Glu Gln Asp 755 760 765 Glu AspGlu Asp Glu Asp Ile Glu Met Gln 770 775 37 772 PRT S. pombe 37 Met LysPhe Tyr Ile Asp Asp Leu Pro Ile Leu Phe Pro Tyr Pro Arg 1 5 10 15 IleTyr Pro Glu Gln Tyr Gln Tyr Met Cys Asp Leu Lys His Ser Leu 20 25 30 AspAla Gly Gly Ile Ala Leu Leu Glu Met Pro Ser Gly Thr Gly Lys 35 40 45 ThrIle Ser Leu Leu Ser Leu Ile Val Ser Tyr Gln Gln His Tyr Pro 50 55 60 GluHis Arg Lys Leu Ile Tyr Cys Ser Arg Thr Met Ser Glu Ile Asp 65 70 75 80Lys Ala Leu Ala Glu Leu Lys Arg Leu Met Ala Tyr Arg Thr Ser Gln 85 90 95Leu Gly Tyr Glu Glu Pro Phe Leu Gly Leu Gly Leu Thr Ser Arg Lys 100 105110 Asn Leu Cys Leu His Pro Ser Val Arg Arg Glu Lys Asn Gly Asn Val 115120 125 Val Asp Ala Arg Cys Arg Ser Leu Thr Ala Gly Phe Val Arg Glu Gln130 135 140 Arg Leu Ala Gly Met Asp Val Pro Thr Cys Glu Phe His Asp AsnLeu 145 150 155 160 Glu Asp Leu Glu Pro His Ser Leu Ile Ser Asn Gly ValTrp Thr Leu 165 170 175 Asp Asp Ile Thr Glu Tyr Gly Glu Lys Thr Thr ArgCys Pro Tyr Phe 180 185 190 Thr Val Arg Arg Met Leu Pro Phe Cys Asn ValIle Ile Tyr Ser Tyr 195 200 205 His Tyr Leu Leu Asp Pro Lys Ile Ala GluArg Val Ser Arg Glu Leu 210 215 220 Ser Lys Asp Cys Ile Val Val Phe AspGlu Ala His Asn Ile Asp Asn 225 230 235 240 Val Cys Ile Glu Ser Leu SerIle Asp Leu Thr Glu Ser Ser Leu Arg 245 250 255 Lys Ala Ser Lys Ser IleLeu Ser Leu Glu Gln Lys Val Asn Glu Val 260 265 270 Lys Gln Ser Asp SerLys Lys Leu Gln Asp Glu Tyr Gln Lys Leu Val 275 280 285 Arg Gly Leu GlnAsp Ala Asn Ala Ala Asn Asp Glu Asp Gln Phe Met 290 295 300 Ala Asn ProVal Leu Pro Glu Asp Val Leu Lys Glu Ala Val Pro Gly 305 310 315 320 AsnIle Arg Arg Ala Glu His Phe Ile Ala Phe Leu Lys Arg Phe Val 325 330 335Glu Tyr Leu Lys Thr Arg Met Lys Val Leu His Val Ile Ala Glu Thr 340 345350 Pro Thr Ser Phe Leu Gln His Val Lys Asp Ile Thr Phe Ile Asp Lys 355360 365 Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Thr Ser Leu Val Arg Ala370 375 380 Leu Gln Ile Ser Leu Val Glu Asp Phe His Ser Leu Gln Gln ValVal 385 390 395 400 Ala Phe Ala Thr Leu Val Ala Thr Tyr Glu Arg Gly PheIle Leu Ile 405 410 415 Leu Glu Pro Phe Glu Thr Glu Asn Ala Thr Val ProAsn Pro Ile Leu 420 425 430 Arg Phe Ser Cys Leu Asp Ala Ser Ile Ala IleLys Pro Val Phe Glu 435 440 445 Arg Phe Arg Ser Val Ile Ile Thr Ser GlyThr Leu Ser Pro Leu Asp 450 455 460 Met Tyr Pro Lys Met Leu Gln Phe AsnThr Val Met Gln Glu Ser Tyr 465 470 475 480 Gly Met Ser Leu Ala Arg AsnCys Phe Leu Pro Met Val Val Thr Arg 485 490 495 Gly Ser Asp Gln Val AlaIle Ser Ser Lys Phe Glu Ala Arg Asn Asp 500 505 510 Pro Ser Val Val ArgAsn Tyr Gly Asn Ile Leu Val Glu Phe Ser Lys 515 520 525 Ile Thr Pro AspGly Leu Val Ala Phe Phe Pro Ser Tyr Leu Tyr Leu 530 535 540 Glu Ser IleVal Ser Ser Trp Gln Ser Met Gly Ile Leu Asp Glu Val 545 550 555 560 TrpLys Tyr Lys Leu Ile Leu Val Glu Thr Pro Asp Pro His Glu Thr 565 570 575Thr Leu Ala Leu Glu Thr Tyr Arg Ala Ala Cys Ser Asn Gly Arg Gly 580 585590 Ala Val Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Val Asp 595600 605 Phe Asp His His Tyr Gly Arg Ala Val Ile Met Phe Gly Ile Pro Tyr610 615 620 Gln Tyr Thr Glu Ser Arg Val Leu Lys Ala Arg Leu Glu Phe LeuArg 625 630 635 640 Asp Thr Tyr Gln Ile Arg Glu Ala Asp Phe Leu Thr PheAsp Ala Met 645 650 655 Arg His Ala Ala Gln Cys Leu Gly Arg Val Leu ArgGly Lys Asp Asp 660 665 670 His Gly Ile Met Val Leu Ala Asp Lys Arg TyrGly Arg Ser Asp Lys 675 680 685 Arg Thr Lys Leu Pro Lys Trp Ile Gln GlnTyr Ile Thr Glu Gly Ala 690 695 700 Thr Asn Leu Ser Thr Asp Met Ser LeuAla Leu Ala Lys Lys Phe Leu 705 710 715 720 Arg Thr Met Ala Gln Pro PheThr Ala Ser Asp Gln Glu Gly Ile Ser 725 730 735 Trp Trp Ser Leu Asp AspLeu Leu Ile His Gln Lys Lys Ala Leu Lys 740 745 750 Ser Ala Ala Ile GluGln Ser Lys His Glu Asp Glu Met Asp Ile Asp 755 760 765 Val Val Glu Thr770 38 760 PRT Homo sapien 38 Met Lys Leu Asn Val Asp Gly Leu Leu ValTyr Phe Pro Tyr Asp Tyr 1 5 10 15 Ile Tyr Pro Glu Gln Phe Ser Tyr MetArg Glu Leu Lys Arg Thr Leu 20 25 30 Asp Ala Lys Gly His Gly Val Leu GluMet Pro Ser Gly Thr Gly Lys 35 40 45 Thr Val Ser Leu Leu Ala Leu Ile MetAla Tyr Gln Arg Ala Tyr Pro 50 55 60 Leu Glu Val Thr Lys Leu Ile Tyr CysSer Arg Thr Val Pro Glu Ile 65 70 75 80 Glu Lys Val Ile Glu Glu Leu ArgLys Leu Leu Asn Phe Tyr Glu Lys 85 90 95 Gln Glu Gly Glu Lys Leu Pro PheLeu Gly Leu Ala Leu Ser Ser Arg 100 105 110 Lys Asn Leu Cys Ile His ProGlu Val Thr Pro Leu Arg Phe Gly Lys 115 120 125 Asp Val Asp Gly Lys CysHis Ser Leu Thr Ala Ser Tyr Val Arg Ala 130 135 140 Gln Tyr Gln His AspThr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu 145 150 155 160 Phe Asp AlaHis Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn 165 170 175 Leu AspAsp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr 180 185 190 PheLeu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser 195 200 205Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu 210 215220 Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp 225230 235 240 Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg ThrLeu 245 250 255 Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr ValLeu Arg 260 265 270 Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu TyrArg Arg Leu 275 280 285 Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg GluThr Asp Ala His 290 295 300 Leu Ala Asn Pro Val Leu Pro Asp Glu Val LeuGln Glu Ala Val Pro 305 310 315 320 Gly Ser Ile Arg Thr Ala Glu His PheLeu Gly Phe Leu Arg Arg Leu 325 330 335 Leu Glu Tyr Val Lys Trp Arg LeuArg Val Gln His Val Val Gln Glu 340 345 350 Ser Pro Pro Ala Phe Leu SerGly Leu Ala Gln Arg Val Cys Ile Gln 355 360 365 Arg Lys Pro Leu Arg PheCys Ala Glu Arg Leu Arg Ser Leu Leu His 370 375 380 Thr Leu Glu Ile ThrAsp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu 385 390 395 400 Ala Asn PheAla Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile 405 410 415 Ile IleGlu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile 420 425 430 LeuHis Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe 435 440 445Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu 450 455460 Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr 465470 475 480 Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile IleGly 485 490 495 Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu ThrArg Glu 500 505 510 Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu LeuGlu Met Ser 515 520 525 Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe ThrSer Tyr Gln Tyr 530 535 540 Met Glu Ser Thr Val Ala Ser Trp Tyr Glu GlnGly Ile Leu Glu Asn 545 550 555 560 Ile Gln Arg Asn Lys Leu Leu Phe IleGlu Thr Gln Asp Gly Ala Glu 565 570 575 Thr Ser Val Ala Leu Glu Lys TyrGln Glu Ala Cys Glu Asn Gly Arg 580 585 590 Gly Ala Ile Leu Leu Ser ValAla Arg Gly Lys Val Ser Glu Gly Ile 595 600 605 Asp Phe Val His His TyrGly Arg Ala Val Ile Met Phe Gly Val Pro 610 615 620 Tyr Val Tyr Thr GlnSer Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu 625 630 635 640 Arg Asp GlnPhe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala 645 650 655 Met ArgHis Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr 660 665 670 AspTyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp 675 680 685Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala 690 695700 Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe 705710 715 720 Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu GlyLeu 725 730 735 Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr LeuLys Arg 740 745 750 Ile Glu Gln Ile Ala Gln Gln Leu 755 760

What is claimed is:
 1. A purified DNA molecule encoding a mammalian NHLprotein.
 2. A purified DNA molecule of claim 1 encoding a human NHLprotein which comprises the amino acid sequence MPKIVLNGVT VDFPFQPYKCQQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR (SEQ ID NO:2) EHLRDGISARKIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT QVINELRNTSYRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE KSLEQELASPILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI DLKGTVVIFDEAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS ADSPSPGLNMELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ TKGCILDSLDQIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS YKVHIHPDAGHRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG TLAPVSSFALEMQIPFPVCL ENPHIIDKHQ IWVGVVPRGP DGAQLSSAFD RRFSEECLSS LGKALGNIARVVPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE TISAYYARVAAPGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKM QFLDEMKGQGGAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA RAQLPSWVRPHVRVYDNFGH VIROVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP GPFFSTRKAKSLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH SEQRAGSPGEEQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM VAVKQELSQANFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH KQQFEEVCIQLTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE HLNQGRPHLSPRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL AALTAYKQDDDLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY PGMEPPGPQEERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA GPSQSSGPPHGPAASEWGL*.


3. An expression vector for expressing a NHL protein in a recombinanthost cell wherein said expression vector comprises a DNA molecule ofclaim
 2. 4. A host cell which expresses a recombinant NHL proteinwherein said host cell contains the expression vector of claim
 3. 5. Aprocess for expressing a NHL protein in a recombinant host cell,comprising: (a) transfecting the expression vector of claim 3 into asuitable host cell; and, (b) culturing the host cells of step (a) underconditions which allow expression of said NHL protein from saidexpression vector.
 6. A purified DNA molecule encoding a human NHLprotein which consists of the amino acid sequence MPKIVLNGVT VDFPFQPYKCQQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR (SEQ ID NO:2) EHLRDGISARKIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT QVINELRNTSYRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE KSLEQELASPILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI DLKGTVVIFDEAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS ADSPSPGLNMELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ TKGCILDSLDQIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS YKVHIHPDAGHRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG TLAPVSSFALEMQIPFPVCL ENPHIIDKHQ IWVGVVPRGP DGAQLSSAFD RRFSEECLSS LGKALGNIARVVPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE TISAYYARVAAPGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKM QFLDEMKGQGGAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA RAQLPSWVRPHVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP GPFFSTRKAKSLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH SEQRAGSPGEEQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM VAVKQELSQANFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH KQQFEEVCIQLTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE HLNQGRPHLSPRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL AALTAYKQDDDLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY PGMEPPGPQEERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA GPSQSSGPPHGPAASEWGL*.


7. An expression vector for expressing a NHL protein in a recombinanthost cell wherein said expression vector comprises a DNA molecule ofclaim
 6. 8. A host cell which expresses a recombinant NHL proteinwherein said host cell contains the expression vector of claim
 7. 9. Aprocess for expressing a NHL protein in a recombinant host cell, 5comprising: (a) transfecting the expression vector of claim 7 into asuitable host cell; and, (b) culturing the host cells of step (a) underconditions which allow expression of said NHL protein from saidexpression vector.
 10. A purified DNA molecule which comprises thenucleotide sequence as set forth in SEQ ID NO:
 1. 11. An expressionvector for expressing a NHL protein in a recombinant host cell whereinsaid expression vector comprises a DNA molecule of claim
 10. 12. A hostcell which expresses a recombinant NHL protein wherein said host cellcontains the expression vector of claim
 11. 13. A purified DNA moleculewhich consists of the nucicotide sequence as set forth in SEQ ID NO: 1.14. An expression vector for expressing a NHL protein in a recombinanthost cell wherein said expression vector comprises a DNA molecule ofclaim
 13. 15. A host cell which expresses a recombinant NHL proteinwherein said host cell contains the expression vector of claim
 14. 16. Apurified DNA molecule of claim 13 which consists of the nucleotidesequence from about nucleotide 828 to about nucleotide 4587, as setforth in SEQ ID NO:
 1. 17. An expression vector for expressing a NHL,protein in a recombinant host cell wherein said expression vectorcomprises a DNA molecule of claim
 16. 18. A host cell which expresses arecombinant NHL protein wherein said host cell contains the expressionvector of claim
 17. 19. A substantially purified NHL protein whichcomprises the amino acid sequence as set forth in SEQ ID NO:
 2. 20. Asubstantially purified NHL protein which consists of the amino acidsequence as set forth in SEQ ID NO:
 2. 21. A substantially purified NHLprotein which comprises the amino acid sequence as set forth in SEQ IDNO: 2, wherein said protein is a product of a DNA expression vectorcomprising SEQ ID NO: 1 and contained within a recombinant host cell.22. A method of identifying modulators of NHL activity, comprising: (a)combining a test compound with a NHL protein, wherein NHL comprises theamino acid sequence as set forth in SEQ ID NO: 2; and, (b) measuring theeffect of the test compound on the NHL protein.
 23. An isolated DNAmolecule which comprises the nucleotide sequence as set forth in SEQ IDNO:
 3. 24. An isolated DNA molecule of claim 20 which comprises fromabout nucleotide 47000 to about nucleotide 85500 of SEQ ID NO:
 3. 25. Anisolated DNA molecule of claim 23 which comprises from about nucleotide47095 to about nucleotide 85316 of SEQ ID NO:
 3. 26. A substantiallypurified NHL protein of claim 21 wherein said protein is a product of aDNA expression vector comprising from about nucleotide 828 to nucleotide4587, as set forth in SEQ ID NO: 1, and contained within a recombinanthost cell.